Nature Reviews Microbiology contents October 2012 Volume 10 Number 10 pp 667-725

TABLE OF CONTENTS
October 2012 Volume 10 Number 10
Impact Factor 21.182 *	In this issue Editorial Research Highlights News and Analysis Progress Reviews Perspectives Also this month  Featured article: Understanding and learning from the success of prophylactic human papillomavirus vaccines John T. Schiller & Douglas R. Lowy
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EDITORIAL		Top
A day off in Denmark p667 | doi:10.1038/nrmicro2892 A day off in the middle of the schedule of a recent microbial ecology conference highlighted the importance of taking time out. Abstract | Full Text | PDF
RESEARCH HIGHLIGHTS Top Viral evolution: Accordion adaptations go viral p669 | doi:10.1038/nrmicro2883 Poxviruses use a genomic accordion to stay abreast in the arms race with host cell defences. PDF Bacterial pathogenesis: E. coli claims the driving seat for cancer p670 | doi:10.1038/nrmicro2878 Inflammation of the gut results in an altered microbiota and enriches for colibactin-producing E. coli, which promotes colorectal cancer. PDF Bacterial pathogenicity: A competent escape for Listeria p670 | doi:10.1038/nrmicro2885 The L. monocytogenes competence system has a key role in phagosomal escape, and activation of this system is controlled by a prophage excision event. PDF Bacterial physiology: A Fab(H) way of controlling size for E. coli p670 | doi:10.1038/nrmicro2886 E. coli regulates cell size and growth rate in response to nutrient availability by altering fatty acid biosynthesis and, therefore, expansion of the cell envelope. PDF Fungal pathogenesis: C. albicans makes an entrance p672 | doi:10.1038/nrmicro2881 C. albicans invades oral epithelial cells by interacting with host proteins EGFR and HER2. PDF Plant pathogens: Oomycete kinase blights potatoes p672 | doi:10.1038/nrmicro2884 The effector CRN8 is an active kinase that is secreted into the plant by P. infestans to enhance virulence. PDF IN THE NEWS Antibacterial vitamin p672 | doi:10.1038/nrmicro2891 PDF Viral pathogenesis: HIV hitchhikes on migratory T cells p673 | doi:10.1038/nrmicro2877 HIV-infected CD4+ T cells have a reduced rate of migration and an elongated morphology, which might represent a strategy for direct cell-to-cell transfer of the virus. PDF IN BRIEF Bacterial genomics: Regulators or by-products? | Parasite biology: (Not) helping Plasmodium break in | Environmental microbiology: Re-evaluating the abundance of microorganisms PDF Microbiology JOBS of the week Chair, Department of Microbiology and Immunology The University of Texas Health Science Center Tenure-track Faculty Position for the Department of Molecular Genetics and Microbiology Duke University Medical Center Chair in Molecular Microbiology University of Aberdeen Postdoc Position in Chemical Biology / Microbiology / Biophysics Uppsala University, Department of Cell and Molecular biology Ph.D. Assistantship in Environmental Microbiology Virginia Tech More Science jobs from Microbiology EVENT International Conference on Clinical Microbiology & Microbial Genomics 12.-14.11.12 US More science events from
NEWS AND ANALYSIS		Top
GENOME WATCH Metagenomics with guts Magdalena Zarowiecki p674 | doi:10.1038/nrmicro2879 This month's Genome Watch describes two recent studies that used metagenomic data to characterize the role of the human gut microbiota in disease. PDF
PROGRESS		Top
Restricting HIV the SAMHD1 way: through nucleotide starvation Diana Ayinde, Nicoletta Casartelli & Olivier Schwartz p675 | doi:10.1038/nrmicro2862 SAMHD1 has emerged as a novel HIV restriction factor that inhibits viral replication by limiting dNTP availability. Here, Schwartz and colleagues discuss the studies that led to the identification and characterization of SAMHD1, and speculate on why HIV-1 does not encode the SAMHD1-targeting protein, Vpx. Abstract | Full Text | PDF
REVIEWS		Top
Understanding and learning from the success of prophylactic human papillomavirus vaccines John T. Schiller & Douglas R. Lowy p681 | doi:10.1038/nrmicro2872 The two commercially available prophylactic vaccines that target human papilloma virus type 16 (HPV16) and HPV18 have proved extremely effective. Here, Schiller and Lowy summarize the characteristics of both the vaccines and HPV that have contributed to this success and speculate on whether or not this information could be used to direct the development of vaccines against other sexually transmitted viruses. Abstract | Full Text | PDF
Fungal Hsp90: a biological transistor that tunes cellular outputs to thermal inputs Michelle D. Leach, Edda Klipp, Leah E. Cowen & Alistair J. P. Brown p693 | doi:10.1038/nrmicro2875 Fungal heat shock protein 90 (Hsp90) is an essential chaperone that regulates a range of cellular processes by ensuring the correct folding of a specific group of client proteins. In this Review, Brown and colleagues describe the roles and regulation of Hsp90 and discuss how it acts as a biological transistor to modulate fungal signalling networks. Abstract | Full Text | PDF | Supplementary information
Distribution, formation and regulation of gas vesicles Felicitas Pfeifer p705 | doi:10.1038/nrmicro2834 Many bacteria and archaea synthesize intracellular gas-filled proteinaceous structures known as gas vesicles to act as flotation devices in aqueous environments. Here, Felicitas Pfeifer describes the basic properties of these interesting structures, the proteins that form them, the gene clusters that encode them and the regulation of their production. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION The keystone-pathogen hypothesis George Hajishengallis, Richard P. Darveau & Michael A. Curtis p717 | doi:10.1038/nrmicro2873 In this Opinion article, Hajishengallis and colleagues propose that certain low-abundance microorganisms, termed 'keystone pathogens', can disrupt a normally benign commensal microbiota, leading to a microbial community structure that is associated with the development of disease. Abstract | Full Text | PDF
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