Nature Reviews Microbiology contents November 2012 Volume 10 Number 11 pp 727-797

TABLE OF CONTENTS
November 2012 Volume 10 Number 11
Impact Factor 21.182 *	In this issue Editorial Research Highlights News and Analysis Progress Reviews Perspectives Also this month  Featured article: Merging mythology and morphology: the multifaceted lifestyle of Proteus mirabilis Chelsie E. Armbruster & Harry L. T. Mobley
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EDITORIAL		Top
Turn on, tune in, speak up p727 | doi:10.1038/nrmicro2904 Despite low levels of uptake and active engagement, social media and other online tools can be of great benefit to microbiology researchers, and their use is to be encouraged. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Bacterial evolution: Decoding the bacterial fossil record p729 | doi:10.1038/nrmicro2895 Long-term experimental evolution of Escherichia coli reveals that a promoter capture event and subsequent amplification underlie the emergence of a novel function. PDF Bacterial physiology: Uncovering the circadian clockwork p730 | doi:10.1038/nrmicro2896 Stacking interactions between two rings formed in the KaiC homohexamer drive the cyanobacterial circadian oscillator. PDF IN THE NEWS New coronavirus p730 | doi:10.1038/nrmicro2906 PDF Host response: Double trouble for TB p730 | doi:10.1038/nrmicro2908 Two recent papers provide evidence to support a role for efferocytosis at different points in the host response to Mycobacterium tuberculosis infection. PDF Cellular microbiology: Bacterial tRNAs fatten up p731 | doi:10.1038/nrmicro2897 The first report of geranylated RNA nucleotides, which were discovered in the anticodon loops of bacterial tRNAs, and affect codon bias and frameshifting during translation. PDF Host response: Codon-usage-based inhibition puts HIV to sleep p732 | doi:10.1038/nrmicro2898 The interferon-stimulated early response gene SLFN11 specifically inhibits HIV protein synthesis in a codon-usage-based manner. PDF Viral infection: Gift wrapped by the plasma membrane p732 | doi:10.1038/nrmicro2905 HSV-1 obtains its envelope from the plasma membrane. PDF Microbial ecology: Non-coding RNAs make E. coli unpalatable p732 | doi:10.1038/nrmicro2909 Endogenous non-coding RNAs from Escherichia coli alter Caenorhabditis elegans gene expression to protect the bacterium from foraging by the worm. PDF IN BRIEF Fungal pathogenesis: Defining the fungal filamentous switch | Parasite biology: Targeting Plasmodium epigenetic regulation | Microbiome: Gut microbiome as a marker for diabetes PDF Microbiology JOBS of the week Lectureships in Molecular Microbiology Imperial College London Postdoctoral Associate In The Field Of Plant Biology And Microbiology Stony Brook University - Department of Biochemistry and Cell Biology Assistant professors in Environmental Microbiology; and Plant Biology / Phycology The American University of Beirut Faculty Position Microbiology University of Connecticut, Department of Molecular and Cell Biology Head 5-year Groups in the Institut Pasteur in Microbiology and Virology Institut Pasteur More Science jobs from Microbiology EVENT International Conference on Clinical Microbiology & Microbial Genomics 12.-14.11.12 US More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Bacterial frequent flyers Ankur Mutreja p734 | doi:10.1038/nrmicro2899 This month's Genome Watch describes how sequencing technology is providing insight into the geographical relationships and global travel of bacterial pathogens. PDF
PROGRESS		Top
The interplay between the intestinal microbiota and the brain Stephen M. Collins, Michael Surette & Premysl Bercik p735 | doi:10.1038/nrmicro2876 A bidirectional neurohumoral communication system known as the gut-brain axis integrates the activities of the intestine and the brain. In this Progress article, Collins, Surette and Bercik describe recent evidence suggesting that the intestinal microbiota is intimately connected with the gut-brain axis and can influence animal behaviour, development and health. Abstract | Full Text | PDF
REVIEWS		Top
Merging mythology and morphology: the multifaceted lifestyle of Proteus mirabilis Chelsie E. Armbruster & Harry L. T. Mobley p743 | doi:10.1038/nrmicro2890 Proteus mirabilis is one of the leading causes of catheter-associated urinary tract infections. Here, Armbruster and Mobley review the many recent advances in our understanding of P. mirabilis pathogenicity, including the elucidation of the intricate connections between metabolism, swarming motility and urease activity. Abstract | Full Text | PDF
The ABCs of plasmid replication and segregation Uelinton M. Pinto, Katherine M. Pappas & Stephen C. Winans p755 | doi:10.1038/nrmicro2882 RepABC family plasmids are found exclusively in alphaproteobacteria. The replication and partitioning proteins of these plasmids are encoded by a single operon, the repABC cassette. Here, Pinto, Pappas and Winans review the regulation of RepABC plasmid replication and partitioning, including the mechanisms that allow plasmid copynumber to be increased in response to external cues. Abstract | Full Text | PDF | Supplementary information
Modulation of innate immunity by Toxoplasma gondii virulence effectors Christopher A. Hunter & L. David Sibley p766 | doi:10.1038/nrmicro2858 The intracellular parasite Toxoplasma gondii can infect a range of hosts and occasionally causes serious disease in humans. In this Review, Hunter and Sibley summarize recent studies that implicate rhoptry kinases and a dense-granule protein as mediators of acute virulence in the mouse model. They also describe the complex interplay between these parasite effector proteins and the innate immune system. Abstract | Full Text | PDF | Supplementary information
Emerging themes in SecA2-mediated protein export Meghan E. Feltcher & Miriam Braunstein p779 | doi:10.1038/nrmicro2874 Most protein export in bacteria occurs through the Sec pathway and relies on the essential ATPase SecA to push substrates through the SecYEG translocon. Here, Braunstein and Feltcher describe how mycobacteria and some Gram-positive bacteria secrete certain substrates using additional versions of SecA and other Sec components. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION From genotype to phenotype: can systems biology be used to predict Staphylococcus aureus virulence? Nicholas K. Priest, Justine K. Rudkin, Edward J. Feil, Jean M. H. van den Elsen, Ambrose Cheung, Sharon J. Peacock, Maisem Laabei, David A. Lucks, Mario Recker & Ruth C. Massey p791 | doi:10.1038/nrmicro2880 Predicting the virulence of a particular bacterial strain is a complex task that currently cannot be achieved from genome sequence data alone. In this Opinion article, Massey and colleagues present a framework for the construction of a systems biology-based tool that they think could be used to predict virulence phenotypes from Staphylococcus aureus genomic sequences using existing technologies. Abstract | Full Text | PDF
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