Nature Reviews Immunology Contents January 2013 Volume 13 Number 1 pp 1-66

TABLE OF CONTENTS
January 2013 Volume 13 Number 1
Impact Factor 33.287 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Mechanisms of T cell tolerance towards the allogeneic fetus Adrian Erlebacher
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RESEARCH HIGHLIGHTS Top Inflammasome: Turning on and off NLRP3 p1 | doi:10.1038/nri3366 Ca2+ and cAMP, as well as NO, regulate the assembly of the NLRP3 inflammasome. PDF Lymphocyte development: PAXIP1 — a gatekeeper of thymocyte development p2 | doi:10.1038/nri3367 PAXIP1 controls transcription and double-strand break repair during thymocyte development. PDF Immunotherapy: Immunological bullets against Alzheimer's disease p2 | doi:10.1038/nri3368 p40-specific antibodies ameliorate pathology in a mouse model of Alzheimer's disease. PDF T cell responses: Antiviral immunity ticks both T-boxes p3 | doi:10.1038/nri3372 EOMES and T-bet regulate the balance between T cell proliferation and cytotoxic function during chronic viral infection. PDF HIV: A dead calm p4 | doi:10.1038/nri3364 Apoptotic microparticles in the serum of patients with HIV block dendritic cell activation. PDF Antibodies: Getting the trigger the right way round p4 | doi:10.1038/nri3378 IgG concentrations determine the binding orientation of IgG on S. pyogenes and thus opsonization and killing. PDF Cell migration: Pericytes — route planners p5 | doi:10.1038/nri3371 Pericytes interact with innate immune cells to promote their interstitial migration and effector functions. PDF Autoimmunity: Particulate promotion of tolerance p6 | doi:10.1038/nri3373 Antigen-coupled nanoparticles induce T cell tolerance and can attenuate autoimmune disease. PDF Mucosal immunology: Bewildered progenitors p6 | doi:10.1038/nri3377 Colitis involves the cytokine-driven expansion and differentiation of HSCs and GMPs. PDF IN BRIEF Regulatory T cells: The role of PTPN22 in T cell homeostasis | T cell responses: A colitis-associated glycome on CD4+ T cells | Immunometabolism: Adipose tissue inflammation | Macrophages: SOCS2 and SOCS3 in macrophage polarization | Mucosal immunology: IRF3 maintains gut homeostasis | Gene regulation: STATs control subset-specific enhancer activation PDF Immunology JOBS of the week Postdoctoral Positions in Inflammatory Signaling and Epigenetic Regulation in Immunology and Osteoimmunology Hospital for Special Surgery at Weill Cornell Medical College Technical (Field) Sales Specialist- Molecular biology / Immunology / Cells Hudson Shribman Scientfic Recruitment Ltd Postdoctoral Fellowships in Immunology Trinity College Dublin / St. James's Hospital Postdoctoral Position in Immunology University of Chicago PhD Student and Postdoc Positions in Tumor Immunology and Cancer Stem Cell Research University Clinics Freiburg More Science jobs from Immunology EVENT 5th ImmunoTherapeutics & ImmunoMonitoring 31.01.-01.02.13 San Diego, US More science events from
REVIEWS		Top
Eosinophils: changing perspectives in health and disease Helene F. Rosenberg, Kimberly D. Dyer & Paul S. Foster p9 | doi:10.1038/nri3341 This Review describes the unique biology of the eosinophil. The authors explain how eosinophils interact with other leukocyte populations to promote protective immunity following infection. They also discuss the pathological roles of eosinophils in allergic-type diseases, such as asthma and the hypereosinophilic syndromes. Abstract | Full Text | PDF | Supplementary information
Mechanisms of T cell tolerance towards the allogeneic fetus Adrian Erlebacher p23 | doi:10.1038/nri3361 Several mechanisms exist to prevent immune-mediated rejection of the allogeneic fetus. Here, Adrian Erlebacher provides an in-depth review of recent advances in our understanding of the mechanisms that control the responses of maternal T cells to antigens expressed by the conceptus. Abstract | Full Text | PDF
Thrombosis as an intravascular effector of innate immunity Bernd Engelmann & Steffen Massberg p34 | doi:10.1038/nri3345 Thrombosis is the most frequent cause of mortality worldwide. In this Review, the authors propose that thrombosis might also have a conserved physiological role in immune defence via a process termed immunothrombosis. However, if uncontrolled, immunothrombosis facilitates pathological clot formation. Abstract | Full Text | PDF | Supplementary information
The broad-spectrum antiviral functions of IFIT and IFITM proteins Michael S. Diamond & Michael Farzan p46 | doi:10.1038/nri3344 Recent interest in identifying interferon-stimulated genes that have activity against a wide range of viruses has advanced our understanding of the IFIT and IFITM families and shown the many mechanisms by which host factors can restrict viral replication. Abstract | Full Text | PDF
PERSPECTIVES		Top
VIEWPOINT The resolution of inflammation Christopher D. Buckley, Derek W. Gilroy, Charles N. Serhan, Brigitta Stockinger & Paul P. Tak p59 | doi:10.1038/nri3362 In this Viewpoint article, five leading immunologists discuss the processes involved in the resolution of inflammation. Could drugs that promote pro-resolution pathways be more effective than drugs that block pro-inflammatory mediators in treating certain chronic inflammatory diseases? The contributors debate this and other key issues in the field. Abstract | Full Text | PDF
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