Nature Reviews Neuroscience contents December 2012 Volume 13 Number 12 pp 811-878

TABLE OF CONTENTS
December 2012 Volume 13 Number 12
Impact Factor 30.455 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: The mechanobiology of brain function William J. Tyler
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RESEARCH HIGHLIGHTS Top Synaptic plasticity: Neuroligin 1 does the splits p811 | doi:10.1038/nrn3392 Acute activity-induced cleavage of neuroligin 1 acts as a local homeostatic mechanism to regulate structural and functional synaptic plasticity at individual synapses. PDF Learning and memory: Dopamine boosts ageing memories p812 | doi:10.1038/nrn3385 Dopamine release in the hippocampus has been shown to be essential for memory consolidation in rodents. Similarly, Chowdhury et al. now demonstrate that, in humans, the persistence of episodic memory is enhanced following pharmacological increase in hippocampal dopamine. PDF Perception: Facing reality p812 | doi:10.1038/nrn3395 In the human brain, parts of the fusiform gyrus respond selectively to images of faces. Parvizi et al. show that electrical perturbation of these areas causes the perception of faces to become distorted. PDF Neurotransmission: Anxious interactions p813 | doi:10.1038/nrn3378 Interleukin-1β induces anxiety and affects striatal neurotransmission through an interaction with the endocannabinoid system PDF Neuronal circuits: Distinctly motivated circuits p814 | doi:10.1038/nrn3384 Distinct circuits in the ventral tegmental area regulate reward and aversion in mice. PDF Spatial processing: Monkey brains make space for grid cells p814 | doi:10.1038/nrn3394 A single-neuron recording study shows that grid cells exist in primates. PDF Neurotransmission: GABA calls stop in the striatum p815 | doi:10.1038/nrn3382 Dopaminergic midbrain neurons that project to the striatum can also inhibit striatal output by releasing GABA, which is packaged into vesicles by the vesicular monoamine transmitter VMAT2. PDF Reward: Finding the paths to food reward p816 | doi:10.1038/nrn3397 Octopamine-dependent reward-related signalling in fruitflies requires interactions with dopamine neurons. PDF Behavioural neuroscience: Ancient behavioural modulators p816 | doi:10.1038/nrn3398 Two new studies reveal the existence of an oxytocin-vasopressin-related signalling system in Caenorhabditis elegans that modulates certain worm behaviours. PDF IN BRIEF Cancer: Neurons and astrocytes can make gliomas | Neurodevelopmental disorders: Tackling fragile X by curbing translation | Sensory transduction: Photoreceptors get moving | Stem cells: What happens to transplanted stem cells? | Learning and memory: Getting in sync with working memory | Sleep: The hypnotic powers of anaesthetics | Cortical plasticity: Plasticity gets sex-specific | Neurogenetics: Probing genomic diversity in neurons PDF Neuroscience JOBS of the week PhD in Social, Genetic and Developmental Psychiatry (1+3 Programme) King's College London (Institute of Psychiatry PhD Position: Intention and Action (1,0 fte) Donders Institute, Centre for Cognitive Neuroimaging Postdoc position on design, fabrication and characterization of an infrared plasmonic lens Fondazione Istituto Italiano di Tecnologia Postdoctoral Position in Nanotechnology & Neuroengineering University of California - Davis postdoctoral fellow UT Southwestern Medical Center at Dallas, TX More Science jobs from Neuroscience EVENT Neurodegeneration Conference 2012 27.11.-01.12.12 Mexico More science events from
REVIEWS		Top
Separated at birth? The functional and molecular divergence of OLIG1 and OLIG2 Dimphna H. Meijer, Michael F. Kane, Shwetal Mehta, Hongye Liu, Emily Harrington, Christopher M. Taylor, Charles D. Stiles & David H. Rowitch p819 | doi:10.1038/nrn3386 Despite their structural similarities and seemingly coordinated expression patterns, oligodendrocyte transcription factor 1 (OLIG1) and OLIG2 have largely non-overlapping roles in CNS development, brain diseases and neural repair. Here, the authors review the molecular factors that may account for the divergent functions of these proteins. Abstract | Full Text | PDF | Supplementary information
Encoding asymmetry within neural circuits Miguel L. Concha, Isaac H. Bianco & Stephen W. Wilson p832 | doi:10.1038/nrn3371 Many animals, from worms to humans, show structural and functional asymmetries in their nervous systems. Concha, Bianco and Wilson describe two fundamental types of nervous system asymmetry and discuss how they emerge during development and influence behaviour. Abstract | Full Text | PDF
Down syndrome: the brain in trisomic mode Mara Dierssen p844 | doi:10.1038/nrn3314 Down syndrome is the most common genetic form of intellectual disability. In this Review, Mara Dierssen examines the underlying mechanisms that give rise to brain dysfunction in Down syndrome and discusses therapeutic approaches that are under investigation to combat cognitive deficits associated with this condition. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
OPINION Sex differences in pain and pain inhibition: multiple explanations of a controversial phenomenon Jeffrey S. Mogil p859 | doi:10.1038/nrn3360 Chronic pain is more prevalent in women than in men. In this Perspective, Jeffrey Mogil argues that this sex bias in clinical pain is due to a sex difference in pain sensitivity and discusses various underlying mechanisms that might account for this difference. Abstract | Full Text | PDF | Supplementary information
OPINION The mechanobiology of brain function William J. Tyler p867 | doi:10.1038/nrn3383 All cells are influenced by mechanical forces, but the effects of mechanical energy in the brain have received relatively little attention. William Tyler summarizes the main mechanical events that take place in neurons and their effects on neuronal function, and argues for an increased consideration of mechanobiology in neuroscience. Abstract | Full Text | PDF
Erratum: Distributed synergistic plasticity and cerebellar learning Zhenyu Gao, Boeke J. van Beugen & Chris I. De Zeeuw p878 | doi:10.1038/nrn3391 Full Text | PDF
Corrigendum: Distributed synergistic plasticity and cerebellar learning Guilherme Neves, Sam F. Cooke & Tim V. P. Bliss p878 | doi:10.1038/nrn3396 Full Text | PDF
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