Nature Communications - 18 September 2012

Weekly Content Alert 18 September 2012 Featured image: Kawamura et al. show that rab7 controls a microautophagy-like process involved in endocytosis in mouse embryos. Latest content: Articles Journal homepage Recommend to library Web feed   Advertisement Feel like your paper is lost in a sea of submissions? Scientific Reports publishes your research quickly and efficiently, and makes it freely available to the global scientific community. Learn more with our one minute illustrative video.     Latest Articles View all Articles     Enhanced HSP70 lysine methylation promotes proliferation of cancer cells through activation of Aurora kinase B  OPEN Hyun-Soo Cho, Tadahiro Shimazu, Gouji Toyokawa, Yataro Daigo, Yoshihiko Maehara, Shinya Hayami, Akihiro Ito, Ken Masuda, Noriko Ikawa, Helen I. Field, Eiju Tsuchiya, Shin-ichi Ohnuma, Bruce A.J. Ponder, Minoru Yoshida, Yusuke Nakamura and Ryuji Hamamoto HSP70 is a molecular chaperone that aids protein folding. In this study, HSP70 is shown to be methylated and this post-translationally modified protein is elevated in expression in human cancers and promotes the activity of Aurora kinase B. 18 Sep | Nat Commun 3:1072 doi:10.1038/ncomms2074 (2012) Biological sciences Biochemistry  Cancer  Abstract | Full Text | PDF (1,103 kB) | Supplementary Information Delivery of endosomes to lysosomes via microautophagy in the visceral endoderm of mouse embryos Nobuyuki Kawamura, Ge-Hong Sun-Wada, Minako Aoyama, Akihiro Harada, Shunsuke Takasuga, Takehiko Sasaki and Yoh Wada Nutrients and growth factors initiate endocytotic processes in the embryonic endoderm that control embryonic patterning. Here, Kawamura et al. show that the small GTP-binding protein rab7 controls a unique microautophagy-like process that is involved in endocytosis in the endoderm of mouse embryos. 18 Sep | Nat Commun 3:1071 doi:10.1038/ncomms2069 (2012) Biological sciences Cell biology  Developmental biology  Abstract | Full Text | PDF (2,186 kB) | Supplementary Information Endogenous Wnt signalling in human embryonic stem cells generates an equilibrium of distinct lineage-specified progenitors OPEN Timothy A. Blauwkamp, Shelly Nigam, Reza Ardehali, Irving L. Weissman and Roel Nusse Human embryonic stem cell cultures are morphologically heterogeneous. Here, differences in Wnt signalling are shown to contribute to this heterogeneity, cells containing high levels of Wnt form endodermal and cardiac cells, whereas cells with low Wnt form neuroectodermal cells, when differentiation is induced. 18 Sep | Nat Commun 3:1070 doi:10.1038/ncomms2064 (2012) Biological sciences Developmental biology  Abstract | Full Text | PDF (2,208 kB) | Supplementary Information Time-domain classification of charge-density-wave insulators S. Hellmann, T. Rohwer, M. Kalläne, K. Hanff, C. Sohrt, A. Stange, A. Carr, M.M. Murnane, H.C. Kapteyn, L. Kipp, M. Bauer and K. Rossnagel Insulators can be classified according to the kind of electronic interactions they are dominated by. Hellmann et al. used time- and angle-resolved photoelectron spectroscopy to determine the dominant interactions in a series of transition metal dichalcogenides. 18 Sep | Nat Commun 3:1069 doi:10.1038/ncomms2078 (2012) Physical sciences Condensed matter  Abstract | Full Text | PDF (771 kB) Observation of Landau levels in potassium-intercalated graphite under a zero magnetic field OPEN Donghui Guo, Takahiro Kondo, Takahiro Machida, Keigo Iwatake, Susumu Okada and Junji Nakamura A signature of the Dirac-like physics of charge carriers in graphene is the occurrence of an anomalous Hall effect, resulting in a quantization of the Landau levels. Guo et al. observe Landau levels of Dirac fermions in potassium-intercalated graphite arising in the absence of an applied magnetic field. 18 Sep | Nat Commun 3:1068 doi:10.1038/ncomms2072 (2012) Physical sciences Applied physics  Condensed matter Materials science Abstract | Full Text | PDF (714 kB) | Supplementary Information Controllable chirality-induced geometrical Hall effect in a frustrated highly correlated metal B.G. Ueland, C.F. Miclea, Yasuyuki Kato, O. Ayala–Valenzuela, R.D. McDonald, R. Okazaki, P.H. Tobash, M.A. Torrez, F. Ronning, R. Movshovich, Z. Fisk, E.D. Bauer, Ivar Martin and J.D. Thompson The anomalous Hall effect is a macroscopic manifestation of a quantum mechanical effect. Here, Ueland et al. report the observation of a high Hall conductivity in the heavy-fermion compound UCu5, a metallic system, and explain its origin in terms of geometric frustration effects. 18 Sep | Nat Commun 3:1067 doi:10.1038/ncomms2075 (2012) Physical sciences Condensed matter  Materials science Abstract | Full Text | PDF (761 kB) | Supplementary Information Dynamic evolution of venom proteins in squamate reptiles Nicholas R. Casewell, Gavin A. Huttley and Wolfgang Wüster The evolution of venom toxins is an area of intense study but has been hampered by the lack of non-toxin protein homologues. Here, phylogenetic analyses of non-toxin genes sourced from transcriptomic studies are found placed within groups of venom toxins, revealing dynamic changes in the sites of toxin expression. 18 Sep | Nat Commun 3:1066 doi:10.1038/ncomms2065 (2012) Biological sciences Evolution  Genetics  Abstract | Full Text | PDF (528 kB) | Supplementary Information First-order coil-globule transition driven by vibrational entropy Carlo Maffi, Marco Baiesi, Lapo Casetti, Francesco Piazza and Paolo De Los Rios The coil-globule transition undergone by polymers in solution delineates a transition from expanded coils to collapsed globules, depending on the polarity of the solvent. This study examines the influence of vibrational entropy on the transition, and finds it can induce a crossover from a second-order to a first-order transition. 18 Sep | Nat Commun 3:1065 doi:10.1038/ncomms2055 (2012) Physical sciences Materials science Abstract | Full Text | PDF (449 kB) Tunable ferroelectricity in artificial tri-layer superlattices comprised of non-ferroic components K. Rogdakis, J.W. Seo, Z. Viskadourakis, Y. Wang, L.F.N. Ah Qune, E. Choi, J.D. Burton, E.Y. Tsymbal, J. Lee and C. Panagopoulos Ferroelectric materials are appealing for use in a range of technological applications. This study demonstrates the onset of ferroelectric behaviour in a superlattice structure that consists of three non-ferroelectric layers, suggesting ferroelectricity can also be induced by interface effects. 18 Sep | Nat Commun 3:1064 doi:10.1038/ncomms2061 (2012) Physical sciences Applied physics  Materials science  Abstract | Full Text | PDF (619 kB) | Supplementary Information The elusive Heisenberg limit in quantum-enhanced metrology OPEN Rafał Demkowicz-Dobrzański, Jan Kołodyński and Mădălin Guţă Quantum metrology employs the properties of quantum states to further enhance the accuracy of some of the most precise measurement schemes to date. Here, a method for estimating the upper bounds to achievable precision in quantum-enhanced metrology protocols in the presence of decoherence is presented. 18 Sep | Nat Commun 3:1063 doi:10.1038/ncomms2067 (2012) Physical sciences Atomic and molecular physics  Optical physics  Abstract | Full Text | PDF (631 kB) | Supplementary Information Production of α-L-iduronidase in maize for the potential treatment of a human lysosomal storage disease Xu He, Thomas Haselhorst, Mark von Itzstein, Daniel Kolarich, Nicolle H. Packer, Tracey M. Gloster, David J. Vocadlo, Lorne A. Clarke, Yi Qian and Allison R. Kermode The lysosomal storage disease mucopolysaccharidosis I is treated with recombinant α-L-iduronidase but production of the enzyme is expensive. In this study, α-L-iduronidase is compartmentalized within the endosperm of maize via a unique mRNA strategy yielding the active, correctly glycosylated protein. 18 Sep | Nat Commun 3:1062 doi:10.1038/ncomms2070 (2012) Biological sciences Biotechnology  Molecular biology Plant sciences Abstract | Full Text | PDF (1,274 kB) | Supplementary Information p47 negatively regulates IKK activation by inducing the lysosomal degradation of polyubiquitinated NEMO Yuri Shibata, Masaaki Oyama, Hiroko Kozuka-Hata, Xiao Han, Yuetsu Tanaka, Jin Gohda and Jun-ichiro Inoue The IKK complex activates the NF-κB pathway and can culminate in inflammation, which needs to be tightly controlled. NEMO is part of the IKK complex and, in this study, is shown to associate with the golgi-reassembly protein p47, resulting in the lysosomal degradation of NEMO and inhibition of NF-κB activation. 18 Sep | Nat Commun 3:1061 doi:10.1038/ncomms2068 (2012) Biological sciences Cell biology  Abstract | Full Text | PDF (1,194 kB) | Supplementary Information   Nature Comminications JOBS of the week Postdoctoral Fellow in Spinal Cord Systems Research University of Calgary Postdoc in regulatory genomics University of Iowa Carver College of Medicine Postdoctoral position University of Murcia (Spain) Internship in E-marketing & Communication in a startup specialized in e-marketing and e-watch in Biosciences. 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