Nature Immunology Contents: January 2013 Volume 14 pp 1 - 99

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ReichertSPR.com TABLE OF CONTENTS January 2013 Volume 14, Issue 1 Meeting Report Commentary News and Views Research Highlights Review Articles Resource Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Reviews Immunology POSTER-THE IMMUNE RESPONSE TO HIV Authors: Nina Bhardwaj, Florian Hladik and Susan Moir www.nature.com/nri/posters/hiv Produced with support from STEMCELL Technologies   Meeting Report Top Antibody gene transfer for HIV immunoprophylaxis   pp1 - 5 Alejandro B Balazs and Anthony P West Jr doi:10.1038/ni.2480 Commentary Top Job-search basics: how to convert a CV into a resume   pp6 - 9 Derek Haseltine doi:10.1038/ni.2453 News and Views Top T. rex attacks the lysosome   pp10 - 12 Anna Katharina Simon and Andrea Ballabio doi:10.1038/ni.2497 The mechanisms by which cells detect and fight foreign organisms is crucial for the host defense against infection. The sensing of cytosolic DNA is pivotal in this process, is kept in check by the exonuclease Trex1 and has been linked to lysosomal biogenesis via the transcription factor TFEB in an interferon-independent manner. See also: Article by Hasan et al. Just say NO to NLRP3   pp12 - 14 Manira Rayamajhi and Edward A Miao doi:10.1038/ni.2493 Feedback inhibition by interferon-γ blocks the NLRP3 inflammasome by triggering inducible nitric oxide synthase (iNOS), and the resulting nitric oxide (NO) thio-nitrosylates NLRP3, shutting it down. This prevents excessive immunopathology during chronic infection with Mycobacterium tuberculosis. See also: Article by Mishra et al. Learning in motion: pericytes instruct migrating innate leukocytes   pp14 - 15 Ronen Alon and Sussan Nourshargh doi:10.1038/ni.2489 During sterile inflammation, emigrating leukocytes sequentially engage subsets of pericytes associated with blood vessels and acquire adhesive, migratory and survival signals. See also: Article by Stark et al. Act1-hsp90 heats up TH17 inflammation   pp16 - 17 Pawan Kumar and Jay K Kolls doi:10.1038/ni.2498 Psoriasis is associated with the TH17 subset of helper T cells. Dysregulation of interleukin 17 (IL-17) signaling leads to enhanced TH17 differentiation, more production of IL-22 and IL-22-dependent skin inflammation. See also: Article by Wang et al. Immunology JOBS of the week Postdoctoral position in Immunology and Immunotherapy Inserm (French Institute of Health and Medical Research) Postdoctoral Fellowship in Microbiology / Immunology Prof Kristian Riesbeck Microbiology / Virology Director Level Positions - Center for Immunology and Infectious Disease SRI International, Biosciences Division Manager outsourcing clinical immunology Crucell Holland B.V. Postdoc Position in Immunology Novartis More Science jobs from Immunology EVENT 5th ImmunoTherapeutics & ImmunoMonitoring 31st Jan - 1st Feb 2013 San Diego, US More science events from Research Highlights Top Viral infection: the clot thickens | Mimicking nickel allergy | It takes two | Activation by calcium | Building enhancers | Plasma-cell survival Review Top STING and the innate immune response to nucleic acids in the cytosol   pp19 - 26 Dara L Burdette and Russell E Vance doi:10.1038/ni.2491 Articles Top ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system   pp27 - 33 Amy E Lin, Gregor Ebert, Yongkai Ow, Simon P Preston, Jesse G Toe, James P Cooney, Hamish W Scott, Masato Sasaki, Samuel D Saibil, Dilan Dissanayake, Raymond H Kim, Andrew Wakeham, Annick You-Ten, Arda Shahinian, Gordon Duncan, Jennifer Silvester, Pamela S Ohashi, Tak W Mak and Marc Pellegrini doi:10.1038/ni.2478 ARIH2 is a RING-between-RING E3 ligase. Pellegrini and colleagues show that ARIH2 is needed to limit excessive NF-κB signaling in DCs. Loss of ARIH2 is associated with embryonic death due to excessive inflammatory responses. Neutrophil infiltration during inflammation is regulated by PILRα via modulation of integrin activation   pp34 - 40 Jing Wang, Ikuo Shiratori, Junji Uehori, Masahito Ikawa and Hisashi Arase doi:10.1038/ni.2456 Modulation of integrin activation can contribute to regulation of inflammation. Arase and colleagues demonstrate that PILRα, an ITIM-containing inhibitory receptor, negatively regulates integrin activation and neutrophil infiltration during inflammation. Capillary and arteriolar pericytes attract innate leukocytes exiting through venules and 'instruct' them with pattern-recognition and motility programs   pp41 - 51 Konstantin Stark, Annekathrin Eckart, Selgai Haidari, Anca Tirniceriu, Michael Lorenz, Marie-Luise von Brühl, Florian Gärtner, Alexander Georg Khandoga, Kyle R Legate, Robert Pless, Ingrid Hepper, Kirsten Lauber, Barbara Walzog and Steffen Massberg doi:10.1038/ni.2477 The signals involved in coordinating the navigation of myeloid cells in tissues are incompletely understood. Massberg and colleagues show that NG2+ pericytes control the pattern and efficacy of interstitial leukocyte migration. See also: News and Views by Alon & Nourshargh Nitric oxide controls the immunopathology of tuberculosis by inhibiting NLRP3 inflammasome-dependent processing of IL-1β   pp52 - 60 Bibhuti B Mishra, Vijay A K Rathinam, Gregory W Martens, Amanda J Martinot, Hardy Kornfeld, Katherine A Fitzgerald and Christopher M Sassetti doi:10.1038/ni.2474 Chronic infections can result in harmful production of the proinflammatory cytokine IL-1 generated via the NLRP3 inflammasome. Sassetti et al. demonstrate that IL-1 activated by Mycobacteria results in nitrosylation and consequent regulation of the NLRP3 inflammasome. See also: News and Views by Rayamajhi & Miao Trex1 regulates lysosomal biogenesis and interferon-independent activation of antiviral genes   pp61 - 71 Maroof Hasan, James Koch, Dinesh Rakheja, Asit K Pattnaik, James Brugarolas, Igor Dozmorov, Beth Levine, Edward K Wakeland, Min Ae Lee-Kirsch and Nan Yan doi:10.1038/ni.2475 Trex1 is a cytosolic exonuclease that limits sensing of intracellular DNA. Yan and colleagues show that Trex1 deficiency spontaneously heightens adaptor STING-dependent proinflammatory responses via a pathway involving regulation of lysosomal biogenesis. See also: News and Views by Simon & Ballabio The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90   pp72 - 81 Chenhui Wang, Ling Wu, Katarzyna Bulek, Bradley N Martin, Jarod A Zepp, Zizhen Kang, Caini Liu, Tomasz Herjan, Saurav Misra, Julie A Carman, Ji Gao, Ashok Dongre, Shujie Han, Kevin D Bunting, Jennifer S Ko, Hui Xiao, Vijay K Kuchroo, Wenjun Ouyang and Xiaoxia Li doi:10.1038/ni.2479 Psoriasis is associated with heightened TH17 responses. Li and colleagues show that the IL-17R signaling adaptor Act1 requires the chaperone protein hsp90. Defective signaling leads to exuberant IL-22 production and enhanced disease. See also: News and Views by Kumar & Kolls Conformational states of the kinase Lck regulate clustering in early T cell signaling   pp82 - 89 Jérémie Rossy, Dylan M Owen, David J Williamson, Zhengmin Yang and Katharina Gaus doi:10.1038/ni.2488 Gaus and colleagues show that the conformational states of the tyrosine kinase Lck intrinsically control its distribution and clustering at the plasma membrane. Resource Top Shared and distinct transcriptional programs underlie the hybrid nature of iNKT cells   pp90 - 99 Nadia R Cohen, Patrick J Brennan, Tal Shay, Gerald F Watts, Manfred Brigl, Joonsoo Kang, Michael B Brenner and ImmGen Project Consortium doi:10.1038/ni.2490 Using the Immunological Genome compendium, Brenner and colleagues shed light on the transcriptional programs that operate during the course of iNKT cell development and in peripheral CD4+ and CD4- iNKT cell subsets. 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