Nature Reviews Genetics Contents January 2013 Volume 14 Number 1 pp 1-75

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TABLE OF CONTENTS
January 2013 Volume 14 Number 1
Impact Factor 38.075 *	In this issue Comment Research Highlights Reviews Correspondence Also this month Article series: Study designs  Featured article: Studying genomic processes at the single-molecule level: introducing the tools and applications David Dulin, Jan Lipfert, M. Charl Moolman & Nynke H. Dekker
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Comment: The nature of confounding in genome-wide association studies Bjarni J. Vilhjalmsson & Magnus Nordborg p1 | doi:10.1038/nrg3382 Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Disease genomics: Seeking rarer variants for less p3 | doi:10.1038/nrg3387 PDF Small RNA: RNAi doesn't overdo it p4 | doi:10.1038/nrg3388 PDF Epigenetics: Bacterial DNA methylation gets SMRT p4 | doi:10.1038/nrg3389 PDF Evolution: Explosive human genetic variation p5 | doi:10.1038/nrg3390 PDF Human epigenetics: Showing your age p6 | doi:10.1038/nrg3391 PDF Evolution: Positively selecting CTCF binding p6 | doi:10.1038/nrg3392 PDF Genomics: Sequence resources for crucial crops p6 | doi:10.1038/nrg3393 PDF IN BRIEF Phylogenetics: Efficient method for estimating divergence times | Translational genomics: Sequencing to detect tumour DNA in circulation | Molecular profiling: mRNA profiling of activated neurons | Mouse models: Uncovering the unexpected for Cre | Stem cells: TAFs regulate stem cell promoters | Gene expression: Human cytomegalovirus protein repertoire | Genome instability: A U-turn for mutagenesis? | Chromatin: pH regulation by histone acetylation PDF Genetics JOBS of the week Postdoctoral Scientist - Genetics of Longevity University of Colorado Anschutz Medical Campus Post-doctoral Research Fellow – Statistical Genetics Fred Hutchinson Cancer Research Center Postdoctoral Position in Phylogeny & Population Genetics Institute of Population Genetics, Vetmeduni Vienna Postdoctoral Research Fellow - Cardiovascular Genetics MERCK & COMPANY INC. Faculty in Analytic and Translational Genetics Massachusetts General Hospital More Science jobs from Genetics EVENT Complex Disease Genetics for Clinicians 24.-25.01.13 Cambridge, UK More science events from
REVIEWS		Top
Studying genomic processes at the single-molecule level: introducing the tools and applications David Dulin, Jan Lipfert, M. Charl Moolman & Nynke H. Dekker p9 | doi:10.1038/nrg3316 This Review introduces the applications of single-molecule approaches to the study of genomic processes such as transcription and translation. The authors explain the basic principles of key techniques and provide examples of recent insights from in vitro and in vivo studies. Abstract | Full Text | PDF
Article series: Study designs Cancer pharmacogenomics: strategies and challenges Heather E. Wheeler, Michael L. Maitland, M. Eileen Dolan, Nancy J. Cox & Mark J. Ratain p23 | doi:10.1038/nrg3352 In addition to somatic mutations in tumours, inherited genetic variants can influence how a patient with cancer responds to drug treatment. This Review considers best practice in design and analysis for pharmacogenomic studies to identify such variants, potentially leading to personalized oncology. Abstract | Full Text | PDF
Next-generation proteomics: towards an integrative view of proteome dynamics A. F. Maarten Altelaar, Javier Munoz & Albert J. R. Heck p35 | doi:10.1038/nrg3356 Despite their complexity and dynamics, proteomes are starting to be comprehensively characterized; this has been made possible particularly by various technical advances in mass spectrometry. This Review highlights how proteomic studies are contributing to our understanding of various cellular processes in health and disease. Abstract | Full Text | PDF
How important are transposons for plant evolution? Damon Lisch p49 | doi:10.1038/nrg3374 Transposable elements are important sources of genetic and epigenetic variation in plant genomes. The author discusses the evidence that this variation has been important for plant evolution and how new genomic resources should allow a systematic assessment of this issue. Abstract | Full Text | PDF
Chromatin and the genome integrity network Manolis Papamichos-Chronakis & Craig L. Peterson p62 | doi:10.1038/nrg3345 A potential role for chromatin in the maintenance of genome integrity has recently emerged. The potential roles for chromatin regulators in coordinating signalling from chromatin during the replication and repair processes, in addition to evidence for a role for chromatin remodellers in accurate segregation, are presented. Abstract | Full Text | PDF | Supplementary information
CORRESPONDENCE		Top
Correspondence: Mining electronic health records: an additional perspective John F. Hurdle, Ken R. Smith & Geraldine P. Mineau p75 | doi:10.1038/nrg3208-c1 Full Text | PDF
REPLY		Top
Reply: Reply to 'Mining electronic health records: an additional perspective' Peter B. Jensen, Lars J. Jensen & Soren Brunak p75 | doi:10.1038/nrg3208-c2 Full Text | PDF
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