Molecular Systems Biology - New articles published 23 October 2012

Latest Articles 23rd October 2012   Featured Article Report   Web feeds About Open access   Featured Article A functional selection model explains evolutionary robustness despite plasticity in regulatory networks By tracing the evolutionary history of transcriptional networks across 23 fungi, two seemingly contradictory trends are observed: rapid target turnover and conserved function. This is reconciled by a model that invokes strong selection to conserve the overall function of a motif, but not its individual targets. Naomi Habib, Ilan Wapinski, Hanah Margalit, Aviv Regev & Nir Friedman Molecular Systems Biology 8:619; doi:10.1038/msb.2012.50; published 23 October 2012 Full Text | PDF | Supp. Inf. | Review Process Report Sequestration-based bistability enables tuning of the switching boundaries and design of a latch Engineering of the sigma/anti-sigma system in Escherichia coli shows that sequestration combined with positive feedback can be used to build a bistable memory device. The minimal requirement of this design makes it potentially scalable and generalizable. David Chen & Adam P Arkin Molecular Systems Biology 8:620; doi:10.1038/msb.2012.52; published 23 October 2012 Full Text | PDF | Supp. Inf. | Review Process

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