Nature Reviews Molecular Cell Biology contents November 2012 Volume 13 Number 11

TABLE OF CONTENTS
November 2012 Volume 13 Number 11		Advertisement
Impact Factor 39.123 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: NMD: a multifaceted response to premature translational termination Stephanie Kervestin & Allan Jacobson	Don’t wash away your cells! Tecan's HydroSpeed™ Year-to-End Offer! • HydroSpeed plate washer • offers extra gentle Cell • Protection™ wash • settings • High cell recovery using • tuneable aspiration • settings • Anti-Clogging™ function • for reliable ELISA washing Click for YOUR offer
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RESEARCH HIGHLIGHTS Top Stem cells: An ageing decline p681 | doi:10.1038/nrm3464 Age-dependent decline in muscle stem cell function is due to increased fibroblast growth factor (FGF) signalling from the niche. PDF Cell death: Some like it hot p682 | doi:10.1038/nrm3455 A conserved mechanism protects against heatstroke-mediated necrosis and neurodegeneration. PDF Development: Knowing left from right p682 | doi:10.1038/nrm3456 Sensing of nodal flow for symmetry breaking occurs via PKD2 localized at cilia. PDF Chromatin: Histone sibling rivalry p683 | doi:10.1038/nrm3462 The asymmetric modification of sister histones can alter the nucleosome functional state. PDF Chromatin: Defining heterochromatin p684 | doi:10.1038/nrm3450 The sequence-specific transcription factors PAX3 and PAX9 promote heterochromatin formation. PDF IN THE NEWS Bold moves p684 | doi:10.1038/nrm3451 The 2012 Lasker award recognized basic cytoskeletal research and early molecular cloning studies. PDF DNA replication: It's a matter of time p684 | doi:10.1038/nrm3452 Taz1 is recruited to telomeric sequences and regulates replication timing in fission yeast. PDF Non-coding RNAS: A new member of the family p686 | doi:10.1038/nrm3449 This study describes a new class of lncRNAs flanked by snoRNAs and shows that they have a role in splicing. PDF JOURNAL CLUB A centriolar lifeline p686 | doi:10.1038/nrm3460 Clues into how newly formed procentrioles emerge at a right angle from the mother centriole. PDF IN BRIEF Organelle dynamics: Cell starvation through proteasome block | Cell signalling: Mediating hormonal crosstalk | Membrane dynamics: ER connections boost phagocytosis PDF Molecular Cell Biology JOBS of the week Assistant Professor, Molecular Genetics Faculty Position Oregon Health & Science University (OHSU) Faculty Positions in Molecular Cell Biology Department of Biological Sciences, Virginia Tech Postdoctoral Associates Biochemistry / Structural Cell & Molecular Biology University at Albany Molecular Imaging Biologist Hadassah Hebrew University Hospital, Cyclotron- Radiochemistry- microPET unit PhD Positions at International Max Planck Research School for Molecular and Cellular Life Sciences: From Biology to Medicine Max Planck Institute of Biochemistry, Max Planck Institute of Neurobiology, Ludwig-Maximilians-Universit�t (LMU) Munich and Technical University Munich (TUM) More Science jobs from Molecular Cell Biology EVENT ElecMol12: Sixth International Meeting on Molecular Electronics 03.-07.12.12 Grenoble, France More science events from
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REVIEWS		Top
Nuclear pore complex composition: a new regulator of tissue-specific and developmental functions Marcela Raices & Maximiliano A. D'Angelo p687 | doi:10.1038/nrm3461 The multiprotein nuclear pore complexes (NPCs) that mediate nucleocytoplasmic transport are universal and essential for cell viability. However, cell type-specific expression of particular NPC components and specialized NPC functions now point towards a previously unrecognized heterogeneity in these ancient pores. Abstract | Full Text | PDF
NMD: a multifaceted response to premature translational termination Stephanie Kervestin & Allan Jacobson p700 | doi:10.1038/nrm3454 Nonsense-mediated decay (NMD) is one of the surveillance pathways that ensure fidelity in gene expression by recognizing and degrading aberrant mRNAs. How the factors involved in NMD discriminate between normal and prematurely terminated mRNAs, and how they carry out their functions downstream of recognition, has been the subject of intense investigation. Abstract | Full Text | PDF
Induced pluripotent stem cells: the new patient? Milena Bellin, Maria C. Marchetto, Fred H. Gage & Christine L. Mummery p713 | doi:10.1038/nrm3448 Worldwide increases in life expectancy have been paralleled by a greater prevalence of chronic and age-associated disorders, particularly of the cardiovascular, neural and metabolic systems. Patient-specific induced pluripotent stem (iPS) cells are finding applications in disease modelling, drug testing and drug discovery, thus enabling researchers to undertake studies for treating diseases 'in a dish'. Abstract | Full Text | PDF | Supplementary information
Corrigendum: Minimizing the damage: repair pathways keep mitochondrial DNA intact Lawrence Kazak, Aurelio Reyes & Ian J. Holt p726 | doi:10.1038/nrm3458 Full Text | PDF
PERSPECTIVES		Top
OPINION Surveillance pathways rescuing eukaryotic ribosomes lost in translation Marc Graille & Bertrand Séraphin p727 | doi:10.1038/nrm3457 Three surveillance pathways specialize in the degradation of mRNA molecules trapped in stalled translation complexes: the non-stop decay (NSD), the no-go decay (NGD) and the 18S-rRNA decay (18S-NRD) pathways. These quality control mechanisms degrade faulty mRNAs and contribute to maintaining the production of functional proteins. Abstract | Full Text | PDF
INNOVATION Advances in tomography: probing the molecular architecture of cells Karen Fridman, Asaf Mader, Monika Zwerger, Natalie Elia & Ohad Medalia p736 | doi:10.1038/nrm3453 Cryo-electron tomography has provided a means of characterizing the architecture of macromolecular complexes in their native environment, and facilitated a better understanding of cellular processes. By combining this method with fluorescence and super-resolution microscopy, the full potential of this approach can be realized. Abstract | Full Text | PDF
VIEWPOINT New dimensions in cell migration Peter Friedl, Erik Sahai, Stephen Weiss & Kenneth M. Yamada p743 | doi:10.1038/nrm3459 Researchers assess the contribution of studies in three-dimensional (3D) systems to our understanding of cell migration, both in terms of the mechanisms used to drive single cell and collective cell migration and how cells adapt to a changing environment. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2011

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