Nature contents: 13 September 2012

Can't view this email? Click here to view in your browser.     Volume 489 Number 7415      nature •Visit Nature homepage •Subscribe to Nature •View Table of Contents The science that matters. Every week.                       Ultrafast 3D Imaging of Tissue Samples in the FE-SEM SIGMA 3View from Carl Zeiss with integrated ultramicrotome from Gatan Inc. enables acquisition of high resolution 3D data from embedded cell and tissue samples. In the shortest possible time. Profit from variable pressure for optimal charge neutralization and unbeatable long term stability. Find out more: download a free white paper and visit us at EMC 2012.             Jump to the content that matters to you View Table of Contents ▶ ▼ News & Comment   ▼ Biological Sciences   ▼ Chemical Sciences   ▼ Physical Sciences   ▼ Earth & Environmental Sciences   ▼ Careers & Jobs       This week's highlights     Specials - Insight: Gut microbes and health     The beneficial effects of gut microbes have been documented for more than a century, but with recent technological advances the field is now moving on apace. Four reviews in this Insight supplement capture some of the most exciting microbiota research going on at the moment and hint at new ways of targeting the microbiota for clinical intervention. ▼ more       Physical Sciences More Physical sciences ▼   Quantum teleportation over 143 kilometres using active feed-forward   Since the first experimental demonstration of quantum teleportation physicists have gradually extended the distance over which the quantum information is distributed. This paper reports long-distance quantum teleportation across a 'record' 143 km of free space between the two Canary Islands of La Palma and Tenerife. Significantly, this route bears comparison with the path between a satellite and a ground station.       Biological Sciences More Biological sciences ▼   A 61-million-person experiment in social influence and political mobilization   This study followed the behaviour of millions of voting-age individuals who accessed Facebook on US Election Day in 2010. Users saw either a message with information about voting and an 'I voted' button, or the same message but with the profile photos of up to six of the user's Facebook friends who had already clicked the 'I voted' button. The results reveal much about the effectiveness of online campaigning — in time to influence the 2012 presidential campaigns.                   BD™ SMC4 - Making iPSC reprogramming and expansion more efficient. BD SMC4 Small Molecule Cocktail, developed by BD and Fate Therapeutics, increases reprogramming efficiency and enables improved expansion and maintenance of SMC4 derived hiPS cells in both feeder cells and feeder-free conditions. Learn more at bdbiosciences.com/smc4                 Biological Sciences More Biological sciences ▼   Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study   Restricting food intake has been shown to extend life span improve health in various species. But this 23-year study of caloric restriction in rhesus macaque monkeys suggests that the effects of caloric restriction in long-lived animals are far from straightforward. So eating a bit less may not be the recipe for a long and healthy life after all.       Podcast & Video     In this week's podcast: HIV vaccines, microwave superweapons and how to predict the success of scientists.         News & Comment Read daily news coverage▶ ▲top             THIS WEEK           Editorials                   Count on me ▶     Sometimes, the use of metrics to assess the value of scientists is unavoidable. So let's come up with the best measure possible.             Secret weapons ▶     US military furtiveness is hindering progress and the development of technology.             The name game ▶     After several years of wrangling, zoologists can now name new species online only.             World View                   Predatory publishers are corrupting open access ▶     Journals that exploit the author-pays model damage scholarly publishing and promote unethical behaviour by scientists, argues Jeffrey Beall.             Seven Days                   Seven days: 7–13 September 2012 ▶     The week in science: Arctic oil drilling begins, shale-gas warnings, and a vaccine offers partial protection from dengue.           NEWS IN FOCUS           Ice loss shifts Arctic cycles ▶     Record shrinkage confounds models and portends atmospheric and ecological change.             Europe on alert for flying invaders ▶     Spread of disease-carrying mosquitoes prompts guidelines for boosting surveillance.             EU battles over research billions ▶     Politicians will spend the next few months negotiating cuts to Horizon 2020's budget.             Misconduct ruling is silent on intent ▶     Psychologist Marc Hauser admits errors but not fraud.             Cameras to focus on dark energy ▶     A pair of detectors that measure minute distortions in images of distant galaxies will probe the riddle of cosmic acceleration.             India moves to tackle antibiotic resistance ▶     Drug regulator aims to restrict over-the-counter sales.             Features                   Deep-sea research: Dive master ▶     The US flagship submersible Alvin is getting a partial upgrade. But deep-sea exploration faces some rough water.             Microwave weapons: Wasted energy ▶     Despite 50 years of research on high-power microwaves, the us military has yet to produce a usable weapon.           COMMENT           Future impact: Predicting scientific success ▶     Daniel E. Acuna, Stefano Allesina and Konrad P. Kording present a formula to estimate the future h-index of life scientists.             Science policy: Well-funded investigators should receive extra scrutiny ▶     An added layer of review for elite grant-holders upholds the mission of the National Institutes of Health, says Jeremy M. Berg.             Books and Arts                   Science fiction: The radium age ▶     Joshua Glenn explores the dark, fascinating, largely forgotten science fiction of the early twentieth century.             Books in brief ▶             Q&A: Archivist of ice ▶     For six years, photographer James Balog has trained his lens on ice, capturing time-lapse images that have helped scientists to study how glaciers and ice sheets respond to climate conditions. With the documentary Chasing Ice soon to debut in US cinemas, Balog talks about the loss of landscapes.             Physics: Modelling Feynman ▶     Daniel Cressey marvels at a gleaming depiction of the subatomic by the world's leading information designer.             Correspondence                   Policy: Clarify the limits of climate models David A Stainforth & Leonard A. Smith | Genomics: ENCODE leads the way on big data Mark Gerstein | Media: Animal variants in sexual behaviour Rowan Hooper | Research practice: A code of conduct for European scientists Nils Axelsen & Xavier Bosch | History of science: Wallace pioneered astrobiology too U. Kutschera           Correction                   Correction ▶               Specials - Insight: Gut microbes and health ▲top               Gut microbes and health ▶     Claudia Lupp, Magdalena Skipper & Ursula Weiss             Diversity, stability and resilience of the human gut microbiota ▶     Catherine A. Lozupone, Jesse I. Stombaugh, Jeffrey I. Gordon, Janet K. Jansson & Rob Knight             Reciprocal interactions of the intestinal microbiota and immune system ▶     Craig L. Maynard, Charles O. Elson, Robin D. Hatton & Casey T. Weaver             Functional interactions between the gut microbiota and host metabolism ▶     Valentina Tremaroli & Fredrik Bäckhed             Genomic approaches to studying the human microbiota ▶     George M. Weinstock         Sponsors                       International Journal of Obesity (IJO) Read the Special Issue: Geriatric Obesity Read a couple of article from the issue listed below: - Association of midlife obesity and cardiovascular risk with old age frailty: a 26-year follow-up of initially healthy men - Alcohol consumption and body weight change in postmenopausal women: results from the Womens health Initiative Read the full issue today! www.nature.com/ijo               Biological Sciences ▲top             RESEARCH           Latest Online                   Small heat-shock proteins protect from heat-stroke-associated neurodegeneration ▶     Nikos Kourtis, Vassiliki Nikoletopoulou & Nektarios Tavernarakis     Heat stroke triggers necrotic cell death and neurodegeneration in Caenorhabditis elegans, but hormetic preconditioning at a mildly elevated temperature strongly protects C. elegans from necrosis induced by several insults, including heat, and shields mammalian neurons from heat cytotoxicity, suggesting that this protective mechanism is conserved.             Restoration of auditory evoked responses by human ES-cell-derived otic progenitors ▶     Wei Chen, Nopporn Jongkamonwiwat, Leila Abbas, Sarah Jacob Eshtan, Stuart L. Johnson et al.     Two types of human ES-cell-derived otic progenitors are shown to have the ability to differentiate in vitro into hair-cell-like cells and auditory neurons, and to engraft, differentiate and improve auditory-evoked response thresholds when transplanted into an auditory neuropathy model; this indicates that it may be possible to use cell-based therapeutic strategies to recover damaged sensory circuitry in deafness.             Attention deficits without cortical neuronal deficits ▶     Alexandre Zénon & Richard J. Krauzlis     Transient inactivation of the superior colliculus in primates during a motion-change-detection task is shown to lead to large deficits in visual attention while the enhanced response of neurons in the visual cortex to attended stimuli remains unchanged; this shows that processes independent of those occurring in the visual cortex have key roles in visual attention.             Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2 ▶     Morgane Rolland, Paul T. Edlefsen, Brendan B. Larsen, Sodsai Tovanabutra, Eric Sanders-Buell et al.     Genetic analysis of breakthrough infections in people vaccinated against HIV-1 show that vaccine efficacy increased by up to 80% against viruses carrying two mutations in Env V2, but also raises the possibility of population-level adaptation to the vaccine.             Comprehensive genomic characterization of squamous cell lung cancers  OPEN ▶     The Cancer Genome Atlas Research Network     Comprehensive analyses of 178 lung squamous cell carcinomas by The Cancer Genome Atlas project show that the tumour type is characterized by complex genomic alterations, with statistically recurrent mutations in 11 genes, including TP53 in nearly all samples; a potential therapeutic target is identified in most of the samples studied.             The yeast Fun30 and human SMARCAD1 chromatin remodellers promote DNA end resection ▶     Thomas Costelloe, Raphaël Louge, Nozomi Tomimatsu, Bipasha Mukherjee, Emmanuelle Martini et al.     Fun30 and SMARCAD1 are identified as chromatin remodellers that promote DNA end resection during DNA repair and preserve genome stability in yeast and humans, respectively.             The Fun30 nucleosome remodeller promotes resection of DNA double-strand break ends ▶     Xuefeng Chen, Dandan Cui, Alma Papusha, Xiaotian Zhang, Chia-Dwo Chu et al.     Nucleolytic degradation of 5′ strands at DNA double-strand breaks in yeast is shown to be facilitated by the nucleosome remodeller Fun30, particularly within chromatin bound by the checkpoint adaptor protein known to inhibit resection, Rad9.             Initiation of transcription-coupled repair characterized at single-molecule resolution ▶     Kévin Howan, Abigail J. Smith, Lars F. Westblade, Nicolas Joly, Wilfried Grange et al.     The early stages of transcription-coupled DNA repair are observed at single-molecule resolution; the Escherichia coli DNA translocase molecule Mfd is shown to promote RNA polymerase dissociation by catalysing two irreversible, ATP-dependent transitions.             Articles and Letters                   Distinct contribution of stem and progenitor cells to epidermal maintenance ▶     Guilhem Mascré, Sophie Dekoninck, Benjamin Drogat, Khalil Kass Youssef, Sylvain Brohée et al.     Whether a single group of stem cells or multiple populations contribute to the homeostasis of the interfollicular epidermis is controversial; here the authors use lineage tracing and mathematical modelling to show that the progenitors that maintain mouse epidermis are underpinned by slow-cycling stem cells that become mobilized on injury.             RPN-6 determines C. elegans longevity under proteotoxic stress conditions ▶     David Vilchez, Ianessa Morantte, Zheng Liu, Peter M. Douglas, Carsten Merkwirth et al.     This study shows that nematodes without a germ line re-allocate resources to the soma, resulting in elevated proteasome activity, clearance of damaged proteins and increased longevity; this activity is associated with the increased expression of rpn-6 mediated by the transcription factor DAF-16.             Stereocontrolled organocatalytic synthesis of prostaglandin PGF2α in seven steps ▶     Graeme Coulthard, William Erb & Varinder K. Aggarwal     A concise new synthesis of the most complex of the prostaglandins—diverse hormone-like chemical messengers—should make existing prostaglandin-based drugs cheaper and also facilitate other related syntheses.             Averting biodiversity collapse in tropical forest protected areas ▶     William F. Laurance, D. Carolina Useche, Julio Rendeiro, Margareta Kalka, Corey J. A. Bradshaw et al.     Analysis of changes in functional groups of species and potential drivers of environmental change for protected areas across the world’s major tropical regions reveals large variation between reserves that have been effective and those experiencing an erosion of biodiversity, and shows that environmental changes immediately outside reserves are nearly as important as those inside in determining their ecological fate.             A 61-million-person experiment in social influence and political mobilization ▶     Robert M. Bond, Christopher J. Fariss, Jason J. Jones, Adam D. I. Kramer, Cameron Marlow et al.     Political mobilization messages delivered to 61 million Facebook users during the 2010 US congressional elections directly influenced political self-expression, information seeking and real-world voting behaviour of millions of people and their friends, with social transmission occurring mainly between close friends and having a greater effect than the direct effect of the messages themselves.             Activity in motor–sensory projections reveals distributed coding in somatosensation ▶     Leopoldo Petreanu, Diego A. Gutnisky, Daniel Huber, Ning-long Xu, Dan H. O’Connor et al.     Imaging of activity in long-range axons is reported in mice performing tactile object-localization with their whiskers; the feedback projection from the motor cortex to the somatosensory cortex provides information to integrate whisker movement information and touch, which are key components of object identification.             Increased proteasome activity in human embryonic stem cells is regulated by PSMD11 ▶     David Vilchez, Leah Boyer, Ianessa Morantte, Margaret Lutz, Carsten Merkwirth et al.     Human embryonic stem cells (hESCs) are shown to have high 26S/30S proteasome activity owing to increased expression of the 19S proteasome subunit PSMD11; FOXO4 regulates proteasome activity in hESCs by modulating PSMD11 expression, and the high proteasome activity decreases after induced differentiation.             Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling ▶     Marcus Dühren-von Minden, Rudolf Übelhart, Dunja Schneider, Thomas Wossning, Martina P. Bach et al.     B-cell receptor (BCR) signalling in chronic lymphocytic leukaemia (CLL) is found not to be dependent on exogenous antigens; instead, signalling may involve the binding of the BCR heavy-chain complementarity-determining region to self epitopes on the same receptor, a finding that may have important implications for understanding the pathogenesis of CLL and potential therapeutic approaches.             HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycle ▶     Matthew A. Deardorff, Masashige Bando, Ryuichiro Nakato, Erwan Watrin, Takehiko Itoh et al.     The deacetylase enzyme HDAC8 is identified as a crucial regulator of cohesin in humans, and loss-of-function mutations in the HDAC8 gene are found in patients with Cornelia de Lange syndrome.             Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study ▶     Julie A. Mattison, George S. Roth, T. Mark Beasley, Edward M. Tilmont, April M. Handy et al.     The results of a 23-year study of caloric restriction in rhesus macaques are reported; restricted caloric intake did not increase survival, but improved the metabolic profile of monkeys started at older ages and showed a trend towards delaying age-associated disease in monkeys started at a young age.             Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts ▶     Yuji Shiba, Sarah Fernandes, Wei-Zhong Zhu, Dominic Filice, Veronica Muskheli et al.     A guinea-pig model of cardiac injury is used to show that human embryonic stem-cell-derived cardiomyocyte grafts can electrically integrate into the injured heart, improving mechanical function and reducing spontaneous and induced ventricular tachycardia; this is a major step towards clinical adoption of cell replacement therapies for cardiovascular diseases using human cardiomyocytes.             News & Views                   Ageing: Mixed results for dieting monkeys ▶     Steven N. Austad             Social science: Poked to vote ▶     Sinan Aral             Organic synthesis: A biochemical messenger made easily ▶     Erik J. Sorensen             Cell biology: Dormant and restless skin stem cells ▶     Laura De Rosa & Michele De Luca             Corrigenda                   Corrigendum: Recurrent network activity drives striatal synaptogenesis ▶     Yevgenia Kozorovitskiy, Arpiar Saunders, Caroline A. Johnson, Bradford B. Lowell & Bernardo L. Sabatini             Corrigendum: Biodiversity loss and its impact on humanity ▶     Bradley J. Cardinale, J. Emmett Duffy, Andrew Gonzalez, David U. Hooper, Charles Perrings et al.             Erratum                   Erratum: Non-invasive prenatal measurement of the fetal genome ▶     H. Christina Fan, Wei Gu, Jianbin Wang, Yair J. Blumenfeld, Yasser Y. El-Sayed et al.             Research Highlights                   Animal behaviour: Seals see glowing prey | Molecular biology: Red-blood-cell regulator | Microbiology: Populations cooperate | Microbiology: Ecosystems compete | Neuroscience: A treatable form of autism | Conservation biology: Tigers and people can coexist | Plant biotechnology: Engineered plants can use phosphite         NEWS & COMMENT           The name game | Europe on alert for flying invaders | Misconduct ruling is silent on intent | Deep-sea research: Dive master | Future impact: Predicting scientific success | Books in brief | Genomics: ENCODE leads the way on big data Mark Gerstein | Media: Animal variants in sexual behaviour Rowan Hooper | History of science: Wallace pioneered astrobiology too U. Kutschera             More Biological Sciences ▶                         The Encyclopaedia of DNA Elements 30 papers published simultaneously in Nature, Genome Research and Genome Biology. Access videos, Features and the collected research papers, and explore the thematic threads that run through them via the Nature ENCODE explorer or the NatureENCODE app. Produced with support from Illumina               Chemical Sciences ▲top             RESEARCH           Latest Online                   Initiation of transcription-coupled repair characterized at single-molecule resolution ▶     Kévin Howan, Abigail J. Smith, Lars F. Westblade, Nicolas Joly, Wilfried Grange et al.     The early stages of transcription-coupled DNA repair are observed at single-molecule resolution; the Escherichia coli DNA translocase molecule Mfd is shown to promote RNA polymerase dissociation by catalysing two irreversible, ATP-dependent transitions.             Articles and Letters                   Stereocontrolled organocatalytic synthesis of prostaglandin PGF2α in seven steps ▶     Graeme Coulthard, William Erb & Varinder K. Aggarwal     A concise new synthesis of the most complex of the prostaglandins—diverse hormone-like chemical messengers—should make existing prostaglandin-based drugs cheaper and also facilitate other related syntheses.             News & Views                   Organic synthesis: A biochemical messenger made easily ▶     Erik J. Sorensen           NEWS & COMMENT           Science fiction: The radium age | Books in brief             More Chemical Sciences ▶               Physical Sciences ▲top             RESEARCH           Latest Online                   Network science: Luck or reason ▶     Albert-László Barabási             Afternoon rain more likely over drier soils ▶     Christopher M. Taylor, Richard A. M. de Jeu, Françoise Guichard, Phil P. Harris & Wouter A. Dorigo     Analysis of observations on six continents reveals a global preference for afternoon rain to fall on locally drier soils—contrary to the predictions of large-scale climate models, and suggesting that such models may exaggerate the occurrence of droughts.             Popularity versus similarity in growing networks ▶     Fragkiskos Papadopoulos, Maksim Kitsak, M. Ángeles Serrano, Marián Boguñá & Dmitri Krioukov     A framework is developed in which new connections to a growing network optimize geometric trade-offs between popularity and similarity, instead of simply preferring popular nodes; this approach accurately describes the large-scale evolution of various networks             Articles and Letters                   Quantum teleportation over 143 kilometres using active feed-forward ▶     Xiao-Song Ma, Thomas Herbst, Thomas Scheidl, Daqing Wang, Sebastian Kropatschek et al.     The benchmark for a global quantum internet — quantum teleportation of independent qubits using active feed-forward over a free-space link whose attenuation corresponds to the path between a satellite and a ground station — has now been successfully achieved over a distance of 143 km, between the Canary Islands of La Palma and Tenerife.             Stabilization of Leidenfrost vapour layer by textured superhydrophobic surfaces ▶     Ivan U. Vakarelski, Neelesh A. Patankar, Jeremy O. Marston, Derek Y. C. Chan & Sigurdur T. Thoroddsen     Textured superhydrophobic surfaces—well known for their water-repelling properties—can be used to control the boiling state of a liquid in contact with a hot surface, suppressing the unwanted nucleation of bubbles.             Observations of increased tropical rainfall preceded by air passage over forests ▶     D. V. Spracklen, S. R. Arnold & C. M. Taylor     Remote sensing and simulated atmospheric transport patterns are used to show that air passage over tropical forests produces about twice as much rain as passage over sparse vegetation; in an idealized Amazonian deforestation scenario, a reduction in seasonal precipitation of approximately 12–21% is estimated.             A 61-million-person experiment in social influence and political mobilization ▶     Robert M. Bond, Christopher J. Fariss, Jason J. Jones, Adam D. I. Kramer, Cameron Marlow et al.     Political mobilization messages delivered to 61 million Facebook users during the 2010 US congressional elections directly influenced political self-expression, information seeking and real-world voting behaviour of millions of people and their friends, with social transmission occurring mainly between close friends and having a greater effect than the direct effect of the messages themselves.             News & Views                   Biogeochemistry: Drought and tropical soil emissions ▶     Cory C. Cleveland & Benjamin W. Sullivan             Environmental science: The rainforest's water pump ▶     Luiz E. O. C. Aragão             Network science: Luck or reason ▶     Albert-László Barabási             Erratum                   Erratum: An origin of the radio jet in M87 at the location of the central black hole ▶     Kazuhiro Hada, Akihiro Doi, Motoki Kino, Hiroshi Nagai, Yoshiaki Hagiwara et al.             Research Highlights                   Astronomy: On the origin of Ia supernovae | Materials: Hydrogel makes buildings sweat | Climate science: Calm Sun promotes chilly winters         NEWS & COMMENT           Secret weapons | Cameras to focus on dark energy | Microwave weapons: Wasted energy | Science fiction: The radium age | Books in brief | Q&A: Archivist of ice | Physics: Modelling Feynman | Policy: Clarify the limits of climate models David A Stainforth & Leonard A. Smith           CAREERS           Turning point: Alberto Gonzalez Fairén             More Physical Sciences ▶               Earth & Environmental Sciences ▲top             RESEARCH           Latest Online                   Afternoon rain more likely over drier soils ▶     Christopher M. Taylor, Richard A. M. de Jeu, Françoise Guichard, Phil P. Harris & Wouter A. Dorigo     Analysis of observations on six continents reveals a global preference for afternoon rain to fall on locally drier soils—contrary to the predictions of large-scale climate models, and suggesting that such models may exaggerate the occurrence of droughts.             Articles and Letters                   Observations of increased tropical rainfall preceded by air passage over forests ▶     D. V. Spracklen, S. R. Arnold & C. M. Taylor     Remote sensing and simulated atmospheric transport patterns are used to show that air passage over tropical forests produces about twice as much rain as passage over sparse vegetation; in an idealized Amazonian deforestation scenario, a reduction in seasonal precipitation of approximately 12–21% is estimated.             Ploughing the deep sea floor ▶     Pere Puig, Miquel Canals, Joan B. Company, Jacobo Martín, David Amblas et al.     Bottom trawling is a fishing technique whereby heavy nets and gear scrape along the sea bed, and is shown here to disturb sediment fluxes and modify the sea floor morphology over large spatial scales.             Averting biodiversity collapse in tropical forest protected areas ▶     William F. Laurance, D. Carolina Useche, Julio Rendeiro, Margareta Kalka, Corey J. A. Bradshaw et al.     Analysis of changes in functional groups of species and potential drivers of environmental change for protected areas across the world’s major tropical regions reveals large variation between reserves that have been effective and those experiencing an erosion of biodiversity, and shows that environmental changes immediately outside reserves are nearly as important as those inside in determining their ecological fate.             News & Views                   Biogeochemistry: Drought and tropical soil emissions ▶     Cory C. Cleveland & Benjamin W. Sullivan             Environmental science: The rainforest's water pump ▶     Luiz E. O. C. Aragão             Corrigendum                   Corrigendum: Biodiversity loss and its impact on humanity ▶     Bradley J. Cardinale, J. Emmett Duffy, Andrew Gonzalez, David U. Hooper, Charles Perrings et al.             Research Highlights                   Conservation biology: Tigers and people can coexist | Climate science: Calm Sun promotes chilly winters         NEWS & COMMENT           Ice loss shifts Arctic cycles | Deep-sea research: Dive master | Books in brief | Q&A: Archivist of ice | Policy: Clarify the limits of climate models David A Stainforth & Leonard A. Smith | History of science: Wallace pioneered astrobiology too U. Kutschera             More Earth & Environmental Sciences ▶                         Nature Outlook: Human Papillomavirus It might have taken 30 years from identification of HPV as the cause of cervical cancer to the first vaccine reaching the market, but there is still much to understand about HPV biology and an urgent need to improve on existing vaccines and diagnostic tests. Access the Outlook free online for six months. Produced with support from: VACTIA - The Center for Vaccine Research and Immunology, The Finnish Medical Association, PreHdict               Careers & Jobs ▲top               Working together ▶     The right administrative system can ease the job search for dual-career couples, argues Mary Anne Holmes.                   Turning point: Alberto Gonzalez Fairén ▶     Astrobiologist's passion for Mars science creates job opportunities in the United States and Europe.                   Careers related news & comment                   Count on me | Predatory publishers are corrupting open access | EU battles over research billions | Misconduct ruling is silent on intent | Deep-sea research: Dive master | Future impact: Predicting scientific success | Science policy: Well-funded investigators should receive extra scrutiny | Q&A: Archivist of ice | Genomics: ENCODE leads the way on big data Mark Gerstein | Research practice: A code of conduct for European scientists Nils Axelsen & Xavier Bosch             naturejobs.com Science jobs of the week       Clinical Trials Manager     Guy's & St. Thomas' NHS Foundation Trust            Research Fellow     University of Exeter            Research Opportunities in Medical Oncology     Washington University in St Louis - School Of Medicine            Postdoc Virology / Immunology     Academic Medical Center of the University of Amsterdam          No matter what your career stage, student, postdoc or senior scientist, you will find articles on naturejobs.com to help guide you in your science career. 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