TABLE OF CONTENTS
| January 2013 Volume 45, Issue 1 |  | | |  |  Editorial
Correspondence
Meeting Report
News and Views
Research Highlights
Articles
Letters | | | | | | | Advertisement |  | Nature Biotechnology
Focus on DNA Sequencing Technology
Performance gains and falling costs have fueled diverse applications of high-throughput DNA sequencing. This focus issue summarizes the current status of these technologies as applied to life sciences and medical research.
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Produced with support from:  | | | | | Editorial |  Top | |  | | Genomics, bears, fruit p1
doi:10.1038/ng.2519
The origins of three species and the adaptive evolution of their genomes under natural and agricultural selection are investigated in this issue. | | Correspondence | Top | | | | The classification of intestinal polyposis p2
Peh Yean Cheah, Kiat Hon Lim, Poh Koon Koh and Choong Leong Tang
doi:10.1038/ng.2474
See also: Correspondence by Tomlinson et al. | | | | Reply to "The classification of intestinal polyposis" pp2 - 3
Ian Tomlinson, Emma Jaeger, Simon Leedham and Huw Thomas
doi:10.1038/ng.2475
See also: Correspondence by Cheah et al. | | Meeting Report | Top | | | | Translating genes into health pp4 - 5
Larry J Kricka and Chiara Di Resta
doi:10.1038/ng.2510
A major challenge for genomics is to provide clinical benefits to the genetically diverse human population. Genome science has achieved a catalog of mutations and informative SNPs. Next-generation sequencing is rapidly delivering thousands of complete human genomes, but understanding and applying genomic knowledge remains a daunting undertaking. These challenges and opportunities for genomic medicine were central themes of the Golden Helix Symposium held in Turin, Italy, 18-21 April 2012. | | News and Views | Top | | | | | | Research Highlights | Top | | | | Recurrent fusion in pediatric AMKL | TREM2 and Alzheimer's disease | Migration from trees to graphs | MED12 in cancer drug resistance | Autism candidate gene resequencing | Articles | Top | | | | Integrated genomic analyses identify ARID1A and ARID1B alterations in the childhood cancer neuroblastoma pp12 - 17
Mark Sausen, Rebecca J Leary, Siân Jones, Jian Wu, C Patrick Reynolds, Xueyuan Liu, Amanda Blackford, Giovanni Parmigiani, Luis A Diaz Jr, Nickolas Papadopoulos, Bert Vogelstein, Kenneth W Kinzler, Victor E Velculescu & Michael D Hogarty
doi:10.1038/ng.2493
Victor Velculescu, Michael Hogarty and colleagues report whole-genome and exome sequences of neuroblastoma, the most common solid tumor in children. They identify recurrent somatic mutations in the chromatin-remodeling genes ARID1A and ARID1B. | | | | Recurrent SETBP1 mutations in atypical chronic myeloid leukemia pp18 - 24
Rocco Piazza, Simona Valletta, Nils Winkelmann, Sara Redaelli, Roberta Spinelli, Alessandra Pirola, Laura Antolini, Luca Mologni, Carla Donadoni, Elli Papaemmanuil, Susanne Schnittger, Dong-Wook Kim, Jacqueline Boultwood, Fabio Rossi, Giuseppe Gaipa, Greta P De Martini, Paola Francia di Celle, Hyun Gyung Jang, Valeria Fantin, Graham R Bignell, Vera Magistroni, Torsten Haferlach, Enrico Maria Pogliani, Peter J Campbell, Andrew J Chase, William J Tapper, Nicholas C P Cross & Carlo Gambacorti-Passerini
doi:10.1038/ng.2495
Carlo Gambacorti-Passerini and colleagues identify recurrent SETBP1 mutations in atypical chronic myeloid leukemia. The mutations, which cluster in a small region of SETBP1, are associated with high white blood cell counts and poor prognosis. | | | | Large-scale association analysis identifies new risk loci for coronary artery disease pp25 - 33
The CARDIoGRAMplusC4D Consortium, Panos Deloukas, Stavroula Kanoni, Christina Willenborg, Martin Farrall, Themistocles L Assimes, John R Thompson, Erik Ingelsson, Danish Saleheen, Jeanette Erdmann, Benjamin A Goldstein, Kathleen Stirrups, Inke R König, Jean-Baptiste Cazier, Åsa Johansson, Alistair S Hall, Jong-Young Lee, Cristen J Willer, John C Chambers, Tõnu Esko, Lasse Folkersen, Anuj Goel, Elin Grundberg, Aki S Havulinna, Weang K Ho, Jemma C Hopewell, Niclas Eriksson, Marcus E Kleber, Kati Kristiansson, Per Lundmark, Leo-Pekka Lyytikäinen, Suzanne Rafelt, Dmitry Shungin, Rona J Strawbridge, Gudmar Thorleifsson, Emmi Tikkanen, Natalie Van Zuydam, Benjamin F Voight, Lindsay L Waite, Weihua Zhang, Andreas Ziegler, Devin Absher, David Altshuler, Anthony J Balmforth, Inês Barroso, Peter S Braund, Christof Burgdorf, Simone Claudi-Boehm, David Cox, Maria Dimitriou, Ron Do, DIAGRAM Consortium, CARDIOGENICS Consortium, Alex S F Doney, NourEddine El Mokhtari, Per Eriksson, Krista Fischer, Pierre Fontanillas, Anders Franco-Cereceda, Bruna Gigante, Leif Groop, Stefan Gustafsson, Jörg Hager, Göran Hallmans, Bok-Ghee Han, Sarah E Hunt, Hyun M Kang, Thomas Illig, Thorsten Kessler, Joshua W Knowles, Genovefa Kolovou, Johanna Kuusisto, Claudia Langenberg, Cordelia Langford, Karin Leander, Marja-Liisa Lokki, Anders Lundmark, Mark I McCarthy, Christa Meisinger, Olle Melander, Evelin Mihailov, Seraya Maouche, Andrew D Morris, Martina Müller-Nurasyid, MuTHER Consortium, Kjell Nikus, John F Peden, N William Rayner, Asif Rasheed, Silke Rosinger, Diana Rubin, Moritz P Rumpf, Arne Schäfer, Mohan Sivananthan, Ci Song, Alexandre F R Stewart, Sian-Tsung Tan, Gudmundur Thorgeirsson, C Ellen van der Schoot, Peter J Wagner, Wellcome Trust Case Control Consortium, George A Wells, Philipp S Wild, Tsun-Po Yang, Philippe Amouyel, Dominique Arveiler, Hanneke Basart, Michael Boehnke, Eric Boerwinkle, Paolo Brambilla, Francois Cambien, Adrienne L Cupples, Ulf de Faire, Abbas Dehghan, Patrick Diemert, Stephen E Epstein, Alun Evans, Marco M Ferrario, Jean Ferrières, Dominique Gauguier, Alan S Go, Alison H Goodall, Villi Gudnason, Stanley L Hazen, Hilma Holm, Carlos Iribarren, Yangsoo Jang, Mika Kähönen, Frank Kee, Hyo-Soo Kim, Norman Klopp, Wolfgang Koenig, Wolfgang Kratzer, Kari Kuulasmaa, Markku Laakso, Reijo Laaksonen, Ji-Young Lee, Lars Lind, Willem H Ouwehand, Sarah Parish, Jeong E Park, Nancy L Pedersen, Annette Peters, Thomas Quertermous, Daniel J Rader, Veikko Salomaa, Eric Schadt, Svati H Shah, Juha Sinisalo, Klaus Stark, Kari Stefansson, David-Alexandre Trégouët, Jarmo Virtamo, Lars Wallentin, Nicholas Wareham, Martina E Zimmermann, Markku S Nieminen, Christian Hengstenberg, Manjinder S Sandhu, Tomi Pastinen, Ann-Christine Syvänen, G Kees Hovingh, George Dedoussis, Paul W Franks, Terho Lehtimäki, Andres Metspalu, Pierre A Zalloua, Agneta Siegbahn, Stefan Schreiber, Samuli Ripatti, Stefan S Blankenberg, Markus Perola, Robert Clarke, Bernhard O Boehm, Christopher O'Donnell, Muredach P Reilly, Winfried März, Rory Collins, Sekar Kathiresan, Anders Hamsten, Jaspal S Kooner, Unnur Thorsteinsdottir, John Danesh, Colin N A Palmer, Robert Roberts, Hugh Watkins, Heribert Schunkert & Nilesh J Samani
doi:10.1038/ng.2480
Panos Deloukas, Nilesh Samani and colleagues report a large-scale association analysis using the Metabochip array in 63,746 coronary artery disease cases and 130,681 controls. They identify 15 susceptibility loci, refine previous associations and use network analysis to highlight biological pathways. | | | | H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs pp34 - 42
Jiekai Chen, He Liu, Jing Liu, Jing Qi, Bei Wei, Jiaqi Yang, Hanquan Liang, You Chen, Jing Chen, Yaran Wu, Lin Guo, Jieying Zhu, Xiangjie Zhao, Tianran Peng, Yixin Zhang, Shen Chen, Xuejia Li, Dongwei Li, Tao Wang and Duanqing Pei
doi:10.1038/ng.2491
Duanqing Pei and colleagues show that BMP signaling to histone H3 lysine 9 methylation is a barrier to reprogramming somatic cells into induced pluripotent cells (iPSCs) and that its removal promotes the formation of fully reprogrammed iPSCs from pre-iPSCs. pre-iPSCs exhibit pluripotent properties but do not activate the core pluripotent network. | | | | Genome-wide association study dissects the genetic architecture of oil biosynthesis in maize kernels pp43 - 50
Hui Li, Zhiyu Peng, Xiaohong Yang, Weidong Wang, Junjie Fu, Jianhua Wang, Yingjia Han, Yuchao Chai, Tingting Guo, Ning Yang, Jie Liu, Marilyn L Warburton, Yanbing Cheng, Xiaomin Hao, Pan Zhang, Jinyang Zhao, Yunjun Liu, Guoying Wang, Jiansheng Li and Jianbing Yan
doi:10.1038/ng.2484
Maize oil is an important food and energy source. Now, Jianbing Yan and colleagues report a genome-wide association study in maize for maize kernel oil composition. They analyzed 368 maize lines with 1.06 million SNPs genome-wide and found 74 loci associated with maize kernel oil concentration and fatty acid composition. | | | | The draft genome of watermelon (Citrullus lanatus) and resequencing of 20 diverse accessions pp51 - 58
Shaogui Guo, Jianguo Zhang, Honghe Sun, Jerome Salse, William J Lucas, Haiying Zhang, Yi Zheng, Linyong Mao, Yi Ren, Zhiwen Wang, Jiumeng Min, Xiaosen Guo, Florent Murat, Byung-Kook Ham, Zhaoliang Zhang, Shan Gao, Mingyun Huang, Yimin Xu, Silin Zhong, Aureliano Bombarely, Lukas A Mueller, Hong Zhao, Hongju He, Yan Zhang, Zhonghua Zhang, Sanwen Huang, Tao Tan, Erli Pang, Kui Lin, Qun Hu, Hanhui Kuang, Peixiang Ni, Bo Wang, Jingan Liu, Qinghe Kou, Wenju Hou, Xiaohua Zou, Jiao Jiang, Guoyi Gong, Kathrin Klee, Heiko Schoof, Ying Huang, Xuesong Hu, Shanshan Dong, Dequan Liang, Juan Wang, Kui Wu, Yang Xia, Xiang Zhao, Zequn Zheng, Miao Xing, Xinming Liang, Bangqing Huang, Tian Lv, Junyi Wang, Ye Yin, Hongping Yi, Ruiqiang Li, Mingzhu Wu, Amnon Levi, Xingping Zhang, James J Giovannoni, Jun Wang, Yunfu Li, Zhangjun Fei & Yong Xu
doi:10.1038/ng.2470
Zhangjun Fei and colleagues report the draft genome of a Chinese elite watermelon inbred line 97103 and resequencing of 20 diverse accessions that represent the three subspecies of Citrullus lunatus. Comparative genome-wide analyses identify the extent of genetic diversity and population structure of watermelon germplasm.
See also: News and Views by Wincker | | | | The draft genome of sweet orange (Citrus sinensis) pp59 - 66
Qiang Xu, Ling-Ling Chen, Xiaoan Ruan, Dijun Chen, Andan Zhu, Chunli Chen, Denis Bertrand, Wen-Biao Jiao, Bao-Hai Hao, Matthew P Lyon, Jiongjiong Chen, Song Gao, Feng Xing, Hong Lan, Ji-Wei Chang, Xianhong Ge, Yang Lei, Qun Hu, Yin Miao, Lun Wang, Shixin Xiao, Manosh Kumar Biswas, Wenfang Zeng, Fei Guo, Hongbo Cao, Xiaoming Yang, Xi-Wen Xu, Yun-Jiang Cheng, Juan Xu, Ji-Hong Liu, Oscar Junhong Luo, Zhonghui Tang, Wen-Wu Guo, Hanhui Kuang, Hong-Yu Zhang, Mikeal L Roose, Niranjan Nagarajan, Xiu-Xin Deng & Yijun Ruan
doi:10.1038/ng.2472
Yijun Ruan and colleagues report the draft genome of the sweet orange, Citrus sinensis. Their data suggests sweet orange originated from a cross between pummelo and mandarin.
See also: News and Views by Wincker | | Letters | Top | | | | Whole-genome sequencing of giant pandas provides insights into demographic history and local adaptation pp67 - 71
Shancen Zhao, Pingping Zheng, Shanshan Dong, Xiangjiang Zhan, Qi Wu, Xiaosen Guo, Yibo Hu, Weiming He, Shanning Zhang, Wei Fan, Lifeng Zhu, Dong Li, Xuemei Zhang, Quan Chen, Hemin Zhang, Zhihe Zhang, Xuelin Jin, Jinguo Zhang, Huanming Yang, Jian Wang, Jun Wang and Fuwen Wei
doi:10.1038/ng.2494
Fuwen Wei, Jun Wang and colleagues report whole-genome sequencing of 34 wild giant pandas. Their population genetic analysis provides insights into demographic history and local adaptation. | | | | Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma pp72 - 75
De-Ke Jiang, Jielin Sun, Guangwen Cao, Yao Liu, Dongxin Lin, Yu-Zhen Gao, Wei-Hua Ren, Xi-Dai Long, Hongxing Zhang, Xiao-Pin Ma, Zhong Wang, Wei Jiang, Tao-Yang Chen, Yong Gao, Liang-Dan Sun, Ji-Rong Long, Hui-Xing Huang, Dan Wang, Hongjie Yu, Pengyin Zhang, Li-Sha Tang, Bo Peng, Hao Cai, Ting-Ting Liu, Ping Zhou, Fang Liu, Xiaoling Lin, Sha Tao, Bo Wan, He-Xi Ge Sai-Yin, Lun-Xiu Qin, Jianhua Yin, Li Liu, Chen Wu, Yan Pei, Yuan-Feng Zhou, Yun Zhai, Pei-Xin Lu, Aihua Tan, Xian-Bo Zuo, Jia Fan, Jiang Chang, Xiaoli Gu, Neng-Jin Wang, Yang Li, Yin-Kun Liu, Kan Zhai, Hongwei Zhang, Zhibin Hu, Jun Liu, Qing Yi, Yongbing Xiang, Rong Shi, Qiang Ding, Wei Zheng, Xiao-Ou Shu, Zengnan Mo, Yin Yao Shugart, Xue-Jun Zhang, Gangqiao Zhou, Hongbing Shen, S Lilly Zheng, Jianfeng Xu & Long Yu
doi:10.1038/ng.2483
Long Yu and colleagues report a genome-wide association study for hepatitis B virus-related hepatocellular carcinoma (HBV-HCC). They report that genetic variants in STAT4 and HLA-DQ genes confer risk of HBV-HCC. | | | | New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism pp76 - 82
Momoko Horikoshi, Hanieh Yaghootkar, Dennis O Mook-Kanamori, Ulla Sovio, H Rob Taal, Branwen J Hennig, Jonathan P Bradfield, Beate St Pourcain, David M Evans, Pimphen Charoen, Marika Kaakinen, Diana L Cousminer, Terho Lehtimäki, Eskil Kreiner-Møller, Nicole M Warrington, Mariona Bustamante, Bjarke Feenstra, Diane J Berry, Elisabeth Thiering, Thiemo Pfab, Sheila J Barton, Beverley M Shields, Marjan Kerkhof, Elisabeth M van Leeuwen, Anthony J Fulford, Zoltán Kutalik, Jing Hua Zhao, Marcel den Hoed, Anubha Mahajan, Virpi Lindi, Liang-Kee Goh, Jouke-Jan Hottenga, Ying Wu, Olli T Raitakari, Marie N Harder, Aline Meirhaeghe, Ioanna Ntalla, Rany M Salem, Karen A Jameson, Kaixin Zhou, Dorota M Monies, Vasiliki Lagou, Mirna Kirin, Jani Heikkinen, Linda S Adair, Fowzan S Alkuraya, Ali Al-Odaib, Philippe Amouyel, Ehm Astrid Andersson, Amanda J Bennett, Alexandra I F Blakemore, Jessica L Buxton, Jean Dallongeville, Shikta Das, Eco J C de Geus, Xavier Estivill, Claudia Flexeder, Philippe Froguel, Frank Geller, Keith M Godfrey, Frédéric Gottrand, Christopher J Groves, Torben Hansen, Joel N Hirschhorn, Albert Hofman, Mads V Hollegaard, David M Hougaard, Elina Hyppönen, Hazel M Inskip, Aaron Isaacs, Torben Jørgensen, Christina Kanaka-Gantenbein, John P Kemp, Wieland Kiess, Tuomas O Kilpeläinen, Norman Klopp, Bridget A Knight, Christopher W Kuzawa, George McMahon, John P Newnham, Harri Niinikoski, Ben A Oostra, Louise Pedersen, Dirkje S Postma, Susan M Ring, Fernando Rivadeneira, Neil R Robertson, Sylvain Sebert, Olli Simell, Torsten Slowinski, Carla M T Tiesler, Anke Tönjes, Allan Vaag, Jorma S Viikari, Jacqueline M Vink, Nadja Hawwa Vissing, Nicholas J Wareham, Gonneke Willemsen, Daniel R Witte, Haitao Zhang, Jianhua Zhao, The Meta-Analyses of Glucose- and Insulin-related traits Consortium (MAGIC) & James F Wilson, Michael Stumvoll, Andrew M Prentice, Brian F Meyer, Ewan R Pearson, Colin A G Boreham, Cyrus Cooper, Matthew W Gillman, George V Dedoussis, Luis A Moreno, Oluf Pedersen, Maiju Saarinen, Karen L Mohlke, Dorret I Boomsma, Seang-Mei Saw, Timo A Lakka, Antje Körner, Ruth J F Loos, Ken K Ong, Peter Vollenweider, Cornelia M van Duijn, Gerard H Koppelman, Andrew T Hattersley, John W Holloway, Berthold Hocher, Joachim Heinrich, Chris Power, Mads Melbye, Mònica Guxens, Craig E Pennell, Klaus Bønnelykke, Hans Bisgaard, Johan G Eriksson, Elisabeth Widén, Hakon Hakonarson, André G Uitterlinden, Anneli Pouta, Debbie A Lawlor, George Davey Smith, Timothy M Frayling, Mark I McCarthy, Struan F A Grant, Vincent W V Jaddoe, Marjo-Riitta Jarvelin, Nicholas J Timpson, Inga Prokopenko & Rachel M Freathy for Early Growth Genetics (EGG) Consortium
doi:10.1038/ng.2477
Rachel Freathy and colleagues report results of a large-scale genome-wide association study of birth weight. They identify four loci newly associated with this trait and find overlap between birth weight-associated loci and those influencing adult height and metabolism. | | | | Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy pp83 - 87
Thomas Cullup, Ay Lin Kho, Carlo Dionisi-Vici, Birgit Brandmeier, Frances Smith, Zoe Urry, Michael A Simpson, Shu Yau, Enrico Bertini, Verity McClelland, Mohammed Al-Owain, Stefan Koelker, Christian Koerner, Georg F Hoffmann, Frits A Wijburg, Amber E ten Hoedt, R Curtis Rogers, David Manchester, Rie Miyata, Masaharu Hayashi, Elizabeth Said, Doriette Soler, Peter M Kroisel, Christian Windpassinger, Francis M Filloux, Salwa Al-Kaabi, Jozef Hertecant, Miguel Del Campo, Stefan Buk, Istvan Bodi, Hans-Hilmar Goebel, Caroline A Sewry, Stephen Abbs, Shehla Mohammed, Dragana Josifova, Mathias Gautel and Heinz Jungbluth
doi:10.1038/ng.2497
Heinz Jungbluth and colleagues report the identification of mutations in EPG5 that cause Vici syndrome, characterized by callosal agenesis, cataracts, cardiomyopathy, combined immunodeficiency and hypopigmentation. EPG5 encodes a regulator of autophagy, and the identified mutations cause defective autophagosomal function. | | | | Mutations in GNAL cause primary torsion dystonia pp88 - 92
Tania Fuchs, Rachel Saunders-Pullman, Ikuo Masuho, Marta San Luciano, Deborah Raymond, Stewart Factor, Anthony E Lang, Tsao-Wei Liang, Richard M Trosch, Sierra White, Edmond Ainehsazan, Denis Hervé, Nutan Sharma, Michelle E Ehrlich, Kirill A Martemyanov, Susan B Bressman & Laurie J Ozelius
doi:10.1038/ng.2496
Laurie Ozelius and colleagues identify mutations in GNAL in families with primary torsion dystonia, a movement disorder characterized by repetitive twisting muscle contractions and postures. GNAL encodes G[alpha]olf, a stimulatory G protein [alpha] subunit. | | | | Mutations in AP2S1 cause familial hypocalciuric hypercalcemia type 3 pp93 - 97
M Andrew Nesbit, Fadil M Hannan, Sarah A Howles, Anita A C Reed, Treena Cranston, Clare E Thakker, Lorna Gregory, Andrew J Rimmer, Nigel Rust, Una Graham, Patrick J Morrison, Steven J Hunter, Michael P Whyte, Gil McVean, David Buck and Rajesh V Thakker
doi:10.1038/ng.2492
Rajesh Thakker and colleagues show that missense mutations affecting codon 15 of AP2S1 cause familial hypocalciuric hypercalcemia type 3, a disorder of calcium homeostasis. AP2S1 encodes a protein involved in clathrin-mediated endocytosis, and the mutations probably cause disease by disrupting internalization of the calcium-sensing receptor CaSR. | | | | Dclk1 distinguishes between tumor and normal stem cells in the intestine pp98 - 103
Yuki Nakanishi, Hiroshi Seno, Ayumi Fukuoka, Taro Ueo, Yuichi Yamaga, Takahisa Maruno, Naoko Nakanishi, Keitaro Kanda, Hideyuki Komekado, Mayumi Kawada, Akihiro Isomura, Kenji Kawada, Yoshiharu Sakai, Motoko Yanagita, Ryoichiro Kageyama, Yoshiya Kawaguchi, Makoto M Taketo, Shin Yonehara and Tsutomu Chiba
doi:10.1038/ng.2481
Hiroshi Seno and colleagues report that Dclk1 selectively marks intestinal tumor stem cells. They further show that specific ablation of these cells in a mouse tumor model results in a pronounced regression of polyps without apparent damage to normal intestinal tissue.
See also: News and Views by Metcalfe & de Sauvage | | | | MCT1-mediated transport of a toxic molecule is an effective strategy for targeting glycolytic tumors pp104 - 108
Kivanç Birsoy, Tim Wang, Richard Possemato, Omer H Yilmaz, Catherine E Koch, Walter W Chen, Amanda W Hutchins, Yetis Gultekin, Tim R Peterson, Jan E Carette, Thijn R Brummelkamp, Clary B Clish & David M Sabatini
doi:10.1038/ng.2471
David Sabatini and colleagues report an insertional mutagenesis screen in haploid cells for resistance to the cancer drug candidate 3-bromopyruvate (3-BrPA). They find that SLC16A1, the gene that encodes MCT1, is frequently inactivated. MCT1 expression is required and sufficient for 3-BrPA uptake by cancer cells and may be used to predict cancers that are sensitive to 3-BrPA. | | | | Emergence and global spread of epidemic healthcare-associated Clostridium difficile pp109 - 113
Miao He, Fabio Miyajima, Paul Roberts, Louise Ellison, Derek J Pickard, Melissa J Martin, Thomas R Connor, Simon R Harris, Derek Fairley, Kathleen B Bamford, Stephanie D'Arc, Jon Brazier, Derek Brown, John E Coia, Gill Douce, Dale Gerding, Hee Jung Kim, Tse Hsien Koh, Haru Kato, Mitsutoshi Senoh, Tom Louie, Stephen Michell, Emma Butt, Sharon J Peacock, Nick M Brown, Tom Riley, Glen Songer, Mark Wilcox, Munir Pirmohamed, Ed Kuijper, Peter Hawkey, Brendan W Wren, Gordon Dougan, Julian Parkhill and Trevor D Lawley
doi:10.1038/ng.2478
Trevor Lawley and colleagues report whole-genome sequencing of a large global collection of Clostridium difficile, the most common cause of healthcare-associated infection in the developed world. Their phylogenetic analysis traces the spread of this pathogen through healthcare-associated epidemics worldwide.
See also: News and Views by Rasko | | | Top | |  | | Advertisement | | 
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