Nature Immunology Contents: December 2012 Volume 13 pp 1129 - 1221

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Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Nature Insight: Metabolism and Disease Metabolic diseases are a threat to global health. This Insight focuses on some of the underlying biology that can contribute to these disorders, including the central nervous system's control of metabolism, circadian cancer metabolism and mitochondrial disorders, as well as metabolic phenotyping. Access the Insight online.   Historical Commentary Top Immunology beats cancer: a blueprint for successful translation   pp1129 - 1132 Drew M Pardoll doi:10.1038/ni.2392 News and Views Top HOIL and water: the two faces of HOIL-1 deficiency   pp1133 - 1135 Michael J Ombrello, Daniel L Kastner and Joshua D Milner doi:10.1038/ni.2471 Autoinflammation and immunodeficiency are rare in humans, but the rate of discovery of these conditions has increased. Three patients have now been characterized in whom deficiency in HOIL-1, a component of the LUBAC complex, leads to these conditions. See also: Article by Boisson et al. Nonclassical NK cell education   pp1135 - 1137 Werner Held doi:10.1038/ni.2470 Diseased host cells are eliminated more effectively when natural killer cells grow up in the presence of classical major histocompatibility complex (MHC) class I molecules. The nonclassical MHC class I molecule H2-M3 can exert an analogous effect. See also: Article by Andrews et al. Innate sensing of bacterial cyclic dinucleotides: more than just STING   pp1137 - 1139 Andrew G Bowie doi:10.1038/ni.2469 Bacterial cyclic dinucleotides are recognized by the innate immune system, and this leads to the induction of type I interferons. The mammalian helicase DDX41 directly binds cyclic dinucleotides and mediates the signaling pathway to the induction of type I interferons. See also: Article by Parvatiyar et al. A less-canonical, canonical NF-κB pathway in DCs   pp1139 - 1141 Matthew S Hayden doi:10.1038/ni.2476 Mathematical modeling shows that two members of the NF-κB family of transcription factors, RelB and p50, form heterodimers and participate in the canonical NF-κB pathway in dendritic cells. See also: Article by Shih et al. IL-2 and IL-15 signaling complexes: different but the same   pp1141 - 1142 Shinji Ikemizu, Mami Chirifu and Simon J Davis doi:10.1038/ni.2472 Interleukin 2 (IL-2) and IL-15 use receptors with the same signaling subunits. New structural data show that the signaling complexes they form are topologically nearly identical, which suggests that other factors are responsible for the distinct signaling properties of these complexes. See also: Article by Ring et al. Immunology JOBS of the week Postdoctoral Position in Immunology University of Zurich - Faculty of Medicine Postdoctoral Fellow, Immunology / Neuroimmunology Research Thomas Jefferson University Open Rank Faculty Position and Postdocs in Immunology Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences More Science jobs from Immunology EVENT Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances 2nd Dec - 5th Dec 2012 FL, US More science events from Research Highlights Top Ploidy spotting | Regulating LUBAC | Vaccine strategies | Default fate | Macrophage regulation | Aging T cells Review Top Re(de)fining the dendritic cell lineage   pp1145 - 1154 Ansuman T Satpathy, Xiaodi Wu, Jorn C Albring and Kenneth M Murphy doi:10.1038/ni.2467 Articles Top The helicase DDX41 recognizes the bacterial secondary messengers cyclic di-GMP and cyclic di-AMP to activate a type I interferon immune response   pp1155 - 1161 Kislay Parvatiyar, Zhiqiang Zhang, Rosane M Teles, Songying Ouyang, Yan Jiang, Shankar S Iyer, Shivam A Zaver, Mirjam Schenk, Shang Zeng, Wenwan Zhong, Zhi-Jie Liu, Robert L Modlin, Yong-jun Liu and Genhong Cheng doi:10.1038/ni.2460 Activation of type I interferon by c-di-GMP and c-di-AMP depends on the adaptor STING. Cheng and colleagues show that these bacterial secondary messengers are detected by the helicase DDX41, which forms a complex with STING. See also: News and Views by Bowie Control of RelB during dendritic cell activation integrates canonical and noncanonical NF-κB pathways   pp1162 - 1170 Vincent F-S Shih, Jeremy Davis-Turak, Monica Macal, Jenny Q Huang, Julia Ponomarenko, Jeffrey D Kearns, Tony Yu, Riku Fagerlund, Masataka Asagiri, Elina I Zuniga and Alexander Hoffmann doi:10.1038/ni.2446 Noncanonical RelB-NF-κB2 heterodimers function in homeostatic signaling. Hoffmann and colleagues show that RelB-p50 complexes, regulated by IκB, exist in dendritic cells and contribute to inflammatory gene expression via canonical NF-κB pathway activation. See also: News and Views by Hayden Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells   pp1171 - 1177 Daniel M Andrews, Lucy C Sullivan, Nikola Baschuk, Christopher J Chan, Richard Berry, Claire L Cotterell, Jie Lin, Heloise Halse, Sally V Watt, Jennifer Poursine-Laurent, Chyung-Ru Wang, Anthony A Scalzo, Wayne M Yokoyama, Jamie Rossjohn, Andrew G Brooks and Mark J Smyth doi:10.1038/ni.2468 NK cell licensing is governed by the interaction of Ly49 receptors with peptide-MHC complexes. Smyth and colleagues show that the nonclassical MHC class I molecule H2-M3 can also license NK cell functional development. See also: News and Views by Held Immunodeficiency, autoinflammation and amylopectinosis in humans with inherited HOIL-1 and LUBAC deficiency   pp1178 - 1186 Bertrand Boisson, Emmanuel Laplantine, Carolina Prando, Silvia Giliani, Elisabeth Israelsson, Zhaohui Xu, Avinash Abhyankar, Laura Israël, Giraldina Trevejo-Nunez, Dusan Bogunovic, Alma-Martina Cepika, Donna MacDuff, Maya Chrabieh, Marjorie Hubeau, Fanny Bajolle, Marianne Debré, Evelina Mazzolari, Donatella Vairo, Fabrice Agou, Herbert W Virgin, Xavier Bossuyt, Caroline Rambaud, Fabio Facchetti, Damien Bonnet, Pierre Quartier, Jean-Christophe Fournet, Virginia Pascual, Damien Chaussabel, Luigi D Notarangelo, Anne Puel, Alain Israël, Jean-Laurent Casanova and Capucine Picard doi:10.1038/ni.2457 The linear ubiquitination complex (LUBAC) is poorly understood in humans. Casanova and colleagues identify natural mutations in a component of human LUBAC and use this to dissect its function in vivo and in vitro. See also: News and Views by Ombrello et al. Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15   pp1187 - 1195 Aaron M Ring, Jian-Xin Lin, Dan Feng, Suman Mitra, Mathias Rickert, Gregory R Bowman, Vijay S Pande, Peng Li, Ignacio Moraga, Rosanne Spolski, Engin Özkan, Warren J Leonard and K Christopher Garcia doi:10.1038/ni.2449 The receptors for IL-2 and IL-15 share many characteristics, but mice deficient in either receptor have very different phenotypes. Garcia and colleagues present the quaternary structure of the complex of IL-15 and its receptor, as well as insights into its unique signaling properties. See also: News and Views by Ikemizu et al. Global changes in the nuclear positioning of genes and intra- and interdomain genomic interactions that orchestrate B cell fate   pp1196 - 1204 Yin C Lin, Christopher Benner, Robert Mansson, Sven Heinz, Kazuko Miyazaki, Masaki Miyazaki, Vivek Chandra, Claudia Bossen, Christopher K Glass and Cornelis Murre doi:10.1038/ni.2432 Lineage development is accompanied by specification of gene expression. Murre and colleagues show that during B cell development, many genes relocate in the nucleus, driven by chromatin-looping interactions with transcription factors. Localized epigenetic changes induced by DH recombination restricts recombinase to DJH junctions   pp1205 - 1212 Ramesh Subrahmanyam, Hansen Du, Irina Ivanova, Tirtha Chakraborty, Yanhong Ji, Yu Zhang, Frederick W Alt, David G Schatz and Ranjan Sen doi:10.1038/ni.2447 The Igh locus undergoes a precise order of gene rearrangement during V(D)J recombination. Sen and colleagues show the recruitment of the RAG recombinase is confined to DJH junctions by highly localized epigenetic modifications. The CD46-Jagged1 interaction is critical for human TH1 immunity   pp1213 - 1221 Gaëlle Le Friec, Devon Sheppard, Pat Whiteman, Christian M Karsten, Salley Al-Tilib Shamoun, Adam Laing, Laurence Bugeon, Margaret J Dallman, Teresa Melchionna, Chandramouli Chillakuri, Richard A Smith, Christian Drouet, Lionel Couzi, Veronique Fremeaux-Bacchi, Jörg Köhl, Simon N Waddington, James M McDonnell, Alastair Baker, Penny A Handford, Susan M Lea and Claudia Kemper doi:10.1038/ni.2454 The complement receptor CD46 and the Notch-Jagged system are important for the differentiation of helper T cells. Kemper and colleagues demonstrate that Jagged1 is a physiological ligand for CD46 and is critical for the generation of T helper type 1 cells in humans. 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