Laboratory Investigation - Table of Contents alert Volume 93 Issue 1

TABLE OF CONTENTS Volume 93, Issue 1 (January 2013) In this issue Inside LI Editorial Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement This month’s recommended article by the editors of LI: β1 integrin–extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function   Inside LI Top Inside Lab Invest 2013 93: 2-3; 10.1038/labinvest.2012.169 Full Text Editorial Top Pancreatic stellate cells: small cells with a big role in tissue homeostasis Anna L Means 2012 93: 4-7; 10.1038/labinvest.2012.161 Full Text Research Articles Top HEPATIC AND PANCREATIC SYSTEMS OPA1 downregulation is involved in sorafenib-induced apoptosis in hepatocellular carcinoma Sorafenib, used to treat advanced hepatocellular carcinoma (HCC), triggers cell growth inhibition and apoptosis in HCC cells by directly targeting the mitochondria. Treatment with sorafenib induces rapid mitochondrial fragmentation, which is associated with the deregulation of mitochondriafusion-related protein OPA1. OPA1 may be a novel therapeutic target for HCC. Xiangxuan Zhao, Changhai Tian, William M Puszyk, Olorunseun O Ogunwobi, Mengde Cao, Ton Wang, Roniel Cabrera, David R Nelson and Chen Liu 2012 93: 8-19; advance online publication, October 29, 2012; 10.1038/labinvest.2012.144 Abstract | Full Text Steatosis does not impair liver regeneration after partial hepatectomy Western diet-induced steatosis, or fatty liver, enhances liver cell proliferation after partial hepatectomy. The mechanism involves increased hepatocyte growth factor and leptin signaling as well as MAP kinase 1/2 phosphorylation. Induction of mild steatosis may therefore be beneficial for patient outcome after hepatectomy or liver transplant. Svenja Sydor, Yanli Gu, Martin Schlattjan, Lars P Bechmann, Ursula Rauen, Jan Best, Andreas Paul, Hideo A Baba, Jan-Peter Sowa, Guido Gerken and Ali Canbay 2012 93: 20-30; advance online publication, October 15, 2012; 10.1038/labinvest.2012.142 Abstract | Full Text β1 integrin–extracellular matrix interactions are essential for maintaining exocrine pancreas architecture and function Integrin receptors integrate extracellular matrix (ECM) signals inside the cell. Mice deficient in β1 integrin show impaired glucose tolerance and reduced pancreatic beta-cell function consistent with the onset of diabetes. These mice also display decreases in pancreatic enzyme levels. ECM and β1 integrin interactions are therefore essential for maintaining exocrine pancreatic integrity and function. Matthew M Riopel, Jinming Li, Shangxi Liu, Andrew Leask and Rennian Wang 2012 93: 31-40; advance online publication, October 15, 2012; 10.1038/labinvest.2012.147 Abstract | Full Text ERK pathway and sheddases play an essential role in ethanol-induced CX3CL1 release in pancreatic stellate cells The role of the chemokine CX3CL1 in the progression of alcoholic chronic pancreatitis (CP) is revealed in this study. Ethanol increases CX3CL1 release from pancreatic stellate cells, which activates the ERK/MAPK pathway and the sheddase ADAM 17. CX3CL1 may therefore be a target for treatment of fibrosis in these patients. Masahiko Uchida, Tetsuhide Ito, Taichi Nakamura, Hisato Igarashi, Takamasa Oono, Nao Fujimori, Ken Kawabe, Koichi Suzuki, Robert T Jensen and Ryoichi Takayanagi 2012 93: 41-53; advance online publication, November 12, 2012; 10.1038/labinvest.2012.156 Abstract | Full Text Morphological and microarray analyses of human hepatocytes from xenogeneic host livers Human hepatocyte-chimeric mice were constructed as a model for the study of human liver function. The humanized chimeric mouse livers were structurally normal, with human hepatocytes and mouse hepatic sinusoidal cells. The chimeric livers expressed human genes at levels similar to those in human livers, thus validating the potential utility of the animal model. Chise Tateno, Fuyuki Miya, Kenjiro Wake, Miho Kataoka, Yuji Ishida, Chihiro Yamasaki, Ami Yanagi, Masakazu Kakuni, Eddie Wisse, Fons Verheyen, Kouji Inoue, Kota Sato, Atsushi Kudo, Shigeki Arii, Toshiyuki Itamoto, Toshimasa Asahara, Tatsuhiko Tsunoda and Katsutoshi Yoshizato 2012 93: 54-71; advance online publication, November 12, 2012; 10.1038/labinvest.2012.158 Abstract | Full Text BREAST, SKIN, SOFT TISSUE AND BONE Overexpression of TNF-α-converting enzyme in fibroblasts augments dermal fibrosis after inflammation Dermal fibrosis due to inflammation is more severe in transgenic mice overexpressing TNF-α converting enzyme (TACE) than in wild-type mice. The activation of TACE, a sheddase, in dermal fibroblasts activates epidermal growth factor receptor (EGFR), which induces type I collagen expression. TACE and EGFRs may therefore be targets for treatment of dermal fibrosis. Shinji Fukaya, Yuki Matsui, Utano Tomaru, Ai Kawakami, Sayuri Sogo, Toshiyuki Bohgaki, Tatsuya Atsumi, Takao Koike, Masanori Kasahara and Akihiro Ishizu 2012 93: 72-80; advance online publication, November 12, 2012; 10.1038/labinvest.2012.153 Abstract | Full Text A physiological role for connective tissue growth factor in early wound healing Connective tissue growth factor (CTGF) is a proifibrotic molecule that is transiently expressed by mesenchymal stem cells and fibroblasts in the early phase of wound repair. Understanding how CTGF serves a pro-reparative role may help develop stage-specific strategies to augment or inhibit CTGF and thus improve healing while minimizing fibrosis. Maria P Alfaro, Desirae L Deskins, Meredith Wallus, Jayasri DasGupta, Jeffrey M Davidson, Lillian B Nanney, Michelle A Guney, Maureen Gannon and Pampee P Young 2012 93: 81-95; advance online publication, November 19, 2012; 10.1038/labinvest.2012.162 Abstract | Full Text ORAL AND GASTROINTESTINAL SYSTEMS Sonic Hedgehog contributes to gastric mucosal restitution after injury In a mouse model with conditional deletion of the gastric morphogen Sonic Hedgehog (Shh), re-expression of Shh contributes to gastric regeneration after induction of ulcers. Since eradication of Helicobacter pylori is known to correlate with re-expression of Shh, regeneration of gastric epithelium and ulcer healing, the findings from this model may have clinical significance. Chang Xiao, Rui Feng, Amy C Engevik, Jason R Martin, Julie A Tritschler, Michael Schumacher, Robert Koncar, Joseph Roland, Ki Taek Nam, James R Goldenring and Yana Zavros 2012 93: 96-111; advance online publication, October 22, 2012; 10.1038/labinvest.2012.148 Abstract | Full Text The unfolded protein response is activated in Helicobacter-induced gastric carcinogenesis in a non-cell autonomous manner In gastric cancer, the endoplasmic reticulum (ER) stress sensor GRP78 is associated with Helicobacter pylori exposure. This heralds activation of the unfolded protein response, which arises in intestinal metaplasia before onset of neoplasia. ER stress from aberrant mucin production in intestinal metaplasia may therefore promote neoplasia. Mhairi Baird, Pei Woon Ang, Ian Clark, Danial Bishop, Masanobu Oshima, Matthew C Cook, Christine Hemmings, Shigeo Takeishi, Dan Worthley, Alex Boussioutas, Timothy C Wang and Doug Taupin 2012 93: 112-122; advance online publication, October 29, 2012; 10.1038/labinvest.2012.131 Abstract | Full Text GENITOURINARY AND REPRODUCTIVE SYSTEMS SOCS-3 is downregulated in progressive CKD patients and regulates proliferation in human renal proximal tubule cells in a STAT1/3 independent manner Downregulation of SOCS-3, a negative regulator of STAT signaling, is associated with unfavorable prognosis in patients with chronic kidney disease. However, SOCS-3 also regulates proliferation of kidney tubule cells independent of STAT. Low levels of SOCS-3 appear to inhibit de-differentiation and proliferation, fundamental mechanisms of kidney repair and regeneration. Hannes Neuwirt, Iris E Eder, Martin Puhr and Michael Rudnicki 2012 93: 123-134; advance online publication, October 29, 2012; 10.1038/labinvest.2012.154 Abstract | Full Text Adenosine A2B receptor-mediated VEGF induction promotes diabetic glomerulopathy A new pathogenic mechanism for the onset of diabetic kidney disease is proposed. Aberrant adenosine signaling in glomeruli promotes excessive VEGF production, leading to the progression of diabetic glomerulopathy. The adenosine A2B receptor is thus a new target for pharmacological intervention in diabetic kidney disease. Angel Cárdenas, Camilo Toledo, Carlos Oyarzún, Angélica Sepúlveda, Claudia Quezada, Elena Guillén-Gómez, Montserrat M Díaz-Encarnación, Marçal Pastor-Anglada and Rody San Martín 2012 93: 135-144; advance online publication, October 15, 2012; 10.1038/labinvest.2012.143 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. 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