Nature Reviews Neuroscience contents January 2013 Volume 14 Number 1 pp 1-75

TABLE OF CONTENTS
January 2013 Volume 14 Number 1
Impact Factor 30.455 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Neurotrophin regulation of neural circuit development and function Hyungju Park & Mu-ming Poo
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RESEARCH HIGHLIGHTS Top Cognitive neuroscience: Rules of neural engagement p1 | doi:10.1038/nrn3417 A new study suggests that synchronization in neuronal assemblies in the dorsolateral prefrontal cortex supports rule selection. PDF Circadian rhythms: Light hits mood head-on p2 | doi:10.1038/nrn3410 Alterations in the light-dark cycle can cause depression and learning deficits without disrupting circadian rhythms or sleep. LeGates et al. show that light exposure detected by intrinsically photosensitive retinal ganglion cells directly influences mood. PDF Learning and memory: Teaching the accumbens a valuable lesson p2 | doi:10.1038/nrn3419 The role of GABAergic projections from the ventral tegmental area to the nucleus accumbens (NAc) in associative learning is poorly understood. Brown et al. now show that these neurons terminate on a class of interneurons only sparsely represented in the NAc and enhance associative learning by halting their tonic firing. PDF Functional imaging: Peeling back the layers of BOLD p3 | doi:10.1038/nrn3408 The neurovascular mechanisms that underlie functional MRI are still unclear. Now, Goense et al. show that positive and negative responses arise from different, layer-specific processes. PDF Psychiatric disorders: A motivating microcircuit p4 | doi:10.1038/nrn3415 An optogenetic study reveals a medial prefrontal cortex-dorsal raphe nucleus pathway that specifically controls action selection in a challenging environment. PDF Learning and memory: Stressful pathways to memory p4 | doi:10.1038/nrn3416 This study shows that stress-induced glucocorticoid signalling acts rapidly through various signalling pathways to promote memory consolidation. PDF Immunotherapy: Immunological bullets against Alzheimer's disease p4 | doi:10.1038/nrn3418 p40-specific antibodies ameliorate pathology in a mouse model of Alzheimer's disease. PDF IN BRIEF Pain: Placebo and personality | Neurodegenerative disease: Immune cell migration in Huntington's disease | Sensory processing: Inhibition in the awake cortex | Behavioural neuroscience: Don't stand so close to me ... | Taste receptors: Sensing nutrients from within | Sensory systems: Converging on olfactory white | Techniques: The active hunt for ribosomes | Neurogenesis: The α-synuclein influence PDF Neuroscience JOBS of the week PostDoc Position in Systems Neurophysiology Laboratory of Cortico-Hippocampal Interactions, Center for Integrative Neuroscience, University of Tuebingen Postdoctoral fellow Galit Pelled Regulatory Compliance Manager Allen Institute for Brain Science Multiple Faculty Positions Bilkent University, Department of Psychology PhD Position in Human Genetics / Neurogenetics / Bioinformatics / Functional Genomics Max Planck Institute for Psycholinguistics (MPI) More Science jobs from Neuroscience EVENT Biomarkers for Brain Disorders: Challenges and Opportunities 03.-05.02.13 Cambridge, UK More science events from
REVIEWS		Top
Neurotrophin regulation of neural circuit development and function Hyungju Park & Mu-ming Poo p7 | doi:10.1038/nrn3379 Neurotrophins are key regulators of neural circuit development and function. In this Review, Park and Poo examine the mechanisms underlying this regulation, with a specific focus on brain-derived neurotrophic factor — the most widely expressed and studied neurotrophin in the brain. Abstract | Full Text | PDF
Wired on sugar: the role of the CNS in the regulation of glucose homeostasis Bernadette E. Grayson, Randy J. Seeley & Darleen A. Sandoval p24 | doi:10.1038/nrn3409 Sandoval and colleagues discuss emerging evidence for a role of the CNS in the regulation of glucose homeostasis and show that this regulation involves several neural circuits and mechanisms that also control energy balance. Disruption of these overlapping pathways may link the metabolic impairments that are associated with obesity and type 2 diabetes. Abstract | Full Text | PDF
The many faces of α-synuclein: from structure and toxicity to therapeutic target Hilal A. Lashuel, Cassia R. Overk, Abid Oueslati & Eliezer Masliah p38 | doi:10.1038/nrn3406 The abnormal accumulation of α-synuclein seems to have a central role in the pathophysiology of Parkinson's disease and related disorders. Masliah and colleagues review current knowledge regarding the conformational, oligomerization and aggregation states of this protein and how they influence α-synuclein function in health and disease. Abstract | Full Text | PDF
The NaV1.7 sodium channel: from molecule to man Sulayman D. Dib-Hajj, Yang Yang, Joel A. Black & Stephen G. Waxman p49 | doi:10.1038/nrn3404 Mutations in SCN9A, which encodes the voltage-gated sodium channel NaV1.7, can lead to severe neuropathic pain in humans. In this Review, Waxman and colleagues examine the mechanistic basis of NaV1.7-linked pain and explore strategies for targeting this channel in pain therapy. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION What are the mechanisms for analogue and digital signalling in the brain? Dominique Debanne, Andrzej Bialowas & Sylvain Rama p63 | doi:10.1038/nrn3361 In CNS neurons, the somatic membrane potential is subject to subthreshold analogue modulation. This analogue component increases the information content of action potentials and has important implications for information processing in neural networks. Abstract | Full Text | PDF
OPINION The circadian clock: a framework linking metabolism, epigenetics and neuronal function Selma Masri & Paolo Sassone-Corsi p69 | doi:10.1038/nrn3393 In this Opinion article, Masri and Sassone-Corsi discuss the complex interconnections between circadian rhythms, metabolic processes and epigenetic regulation of gene transcription. They propose that cellular metabolic state and epigenetic mechanisms might work through the circadian clock to regulate neuronal function and influence disease states. Abstract | Full Text | PDF
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