Nature Biotechnology Contents: Volume 30 pp 1151 - 1254

Advertisement Academy of Military Medical Sciences - Celebrating 60 years of research at one of China's leading organizations for medical science. The Academy of Military Medical Sciences (AMMS) in Beijing has developed beyond its military heritage to become a world leader in medical science with a string of achievements in both military and civilian applications that have resonated around the globe. Find out more about the AMMS in Part 4 of the five-part series of this special sponsor feature on nature.com. TABLE OF CONTENTS December 2012 Volume 30, Issue 12 Editorial News Bioentrepreneur Opinion and Comment Features News and Views Computational Biology Research Careers and Recruitment Advertisement Hamamatsu’s ORCA-Flash4.0 camera now includes ImageConductor Connectivity™, so it’s enabled for both USB 3.0 and high-speed Camera Link. If your imaging speed is 30 fps at full 4-megapixel resolution, then the default USB 3.0 configuration is right for you. If you need something faster, upgrade to an optional Camera Link board to achieve 100 fps at full resolution. Both options deliver low noise, high sensitivity imaging. Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement BIOPHARMA DEALMAKERS Company Profiles and Partnering Opportunities   Advertisement Reichert is making it easier to have an SPR system installed in your lab today with this $4000 offer! FREE Startup FREE Training FREE Fluidics Kit. A $4000 value. Purchase any SPR system and receive free on-site setup and training. Reichert SPR systems are ultra-sensitive and cost-effective for all biomolecular interaction analysis. Visit website for details.  ReichertSPR.com Advertisement Nature Biotechnology Focus on DNA Sequencing Technology Performance gains and falling costs have fueled diverse applications of high-throughput DNA sequencing. This focus issue summarizes the current status of these technologies as applied to life sciences and medical research. Click here to access the Focus. Produced with support from:   Editorial Top Where have the flagships gone?   p1151 doi:10.1038/nbt.2453 There was a time when flagship biotech companies looked very different from pharma. News Top Kits herald new wave of genomics diagnostics for cancer   pp1152 - 1154 Mark Ratner doi:10.1038/nbt1212-1152 First gene therapy approved   p1153 Nuala Moran doi:10.1038/nbt1212-1153 Companies in footrace to deliver RNAi   pp1154 - 1157 Aaron Bouchie doi:10.1038/nbt1212-1154 Merck tests needle-free vaccines   p1155 Suzanne Elvidge doi:10.1038/nbt1212-1155a Linked-in for angels   p1155 Barbara Casassus doi:10.1038/nbt1212-1155b Orphans' matchmaker   p1156 Emma Dorey doi:10.1038/nbt1212-1156 Bacterial shield for seeds   p1158 Emily Waltz doi:10.1038/nbt1212-1158a Belgian biotech's clot-buster approved for aging eyes   p1158 Cormac Sheridan doi:10.1038/nbt1212-1158b Chinese genomics giant BGI plots commercial path   pp1159 - 1160 David Cyranoski doi:10.1038/nbt1212-1159 Cuts loom over research and industry following Obama re-election   pp1161 - 1162 Jeffrey L Fox doi:10.1038/nbt1212-1161 Around the world in a month   p1162 doi:10.1038/nbt1212-1162 FDA to oversee reporting of clinical trials   p1163 Mark Ratner doi:10.1038/nbt1212-1163 Data Page Drug pipeline: Q312   p1164 Laura DeFrancesco doi:10.1038/nbt.2446 Q312: Biotech on a roll   p1165 Walter Yang doi:10.1038/nbt.2457 Advertisement Waters TransOmics Informatics application alert: Qualitative and quantitative characterization of the metabolome, lipidome, and proteome of human hepatocytes stably transfected with Cytochrome P450 2E1 using data indepdendent LC/MS Bioentrepreneur Top Building a business Weathering a storm   pp1166 - 1168 Douglas Fambrough doi:10.1038/nbt.2433 Opinion and Comment Top Correspondence Harmonizing policy on human genetic resources and benefit sharing   pp1169 - 1170 Sachin Chaturvedi, Sara Crager, Miltos Ladikas, Vasantha Muthuswamy, Yeyang Su and Huanming Yang doi:10.1038/nbt.2441 Strengthening African R&D through effective transfer of tropical crop biotech to African institutions   pp1170 - 1172 Herve Vanderschuren doi:10.1038/nbt.2405 Can genomics boost productivity of orphan crops?   pp1172 - 1176 Rajeev K Varshney, Jean-Marcel Ribaut, Edward S Buckler, Roberto Tuberosa, J Antoni Rafalski and Peter Langridge doi:10.1038/nbt.2440 A prototrophic deletion mutant collection for yeast metabolomics and systems biology   pp1176 - 1178 Michael Mulleder, Floriana Capuano, Pinar Pir, Stefan Christen, Uwe Sauer, Stephen G Oliver and Markus Ralser doi:10.1038/nbt.2442 Commentary Setting the stage for biosimilar monoclonal antibodies   pp1179 - 1185 Christian K Schneider, Camille Vleminckx, Iordanis Gravanis, Falk Ehmann, Jean-Hugues Trouvin, Martina Weise and Steffen Thirstrup doi:10.1038/nbt.2447 With the first marketing authorization application for a biosimilar monoclonal antibody now under consideration at the European Medicines Agency, what are the critical issues for regulators? Interchangeability, immunogenicity and biosimilars   pp1186 - 1190 Hans C Ebbers, Stacy A Crow, Arnold G Vulto and Huub Schellekens doi:10.1038/nbt.2438 For authorized biosimilars to achieve full acceptance in the marketplace, it is crucial that they are considered to be therapeutically equivalent and interchangeable with the brand reference product. Features Top What's fueling the biotech engine—2011 to 2012   pp1191 - 1197 Saurabh (Rob) Aggarwal doi:10.1038/nbt.2437 Sales in the biologics sector show modest but healthy growth rates for the fourth consecutive year, with cancer drugs garnering the greatest revenues. As the diabetes epidemic grows and innovation of insulins continues, drug companies in that space are moving up in the ranks. Patents Uncertainty over pharmaceutical and biotech product patents in Pakistan   pp1198 - 1200 Saima Sadaf, Muhammad W Akhtar and Zarina Iqbal doi:10.1038/nbt.2444 Even after the enactment of a patent law in 2000, pharmaceutical and biotech-related inventions are perceived to lack strong product patent protection in Pakistan. Recent patent applications in gene expression   p1201 doi:10.1038/nbt.2454 Advertisement Cellectis bioresearch's Cell Line Customization Services Let the renowned gene customization experts modify your cell line at any gene, at any position. Our services include gene modification, knock-out and targeted transgene integration. Benefit from the fastest turnaround time in the market and high cost efficiency. Request more information News and Views Top An mRNA vaccine for influenza   pp1202 - 1204 Sook-San Wong and Richard J Webby doi:10.1038/nbt.2439 An influenza vaccine made of stabilized mRNA may allow vaccine design and manufacture to keep pace with viral evolution. See also: Research by Petsch et al. Extracting energy from the inner ear   pp1204 - 1205 Kenneth Shepard, Taku Ito and Andrew J Griffith doi:10.1038/nbt.2448 The endocochlear potential in a guinea pig's ear is captured and used to run a low-power radio. See also: Research by Mercier et al. Research Highlights   p1205 doi:10.1038/nbt.2451 Pulling T cells to pathogens   p1206 Christine Borowski doi:10.1038/nbt.2445 Biotechnology JOBS of the week Director of Institute for Bioscience and Biotechnology Research-IBBR Position #118732 University of Maryland and National Institute of Standards and Technology University of Maryland and National Institute of Standards and Technology Intellectual Property Team Leader, Biotechnology (European Patent Attorney) Pharma Professionals Europe Professor of Sustainable Feedstocks and Industrial Biotechnology Warwick University Scientists / Partners for Biotech Startup New Berkeley Biotech Startup Fellowship Department of Biotechnology More Science jobs from Biotechnology EVENT 2nd Biotechnology World Congress February 18-21, 2013 Dubai, UAE More science events from Computational Biology Top Q&A The difficult calls in RNA editing   pp1207 - 1209 H. Craig Mak doi:10.1038/nbt.2452 Accounting for errors arising from different high-throughput sequencing platforms and those arising from the approaches used to call variants are at the center of a controversy in RNA editing. Research Top Articles Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection   pp1210 - 1216 Benjamin Petsch, Margit Schnee, Annette B Vogel, Elke Lange, Bernd Hoffmann, Daniel Voss, Thomas Schlake, Andreas Thess, Karl-Josef Kallen, Lothar Stitz and Thomas Kramps doi:10.1038/nbt.2436 Petsch et al. apply mRNA vaccination for the first time to infectious disease, demonstrating immunogenicity and/or protective effects against influenza virus in mice, ferrets and pigs. See also: News and Views by Wong & Webby Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis   pp1217 - 1224 Daniel R Getts, Aaron J Martin, Derrick P McCarthy, Rachael L Terry, Zoe N Hunter, Woon Teck Yap, Meghann Teague Getts, Michael Pleiss, Xunrong Luo, Nicholas JC King, Lonnie D Shea and Stephen D Miller doi:10.1038/nbt.2434 Microparticles coated with encephalitogenic peptides are effective at treating multiple sclerosis in a mouse model. A bacterial glycosidase enables mannose-6-phosphate modification and improved cellular uptake of yeast-produced recombinant human lysosomal enzymes   pp1225 - 1231 Petra Tiels, Ekaterina Baranova, Kathleen Piens, Charlotte De Visscher, Gwenda Pynaert, Wim Nerinckx, Jan Stout, Franck Fudalej, Paco Hulpiau, Simon Tannler, Steven Geysens, Annelies Van Hecke, Albena Valevska, Wouter Vervecken, Han Remaut and Nico Callewaert doi:10.1038/nbt.2427 Tiels et al. identify a bacterial glycosidase that facilitates improved modification of N-glycans on the Pompe disease enzyme [alpha]-glucosidase. Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing   pp1232 - 1239 Gang Fang, Diana Munera, David I Friedman, Anjali Mandlik, Michael C Chao, Onureena Banerjee, Zhixing Feng, Bojan Losic, Milind C Mahajan, Omar J Jabado, Gintaras Deikus, Tyson A Clark, Khai Luong, Iain A Murray, Brigid M Davis, Alona Keren-Paz, Andrew Chess, Richard J Roberts, Jonas Korlach, Steve W Turner, Vipin Kumar, Matthew K Waldor and Eric E Schadt doi:10.1038/nbt.2432 Fang et al. generate the first genome-wide, strand-specific, single base-pair resolution map of m6A modifications in Escherichia coli. Letters Energy extraction from the biologic battery in the inner ear   pp1240 - 1243 Patrick P Mercier, Andrew C Lysaght, Saurav Bandyopadhyay, Anantha P Chandrakasan and Konstantina M Stankovic doi:10.1038/nbt.2394 The energy of the electrochemical potential in the guinea pig cochlea is harvested and used to power a wireless transmitter. See also: News and Views by Shepard et al. Large-scale screening using familial dysautonomia induced pluripotent stem cells identifies compounds that rescue IKBKAP expression   pp1244 - 1248 Gabsang Lee, Christina N Ramirez, Hyesoo Kim, Nadja Zeltner, Becky Liu, Constantin Radu, Bhavneet Bhinder, Yong Jun Kim, In Young Choi, Bipasha Mukherjee-Clavin, Hakim Djaballah and Lorenz Studer doi:10.1038/nbt.2435 Lee et al. use neural crest precursor cells derived from patient-specific induced pluripotent stem cells to screen a small-molecule library for compounds that correct the cellular phenotype of familial dysautonomia. Errata My data are your data   p1249 Vivien Marx doi:10.1038/nbt1212-1249a Beyond counting tumor cells   p1249 Jim Kling doi:10.1038/nbt1212-1249b Antibody specification beyond the target: claiming a latergeneration therapeutic antibody by its target epitope   p1249 Colin G Sandercock and Ulrich Storz doi:10.1038/nbt1212-1249c Drug pipeline: Q212   p1249 Laura DeFrancesco doi:10.1038/nbt1212-1249d Corrigendum Pharmacogenomics in clinical practice and drug development   p1249 Andrew R Harper and Eric J Topol doi:10.1038/nbt1212-1249e Careers and Recruitment Top Foreign-born scientists: mobility patterns for 16 countries   pp1250 - 1253 Chiara Franzoni, Giuseppe Scellato and Paula Stephan doi:10.1038/nbt.2449 A cross-country survey of research scientists in 16 countries finds considerable variation in immigration and emigration patterns. People People   p1254 doi:10.1038/nbt.2455 Top Advertisement New Partnering Opportunities in Alzheimer's Disease! 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