The EMBO Journal - Table of Contents alert Volume 31 Issue 22

TABLE OF CONTENTS 14 November 2012 | Volume 31, Issue 22 Have you seen? Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement EMBO - Transparency in Scientific Publishing The EMBO Journal has a fair and transparent process to rapidly publish your best science. Transparent - No confidential referee remarks - Published referee reports - Detailed decisions - Source Data published alongside figures Fair - Scooping protection - Pre-decision cross-referee commenting - Fixed bar for revisions - Fast process   Have you seen? Top The FUS about arginine methylation in ALS and FTLD Changes in arginine methylation are linked to the pathogenesis of the two neurodegenerative syndromes amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD), yet methylation appears to play distinct roles in both. Hannah M Kaneb, Patrick A Dion and Guy A Rouleau The EMBO Journal (2012), 31, 4249 - 4251; 10.1038/emboj.2012.291 Abstract | Full text | PDF | Related article Published online: 19 October 2012 AgRP neurons: a switch between peripheral carbohydrate and lipid utilization AgRP/NPY neurons are critical regulators of body weight and food intake. Unexpectedly, AgRP-ablated mice show an obese phenotype, which is linked to altered metabolism in liver, muscle and pancreas. Luis Varela and Tamas L Horvath The EMBO Journal (2012), 31, 4252 - 4254; 10.1038/emboj.2012.287 Abstract | Full text | PDF | Related article Published online: 19 October 2012 Pluripotency re-centered around Esrrb Recent studies established the oestrogen-related receptor b (Esrrb) as pivotal Nanog-target gene. This places Esrrb and its novel Ncoa3 co-activator into the centre of pluripotency regulation. Bernadett Papp and Kathrin Plath The EMBO Journal (2012), 31, 4255 - 4257; 10.1038/emboj.2012.285 Abstract | Full text | PDF | Related article | Related article | Related article Published online: 12 October 2012 Articles Top Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS Defective nuclear import of fused in sarcoma (FUS) is linked to amyotrophic lateral sclerosis (ALS). Arginine methylation of FUS reduces its binding to the nuclear import receptor Transportin leading to cytoplasmic accumulation of methylated FUS in ALS-FUS patient samples. Dorothee Dormann, Tobias Madl, Chiara F Valori, Eva Bentmann, Sabina Tahirovic, Claudia Abou-Ajram, Elisabeth Kremmer, Olaf Ansorge, Ian R A Mackenzie, Manuela Neumann and Christian Haass The EMBO Journal (2012), 31, 4258 - 4275; 10.1038/emboj.2012.261 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 September 2012 Hypothalamic AgRP-neurons control peripheral substrate utilization and nutrient partitioning AgRP-neurons control food intake. Ablation of AgRP-neurons reveals their role in regulating metabolism in peripheral tissues, resulting in changes in the balance of lipid and carbohydrate utilization. Mice lacking AgRP-neurons become obese on regular diet but show reduced body weight gain on high-fat diet. Aurélie Joly-Amado, Raphaël G P Denis, Julien Castel, Amélie Lacombe, Céline Cansell, Claude Rouch, Nadim Kassis, Julien Dairou, Patrice D Cani, Renée Ventura-Clapier, Alexandre Prola, Melissa Flamment, Fabienne Foufelle, Christophe Magnan and Serge Luquet The EMBO Journal (2012), 31, 4276 - 4288; 10.1038/emboj.2012.250 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 September 2012 Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment p21 levels in cellular senescence are adjusted, independent of transcription or protein stability, by a novel mechanism that regulates access of Ago2 to the miRNA-targeted p21 mRNA. Bong Cho Kim, Hyung Chul Lee, Je-Jung Lee, Chang-Min Choi, Dong-Kwan Kim, Jae Cheol Lee, Young-Gyu Ko and Jae-Seon Lee The EMBO Journal (2012), 31, 4289 - 4303; 10.1038/emboj.2012.286 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 19 October 2012 Mechanism and functions of membrane binding by the Atg5–Atg12/Atg16 complex during autophagosome formation The conserved Atg5–Atg12/Atg16 complex is essential for autophagosome formation. In vitro reconstitution experiments reveal how the individual subunits of this complex act to tether membranes and to promote subsequent Atg8 conjugation, a key step in autophagy. Julia Romanov, Marta Walczak, Iosune Ibiricu, Stefan Schüchner, Egon Ogris, Claudine Kraft and Sascha Martens The EMBO Journal (2012), 31, 4304 - 4317; 10.1038/emboj.2012.278 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 October 2012 RUNX1 reshapes the epigenetic landscape at the onset of haematopoiesis Correct temporal gene expression patterns and haematopoietic cell fate acquisition are driven by RUNX1-dependent genome-wide reorganization of lineage-specific transcription factors. Monika Lichtinger, Richard Ingram, Rebecca Hannah, Dorothee Müller, Deborah Clarke, Salam A Assi, Michael Lie-A-Ling, Laura Noailles, M S Vijayabaskar, Mengchu Wu, Daniel G Tenen, David R Westhead, Valerie Kouskoff, Georges Lacaud, Berthold Göttgens and Constanze Bonifer The EMBO Journal (2012), 31, 4318 - 4333; 10.1038/emboj.2012.275 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 October 2012 SAS-6 coiled-coil structure and interaction with SAS-5 suggest a regulatory mechanism in C. elegans centriole assembly Oligomerization of the core centriole component SAS-6, thought to underlie establishment of a correct nine-fold symmetric ‘cartwheel’ structure, is guided by specific interactions with its conserved partner SAS-5. Renping Qiao, Gabriela Cabral, Molly M Lettman, Alexander Dammermann and Gang Dong The EMBO Journal (2012), 31, 4334 - 4347; 10.1038/emboj.2012.280 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 October 2012 Atp23 biogenesis reveals a chaperone-like folding activity of Mia40 in the IMS of mitochondria In contrast to all known Mia40 substrates, Atp23 is imported into the mitochondria independently of disulphide-bond formation. Furthermore Mia40 displays chaperone activity, mediating Atp23 folding and preventing its aggregation in vitro. Daniel Weckbecker, Sebastian Longen, Jan Riemer and Johannes M Herrmann The EMBO Journal (2012), 31, 4348 - 4358; 10.1038/emboj.2012.263 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 18 September 2012 ROS-mediated vascular homeostatic control of root-to-shoot soil Na delivery in Arabidopsis A newly discovered defence for plants against salt toxicity is that root reactive oxygen species generated by high soil salinity regulate root–shoot sodium transport, thereby preventing its toxic accumulation in shoots. Caifu Jiang, Eric J Belfield, Aziz Mithani, Anne Visscher, Jiannis Ragoussis, Richard Mott, J Andrew C Smith and Nicholas P Harberd The EMBO Journal (2012), 31, 4359 - 4370; 10.1038/emboj.2012.273 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 12 October 2012 Advertisement Take a look at these articles that recently published in The EMBO Journal HDAC5 is a novel injury-regulated tubulin deacetylase controlling axon regeneration Yongcheol Cho and Valeria Cavalli The EMBO Journal ¦ doi:10.1038/emboj.2012.160 DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis Wei Wang, John Z Zhu, Karen T Chang and Kyung-Tai Min The EMBO Journal | doi:10.1038/emboj.2012.190 N-cadherin specifies first asymmetry in developing neurons Annette Gärtner, Carlos G Dotti et al The EMBO Journal ¦ doi: 10.1038/emboj.2012.41.   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. 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