Nature Reviews Cancer contents October 2012 Volume 12 Number 10 pp 655-732

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TABLE OF CONTENTS
October 2012 Volume 12 Number 10		Advertisement
Impact Factor 37.545 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Genomic instability in cancer The next 10 years  Featured article: Chromothripsis and cancer: causes and consequences of chromosome shattering Josep V. Forment, Abderrahmane Kaidi & Stephen P. Jackson	COMPROMISING WHEN YOU NEED A CUSTOM PANEL FOR TARGETED ENRICHMENT? TargetRich™ custom designs enable you to capture the regions you desire, while delivering the results you need. Your research is too important to compromise. Click here to see the results and see why others are calling us about TargetRich. Call us and let us show you how our custom enrichment solutions can be a part of your solution.
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Nature Outlook: Human Papillomavirus It might have taken 30 years from identification of HPV as the cause of cervical cancer to the first vaccine reaching the market, but there is still much to understand about HPV biology and an urgent need to improve on existing vaccines and diagnostic tests. Access the Outlook free online for six months. Produced with support from: VACTIA - The Center for Vaccine Research and Immunology The Finnish Medical Association PreHdict
RESEARCH HIGHLIGHTS Top Metastasis: Recharging with COCO p655 | doi:10.1038/nrc3361 Reactivation of dormant breast cancer cells at metastatic sites may require these cells to overcome organ-specific suppressive signals in the microenvironment and to activate stem cell-like traits. PDF Immunotherapy: Isolation of TCM cells for tumour immunotherapy p656 | doi:10.1038/nrc3364 A high IL2/IFNG mRNA ratio identifies rare tumour-specific T cells that can persist in humans following adoptive transfer. PDF Microenvironment: A dense danger p656 | doi:10.1038/nrc3375 A new study characterizes the molecular events underlying cancer-associated stromal remodelling. PDF Tumour suppressors: A microdependency of importance? p657 | doi:10.1038/nrc3358 A new study suggests a therapeutic strategy to target retinoblastomas that are deficient for RB and p53. PDF Immunotherapy: Unlicensed to kill p658 | doi:10.1038/nrc3359 Unlicensed natural killer cells are important in the response of patients with high risk neuroblastoma to treatment with GD2-specific monoclonal antibodies. PDF Bacterial pathogenesis: E. coli claims the driving seat for cancer p658 | doi:10.1038/nrc3363 Inflammation of the gut results in an altered microbiota and enriches for colibactin-producing E. coli, which promotes colorectal cancer. PDF Therapeutics: PI3K-PARP combination p658 | doi:10.1038/nrc3372 Two papers report that combined inhibition of PI3K and poly(ADP) ribose polymerase (PARP) is synergistic in BRCA1-defective and BRCA-proficient triple-negative breast cancer. PDF Angiogenesis: The new normal p660 | doi:10.1038/nrc3360 Two papers published in Cancer Cell describe molecular pathways involved in blood vessel normalization, and support the idea that a normalized vasculature can enhance the efficacy of chemotherapy and radiotherapy. PDF Proliferation: Multitasking p660 | doi:10.1038/nrc3374 Two recently published papers examine the metabolic and nonmetabolic functions of PKM2 in greater detail. PDF Mitochondria: Getting together p661 | doi:10.1038/nrc3362 The Hippo pathway has been implicated in the regulation of mitochondrial fusion and the generation of reactive oxygen species. PDF IN BRIEF Biomarkers: Genetic predictors of oral cancer risk | Signalling: STAT3: friend or foe? | Metabolism: Immature disruption | Therapeutics: Dual-pronged proteasomal promise? PDF Cancer JOBS of the week Postdoctoral Position in Cancer Systems Biology Royal College of Surgeons in Ireland Postdoctoral Fellow: Gene Regulation in Breast Cancer / Stem Cell Biology UC Department of Cancer and Cell Biology Post-doctoral Training Fellow (Proteomics and Cancer Biology) The Institute of Cancer Research Postdoctoral Postion in Cancer Biology and Pharmacology Baylor College of Medicine (BCM) Two postdoc positions for projects on cancer metastasis in the Erler Group at BRIC BRIC, Biotech Research & Innovation Centre, University of Copenhagen More Science jobs from Cancer EVENT Frontiers in Cancer Science 2012 05.-08.11.12 Singapore More science events from
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REVIEWS		Top
Article series: Genomic instability in cancer Chromothripsis and cancer: causes and consequences of chromosome shattering Josep V. Forment, Abderrahmane Kaidi & Stephen P. Jackson p663 | doi:10.1038/nrc3352 Chromothripsis is an emerging phenomenon that results in chromosome rearrangements in tumour cells. This Review discusses the possible mechanisms underlying this process and its implications for cancer biology and in the clinic. Abstract | Full Text | PDF
Article series: The next 10 years Paths to stemness: building the ultimate antitumour T cell Luca Gattinoni, Christopher A. Klebanoff & Nicholas P. Restifo p671 | doi:10.1038/nrc3322 Treating cancer patients with T cell-based therapies has shown some some promise in the clinic, but not all patients respond. There could be many reasons for this, some of which might be addressed by using the best possible antitumour T cell. What are the biological properties of such a cell and can we generate one? Abstract | Full Text | PDF
Mitochondria and cancer Douglas C. Wallace p685 | doi:10.1038/nrc3365 What have mitochondria ever done for us? This Review discusses why alterations in cellular processes that require mitochondria are essential for tumorigenesis. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Article series: The next 10 years Controlling escape from angiogenesis inhibitors Barbara Sennino & Donald M. McDonald p699 | doi:10.1038/nrc3366 As part of our Series of articles on The next 10 years in cancer research, this Opinion article discusses what the future may hold for angiogenesis inhibitors as cancer therapeutics. Abstract | Full Text | PDF
OPINION Article series: Genomic instability in cancer Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer Gabriele Sulli, Raffaella Di Micco & Fabrizio d'Adda di Fagagna p709 | doi:10.1038/nrc3344 Chromatin conformation and chromatin modifications affect DNA damage response signalling and hence the associated cellular outcomes of this response. This Opinion article discusses the implications of chromatin alterations in cancer cells on DNA damage responses. Abstract | Full Text | PDF
OPINION Tumorigenesis in Down's syndrome: big lessons from a small chromosome Dean Nižetić & Jürgen Groet p721 | doi:10.1038/nrc3355 Individuals with Down's syndrome have an increased risk of developing leukaemia in childhood, but they also have a significantly reduced risk of developing most solid tumours. However, Down's syndrome shares many features with cancer-prone syndromes, so why is Down's syndrome different? Abstract | Full Text | PDF
Corrigendum: Non-coding RNA production by RNA polymerase III is implicated in cancer Lynne Marshall & Robert J. White p732 | doi:10.1038/nrc3369 Full Text | PDF
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*2010 Journal Citation Report (Thomson Reuters, 2011)

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