Nature contents: 07 February 2013

Can't view this email? Click here to view in your browser.     Volume 494 Number 7435      nature •Visit Nature homepage •Subscribe to Nature •View Table of Contents The science that matters. Every week.                       We've got something to show you...! SEARCH - EXPLORE - DISCOVER - IDENTIFY Tap in to find out more             Jump to the content that matters to you View Table of Contents ▶ ▼ News & Comment   ▼ Biological Sciences   ▼ Chemical Sciences   ▼ Physical Sciences   ▼ Earth & Environmental Sciences   ▼ Careers & Jobs       This week's highlights     Physical Sciences More Physical sciences ▼   An outburst from a massive star 40 days before a supernova explosion   Various lines of evidence suggest that massive stars experience extreme mass-loss shortly before they explode as supernovae. This paper reports one such event: 40 days before the explosion of the type IIn supernova SN 2010mc its progenitor underwent an energetic outburst that released 0.01 solar masses of material at velocities of around 2,000 km per second. The close timing of this mass-loss outburst to the supernova explosion suggests that there is a causal connection between these events— a link that would provide a new way of studying pre-supernova massive-star evolution.       Biological Sciences More Biological sciences ▼   Magnetic-field-controlled reconfigurable semiconductor logic   This synthetic biology study both proposes and demonstrates a system for the DNA-based storage of digital information. Data are being produced at an ever-faster rate, requiring an increasing commitment to the maintenance of digital media in the archives. A record amount of information (including images, text and audio files) was encoded in DNA strands. The resulting DNA archive was shipped from California to Germany, the DNA was sequenced and the information recovered. At the current rate of DNA synthesis cost reduction, DNA-based information storage is expected to become cost effective within a decade for archives likely to be accessed rarely — say every 50 years.       Earth & Environmental Sciences More Earth & Environmental sciences ▼   Towards practical, high-capacity, low-maintenance information storage in synthesized DNA   Biodiversity can stabilize ecological systems as different species thrive in different conditions and buffer the impacts of change. Human land management homogenizes ecological systems, which may stabilize yields at the expense of biodiversity. To establish how such change influences ecosystem resilience, Andrew MacDougall and colleagues monitored productive but species-poor grassland that had been under fire prevention measures since the mid-1800s. Despite resilience to climate fluctuations and invasion, the ecosystem collapsed when fire was experimentally re-introduced. Grasslands survived only where there was a high diversity of native plants. These results imply a hidden vulnerability to sudden environmental change in many of the world's ecosystems.                   Nature Biotechnology Focus on DNA Sequencing Technology Performance gains and falling costs have fueled diverse applications of high-throughput DNA sequencing. This focus issue summarizes the current status of these technologies as applied to life sciences and medical research. Click here to access the Focus! Produced with support from Ion Torrent.                 Podcast & Video     In this week's podcast: the Earth's missing crust, the hidden genetic factors that explain trait heritability, and what we don't know about ice.         News & Comment Read daily news coverage▶ ▲top             THIS WEEK           Editorials                   Unknown territory ▶     Japan is making an overdue effort to regulate experimental stem-cell treatments. A clearly defined legal framework is needed to protect patients.             In a hole ▶     It is in Britain's best interests to keep looking for a site for a deep nuclear-waste repository.             Body of evidence ▶     The identification of a long-dead king is not simply an academic event.             World View                   Genetic privacy needs a more nuanced approach ▶     Because confidentiality of health data cannot be guaranteed, people should consider both the risks and advantages of sharing them, argues Misha Angrist.             Seven Days                   Seven days: 1–7 February 2013 ▶     The week in science: Richard III skeleton discovery confirmed; South Korea launches first satellite from home soil; and a keenly watched TB booster vaccine fails a major clinical trial.           NEWS IN FOCUS           Landsat 8 to the rescue ▶     NASA prepares to launch satellite that will continue historic record of global change.             Quake fears rise at Japan's reactors ▶     Commissioners say that geological faults make some reactors too dangerous to restart.             Alert over South Korea toxic leaks ▶     Government moves to tighten oversight after string of hydrogen fluoride accidents.             LHC set to halt for upgrades ▶     Maintenance, improvement work and data analysis will keep scientists busy as collider's planned closure begins.             Campus girds for lean times ▶     Plush San Francisco medical hub seeks to safeguard academic research.             Features                   Climate adaptation: Survival of the flexible ▶     Many tropical species never experience extreme heat or cold. That may doom them in a warming world.             Translational research: Medicine man ▶     As director of the NIH's bold new translational research centre, Christopher Austin has to show that he can jump-start a tortuous drug-discovery process.           COMMENT           Chemistry: Ten things we need to know about ice and snow ▶     Understanding the molecular behaviour of frozen water is essential for predicting the future of our planet, says Thorsten Bartels-Rausch.             Renewable resources: Build a biomass energy market ▶     Governments must offer incentives to drive a switch to biofuels and other renewables, argues Heinz Kopetz.             Books and Arts                   In retrospect: On Growth and Form ▶     Philip Ball celebrates a classic work on the mathematics that shape living structures, from antlers to cells.             Books in brief ▶             Q&A: Chronicler of conflict ▶     Historian Richard Rhodes writes on the roots of violence and warfare, in particular the development of nuclear weapons. He talks about Reykjavik — his play on nuclear disarmament — and his upcoming book on the Spanish Civil War, That Fine Place.             Correspondence                   Science communication: Royal Institution is ever more relevant Gail Cardew | Experimental biology: Sometimes Bayesian statistics are better Stefan Herzog & Dirk Ostwald | Taxonomy: Species splitting puts conservation at risk Frank E. Zachos | International Linear Collider: Another collider is not the way forward Tommy Ohlsson           Obituary                   Brigitte Askonas (1923–2013) ▶     The 'grand dame' of immunology.             Corrections                   Corrections ▶             Correction ▶                         The Vilcek Foundation congratulates Richard A. Flavell and Ruslan Medzhitov, winners of the Vilcek Prize in Biomedical Science. The winners of the Vilcek Prizes for Creative Promise in Biomedical Science are Hashim Al-Hashimi, Michael Rape, and Joanna Wysocka. The Vilcek Prizes honor immigrant contributions to the arts and sciences. Learn more at Vilcek.org.               Biological Sciences ▲top             RESEARCH           Latest Online                   Ageing: Stem cells on a stress-busting diet ▶     Teresa V. Bowman & Leonard I. Zon             FOXO3A directs a protective autophagy program in haematopoietic stem cells ▶     Matthew R. Warr, Mikhail Binnewies, Johanna Flach, Damien Reynaud, Trit Garg et al.     Autophagy is shown to be an essential mechanism that protects haematopoietic stem cells from metabolic stress; the transcription factor FOXO3A maintains a pro-autophagy gene expression program that poises haematopoietic stem cells to rapidly mount a protective autophagic response upon metabolic stress.             NFIB is a governor of epithelial–melanocyte stem cell behaviour in a shared niche ▶     Chiung-Ying Chang, H. Amalia Pasolli, Eugenia G. Giannopoulou, Géraldine Guasch, Richard M. Gronostajski et al.     NFIB, a transcription factor expressed by epithelial hair follicle stem cells, is shown to coordinate the synchronous maturation of hair follicle stem cells and melanocyte stem cells, thus controlling hair regeneration and pigmentation.             A two-step mechanism for TRF2-mediated chromosome-end protection ▶     Keiji Okamoto, Cristina Bartocci, Iliana Ouzounov, Jolene K. Diedrich, John R. Yates III et al.     The telomere-biding protein TRF2 is shown to protect telomeres from activating the DNA-damage response through two mechanisms: preventing the activation ATM kinase through its dimerization domain, in addition to independently suppressing signalling events occurring downstream of ATM.             APOBEC3B is an enzymatic source of mutation in breast cancer ▶     Michael B. Burns, Lela Lackey, Michael A. Carpenter, Anurag Rathore, Allison M. Land et al.     The DNA cytosine deaminase APOBEC3B is shown to be overexpressed and highly active in most breast cancers; deamination by APOBEC3B could serve as an endogenous, continual source of DNA damage leading to mutations, including C-to-T transitions and other aberrations seen in many breast tumours.             Sensitivity of tropical carbon to climate change constrained by carbon dioxide variability ▶     Peter M. Cox, David Pearson, Ben B. Booth, Pierre Friedlingstein, Chris Huntingford et al.     A linear relationship between the sensitivity of tropical land carbon storage to warming and the sensitivity of the annual growth rate of atmospheric CO2 to tropical temperature anomalies provides a tight constraint on the sensitivity of tropical land carbon to climate change.             Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex ▶     Debora Lika Makino, Marc Baumgärtner & Elena Conti     The crystal structure of a complete yeast exosome (Exo-10) bound to a region of the Rrp6 nuclease and an RNA substrate is determined, demonstrating that the exosome binds and degrades RNA molecules with a channelling mechanism that is largely conserved in all kingdoms of life and is similar to the mechanism used by the proteasome to degrade polypeptides.             T-helper-1-cell cytokines drive cancer into senescence ▶     Heidi Braumüller, Thomas Wieder, Ellen Brenner, Sonja Aßmann, Matthias Hahn et al.     T-helper-1-cell cytokines tumour necrosis factor and interferon-γ are shown to drive tumour cells into senescence in a mouse model of β-cell carcinoma and human carcinoma cells.             Finding the sources of missing heritability in a yeast cross ▶     Joshua S. Bloom, Ian M. Ehrenreich, Wesley T. Loo, Thúy-Lan Võ Lite & Leonid Kruglyak     In a cross between two yeast strains, detected loci are found to explain nearly the entire additive contribution to heritable variation for a number of quantitative traits.             Articles and Letters                   The ‘obligate diploid’ Candida albicans forms mating-competent haploids ▶     Meleah A. Hickman, Guisheng Zeng, Anja Forche, Matthew P. Hirakawa, Darren Abbey et al.     Candida albicans is a prominent human fungal pathogen that until now was thought to be an obligate diploid; here it is shown that C. albicans can form viable haploids, that these haploids are able to mate to form heterozygous diploids, and that haploids and their auto-diploids are significantly less fit in vitro and in vivo than heterozygous progenitors or diploids formed by haploid mating pairs.             Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins ▶     Yazan M. Abbas, Andreas Pichlmair, Maria W. Górna, Giulio Superti-Furga & Bhushan Nagar     Crystal structures reveal insight into how interferon-induced proteins with tetratricopeptide repeats (IFITs) selectively recognize viral RNA.             Towards practical, high-capacity, low-maintenance information storage in synthesized DNA ▶     Nick Goldman, Paul Bertone, Siyuan Chen, Christophe Dessimoz, Emily M. LeProust et al.     An efficient and scalable strategy with robust error correction is reported for encoding a record amount of information (including images, text and audio files) in DNA strands; a ‘DNA archive’ has been synthesized, shipped from the USA to Germany, sequenced and the information read.             Diversity loss with persistent human disturbance increases vulnerability to ecosystem collapse ▶     A. S. MacDougall, K. S. McCann, G. Gellner & R. Turkington     Persistent anthropogenic disturbance is shown simultaneously to drive plant species loss and stabilize some attributes of ecosystem function, analogous to a high-yield, low-diversity agricultural system, but increase the likelihood of irreversible collapse after sudden environmental change.             Suppression of neuroinflammation by astrocytic dopamine D2 receptors via αB-crystallin ▶     Wei Shao, Shu-zhen Zhang, Mi Tang, Xin-hua Zhang, Zheng Zhou et al.     Chronic inflammation is a feature of the ageing brain and some neurodegenerative diseases; the authors show that astrocytes normally suppress neuroinflammation through activation of their DRD2 receptor by CRYAB, potentially opening new avenues for treatments.             tmc-1 encodes a sodium-sensitive channel required for salt chemosensation in C. elegans ▶     Marios Chatzigeorgiou, Sangsu Bang, Sun Wook Hwang & William R. Schafer     The membrane protein TMC-1 is required for salt avoidance behaviour in C. elegans, functions as an ion channel directly activated by NaCl in vitro and is a candidate salt chemosensor; the human homologue of TMC-1 is linked to deafness and may be the cochlear hair-cell mechanotransduction channel.             Negligible immunogenicity of terminally differentiated cells derived from induced pluripotent or embryonic stem cells ▶     Ryoko Araki, Masahiro Uda, Yuko Hoki, Misato Sunayama, Miki Nakamura et al.     Immune rejection may limit the therapeutic use of induced pluripotent stem cells (iPSCs); here, terminally differentiated mouse iPSCs are shown to generate negligible immune rejection in their host.             Studying arrhythmogenic right ventricular dysplasia with patient-specific iPSCs ▶     Changsung Kim, Johnson Wong, Jianyan Wen, Shirong Wang, Cheng Wang et al.     This study demonstrates that an inheritable adult onset heart disease can be modelled in vitro within months with the help of metabolic maturation induction.             Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b ▶     Jan-Wilhelm Kornfeld, Catherina Baitzel, A. Christine Könner, Hayley T. Nicholls, Merly C. Vogt et al.     The livers of obese mice and humans show increased levels of miR-802 resulting in impaired glucose tolerance and decreased insulin sensitivity through silencing of Hnf1b, revealing a novel pathway with potential relevance for type 2 diabetes.             Microbiota restricts trafficking of bacteria to mesenteric lymph nodes by CX3CR1hi cells ▶     Gretchen E. Diehl, Randy S. Longman, Jing-Xin Zhang, Beatrice Breart, Carolina Galan et al.     In mice, commensal bacteria are shown to provide critical signals that limit bacterial trafficking to the mesenteric lymph nodes by immune cells, thus preventing the induction of mucosal immune responses.             ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase ▶     Huihao Zhou, Litao Sun, Xiang-Lei Yang & Paul Schimmel     The crystal structure of prolyl tRNA synthetase simultaneously bound to its substrate ATP and its inhibitor halofuginone, a derivative of a compound used to treat malaria, indicates that (through interactions with ATP) halofuginone occupies both the amino acid and tRNA binding sites on the synthetase, revealing a new model for developing synthetase inhibitors.             Mitotic cell rounding accelerates epithelial invagination ▶     Takefumi Kondo & Shigeo Hayashi     Drosophila epithelial tracheal placode invagination is shown to be driven by mitotic cell rounding along with epithelial growth factor receptor signalling and myosin contractility in neighbouring cells, revealing a new cell-division-independent role for mitotic events in morphogenesis.             News & Views                   Microbiology: The life beneath our feet ▶     Janet K. Jansson & James I. Prosser             Neuroscience: Salty sensations ▶     Bertrand Coste & Ardem Patapoutian             Fungal biology: Multiple mating strategies ▶     Neil A. R. Gow             Ageing: Stem cells on a stress-busting diet ▶     Teresa V. Bowman & Leonard I. Zon             Brief Communications Arising                   Looking from both sides ▶     Hellmut Haberland             Corrigenda                   Corrigendum: The zebrafish dorsal axis is apparent at the four-cell stage ▶     Aniket V. Gore, Shingo Maegawa, Albert Cheong, Patrick C. Gilligan, Eric S. Weinberg et al.             Corrigendum: How cancer metabolism is tuned for proliferation and vulnerable to disruption ▶     Almut Schulze & Adrian L. Harris             Corrigendum: Comprehensive genomic characterization defines human glioblastoma genes and core pathways ▶     The Cancer Genome Atlas Research Network             Research Highlights                   Microbiology: Microbes in malnutrition | Ecology: Mosquitoes battle for territory | Microbiology: The bacterial alchemist | Ecology: Cats are enemy number one | Evolution: Bird behaviour spurs evolution | Reproductive biology: Puberty controlled by DNA changes | Molecular biology: Protein production on the clock         NEWS & COMMENT           Unknown territory | Body of evidence | Genetic privacy needs a more nuanced approach | Landsat 8 to the rescue | Campus girds for lean times | Climate adaptation: Survival of the flexible | Translational research: Medicine man | Tracking metastasis and tricking cancer | Renewable resources: Build a biomass energy market | In retrospect: On Growth and Form | Books in brief | Q&A: Chronicler of conflict | Experimental biology: Sometimes Bayesian statistics are better Stefan Herzog & Dirk Ostwald | Taxonomy: Species splitting puts conservation at risk Frank E. Zachos | Brigitte Askonas (1923–2013)             More Biological Sciences ▶                         Nature Reprint Collection on Epigenetics This collection of articles focuses on histone methylation, its links to human disease and the development of chemical modulators of histone methylation states as leads for chromatin-targeted drug discovery. Produced exclusively with support from Epizyme.               Chemical Sciences ▲top             RESEARCH           Latest Online                   Sensitivity of tropical carbon to climate change constrained by carbon dioxide variability ▶     Peter M. Cox, David Pearson, Ben B. Booth, Pierre Friedlingstein, Chris Huntingford et al.     A linear relationship between the sensitivity of tropical land carbon storage to warming and the sensitivity of the annual growth rate of atmospheric CO2 to tropical temperature anomalies provides a tight constraint on the sensitivity of tropical land carbon to climate change.             Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex ▶     Debora Lika Makino, Marc Baumgärtner & Elena Conti     The crystal structure of a complete yeast exosome (Exo-10) bound to a region of the Rrp6 nuclease and an RNA substrate is determined, demonstrating that the exosome binds and degrades RNA molecules with a channelling mechanism that is largely conserved in all kingdoms of life and is similar to the mechanism used by the proteasome to degrade polypeptides.             Articles and Letters                   Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins ▶     Yazan M. Abbas, Andreas Pichlmair, Maria W. Górna, Giulio Superti-Furga & Bhushan Nagar     Crystal structures reveal insight into how interferon-induced proteins with tetratricopeptide repeats (IFITs) selectively recognize viral RNA.             Towards practical, high-capacity, low-maintenance information storage in synthesized DNA ▶     Nick Goldman, Paul Bertone, Siyuan Chen, Christophe Dessimoz, Emily M. LeProust et al.     An efficient and scalable strategy with robust error correction is reported for encoding a record amount of information (including images, text and audio files) in DNA strands; a ‘DNA archive’ has been synthesized, shipped from the USA to Germany, sequenced and the information read.             ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase ▶     Huihao Zhou, Litao Sun, Xiang-Lei Yang & Paul Schimmel     The crystal structure of prolyl tRNA synthetase simultaneously bound to its substrate ATP and its inhibitor halofuginone, a derivative of a compound used to treat malaria, indicates that (through interactions with ATP) halofuginone occupies both the amino acid and tRNA binding sites on the synthetase, revealing a new model for developing synthetase inhibitors.             Research Highlights                   Microbiology: The bacterial alchemist         NEWS & COMMENT           Alert over South Korea toxic leaks | Chemistry: Ten things we need to know about ice and snow | Brigitte Askonas (1923–2013)             More Chemical Sciences ▶               Physical Sciences ▲top             RESEARCH           Latest Online                   Crystal structure of an RNA-bound 11-subunit eukaryotic exosome complex ▶     Debora Lika Makino, Marc Baumgärtner & Elena Conti     The crystal structure of a complete yeast exosome (Exo-10) bound to a region of the Rrp6 nuclease and an RNA substrate is determined, demonstrating that the exosome binds and degrades RNA molecules with a channelling mechanism that is largely conserved in all kingdoms of life and is similar to the mechanism used by the proteasome to degrade polypeptides.             Articles and Letters                   Structural basis for viral 5′-PPP-RNA recognition by human IFIT proteins ▶     Yazan M. Abbas, Andreas Pichlmair, Maria W. Górna, Giulio Superti-Furga & Bhushan Nagar     Crystal structures reveal insight into how interferon-induced proteins with tetratricopeptide repeats (IFITs) selectively recognize viral RNA.             An outburst from a massive star 40 days before a supernova explosion ▶     E. O. Ofek, M. Sullivan, S. B. Cenko, M. M. Kasliwal, A. Gal-Yam et al.     A mass-loss event 40 days before the explosion of the type IIn supernova SN 2010mc has been detected; the outburst indicates that there is a causal relation between explosive mass-loss events seen in some massive stars before their explosion and the onset of the supernova explosion.             Reconstructing state mixtures from diffraction measurements ▶     Pierre Thibault & Andreas Menzel     An imaging technique has been developed to characterize state mixtures caused by partial coherence and fluctuations in dynamical systems.             Magnetic-field-controlled reconfigurable semiconductor logic ▶     Sungjung Joo, Taeyueb Kim, Sang Hoon Shin, Ju Young Lim, Jinki Hong et al.     A microchannel made from InSb, which has current–voltage characteristics that are strongly dependent on the sign and magnitude of an applied magnetic field, is used to demonstrate that circuits made from such structures can be programmed — and reprogrammed — to perform elementary logic functions, such as AND, OR, NAND and NOR.             Towards practical, high-capacity, low-maintenance information storage in synthesized DNA ▶     Nick Goldman, Paul Bertone, Siyuan Chen, Christophe Dessimoz, Emily M. LeProust et al.     An efficient and scalable strategy with robust error correction is reported for encoding a record amount of information (including images, text and audio files) in DNA strands; a ‘DNA archive’ has been synthesized, shipped from the USA to Germany, sequenced and the information read.             ATP-directed capture of bioactive herbal-based medicine on human tRNA synthetase ▶     Huihao Zhou, Litao Sun, Xiang-Lei Yang & Paul Schimmel     The crystal structure of prolyl tRNA synthetase simultaneously bound to its substrate ATP and its inhibitor halofuginone, a derivative of a compound used to treat malaria, indicates that (through interactions with ATP) halofuginone occupies both the amino acid and tRNA binding sites on the synthetase, revealing a new model for developing synthetase inhibitors.             Reviews and Perspectives                   Spin–orbit coupling in quantum gases ▶     Victor Galitski & Ian B. Spielman     The current experimental and theoretical status of spin–orbit coupling in ultracold atomic systems is discussed, highlighting unique features that enable otherwise impossible physics.             News & Views                   Solid-state physics: A new spin on spintronics ▶     Sayeef Salahuddin             Astrophysics: Going supernova ▶     Alexander Heger             Brief Communications Arising                   Looking from both sides ▶     Hellmut Haberland             Research Highlights                   Physics: A tabletop neutron source         NEWS & COMMENT           LHC set to halt for upgrades | In retrospect: On Growth and Form | Books in brief | Experimental biology: Sometimes Bayesian statistics are better Stefan Herzog & Dirk Ostwald | International Linear Collider: Another collider is not the way forward Tommy Ohlsson           CAREERS           Turning point: Yogesh Joglekar             More Physical Sciences ▶               Earth & Environmental Sciences ▲top             RESEARCH           Latest Online                   Climate science: Global warming and tropical carbon ▶     James T. Randerson             Earth science: All rise for the case of the missing magma ▶     John Maclennan             Thin crust as evidence for depleted mantle supporting the Marion Rise ▶     Huaiyang Zhou & Henry J. B. Dick     Systematic sampling along the Marion Rise of the Southwest Indian Ridge reveals that its crust is discontinuous and thin, indicating that the rise is supported by low-density depleted mantle beneath it.             Sensitivity of tropical carbon to climate change constrained by carbon dioxide variability ▶     Peter M. Cox, David Pearson, Ben B. Booth, Pierre Friedlingstein, Chris Huntingford et al.     A linear relationship between the sensitivity of tropical land carbon storage to warming and the sensitivity of the annual growth rate of atmospheric CO2 to tropical temperature anomalies provides a tight constraint on the sensitivity of tropical land carbon to climate change.             Articles and Letters                   Northern Hemisphere forcing of Southern Hemisphere climate during the last deglaciation ▶     Feng He, Jeremy D. Shakun, Peter U. Clark, Anders E. Carlson, Zhengyu Liu et al.     Changes in ocean circulation are the most plausible explanation for the early Southern Hemisphere deglacial warming and its lead over Northern Hemisphere temperature.             Diversity loss with persistent human disturbance increases vulnerability to ecosystem collapse ▶     A. S. MacDougall, K. S. McCann, G. Gellner & R. Turkington     Persistent anthropogenic disturbance is shown simultaneously to drive plant species loss and stabilize some attributes of ecosystem function, analogous to a high-yield, low-diversity agricultural system, but increase the likelihood of irreversible collapse after sudden environmental change.             News & Views                   Microbiology: The life beneath our feet ▶     Janet K. Jansson & James I. Prosser             Climate science: Global warming and tropical carbon ▶     James T. Randerson             Earth science: All rise for the case of the missing magma ▶     John Maclennan             Corrigendum                   Corrigendum: Closing yield gaps through nutrient and water management ▶     Nathaniel D. Mueller, James S. Gerber, Matt Johnston, Deepak K. Ray, Navin Ramankutty et al.             Erratum                   Erratum: Making sense of palaeoclimate sensitivity ▶     PALAEOSENS Project Members             Research Highlights                   Ecology: Mosquitoes battle for territory | Atmospheric science: Jet-stream shifts linked to ozone | Ecology: Cats are enemy number one         NEWS & COMMENT           Landsat 8 to the rescue | Quake fears rise at Japan's reactors | Climate adaptation: Survival of the flexible | Chemistry: Ten things we need to know about ice and snow             More Earth & Environmental Sciences ▶               Specials - Technology Feature ▲top               Tracking metastasis and tricking cancer ▶     Physics- and engineering-based approaches are helping researchers stop the spread of cancer by anticipating tumour cells' moves and habits.                  Careers & Jobs ▲top               Communication: Two minutes to impress ▶     With ruthless revision, researchers can compose a punchy 'elevator speech' to sell their science to a neighbour, potential employer or politician.                   Turning point: Yogesh Joglekar ▶     Mentoring younger students helps to boost theoretical physicist's profile.                   A voice for adjunct staff ▶     Contingent faculty members should have a say in setting university policy.                   Bias in UK recruitment ▶     White men dominate UK professoriate.                   Minority enrolment falls ▶     US bans on affirmative action linked to reduction in number of minority graduate students in science.                   Careers related news & comment                   Alert over South Korea toxic leaks | Campus girds for lean times | Translational research: Medicine man | Science communication: Royal Institution is ever more relevant Gail Cardew             naturejobs.com Science jobs of the week       Senior Scientific Writer     The Jackson Laboratory for Genomic Medicine            Assistant Professor     University of Manitoba            PhD-Position     University of Regensburg, Molecular and Cellular Anatomy            Research Technician     UNIVERSITY OF SUSSEX          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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