EMBO Reports - Table of Contents alert Volume 31 Issue 10, pp 869-939

TABLE OF CONTENTS October 2012 | Volume 13, Issue 10 Upfront Science & Society Review Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Upfront Top Editorial Lo, what fools these mortals be Somewhere in the Universe, advanced life-forms far wiser than us have surely evolved. Howy wonders whether they are waiting for humanity to grow up before saying hello. Howy Jacobs EMBO reports (2012), 13, 869; 10.1038/embor.2012.138 Full text | PDF Published online: 01 October 2012 Subject Categories: Ethics | Philosophy & History of Science | Societal Issues & Politics Hot off the Press Mitofusins ‘bridge’ the gap between oxidative stress and mitochondrial hyperfusion During stress conditions, mitochondria can undergo hyperfusion to protect the cell. A recent study in EMBO reports identifies a new mechanism by which mitofusins can be activated to initiate mitochondrial during oxidative stress. Michael T Ryan and Diana Stojanovski EMBO reports (2012), 13, 870 - 871; 10.1038/embor.2012.132 Full text | PDF Published online: 11 September 2012 Subject Categories: Membranes & Transport Fighting mycobacteria through ISGylation The role of ISGylation in humans has been a long-standing question. A recent groundbreaking study by the Casanova group shows it is essential in the defence against mycobacterial disease but dispensable for other types of infection. Christian Pohl and Ivan Dikic EMBO reports (2012), 13, 872 - 873; 10.1038/embor.2012.129 Full text | PDF Published online: 31 August 2012 Subject Categories: Molecular Biology of Disease | Immunology | Proteins Meeting Point Everybody wins! Poland hosts thrilling competitions of viruses, RNAi and football teams The ESF–EMBO conference on ‘Antiviral RNAi: From Molecular Biology towards Applications’ took place in June 2012. It brought together scientists working at the interface of RNAi and virus infections in different organisms, covering the complete range from basic mechanisms of RNA silencing to RNAi-based antiviral therapy. Dirk Grimm, Tamas Dalmay and Ronald P van Rij EMBO reports (2012), 13, 874 - 876; 10.1038/embor.2012.136 Abstract | Full text | PDF Published online: 18 September 2012 Subject Categories: Microbiology & Pathogens | RNA Searching for the Holy Grail; protein–protein interaction analysis and modulation The EMBO workshop on ‘Protein–Protein Interaction Analysis & Modulation’ covered protein network analysis, the modulation of protein–protein interactions, and the daunting challenge of integrating interactomes in systems biology and in the modelling of signalling networks. Xavier Morelli and Ted Hupp EMBO reports (2012), 13, 877 - 879; 10.1038/embor.2012.137 Abstract | Full text | PDF Published online: 18 September 2012 Subject Categories: Proteins | Molecular Biology of Disease | Signal Transduction Science & Society Top Sex, mutations and marketing Runaway consumerism imposes social and ecological costs on humans in much the same way that runaway sexual ornamentation imposes survival costs and extinction risks on other animals. Geoffrey Miller EMBO reports (2012), 13, 880 - 884; 10.1038/embor.2012.131 Full text | PDF Published online: 18 September 2012 Subject Categories: Economics & Business | Societal Issues & Politics | Evolution, Environment & Agriculture The postmodern assault on science Postmodernist thought is being used to attack the scientific worldview and undermine scientific truths; a disturbing trend that has gone unnoticed by a majority of scientists. Marcel Kuntz EMBO reports (2012), 13, 885 - 889; 10.1038/embor.2012.130 Full text | PDF Published online: 18 September 2012 Subject Categories: Philosophy & History of Science | Societal Issues & Politics | Evolution, Environment & Agriculture Equally potent? Induced pluripotent stem cells and our ability to transdifferentiate somatic cells might obviate the clinical use of embryonic stem cells in the future. Too many questions currently remain unanswered, however, to abandon embryonic stem cell research. Kristopher L Nazor, Jeanne F Loring and Louise C Laurent EMBO reports (2012), 13, 890 - 894; 10.1038/embor.2012.134 Full text | PDF Published online: 18 September 2012 Subject Categories: Health & Disease | Technology, Development & Applications More than meets the eye Visualizing data can lead to new insights and understanding, but modern research is so complex that the old methods cannot cope. Researchers are developing visual spaces for representing huge quantities of data in a new way. Andrea Rinaldi EMBO reports (2012), 13, 895 - 899; 10.1038/embor.2012.135 Full text | PDF Published online: 18 September 2012 Subject Categories: Technology, Development & Applications | Science Infrastructures & Publishing | Scientific Training & Careers Review Top Rho-associated kinases in tumorigenesis: re-considering ROCK inhibition for cancer therapy ROCK kinases as downstream effectors of Rho GTPases have been implicated in numerous cellular processes including tumorigenesis. Therefore, interference with ROCK activity has been considered to be a potential therapeutic approach to fight cancer. This review highlights some of the recent findings that have extended our understanding of the role of ROCK signalling in cancer into unexpected and potentially clinically important areas. Nicola Rath and Michael F Olson EMBO reports (2012), 13, 900 - 908; 10.1038/embor.2012.127 Abstract | Full text | PDF Published online: 11 September 2012 Subject Categories: Signal Transduction | Cell & Tissue Architecture | Proteins Scientific Reports Top The intracellular redox state is a core determinant of mitochondrial fusion This report shows that oxidized glutathione (GSSG) strongly induces mitochondrial fusion by inducing the generation of disulfide-mediated mitofusin oligomers in response to redox stress. Timothy Shutt, Michèle Geoffrion, Ross Milne and Heidi M McBride EMBO reports (2012), 13, 909 - 915; 10.1038/embor.2012.128 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 September 2012 Subject Categories: Membranes & Transport Cytosolic thioredoxin system facilitates the import of mitochondrial small Tim proteins This report shows that the cytosolic thioredoxin system is required to maintain the mitochondrial small Tim proteins in an import-competent Cys-reduced form and facilitate their import. Romina Durigon, Qi Wang, Efrain Ceh Pavia, Chris M Grant and Hui Lu EMBO reports (2012), 13, 916 - 922; 10.1038/embor.2012.116 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 August 2012 Subject Categories: Membranes & Transport | Proteins R-loops cause replication impairment and genome instability during meiosis This study provides the first evidence that R-loops can form during meiosis in Saccharomyces cerevisiae and Caenorhabditis elegans, and that they impair pre-meiotic replication leading to meiotic accumulation of DNA breaks and genome instability. Maikel Castellano-Pozo, Tatiana García-Muse and Andrés Aguilera EMBO reports (2012), 13, 923 - 929; 10.1038/embor.2012.119 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 August 2012 Subject Categories: Genome Stability & Dynamics Ubiquitin-specific protease-like 1 (USPL1) is a SUMO isopeptidase with essential, non-catalytic functions This study characterizes USPL1—previously believed to be an ubiquitin protease—as a new type of SUMO isopeptidase and identifies the residues important for SUMO binding and cleavage. USPL1—but not its catalytic activity—is essential for cell proliferation. Sarah Schulz, Georgia Chachami, Lukasz Kozaczkiewicz, Ulrike Winter, Nicolas Stankovic-Valentin, Petra Haas, Kay Hofmann, Henning Urlaub, Huib Ovaa, Joachim Wittbrodt, Erik Meulmeester and Frauke Melchior EMBO reports (2012), 13, 930 - 938; 10.1038/embor.2012.125 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 August 2012 Subject Categories: Proteins Corrections Top Erratum To ban or not to ban? Heidi Carmen Howard and Pascal Borry EMBO reports (2012), 13, 939; 10.1038/embor.2012.141 Full text | PDF | Supp. info. Published online: 18 September 2012 Advertisement Follow EMBO on Facebook for access to news, comments and articles make it a place to share information with others interested in the life sciences. https://www.facebook.com/EMBO.excellence.in.life.sciences   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. 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