Nature Reviews Molecular Cell Biology contents October 2012 Volume 13 Number 10 pp601-679

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TABLE OF CONTENTS
October 2012 Volume 13 Number 10		Advertisement
Impact Factor 39.123 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: DNA damage  Featured article: TGFβ signalling in context Joan Massagué	The Future of qPCR is here, and it’s digital The QX100™ Droplet Digital™ PCR system from Bio-Rad provides an absolute measure of target DNA molecules, with unmatched precision and sensitivity. This new PCR technology delivers absolute quantitation for applications that include copy number variation, rare event detection and gene expression. Learn more now.
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The Encyclopaedia of DNA Elements 30 papers published simultaneously in Nature, Genome Research and Genome Biology. Access videos, Features and the collected research papers, and explore the thematic threads that run through them via the Nature ENCODE explorer or the NatureENCODE app. Produced with support from Illumina
RESEARCH HIGHLIGHTS Top DNA damage response: Restricting repair p601 | doi:10.1038/nrm3437 The DUB POH1 and the E3 ligases TRIP12 and UBR5 regulate ubiquitin signalling during the DNA damage response. PDF Cell signalling: Hippo cues p602 | doi:10.1038/nrm3430 GPCRs regulate YAP and TAZ activity through LATS1 and LATS2. PDF Chromatin: Lys36 sets limits for histone exchange p602 | doi:10.1038/nrm3443 Set2 methylation of Lys36 and the recruitment of chromatin remodellers represses histone exchange which limits the incorporation of acetylated histones in coding regions, thereby maintaining chromatin integrity and accurate transcription initiation. PDF IN THE NEWS Not a youth elixir p603 | doi:10.1038/nrm3441 PDF Membrane trafficking: Extracellular space travel p604 | doi:10.1038/nrm3442 Active WNTs are secreted on exosomes. PDF Mitochondria: Getting together p604 | doi:10.1038/nrm3444 The Hippo pathway has been implicated in the regulation of mitochondrial fusion and the generation of reactive oxygen species. PDF Stem cells: Hierarchy in the population p605 | doi:10.1038/nrm3435 Slow-cycling stem cells and more rapidly cycling progenitors contribute to skin maintenance. PDF Cell cycle: Clathrin helps centrosomes come of age p606 | doi:10.1038/nrm3436 Clathrin heavy chain 17 promotes centrosome maturation at the onset of mitosis. PDF Cytoskeleton: Actin regulator substitution p606 | doi:10.1038/nrm3438 WASP can substitute for SCAR function during cell protrusion in Dictyostelium discoideum. PDF IN BRIEF Protein metabolism: Length matters | DNA damage response: Rapid response | Membrane trafficking: A new transport carrier PDF Molecular Cell Biology JOBS of the week Molecular Diagnostics Researach Leader GE Healthcare Postdoctoral Fellow ? Molecular Virologist CSIRO (Australia?s National Science Organisation) Director, Pediatric Molecular Oncology Program Penn State Hershey Children's Hospital Postdoc postion in molecular biology at UCLA UCLA Associate Professor in Molecular Evolutionary Biology University of Copenhagen More Science jobs from Molecular Cell Biology EVENT ElecMol12: Sixth International Meeting on Molecular Electronics 03.-07.12.12 Grenoble, France More science events from
REVIEWS		Top
Endoplasmic reticulum-mitochondria contacts: function of the junction Ashley A. Rowland & Gia K. Voeltz p607 | doi:10.1038/nrm3440 The characterization of dynamic contacts that form between the endoplasmic reticulum and mitochondria have highlighted the different ways in which the functions of these organelles can be coordinated. These structures may also allow co-regulation of distinct processes. Abstract | Full Text | PDF
TGFβ signalling in context Joan Massagué p616 | doi:10.1038/nrm3434 The basic elements of the transforming growth factor-β (TGFβ) pathway came to light more than a decade ago. Since then, the multifunctional nature and medical relevance of this pathway have relentlessly been elucidated. The old mystery of how the context determines the cellular response to TGFβ and its many malfunctions is only starting to be unravelled. Abstract | Full Text | PDF
Group choreography: mechanisms orchestrating the collective movement of border cells Denise J. Montell, Wan Hee Yoon & Michelle Starz-Gaiano p631 | doi:10.1038/nrm3433 The collective migration of border cells in the Drosophila melanogaster ovary has become a key model for dissecting the mechanisms that govern the coordinated movement of groups of cells. This has implications for our understanding of migration in diverse contexts, including during wound healing and tumour metastasis. Abstract | Full Text | PDF | Supplementary information
Assembly of allosteric macromolecular switches: lessons from PKA Susan S. Taylor, Ronit Ilouz, Ping Zhang & Alexandr P. Kornev p646 | doi:10.1038/nrm3432 The activity of protein kinases is regulated by domains that are associated with the kinase core, by interacting proteins and by their incorporation into large macromolecular complexes. Thus, understanding kinase signalling requires the structural characterization of entire complexes, as exemplified by studies of cyclic AMP-dependent protein kinase (PKA). Abstract | Full Text | PDF
Article series: DNA damage Minimizing the damage: repair pathways keep mitochondrial DNA intact Lawrence Kazak, Aurelio Reyes & Ian J. Holt p659 | doi:10.1038/nrm3439 Like nuclear DNA, mitochondrial DNA possesses multiple pathways that function to preserve its integrity following exogenous insults or errors during replication. Because the candidate proteins involved are similar to those carrying out nuclear DNA repair, elucidating the contribution of each repair protein has been challenging. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION A bigger picture: classical cadherins and the dynamic actin cytoskeleton Aparna Ratheesh & Alpha S. Yap p673 | doi:10.1038/nrm3431 Research on the cadherin–junctional actin interaction has focused on how the two physically interact. However, the actin cytoskeleton is dynamic, regulated by a network of proteins, so a broader perspective that takes this into account may provide new insights on cadherin cell–cell contacts and on the role of cadherins in disease. Abstract | Full Text | PDF
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*Journal Citation Reports, Thomson, 2011

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