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|  | | |  | | Leading Article | Top |  | Clinical utility and implications of asparaginase antibodies in acute lymphoblastic leukemiaC Liu, J D Kawedia, C Cheng, D Pei, C A Fernandez, X Cai, K R Crews, S C Kaste, J C Panetta, W P Bowman, S Jeha, J T Sandlund, W E Evans, C-H Pui and M V Relling Leukemia 2012 26: 2303-2309; advance online publication, April 9, 2012; 10.1038/leu.2012.102 Abstract | Full Text |  | Spotlight Review | Top |  | MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte–erythroid progenitor lineage commitmentL Zhang, V G Sankaran and H F Lodish Leukemia 2012 26: 2310-2316; advance online publication, May 23, 2012; 10.1038/leu.2012.137 Abstract | Full Text |  | Review | Top |  | Consensus guidelines for the conduct and reporting of clinical trials in systemic light-chain amyloidosisR L Comenzo, D Reece, G Palladini, D Seldin, V Sanchorawala, H Landau, R Falk, K Wells, A Solomon, A Wechalekar, J Zonder, A Dispenzieri, M Gertz, H Streicher, M Skinner, R A Kyle and G Merlini Leukemia 2012 26: 2317-2325; advance online publication, April 5, 2012; 10.1038/leu.2012.100 Abstract | Full Text |  | Original Articles | Top |  | MOLECULAR TARGETS FOR THERAPY
| Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomideA Lopez-Girona, D Mendy, T Ito, K Miller, A K Gandhi, J Kang, S Karasawa, G Carmel, P Jackson, M Abbasian, A Mahmoudi, B Cathers, E Rychak, S Gaidarova, R Chen, P H Schafer, H Handa, T O Daniel, J F Evans and R Chopra Leukemia 2012 26: 2326-2335; advance online publication, May 3, 2012; 10.1038/leu.2012.119 Abstract | Full Text |  |  |  | Cytotoxic activity of the novel Akt inhibitor, MK-2206, in T-cell acute lymphoblastic leukemiaC Simioni, L M Neri, G Tabellini, F Ricci, D Bressanin, F Chiarini, C Evangelisti, A Cani, P L Tazzari, F Melchionda, P Pagliaro, A Pession, J A McCubrey, S Capitani and A M Martelli Leukemia 2012 26: 2336-2342; advance online publication, May 22, 2012; 10.1038/leu.2012.136 Abstract | Full Text |  |  |  | INFECTIOUS MEDICINE
| Differential regulation of miR-21 and miR-146a by Epstein–Barr virus-encoded EBNA2P Rosato, E Anastasiadou, N Garg, D Lenze, F Boccellato, S Vincenti, M Severa, E M Coccia, R Bigi, M Cirone, E Ferretti, A F Campese, M Hummel, L Frati, C Presutti, A Faggioni and P Trivedi Leukemia 2012 26: 2343-2352; advance online publication, April 19, 2012; 10.1038/leu.2012.108 Abstract | Full Text |  |  |  | ACUTE LEUKEMIAS
| High activity of sorafenib in FLT3-ITD-positive acute myeloid leukemia synergizes with allo-immune effects to induce sustained responsesS K Metzelder, T Schroeder, A Finck, S Scholl, M Fey, K Götze, Y C Linn, M Kröger, A Reiter, H R Salih, T Heinicke, R Stuhlmann, L Müller, A Giagounidis, R G Meyer, W Brugger, M Vöhringer, P Dreger, M Mori, N Basara, K Schäfer-Eckart, B Schultheis, C Baldus, A Neubauer and A Burchert Leukemia 2012 26: 2353-2359; advance online publication, April 16, 2012; 10.1038/leu.2012.105 Abstract | Full Text |  |  |  | Prognostic significance of FLT3 mutational status and expression levels in MLL-AF4+ and MLL-germline acute lymphoblastic leukemiaM C Chillón, M T Gómez-Casares, C E López-Jorge, C Rodriguez-Medina, A Molines, M E Sarasquete, M Alcoceba, J D G-S Miguel, C Bueno, R Montes, F Ramos, J N Rodríguez, P Giraldo, M Ramírez, R García-Delgado, J L Fuster, M González-Díaz and P Menendez Leukemia 2012 26: 2360-2366; advance online publication, June 18, 2012; 10.1038/leu.2012.161 Abstract | Full Text |  |  |  | Impact of minimal residual disease kinetics during imatinib-based treatment on transplantation outcome in Philadelphia chromosome-positive acute lymphoblastic leukemiaS Lee, D-W Kim, B-S Cho, J-H Yoon, S-H Shin, S-A Yahng, S-E Lee, K-S Eom, Y-J Kim, N-G Chung, H-J Kim, C-K Min, J-W Lee, W-S Min and C-W Park Leukemia 2012 26: 2367-2374; advance online publication, June 18, 2012; 10.1038/leu.2012.164 Abstract | Full Text |  |  |  | NORMAL HEMOPOIESIS
| Expansion of bone marrow neutrophils following G-CSF administration in mice results in osteolineage cell apoptosis and mobilization of hematopoietic stem and progenitor cellsP Singh, P Hu, J Hoggatt, A Moh and L M Pelus Leukemia 2012 26: 2375-2383; advance online publication, April 30, 2012; 10.1038/leu.2012.117 Abstract | Full Text |  |  |  | ONCOGENES, FUSION GENES AND TUMOR SUPPRESSOR GENES
| RET fusion genes are associated with chronic myelomonocytic leukemia and enhance monocytic differentiationP Ballerini, S Struski, C Cresson, N Prade, S Toujani, C Deswarte, S Dobbelstein, A Petit, H Lapillonne, E-F Gautier, C Demur, E Lippert, P Pages, V Mansat- De Mas, J Donadieu, F Huguet, N Dastugue, C Broccardo, C Perot and E Delabesse Leukemia 2012 26: 2384-2389; advance online publication, April 19, 2012; 10.1038/leu.2012.109 Abstract | Full Text |  |  |  | TRANSCRIPTIONAL CONTROL AND SIGNAL TRANSDUCTION
| Evidence for a protective role of the STAT5 transcription factor against oxidative stress in human leukemic pre-B cellsE Cholez, V Debuysscher, J Bourgeais, C Boudot, J Leprince, F Tron, B Brassart, A Regnier, E Bissac, E Pecnard, F Gouilleux, K Lassoued and V Gouilleux-Gruart Leukemia 2012 26: 2390-2397; advance online publication, April 23, 2012; 10.1038/leu.2012.112 Abstract | Full Text |  |  |  | MYELOMA
| Primary plasma cell leukemia: clinical and laboratory presentation, gene-expression profiling and clinical outcome with Total Therapy protocolsS Z Usmani, B Nair, P Qu, E Hansen, Q Zhang, N Petty, S Waheed, J D Shaughnessy, Jr, Y Alsayed, C J Heuck, F van Rhee, T Milner, A Hoering, J Szymonifka, R Sexton, J Sawyer, Z Singh, J Crowley and B Barlogie Leukemia 2012 26: 2398-2405; advance online publication, April 17, 2012; 10.1038/leu.2012.107 Abstract | Full Text |  |  |  | A gene expression signature for high-risk multiple myelomaR Kuiper, A Broyl, Y de Knegt, M H van Vliet, E H van Beers, B van der Holt, L el Jarari, G Mulligan, W Gregory, G Morgan, H Goldschmidt, H M Lokhorst, M van Duin and P Sonneveld Leukemia 2012 26: 2406-2413; advance online publication, May 8, 2012; 10.1038/leu.2012.127 Abstract | Full Text |  | Letters to the Editor | Top |  | Impact of serum storage conditions on microRNA stabilityS Grasedieck, N Schöler, M Bommer, J H Niess, H Tumani, A Rouhi, J Bloehdorn, P Liebisch, D Mertens, H Döhner, C Buske, C Langer and Florian Kuchenbauer Leukemia 2012 26: 2414-2416; advance online publication, April 16, 2012; 10.1038/leu.2012.106 Full Text |  |  |  | SPARC is dispensable for murine hematopoiesis, despite its suspected pathophysiological role in 5q-myelodysplastic syndromeK Siva, P Jaako, K Miharada, E Rörby, M Ehinger, G Karlsson and S Karlsson Leukemia 2012 26: 2416-2419; advance online publication, April 5, 2012; 10.1038/leu.2012.97 Full Text |  |  |  | High risks of familial chronic lymphatic leukemia for specific relatives: signposts for genetic discovery?P Rebora, M Lee, K Czene, M G Valsecchi and M Reilly Leukemia 2012 26: 2419-2421; advance online publication, April 16, 2012; 10.1038/leu.2012.103 Full Text |  |  |  | Systemic microRNA-34a delivery induces apoptosis and abrogates growth of diffuse large B-cell lymphoma in vivoV J Craig, A Tzankov, M Flori, C A Schmid, A G Bader and A Müller Leukemia 2012 26: 2421-2424; advance online publication, April 23, 2012; 10.1038/leu.2012.110 Full Text |  |  |  | Multiple myeloma induces the immunosuppressive capacity of distinct myeloid-derived suppressor cell subpopulations in the bone marrowE Van Valckenborgh, E Schouppe, K Movahedi, E De Bruyne, E Menu, P De Baetselier, K Vanderkerken and J A Van Ginderachter Leukemia 2012 26: 2424-2428; advance online publication, April 23, 2012; 10.1038/leu.2012.113 Full Text |  |  |  | A randomized study of decitabine versus conventional care for maintenance therapy in patients with acute myeloid leukemia in complete remissionY Boumber, H Kantarjian, J Jorgensen, S Wen, S Faderl, R Castoro, J Autry, G Garcia-Manero, G Borthakur, E Jabbour, Z Estrov, J Cortes, J-P Issa and F Ravandi Leukemia 2012 26: 2428-2431; advance online publication, June 5, 2012; 10.1038/leu.2012.153 Full Text |  |  |  | Successful xenografts of AML3 samples in immunodeficient NOD/shi-SCID IL2Rγ−/− miceS Patel, Y Zhang, B Cassinat, F Zassadowski, N Ferré, W Cuccuini, J M Cayuela, P Fenaux, D Bonnet, C Chomienne and F Louache Leukemia 2012 26: 2432-2435; advance online publication, June 13, 2012; 10.1038/leu.2012.154 Full Text |  |  |  | IL-15-stimulated CD3/CD19-depleted stem-cell boosts in relapsed pediatric patients after haploidentical SCTM M Pfeiffer, M Schumm, Ingo Müller, R Handgretinger and P Lang Leukemia 2012 26: 2435-2439; advance online publication, June 22, 2012; 10.1038/leu.2012.167 Full Text |  |  |  | Long-term follow-up of FIP1L1-PDGFRA-mutated patients with eosinophilia: survival and clinical outcomeA Pardanani, A D'Souza, R A Knudson, C A Hanson, R P Ketterling and A Tefferi Leukemia 2012 26: 2439-2441; advance online publication, June 18, 2012; 10.1038/leu.2012.162 Full Text |  |  |  | Proteasome inhibition leads to dephosphorylation and downregulation of protein expression of members of the Akt/mTOR pathway in MCLG Hutter, Y Zimmermann, M Rieken, E Hartmann, A Rosenwald, W Hiddemann and M Dreyling Leukemia 2012 26: 2442-2444; advance online publication, May 3, 2012; 10.1038/leu.2012.118 Full Text |  | Corrigenda | Top |  | Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomideA Lopez-Girona, D Mendy, T Ito, K Miller, A K Gandhi, J Kang, S Karasawa, G Carmel, P Jackson, M Abbasian, A Mahmoudi, B Cathers, E Rychak, S Gaidarova, R Chen, P H Schafer, H Handa, T O Daniel, J F Evans and R Chopra Leukemia 2012 26: 2445; 10.1038/leu.2012.235 Full Text |  |  |  | Direct interaction of PU.1 with oncogenic transcription factors reduces its serine phosphorylation and promoter bindingA Seshire, T Rößiger, M Frech, S Beez, H Hagemeyer and E Puccetti Leukemia 2012 26: 2445-2446; 10.1038/leu.2012.170 Full Text |  |  |  |  |  | | Advertisement |  | Ensure your access If you are unable to access the articles in this Table of Contents e-alert, your library may not subscribe to this journal. 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