The EMBO Journal - Table of Contents alert Volume 31 Issue 20

TABLE OF CONTENTS 17 October 2012 | Volume 31, Issue 20 Have you seen? Articles Also new AOP Advertisement Call for entries! Eppendorf Young Investigator Award 2013 Prize money: 15,000 Euro Apply now only Entry deadline: 15 January 2013 Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement The EMBO Journal - Transparency in Scientific Publishing EMBO has developed a fair and transparent process to rapidly publish important science. Transparent Review - Cross-Referee Commenting - Scooping Protection - Informed Evaluation - Source Data - Manuscript Transfers - Flexible Formatting - Single Round - Fast Process EMBO core principles in publishing   Have you seen? Top Che-ating death: CHE1/AATF protects from p53-mediated apoptosis Depending on the context, the tumour suppressor p53 directs cells either to apoptosis or to cell-cycle arrest/senescence, with implications for ageing and cancer. The RNA PolII binding protein CHE1/AATF governs this choice. James G Jackson and Guillermina Lozano The EMBO Journal (2012), 31, 3951 - 3953; 10.1038/emboj.2012.258 Abstract | Full text | PDF | Related article Published online: 07 September 2012 Cargo carriers from the Golgi to the cell surface A novel class of secretory cargo carriers (CARTS) mediates the transport of a select set of proteins from the Golgi to the basolateral cell surface. In contrast to vesicles containing bulky cargoes, CARTS are formed in a myosin-independent manner and use myosin for the transport step only. Suzanne R Pfeffer The EMBO Journal (2012), 31, 3954 - 3955; 10.1038/emboj.2012.249 Abstract | Full text | PDF | Related article Published online: 31 August 2012 Setting sail for glucose homeostasis with the AKAP150-PP2B-anchor Anchoring protein-phosphatase rather than -kinase activity determines insulin secretion from pancreatic β cells. These results offer a new perspective and target for metabolic drug development. Adrian Kee Keong Teo and Rohit N Kulkarni The EMBO Journal (2012), 31, 3956 - 3957; 10.1038/emboj.2012.265 Abstract | Full text | PDF | Related article Published online: 14 September 2012 3′-UTRs as a source of regulatory RNAs in bacteria Bacterial small non-coding RNAs, sRNAs, have up to now been identified primarily in intergenic regions. Chao et al. reveal that the 3'-region of mRNAs is another rich reservoir of sRNAs. Markus Gößringer and Roland K Hartmann The EMBO Journal (2012), 31, 3958 - 3960; 10.1038/emboj.2012.269 Abstract | Full text | PDF | Related article Published online: 25 September 2012 Articles Top AATF/Che-1 acts as a phosphorylation-dependent molecular modulator to repress p53-driven apoptosis DNA damage activates the tumour suppressor p53, resulting in either cell-cycle arrest or apoptosis. One mechanism that selectively represses apoptosis-promoting genes involves phosphorylation of the transcription factor AATF/Che-1 by the p38-activated kinase MK2. Katja Höpker, Henning Hagmann, Safiya Khurshid, Shuhua Chen, Pia Hasskamp, Tamina Seeger-Nukpezah, Katharina Schilberg, Lukas Heukamp, Tobias Lamkemeyer, Martin L Sos, Roman K Thomas, Drew Lowery, Frederik Roels, Matthias Fischer, Max C Liebau, Ulrike Resch, Tülay Kisner, Fabian Röther, Malte P Bartram, Roman Ulrich Müller, Francesca Fabretti, Peter Kurschat, Björn Schumacher, Matthias Gaestel, René H Medema, Michael B Yaffe, Bernhard Schermer, H Christian Reinhardt and Thomas Benzing The EMBO Journal (2012), 31, 3961 - 3975; 10.1038/emboj.2012.236 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 August 2012 A new class of carriers that transport selective cargo from the trans Golgi network to the cell surface Carriers mediating vesicular trafficking from the trans-Golgi network to the cell surface remain ill understood. CARTS, a novel class of transport carriers, are formed in a protein kinase D (PKD)-dependent manner and require myosin II for transport to the plasma membrane. Yuichi Wakana, Josse van Galen, Felix Meissner, Margherita Scarpa, Roman S Polishchuk, Matthias Mann and Vivek Malhotra The EMBO Journal (2012), 31, 3976 - 3990; 10.1038/emboj.2012.235 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 21 August 2012 Anchored phosphatases modulate glucose homeostasis AKAP150 knockout- and mutant knock-in alleles reveal an unexpected role of the adaptor in anchoring phosphatase 2B for efficient insulin secretion from pancreatic β-cells and thus glucose homeostasis. Simon A Hinke, Manuel F Navedo, Allison Ulman, Jennifer L Whiting, Patrick J Nygren, Geng Tian, Antonio J Jimenez-Caliani, Lorene K Langeberg, Vincenzo Cirulli, Anders Tengholm, Mark L Dell’Acqua, L Fernando Santana and John D Scott The EMBO Journal (2012), 31, 3991 - 4004; 10.1038/emboj.2012.244 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 August 2012 An atlas of Hfq-bound transcripts reveals 3′ UTRs as a genomic reservoir of regulatory small RNAs Deep sequencing of Hfq-binding RNAs isolated from Salmonella at different growth stages reveals that the 3′ UTR of bacterial mRNAs are a rich source of regulatory small RNAs which modulate gene expression in trans. Yanjie Chao, Kai Papenfort, Richard Reinhardt, Cynthia M Sharma and Jörg Vogel The EMBO Journal (2012), 31, 4005 - 4019; 10.1038/emboj.2012.229 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 August 2012 Alternative 3′-end processing of long noncoding RNA initiates construction of nuclear paraspeckles Paraspeckle formation is initiated by the long noncoding RNA isoform NEAT1_2. This study identifies 35 paraspeckle proteins, seven of which are essential for paraspeckle formation. One of these, hnRNP K, governs alternative 3′-end processing of NEAT to generate NEAT1_2. Takao Naganuma, Shinichi Nakagawa, Akie Tanigawa, Yasnory F Sasaki, Naoki Goshima and Tetsuro Hirose The EMBO Journal (2012), 31, 4020 - 4034; 10.1038/emboj.2012.251 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 September 2012 A complex immunodeficiency is based on U1 snRNP-mediated poly(A) site suppression An immunodeficiency-linked mutation in the 3′ untranslated region of the endosomal adaptor protein p14 mRNA creates a splice site recognized by the spliceosomal component U1 snRNP. The resulting impaired poly(A)-site 3′ end processing leads to p14 mRNA degradation providing a mechanistic basis for this hereditary immunodeficiency. Jörg Langemeier, Eva-Maria Schrom, Alona Rabner, Maximilian Radtke, Daniela Zychlinski, Anna Saborowski, Georg Bohn, Yael Mandel-Gutfreund, Jochen Bodem, Christoph Klein and Jens Bohne The EMBO Journal (2012), 31, 4035 - 4044; 10.1038/emboj.2012.252 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 11 September 2012 The hSSB1 orthologue Obfc2b is essential for skeletogenesis but dispensable for the DNA damage response in vivo SSB1, a recently identified single-strand binding protein proposed as a master regulator of DNA damage responses in human cells, plays no genome maintenance roles in mice. Niklas Feldhahn, Elisabetta Ferretti, Davide F Robbiani, Elsa Callen, Stephanie Deroubaix, Licia Selleri, Andre Nussenzweig and Michel C Nussenzweig The EMBO Journal (2012), 31, 4045 - 4056; 10.1038/emboj.2012.247 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 August 2012 The Arf GAP ASAP1 provides a platform to regulate Arf4- and Rab11–Rab8-mediated ciliary receptor targeting The Arf GTPase activating protein ASAP1 acts as scaffold for ciliary cargo and components of the ciliogenesis cascade, the GTPases Arf4, Rab11a and Rab8, and the Rab8 guanine nucleotide exchange factor Rabin8. Jing Wang, Yoshiko Morita, Jana Mazelova and Dusanka Deretic The EMBO Journal (2012), 31, 4057 - 4071; 10.1038/emboj.2012.253 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 September 2012 Dimerization and direct membrane interaction of Nup53 contribute to nuclear pore complex assembly Nuclear pore formation depends on membrane curvature. The membrane deforming activity of Nup53 is required for nuclear pore complex (NPC) assembly during interphase. Benjamin Vollmer, Allana Schooley, Ruchika Sachdev, Nathalie Eisenhardt, Anna M Schneider, Cornelia Sieverding, Johannes Madlung, Uwe Gerken, Boris Macek and Wolfram Antonin The EMBO Journal (2012), 31, 4072 - 4084; 10.1038/emboj.2012.256 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 September 2012 Structural basis for Arl3-specific release of myristoylated ciliary cargo from UNC119 UNC119/HRG4 transports myristoylated proteins to the cilia, where they are released by the small G protein Arl3. Crystal structures of Arl3 and Arl2 in complex with UNC119a reveal how Arl3 displaces cargo via a specific allosteric mechanism. Shehab A Ismail, Yong-Xiang Chen, Mandy Miertzschke, Ingrid R Vetter, Carolin Koerner and Alfred Wittinghofer The EMBO Journal (2012), 31, 4085 - 4094; 10.1038/emboj.2012.257 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 September 2012 Advertisement Follow EMBO on Facebook for as-it-happens access to news, comments and articles and make it a place to share information with others interested in the field. www.facebook.com/EMBO.excellence.in.life.sciences   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). 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