Nature Reviews Immunology Contents November 2012 Volume 12 Number 11 pp 741-804

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TABLE OF CONTENTS
November 2012 Volume 12 Number 11		Advertisement
Impact Factor 33.287 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Transcriptional control of effector and memory CD8+ T cell differentiation Susan M. Kaech & Weiguo Cui	Fast Quantitative Western Blotting The new V3 Western Workflow™ from Bio-Rad streamlines your western blot protocol and delivers reliable results faster. visualize and verify results at each step of your experiment, and quantify your proteins with confidence. See more V3 Western Workflow here.
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RESEARCH HIGHLIGHTS Top Tumour immunology: MYCing around with the GC response p741 | doi:10.1038/nri3327 MYC is required for the formation and maintenance of germinal centres. PDF Innate immunity: Inflammasome triggered by cell swelling p742 | doi:10.1038/nri3324 Mechanosensitive ion channels promote inflammasome activation in response to cell swelling. PDF T cells: Colonial competition p742 | doi:10.1038/nri3329 Competition for subthreshold ligands may maintain the size and diversity of the peripheral T cell compartment. PDF Signalling: PI3Kδ keeps TLR4 signalling on track p744 | doi:10.1038/nri3330 PI3Kδ regulates TLR4 signalling by controlling the subcellular localization of TLR4 and TIRAP. PDF T cells: When I get older, losing my miR… p744 | doi:10.1038/nri3331 T cell receptor activation thresholds increase with age in naive CD4+ T cells owing to a loss of miR-181a expression. PDF Tumour immunology: Chromosome overload p745 | doi:10.1038/nri3326 Polyploid tumour cells trigger an immune response through ER stress. PDF T cells: Neuropilin 1 — distinguishing TReg cell subsets p746 | doi:10.1038/nri3323 Distinguishing natural and induced TReg cells on the basis of neuropilin 1 expression. PDF Innate immunity: Bitter enemies p746 | doi:10.1038/nri3332 The bitter taste receptor T2R38 regulates antibacterial immune responses in the upper airways. PDF IN BRIEF Gene regulation: Enhancer accessibility to FOXP3 | T cells: MAIT cells specific for microbial metabolites | Dendritic cells: Hoarding may keep old memories alive | Macrophages: Lipid metabolism linked to anti-inflammatory functions | Signalling: Pellino3 — a self-control strategy for TLR3 | Tumour immunology: Inflammation blinds T cells to melanoma PDF Immunology JOBS of the week Immunology Post-doctoral Position Malaghan Institute of Medical Research Post-Doctoral Research Fellow in Immunology Fred Hutchinson Cancer Research Center Postdoctoral Fellow, Immunology / Neuroimmunology Research Thomas Jefferson University Postdoctoral Position Systems Immunology / microbiome oregon state university Senior Post-Doc Cell Biology applied to Immunology Institut Curie Research Center More Science jobs from Immunology EVENT Tumor Immunology: Multidisciplinary Science Driving Basic and Clinical Advances 02.-05.12.12 FL, US More science events from
REVIEWS		Top
Transcriptional control of effector and memory CD8+ T cell differentiation Susan M. Kaech & Weiguo Cui p749 | doi:10.1038/nri3307 This Review describes how CD8+ T cells coordinate signals mediated by antigens, co-stimulatory molecules, pro-inflammatory cytokines and metabolic state to regulate the transcriptional programmes that determine differentiation to diverse effector and memory cell fates. Abstract | Full Text | PDF
HEVs, lymphatics and homeostatic immune cell trafficking in lymph nodes Jean-Philippe Girard, Christine Moussion & Reinhold Förster p762 | doi:10.1038/nri3298 The recirculation of lymphocytes through lymph nodes and their encounter with dendritic cells is crucial for immunity. Here, the authors review the role of high endothelial venules, lymphatics and lymph node stroma in the trafficking of immune cells in lymph nodes during homeostasis. Abstract | Full Text | PDF
A20: linking a complex regulator of ubiquitylation to immunity and human disease Averil Ma & Barbara A. Malynn p774 | doi:10.1038/nri3313 Human genetic studies associate defective A20 activity with autoimmune and autoinflammatory diseases, as well as with cancer. Here, Ma and Malynn discuss the complex mechanisms through which A20 may control immune cell activation and survival, thereby maintaining homeostasis. Abstract | Full Text | PDF
Humanized mice for immune system investigation: progress, promise and challenges Leonard D. Shultz, Michael A. Brehm, J. Victor Garcia-Martinez & Dale L. Greiner p786 | doi:10.1038/nri3311 This article provides a comprehensive overview of the recent advances in the development and use of humanized mice. The authors consider the remaining challenges and the potential for new advances in our understanding of human immunology through the use of these mice. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors Kenneth J. Oestreich & Amy S. Weinmann p799 | doi:10.1038/nri3321 There has been a tendency to associate the development of distinct CD4+ T cell subsets with the expression of 'master regulator' transcription factors. Here, the authors discuss the shortcomings of this model and explain why 'lineage-specifying' may be a more fitting way to describe these key transcription factors. Abstract | Full Text | PDF
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