TABLE OF CONTENTS
| | 12 September 2012 | Volume 31, Issue 18 |  | | |  |  Have you seen?
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Apply here | | | | | Have you seen? | Top | |  | | Down syndrome DSCR1 causes spine pathology via the Fragile X-related protein FMRP Two major causes of intellectual disability, Down syndrome and Fragile X, involve a shared molecular mechanism that regulates local protein synthesis and spine morphology at synapse. Francesco Roselli The EMBO Journal (2012), 31, 3647 - 3649; 10.1038/emboj.2012.239 Abstract | Full text | PDF Published online: 21 August 2012 | | | | Rif1 choreographs DNA replication timing New work identifies Rif1 as a global determinant of the timing program that controls orderly progression of mammalian DNA replication to ensure stable genetic and epigenetic inheritance. Mirit I Aladjem The EMBO Journal (2012), 31, 3650 - 3652; 10.1038/emboj.2012.238 Abstract | Full text | PDF Published online: 14 August 2012 | | | | Split decisions: oesophageal progenitor cell behaviour The molecular features and functional contributions of epithelial progenitors remain controversial. A recent study in Science reports on seemingly equivalent oesophageal progenitors that maintain tissue homeostasis in the absence of slow cycling cell populations. Valerie Horsley The EMBO Journal (2012), 31, 3653 - 3654; 10.1038/emboj.2012.230 Abstract | Full text | PDF | Related article Published online: 10 August 2012 | | Articles | Top | | | | DSCR1 interacts with FMRP and is required for spine morphogenesis and local protein synthesis Kyung-Tai Min and colleagues report the first molecular link between Down syndrome and Fragile X syndrome. DSCR1 (implicated in Down syndrome) interacts with FMRP (Fragile X syndrome protein) to regulate spine morphogenesis and local protein synthesis in dendrites. Both processes are implicated in synaptic activity and intellectual disabilities. Wei Wang, John Z Zhu, Karen T Chang and Kyung-Tai Min The EMBO Journal (2012), 31, 3655 - 3666; 10.1038/emboj.2012.190 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 August 2012 | | | | Rif1 regulates the replication timing domains on the human genome The homologue of the yeast telomeric protein Rif1 regulates the complex temporal programme of human genome replication, possibly controlling chromatin domain establishment at the G1 ‘timing decision point’. Satoshi Yamazaki, Aii Ishii, Yutaka Kanoh, Masako Oda, Yasumasa Nishito and Hisao Masai The EMBO Journal (2012), 31, 3667 - 3677; 10.1038/emboj.2012.180 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 July 2012 | | | | Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells Rif1 deficiency profoundly alters the spatio-temporal organization of replication in mouse cells, identifying Rif1 as the first global regulator of the mammalian replication-timing programme. Daniela Cornacchia, Vishnu Dileep, Jean-Pierre Quivy, Rossana Foti, Federico Tili, Rachel Santarella-Mellwig, Claude Antony, Geneviève Almouzni, David M Gilbert and Sara B C Buonomo The EMBO Journal (2012), 31, 3678 - 3690; 10.1038/emboj.2012.214 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 July 2012 | | | | Binding of the Atg1/ULK1 kinase to the ubiquitin-like protein Atg8 regulates autophagy The Atg1/ULK1 kinase is an essential component of the core autophagy machinery and needs to be regulated in response to nutrient availability. A novel conserved mechanism to balance autophagic flux during nutrient depletion involves Atg8-dependent targeting of the Atg1–Atg13 complex to autophagy-mediated degradation. Claudine Kraft, Monika Kijanska, Eyal Kalie, Edyta Siergiejuk, Sung Sik Lee, Giuseppe Semplicio, Ingrid Stoffel, Andrea Brezovich, Mayanka Verma, Isabella Hansmann, Gustav Ammerer, Kay Hofmann, Sharon Tooze and Matthias Peter The EMBO Journal (2012), 31, 3691 - 3703; 10.1038/emboj.2012.225 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 August 2012 | | | | A novel molecular mechanism involved in multiple myeloma development revealed by targeting MafB to haematopoietic progenitors Transgenic expression of the MafB oncogene in haematopoietic stem/progenitor cells induces plasma cell neoplasia reminiscent of human multiple myeloma and suggests DNA methylation as cause of malignant transformation. Carolina Vicente-Dueñas, Isabel Romero-Camarero, Inés González-Herrero, Esther Alonso-Escudero, Fernando Abollo-Jiménez, Xiaoyu Jiang, Norma C Gutierrez, Alberto Orfao, Nieves Marín, Luisa María Villar, Ma Carmen Fernández Criado, Belén Pintado, Teresa Flores, Diego Alonso-López, Javier De Las Rivas, Rafael Jiménez, Francisco Javier García Criado, María Begoña García Cenador, Izidore S Lossos, César Cobaleda and Isidro Sánchez-García The EMBO Journal (2012), 31, 3704 - 3717; 10.1038/emboj.2012.227 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 August 2012 | | | | Positional differences of axon growth rates between sensory neurons encoded by runx3 The transcription factor Runx3 controls intrinsic differences in axonal growth rates by regulating the expression of cytoskeletal proteins including Rock1 and 2. Francois Lallemend, Ulrich Sterzenbach, Saida Hadjab-Lallemend, Jorge B Aquino, Goncalo Castelo-Branco, Indranil Sinha, J Carlos Villaescusa, Ditsa Levanon, Yiqiao Wang, Marina C M Franck, Olga Kharchenko, Igor Adameyko, Sten Linnarsson, Yoram Groner, Eric Turner and Patrik Ernfors The EMBO Journal (2012), 31, 3718 - 3729; 10.1038/emboj.2012.228 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 August 2012 | | | | Cacnb4 directly couples electrical activity to gene expression, a process defective in juvenile epilepsy CacnB4, an auxiliary subunit of the voltage-gated calcium channels, plays an additional direct role in transcriptional repression, associating with PP2A phosphatase to alter histone modifications at a TRα-bound promoter. Abir Tadmouri, Shigeki Kiyonaka, Maud Barbado, Matthieu Rousset, Katell Fablet, Seishiro Sawamura, Eloi Bahembera, Karin Pernet-Gallay, Christophe Arnoult, Takafumi Miki, Karin Sadoul, Sylvie Gory-Faure, Caroline Lambrecht, Florian Lesage, Satoshi Akiyama, Saadi Khochbin, Sylvain Baulande, Veerle Janssens, Annie Andrieux, Ricardo Dolmetsch, Michel Ronjat, Yasuo Mori and Michel De Waard The EMBO Journal (2012), 31, 3730 - 3744; 10.1038/emboj.2012.226 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 14 August 2012 | | | | DEAD-box protein DDX3 associates with eIF4F to promote translation of selected mRNAs RNA helicase DDX3 works upstream of 43S ribosomal scanning to release the m7GTP cap from stable secondary structure, thereby promoting efficient translational initiation of a subset of viral and cellular mRNAs. Ricardo Soto-Rifo, Paulina S Rubilar, Taran Limousin, Sylvain de Breyne, Didier Décimo and Théophile Ohlmann The EMBO Journal (2012), 31, 3745 - 3756; 10.1038/emboj.2012.220 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 August 2012 | | | | Holliday junction affinity of the base excision repair factor Endo III contributes to cholera toxin phage integration Integration of toxin-producing phage into the Vibrio cholerae genome co-opts not only bacterial recombinases, but also a host excision repair enzyme, assigning it an unsuspected structural role. Julien Bischerour, Claudia Spangenberg and François-Xavier Barre The EMBO Journal (2012), 31, 3757 - 3767; 10.1038/emboj.2012.219 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 August 2012 | | | | An N-terminal acidic region of Sgs1 interacts with Rpa70 and recruits Rad53 kinase to stalled forks Stalled replication fork maintenance functions of the yeast RecQ helicase Sgs1 can be separated in helicase-dependent DNA polymerase α association, and RPA-dependent Mec1 phosphorylation of Sgs1 upstream of Rad53 recruitment. Anna Maria Hegnauer, Nicole Hustedt, Kenji Shimada, Brietta L Pike, Markus Vogel, Philipp Amsler, Seth M Rubin, Fred van Leeuwen, Aude Guénolé, Haico van Attikum, Nicolas H Thomä and Susan M Gasser The EMBO Journal (2012), 31, 3768 - 3783; 10.1038/emboj.2012.195 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 20 July 2012 | | Corrigendum | Top | | | | BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER Nico Schäuble, Sven Lang, Martin Jung, Sabine Cappel, Stefan Schorr, Özlem Ulucan, Johannes Linxweiler, Johanna Dudek, Robert Blum, Volkhard Helms, Adrienne W Paton, James C Paton, Adolfo Cavalié and Richard Zimmermann The EMBO Journal (2012), 31, 3784; 10.1038/emboj.2012.243 Full text | PDF Published online: 10 August 2012 | | | | Advertisement | | | | | | | | Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. 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