Nature Reviews Microbiology contents January 2013 Volume 11 Number 1 pp 1-66

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TABLE OF CONTENTS
January 2013 Volume 11 Number 1
Impact Factor 21.182 *	In this issue Editorial Research Highlights News and Analysis Progress Reviews Perspectives Also this month  Featured article: Cell death in parasitic protozoa: regulated or incidental? William R. Proto, Graham H. Coombs & Jeremy C. Mottram
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EDITORIAL		Top
The cultural revolution p1 | doi:10.1038/nrmicro2948 Despite the revolutionary advances made through the application of omic approaches, the importance of studying organisms in pure culture should not be forgotten. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Parasitology: Layers of control for Plasmodium protein export p3 | doi:10.1038/nrmicro2947 A second level of export control for Plasmodium falciparum effectors is uncovered. PDF Host response: PO-faced response to SFV p4 | doi:10.1038/nrmicro2933 The phenoloxidase (PO) cascade is an additional weapon in the antiviral armoury of the mosquito. PDF Bacterial virulence: SteC actin rearrangements, step by step p4 | doi:10.1038/nrmicro2936 This study reveals the signalling cascade that is activated by SteC and leads to actin accumulation at Salmonella-containing vacuoles. PDF Bacterial physiology: Solving the MatP compaction puzzle p6 | doi:10.1038/nrmicro2932 A combination of genetic, biochemical and structural approaches reveals how the nucleoid-associated protein MatP compacts the E. coli chromosome using a bridging mechanism. PDF Bacterial pathogenesis: Salmonella's skeleton key p6 | doi:10.1038/nrmicro2938 A single T3SS effector protein from S. Typhimurium can expand the narrow host range of S. Typhi by targeting the RAB32-dependent trafficking pathway, which controls the composition of the SCV. PDF Antimicrobials: Leaky barrier boosts antibiotic action p7 | doi:10.1038/nrmicro2931 Rather than inhibiting bacterial growth by completely blocking protein synthesis, macrolide antibiotics permit the translation of a distinct subset of proteins, and this could be even more detrimental to the bacterial cell. PDF IN BRIEF Host response: Killer histones | Bacterial physiology: Pass the (LPS) parcel | Parasite physiology: Moving like Toxoplasma | Environmental microbiology: Zero-valent sulphur and marine methane oxidation | Bacterial physiology: Dual-action riboswitch | Fungal pathogenesis: Fungal fist in a velvet glove PDF Microbiology JOBS of the week Professor of Systems Biology of Microbiology Nankai University Faculty Positions of Professor of Systems Biology of Microbiology, Professor of Synthetic Biology of Microbiology Nankai University Tenure-Track Faculty Position - Geomicrobiology Open Rank Faculty joint with the Department of Microbiology and Molecular Genetics Michigan State University Microbiology / Virology Director Level Positions - Center for Immunology and Infectious Disease SRI International, Biosciences Division Microbiology Faculty Position University of Chicago More Science jobs from Microbiology EVENT Pharmaceutical Microbiology 30. - 31.01.2013 London, United Kingdom More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Genomic polish for shoe-leather epidemiology Steven Y. C. Tong p8 | doi:10.1038/nrmicro2935 This month's Genome Watch describes the advantages of using whole-genome sequencing data for infectious-disease surveillance and infection control. PDF
PROGRESS		Top
Bacterial DNA repair: recent insights into the mechanism of RecBCD, AddAB and AdnAB Dale B. Wigley p9 | doi:10.1038/nrmicro2917 Repair of double-strand DNA breaks by homologous recombination can be carried out in bacteria by RecBCD, AddAB and AdnAB. Here, Dale Wigley discusses recent insights into how these complexes mediate repair, as well as their evolution. Abstract | Full Text | PDF
Co-dependents: MR1-restricted MAIT cells and their antimicrobial function Marielle C. Gold & David M. Lewinsohn p14 | doi:10.1038/nrmicro2918 Mucosal-associated invariant T (MAIT) cells have an intrinsic capacity to recognize a broad microbial repertoire through their invariant T cell receptor, which interacts with antigen presented by MHC class I-related protein 1 (MR1). Here, Marielle Gold and David Lewinsohn highlight recent insights suggesting that this unique, 'innate' T cell subset plays an important part in the early recognition and containment of infection. Abstract | Full Text | PDF
REVIEWS		Top
Regulation of fungal secondary metabolism Axel A. Brakhage p21 | doi:10.1038/nrmicro2916 Fungi produce a diverse array of secondary metabolites that have a range of functions and great pharmacological potential. In this Review, Axel Brakhage describes the regulatory pathways governing the production of these secondary metabolites and discusses how this knowledge provides a new avenue for drug discovery. Abstract | Full Text | PDF
The Bacillus subtilis endospore: assembly and functions of the multilayered coat Peter T. McKenney, Adam Driks & Patrick Eichenberger p33 | doi:10.1038/nrmicro2921 Sporulation in Bacillus subtilis results in the formation of an endospore surrounded by a multilayered protective structure, known as the coat. In this Review, Patrick Eichenberger and colleagues describe recent studies that have illuminated the architecture of the coat and the dynamics of coat assembly. Abstract | Full Text | PDF
RNase E: at the interface of bacterial RNA processing and decay George A. Mackie p45 | doi:10.1038/nrmicro2930 The endoribonuclease RNase E is widespread in bacteria and is crucial for the control of RNA metabolism in the cell. In this Review, George Mackie discusses the role of RNase E in stable RNA processing and mRNA decay, and proposes a new model to reconcile the dynamics of RNA metabolism with the cellular localization of this enzyme. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Cell death in parasitic protozoa: regulated or incidental? William R. Proto, Graham H. Coombs & Jeremy C. Mottram p58 | doi:10.1038/nrmicro2929 Regulated cell death is a key process in plant and animal development, but does it occur in parasitic protozoa? Jeremy Mottram and colleagues assess the evidence of regulated cell death in these organisms and propose that protozoan cell death should be classified as either necrotic or incidental. Abstract | Full Text | PDF
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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