Nature Reviews Genetics Contents November 2012 Volume 13 Number 11 pp 755-824

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TABLE OF CONTENTS
November 2012 Volume 13 Number 11		Advertisement
Impact Factor 38.075*	In this issue Research Highlights Reviews Perspectives Also this month Article series: Study designs Genome-wide association studies Applications of next-generation sequencing  Featured article: Evolution of the cancer genome Lucy R. Yates & Peter J. Campbell	Get the most from your NGS data with Sequenom’s MassARRAY® system • Validate from tens to thousands of samples across tens to hundreds of SNPs • Design you own assays against any SNP of interest • Run a variety of applications including genotyping, DNA methylation and somatic mutation analysis
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RESEARCH HIGHLIGHTS Top Stem cells: Revealing the reprogramming program p755 | doi:10.1038/nrg3346 PDF Disease genomics: Associations go metagenome-wide p756 | doi:10.1038/nrg3347 PDF Gene regulation: RNAs feel the heat p756 | doi:10.1038/nrg3350 PDF Bacterial evolution: Decoding fossil records p757 | doi:10.1038/nrg3348 PDF Plant genetics: A killer-protector mechanism in hybrid sterility p758 | doi:10.1038/nrg3349 PDF IN BRIEF Complex traits: Variant associated with phenotypic variability | Gene expression: Uncovering sex-biased eQTLs | Epigenetics: Asymmetric complexity of the histone code | Cancer: Retrotransposition in colorectal cancer | Translational genetics: Whole-genome sequencing diagnostics for newborns | Non-coding RNA: Bacterial ncRNAs alter gene expression in worms | Transcription: MYC provides a global boost | Evolution: Coevolution revealed PDF Genetics JOBS of the week Tenure Track Position in Evolutionary Genetics Emory University Assistant / Associate Professor- Molecular Biology and Genetics Cornell University Assistant Professor in Human Genetics UT Southwestern Medical Center at Dallas Postdoctoral Research Fellow: Statistical Genetics (ML-24643) Fred Hutchinson Cancer Research Center Junior Professorship (W1) (3 years / tenure track leading to W2) of Clinical Chemistry and Functional Genetics Ludwig-Maximilians-Universität (LMU) Munich More Science jobs from Genetics EVENT Complex Disease Genetics for Clinicians 24.-25.01.13 Cambridge, UK More science events from
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Introducing the knoSYS™100-a genome interpretation supercomputer The knoSYS™100 is the first fully integrated hardware and software system developed for the interpretation of human whole genomes. Designed to help geneticists discover relevant genetic variation and investigate inherited disease, the knoSYS™100 accepts sequence data produced by all leading platforms. Learn more.
REVIEWS		Top
Article series: Study designs Genetic variation in metabolic phenotypes: study designs and applications Karsten Suhre & Christian Gieger p759 | doi:10.1038/nrg3314 Revealing genetic influences on metabolic phenotypes is important in further understanding the aetiology of many complex diseases. Here, the authors introduce study design considerations and applications for genome-wide association studies with metabolic traits. Abstract | Full Text | PDF
DNA secondary structures: stability and function of G-quadruplex structures Matthew L. Bochman, Katrin Paeschke & Virginia A. Zakian p770 | doi:10.1038/nrg3296 Growing evidence is implicating non-B-form DNA structures in processes related to DNA stability and function, including replication and transcription. In particular, genomic studies are suggesting that sequences that could form G-quadruplex structures are widespread, so there is a need to improve our understanding of these structures. Abstract | Full Text | PDF | Supplementary information
Genetics of germ cell development Bluma J. Lesch & David C. Page p781 | doi:10.1038/nrg3294 Recent advances in genetic technologies have progressed the understanding of the biological pathways mediating the control of germ cell development. In this Review the genes and strategies involved in Drosophila melanogaster, Caenorhabditis elegans and mouse germline development are compared and contrasted. Abstract | Full Text | PDF
Evolution of the cancer genome Lucy R. Yates & Peter J. Campbell p795 | doi:10.1038/nrg3317 The advance of DNA-sequencing technologies is allowing the investigation of cancer genome evolution at an unprecedented resolution. This article presents recent insights into cancer genome heterogeneity and adaptation gained from the application of novel strategies. Abstract | Full Text | PDF
Article series: Genome-wide association studies Genome-wide association studies in mice Jonathan Flint & Eleazar Eskin p807 | doi:10.1038/nrg3335 Genome-wide association studies (GWASs) of mice provide an alternative means of identifying genes and genetic variants that are important for human physiology and disease. This Review describes the various resources and strategies for GWASs of mice, emphasizing their advantages and pitfalls relative to human studies. Abstract | Full Text | PDF | Supplementary information
PERSPECTIVES		Top
VIEWPOINT Article series: Applications of next-generation sequencing Next-generation sequencing in the clinic: are we ready? Leslie G. Biesecker, Wylie Burke, Isaac Kohane, Sharon E. Plon & Ron Zimmern p818 | doi:10.1038/nrg3357 We asked five experts their opinions on issues that arise from new clinical tests that are based on next-generation sequencing. Crucial gaps in infrastructure need to be addressed for the results of these tests to be optimally handled. Abstract | Full Text | PDF
Erratum: Revising the human mutation rate: implications for understanding human evolution Aylwyn Scally & Richard Durbin p824 | doi:10.1038/nrg3353 Full Text | PDF
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