TABLE OF CONTENTS
| 09 January 2013 | Volume 32, Issue 1 |  | | |  |  Have you seen?
Review
Articles
Corrigendum
Also new
 AOP | | | |  | | Advertisement | | | | | | Have you seen? | Top | |  | | Neurulation: coordinating cell polarisation and lumen formation In this issue of EMBO J, Buckley et al (2013) describe how neural progenitors undergo highly coordinated apicobasal polarisation required for neural rod midline formation and lumen opening within the zebrafish embryo. Julien Compagnon and Carl-Philipp Heisenberg The EMBO Journal (2013), 32, 1 - 3; 10.1038/emboj.2012.325 Abstract | Full text | PDF | Related article Published online: 04 December 2012 | | | | Double SET point: G9a makes its mark in adipogenesis Histone H3K9 methyltransferase G9a inhibits adipocyte differentiation by repressing PPARgamma. Ana G Cristancho and Mitchell A Lazar The EMBO Journal (2013), 32, 4 - 6; 10.1038/emboj.2012.320 Abstract | Full text | PDF | Related article Published online: 27 November 2012 | | | | The guardian: metabolic and tumour-suppressive effects of SIRT6 In a landmark paper recently published in Cell, Mostoslavsky and colleagues provide the first direct evidence for SIRT6 as tumour suppressor by switching the cellular metabolism. Batya Lerrer and Haim Y Cohen The EMBO Journal (2013), 32, 7 - 8; 10.1038/emboj.2012.332 Abstract | Full text | PDF | Related article Published online: 11 December 2012 | | Review | Top | | | | OXPHOS mutations and neurodegeneration This review surveys neurodegenerative diseases that are caused by defects in mitochondrial oxidative phosphorylation (OXPHOS), which result from mutations in subunits or assembly factors of the respiratory chain or in genes involved in mtDNA maintenance, replication, transcription and translation. Werner J H Koopman, Felix Distelmaier, Jan AM Smeitink and Peter HGM Willems The EMBO Journal (2013), 32, 9 - 29; 10.1038/emboj.2012.300 Abstract | Full text | PDF | Supp. info. Published online: 13 November 2012 Subject Categories: Cellular Metabolism | Neuroscience | Molecular Biology of Disease | | Articles | Top | | | | Mirror-symmetric microtubule assembly and cell interactions drive lumen formation in the zebrafish neural rod Cell division is not required for polarity establishment during neural rod lumen formation in zebrafish. In contrast, symmetric microtubule organisation along the tissue midline and cellular interdigitation localise apical junctional proteins around the tissue midline. Clare E Buckley, Xiaoyun Ren, Laura C Ward, Gemma C Girdler, Claudio Araya, Mary J Green, Brian S Clark, Brian A Link and Jonathan D W Clarke The EMBO Journal (2013), 32, 30 - 44; 10.1038/emboj.2012.305 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 30 November 2012 Subject Categories: Cell and Tissue Architecture | Development | | | | Histone H3K9 methyltransferase G9a represses PPARγ expression and adipogenesis G9a inhibits adipocyte differentiation through histone-methyl-transferase-dependent and -independent regulation of PPARγ and Wnt10a, respectively. Lifeng Wang, Shiliyang Xu, Ji-Eun Lee, Anne Baldridge, Sean Grullon, Weiqun Peng and Kai Ge The EMBO Journal (2013), 32, 45 - 59; 10.1038/emboj.2012.306 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 November 2012 Subject Categories: Chromatin and Transcription | Differentiation and Death | | | | Dissecting the mechanisms of Notch induced hyperplasia This genome-wide approach characterizes the repertoire of Notch targets in proliferative growth. Extensive functional categorizations offer significant new insights into regulatory circuits that govern Notch-mediated hyperplasia. Alexandre Djiane, Alena Krejci, Frédéric Bernard, Silvie Fexova, Katherine Millen and Sarah J Bray The EMBO Journal (2013), 32, 60 - 71; 10.1038/emboj.2012.326 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 December 2012 Subject Categories: Signal Transduction | Genomic and Computational Biology | | | | MEK1 inactivates Myt1 to regulate Golgi membrane fragmentation and mitotic entry in mammalian cells The MEK1 kinase is required for early stages of Golgi fragmentation during mitosis, but its downstream effectors have been elusive. The ER/Golgi-localized protein Myt1 is inactivated in a MEK1-dependent manner to promote Golgi membrane fragmentation and mitotic entry. Julien Villeneuve, Margherita Scarpa, Maria Ortega-Bellido and Vivek Malhotra The EMBO Journal (2013), 32, 72 - 85; 10.1038/emboj.2012.329 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 December 2012 Subject Categories: Membranes and Transport | Signal Transduction | Cell Cycle | | | | TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis Pathogens activate innate immune receptors, triggering inflammasome formation and cell death (pyroptosis). Inflammosome activation is sufficient for release of the chemotactic protein HMGB1 and pyroptosis. Additional signalling events are required to convert HMGB1 into a TLR4 agonist. Sanna Nyström, Daniel J Antoine, Peter Lundbäck, John G Lock, Andreia F Nita, Kari Högstrand, Alf Grandien, Helena Erlandsson-Harris, Ulf Andersson and Steven E Applequist The EMBO Journal (2013), 32, 86 - 99; 10.1038/emboj.2012.328 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 December 2012 Subject Categories: Immunology | | | | The alarmin Mrp8/14 as regulator of the adaptive immune response during allergic contact dermatitis Mrp8/14, an amplifier of innate immune responses, has distinct roles in the adaptive immune system, preventing its hyper-activation by regulating dendritic cell maturation and antigen presentation. Beatrix Petersen, Marc Wolf, Judith Austermann, Peter van Lent, Dirk Foell, Martina Ahlmann, Verena Kupas, Karin Loser, Clemens Sorg, Johannes Roth and Thomas Vogl The EMBO Journal (2013), 32, 100 - 111; 10.1038/emboj.2012.309 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 November 2012 Subject Categories: Immunology | | | | APLF promotes the assembly and activity of non-homologous end joining protein complexes In response to DNA double-strand breaks, Aprataxin-and-PNK-Like Factor (APLF) interacts with Ku80 and assembles a platform for sequential recruitment of several activities into vertebrate NHEJ repair complexes. Gabrielle J Grundy, Stuart L Rulten, Zhihong Zeng, Raquel Arribas-Bosacoma, Natasha Iles, Katie Manley, Antony Oliver and Keith W Caldecott The EMBO Journal (2013), 32, 112 - 125; 10.1038/emboj.2012.304 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 November 2012 Subject Categories: Genome Stability and Dynamics | | | | The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1 Distinct functional properties of the two mammalian single-strand DNA-binding activities, RPA and the hSSB1-containing SOSS1 complex, underlie their preferential involvement in replication and in DNA double-strand break resection, respectively. Soo-Hyun Yang, Ruobo Zhou, Judith Campbell, Junjie Chen, Taekjip Ha and Tanya T Paull The EMBO Journal (2013), 32, 126 - 139; 10.1038/emboj.2012.314 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 November 2012 Subject Categories: Genome Stability and Dynamics | | | | A gene loop containing the floral repressor FLC is disrupted in the early phase of vernalization Arabidopsis flowering requires a cold spell (vernalization) involving downregulation of the FLC flowing repressor, which is linked to a gene loop between the 5′ and 3′ regions of the FLC locus. Loop formation is disrupted during cold exposure coinciding with downregulation of FLC expression and accumulation of antisense transcripts. Pedro Crevillén, Cagla Sonmez, Zhe Wu and Caroline Dean The EMBO Journal (2013), 32, 140 - 148; 10.1038/emboj.2012.324 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 December 2012 Subject Categories: Plant Biology | | | | Auxin reflux between the endodermis and pericycle promotes lateral root initiation The auxin efflux carrier PIN3 regulates auxin transport from the endoderm to pericycle founder cells to promote lateral root formation in Arabidopsis. Peter Marhavý, Marleen Vanstraelen, Bert De Rybel, Ding Zhaojun, Malcolm J Bennett, Tom Beeckman and Eva Benková The EMBO Journal (2013), 32, 149 - 158; 10.1038/emboj.2012.303 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 23 November 2012 Subject Categories: Plant Biology | | Corrigendum | Top | | | | TLR activation regulates damage-associated molecular pattern isoforms released during pyroptosis Sanna Nyström, Daniel J Antoine, Peter Lundbäck, John G Lock, Andreia F Nita, Kari Högstrand, Alf Grandien, Helena Erlandsson-Harris, Ulf Andersson and Steven E Applequist The EMBO Journal (2013), 32, 172; 10.1038/emboj.2012.344 Full text | PDF Published online: 09 January 2013 | | | | Advertisement | | | | | | Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. 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