Nature Chemistry Contents October 2012 Volume 4 Number 10 pp765-862

TABLE OF CONTENTS October 2012 Volume 4, Issue 10 Correspondence Thesis Research Highlights Blogroll News and Views Articles Erratum In Your Element Subscribe   Facebook   RSS   Recommend to library   Twitter   Advertisement Online-only personal subscriptions now available to Nature Chemistry and Nature Chemical Biology For only 49 USD/29 GBP/29 EUR Subscribe now!   Correspondence Top Dark channel fluorescence observations result from concentration effects rather than solvent-solute charge transfer   pp765 - 766 T. Z. Regier, A. J. Achkar, D. Peak, J. S. Tse and D. G. Hawthorn doi:10.1038/nchem.1430 See also: Correspondence by de Groot | Correspondence by Aziz et al. | Article by Aziz et al. Dips and peaks in fluorescence yield X-ray absorption are due to state-dependent decay   pp766 - 767 Frank M. F. de Groot doi:10.1038/nchem.1431 See also: Correspondence by Regier et al. | Correspondence by Aziz et al. | Article by Aziz et al. Reply to 'Dark channel fluorescence...' and 'Dips and peaks...'   pp767 - 768 Emad F. Aziz, Kathrin M. Lange, Sébastien Bonhommeau and Majed Chergui doi:10.1038/nchem.1449 See also: Correspondence by Regier et al. | Correspondence by de Groot | Article by Aziz et al. Thesis Top Knowledge management in chemistry   pp769 - 770 Bruce C. Gibb doi:10.1038/nchem.1459 Bringing knowledge management to bear on the process of scientific research may have benefits for everyone, explains Bruce Gibb. Research Highlights Top Anion binding: Trapping technetium | Malaria treatment: Totally synthetic solution | Electrochemistry: Better together | Crystalline materials: Disorder is in order Blogroll Top Blogroll: Harder than flight   p773 BRSM  doi:10.1038/nchem.1464 News and Views Top Selective functionalization: Shields for small molecules   pp774 - 775 Scott K. Silverman doi:10.1038/nchem.1468 Nucleic acid aptamers have been employed to shield small molecules so that one among many similar reactive functional groups can be modified. This provides access to new chemical entities with potentially interesting properties while avoiding the use of covalent protecting groups. See also: Article by Bastian et al. Chemical virology: Packing polymers in protein cages   pp775 - 777 Jeroen J. L. M. Cornelissen doi:10.1038/nchem.1462 The combination of addressable synthetic macromolecules with proteins of precise structure and function often leads to materials with unique properties, as is now shown by the efficient multi-site initiation of polymer growth inside the cavity of a virus capsid. See also: Article by Lucon et al. Molecular simulations: Force fields for carbon capture   pp777 - 778 Rachel B. Getman doi:10.1038/nchem.1461 Force fields have been generated that enable accurate simulations of interactions occurring between CO2 molecules and metal–organic frameworks featuring 'open' metal sites, which are promising for carbon capture applications. See also: Article by Dzubak et al. Main group chemistry: Bonsai phosphorus   pp779 - 780 Emma E. Coyle and Christopher J. O'Brien doi:10.1038/nchem.1470 Limitation controls reactivity — structural constraint of phosphorus has now enabled the development of a phosphine-catalysed transfer hydrogenation process akin to transition metals. Chemistry JOBS of the week Assistant Professor in Biomedical Chemistry Chemistry Department, University of Massachusetts Amherst Head, Medicinal Chemistry The Centre for Drug Research & Development (CDRD) Associate Professor in Physical Chemistry Department of Chemistry, Aarhus University Postdoc position in medicinal chemistry University of Southern Denmark, Department of Physics, Chemistry and Pharmacy Tenure-Track Assistant Professorship in Chemistry Harvard University More Science jobs from Chemistry EVENT Peptide Chemistry Conference 2012 02.-06.11.12 Riviera Maya, Mexico More science events from Articles Top Use of the interior cavity of the P22 capsid for site-specific initiation of atom-transfer radical polymerization with high-density cargo loading   pp781 - 788 Janice Lucon, Shefah Qazi, Masaki Uchida, Gregory J. Bedwell, Ben LaFrance, Peter E. Prevelige, Jr and Trevor Douglas doi:10.1038/nchem.1442 The site-selective initiation and propagation of an atom-transfer radical polymerization reaction forms an addressable crosslinked polymer constrained within the interior cavity of a virus-like particle derived from the bacteriophage P22. This protein–polymer hybrid is useful as a new vehicle for high-density delivery of small-molecule cargos. See also: News and Views by Cornelissen Selective transformations of complex molecules are enabled by aptameric protective groups   pp789 - 793 Andreas A. Bastian, Alessio Marcozzi and Andreas Herrmann doi:10.1038/nchem.1402 Selective modifications of structurally complex molecules bearing multiple reactive functional groups often require cumbersome multistep synthetic efforts. Here, aptameric protective groups based on short RNA sequences are described — they bind to neamine antibiotics, simultaneously protecting several functionalities and enabling regio- and chemoselective functionalizations. See also: News and Views by Silverman Electrode-assisted catalytic water oxidation by a flavin derivative   pp794 - 801 Ekaterina Mirzakulova, Renat Khatmullin, Janitha Walpita, Thomas Corrigan, Nella M. Vargas-Barbosa, Shubham Vyas, Shameema Oottikkal, Samuel F. Manzer, Christopher M. Hadad and Ksenija D. Glusac doi:10.1038/nchem.1439 So far, reports of molecular electrochemical water oxidation have involved catalytic transition metal complexes. Now it is demonstrated that water can be oxidized, and oxygen evolved, using a simple organic, flavin derivative. Rapid point-of-care detection of the tuberculosis pathogen using a BlaC-specific fluorogenic probe   pp802 - 809 Hexin Xie, Joseph Mire, Ying Kong, MiHee Chang, Hany A. Hassounah, Chris N. Thornton, James C. Sacchettini, Jeffrey D. Cirillo and Jianghong Rao doi:10.1038/nchem.1435 Rapid diagnostic methods that can be applied in resource-limited settings are important in the fight against tuberculosis. Here, fluorogenic probes are described that are activated by BlaC — an enzyme secreted by tubercle bacilli. The probes have enabled detection in unprocessed human sputum of live pathogen in less than 10 min. Ab initio carbon capture in open-site metal–organic frameworks   pp810 - 816 Allison L. Dzubak, Li-Chiang Lin, Jihan Kim, Joseph A. Swisher, Roberta Poloni, Sergey N. Maximoff, Berend Smit and Laura Gagliardi doi:10.1038/nchem.1432 Metal–organic frameworks featuring unsaturated metal sites have emerged as promising materials for CO2 capture, but the host–guest interactions at play have remained poorly understood. An approach based on quantum chemical calculations has now been devised to generate force fields that accurately describe a MOF's metal sites and predict its gas uptake abilities. Thiourea-catalysed ring opening of episulfonium ions with indole derivatives by means of stabilizing non-covalent interactions   pp817 - 824 Song Lin and Eric N. Jacobsen doi:10.1038/nchem.1450 Arylpyrrolidino amidothiourea catalysts are shown to catalyse the enantioselective ring-opening of episulfonium ions by indole derivatives. Catalysis and enantioinduction are achieved by selective transition-state stabilization of the major pathway in the rate- and selectivity-determining step through a network of attractive anion-binding, cation–π and hydrogen-bonding interactions between the catalyst and the reacting partners. Visualization of hierarchically structured zeolite bodies from macro to nano length scales   pp825 - 831 Sharon Mitchell, Nina-Luisa Michels, Karsten Kunze and Javier Pérez-Ramírez doi:10.1038/nchem.1403 Understanding the nature of complex zeolite particles, used as catalysts in industrial reactors, is vital for their further development. Now, an integrated approach to visualizing granules of a hierarchical MFI-type zeolite, on length scales from nanometres to millimetres, is reported. Submicrometre geometrically encoded fluorescent barcodes self-assembled from DNA   pp832 - 839 Chenxiang Lin, Ralf Jungmann, Andrew M. Leifer, Chao Li, Daniel Levner, George M. Church, William M. Shih and Peng Yin doi:10.1038/nchem.1451 Life-science research and biomedical diagnostics call for robust fluorescence barcodes of compact size and high multiplexing capability. Here DNA-origami technology was used to construct a new kind of geometrically encoded barcode with excellent structural stiffness. They hold promise for both in situ and ex situ imaging of diverse biologically relevant entities. The energy barrier in singlet fission can be overcome through coherent coupling and entropic gain   pp840 - 845 Wai-Lun Chan, Manuel Ligges and X-Y. Zhu doi:10.1038/nchem.1436 Better understanding of the mechanisms of singlet fission may facilitate its implementation in solar cells, improving their efficiency. Although singlet fission in tetracene is endothermic, it is now observed not to be thermally activated; rather a quantum coherent process allows access to the higher-energy multi-exciton state, which then forms two triplet excitons through an entropic driving force. Label-free measuring and mapping of binding kinetics of membrane proteins in single living cells   pp846 - 853 Wei Wang, Yunze Yang, Shaopeng Wang, Vinay J. Nagaraj, Qiang Liu, Jie Wu and Nongjian Tao doi:10.1038/nchem.1434 Many biological processes involve the binding of proteins to cell membrane receptors, making these proteins valuable disease biomarkers and therapeutic targets. A label-free plasmonic microscopy method has now been devised to determine the distribution and local binding kinetics of these ‘membrane proteins’, on the surface of single living cells rather than ex situ. Engaging unactivated alkyl, alkenyl and aryl iodides in visible-light-mediated free radical reactions   pp854 - 859 John D. Nguyen, Erica M. D'Amato, Jagan M. R. Narayanam and Corey R. J. Stephenson doi:10.1038/nchem.1452 Visible-light-mediated photocatalytic generation of carbon-centred radicals from alkyl, alkenyl and aryl iodides, which then undergo subsequent hydrogen-atom abstraction or reductive cyclizations, is reported. The protocol is characterized by the use of inexpensive reagents, mild conditions, exceptional functional group tolerance, and good to high yields. Erratum Top Anion-induced reconstitution of a self-assembling system to express a chloride-binding Co10L15 pentagonal prism   p860 Imogen A. Riddell, Maarten M. J. Smulders, Jack K. Clegg, Yana R. Hristova, Boris Breiner, John D. Thoburn and Jonathan R. Nitschke doi:10.1038/nchem.1456 In Your Element Top A touch of indium   p862 Catherine Renouf doi:10.1038/nchem.1460 Catherine Renouf describes how indium went from being a rather inconspicuous element to one whose role as a component of high-technology devices and gadgets may deplete its worldwide resources. Top Advertisement Nature Communications #4 in multidisciplinary sciences with first Impact Factor Nature Communications has joined Nature at the top of the multidisciplinary sciences category with its first impact factor of 7.396* Launched in April 2010, Nature Communications is a multidisciplinary online journal publishing high quality research across all areas of the natural sciences. *2011 Journal Citation Reports® (Thomson Reuters, 2012)   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. 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