Molecular Systems Biology - New articles published 25 September 2012

Latest Articles 25th September 2012   Featured Article Research Articles   Web feeds About Open access   Advertisement Molecular Systems Biology is seeking for an editor to join its in-house editorial team. This is an exciting opportunity to launch an editorial career with a leading journal in the fields of systems biology, synthetic biology and systems medicine. Work on all aspects of the editorial process including critically reading submitted research, organizing peer review, commissioning reviews, & developing journal content and editorial policies. Shape your field, join our team! Apply here: http://bit.ly/RhOEiN   Featured Article Novel biomarkers for pre-diabetes identified by metabolomics A targeted metabolomics approach was used to identify candidate biomarkers of pre-diabetes. The relevance of the identified metabolites is further corroborated with a protein-metabolite interaction network and gene expression data. Rui Wang-Sattler, Zhonghao Yu, Christian Herder, Ana C Messias, Anna Floegel, Ying He, Katharina Heim, Monica Campillos, Christina Holzapfel, Barbara Thorand, Harald Grallert, Tao Xu, Erik Bader, Cornelia Huth, Kirstin Mittelstrass, Angela Döring, Christa Meisinger, Christian Gieger, Cornelia Prehn, Werner Roemisch-Margl, Maren Carstensen, Lu Xie, Hisami Yamanaka-Okumura, Guihong Xing, Uta Ceglarek, Joachim Thiery, Guido Giani, Heiko Lickert, Xu Lin, Yixue Li, Heiner Boeing, Hans-Georg Joost, Martin Hrabé de Angelis, Wolfgang Rathmann, Karsten Suhre, Holger Prokisch, Annette Peters, Thomas Meitinger, Michael Roden, H-Erich Wichmann, Tobias Pischon, Jerzy Adamski & Thomas Illig Molecular Systems Biology 8:615; doi:10.1038/msb.2012.43; published 25 September 2012 Full Text | PDF | Supp. Inf. | Review Process Research Articles Noise drives sharpening of gene expression boundaries in the zebrafish hindbrain Fluctuations in morphogens often lead to gene expression domains with rough boundaries during development. A mechanism is described whereby intracellular noise can help coordinate cellular decisions during patterning and thereby sharpen expression boundaries. Lei Zhang, Kelly Radtke, Likun Zheng, Anna Q Cai, Thomas F Schilling & Qing Nie Molecular Systems Biology 8:613; doi:10.1038/msb.2012.45; published 25 September 2012 Full Text | PDF | Supp. Inf. | Review Process Need-based activation of ammonium uptake in Escherichia coli E. coli uses an energetically costly ammonium uptake process to maintain growth in ammonium-limited conditions. Detailed analysis of this process reveals that cells employ a novel strategy to activate ammonium transport only as necessary for cell growth. Minsu Kim, Zhongge Zhang, Hiroyuki Okano, Dalai Yan, Alexander Groisman & Terence Hwa Molecular Systems Biology 8:616; doi:10.1038/msb.2012.46; published 25 September 2012 Full Text | PDF | Supp. Inf. | Review Process A model of spatially restricted transcription in opposing gradients of activators and repressors Spatial boundaries of transcription in development can be established by opposing activator and repressor gradients. The affinity of TF binding sites sets the boundaries within such regions, but only when one TF binds more cooperatively than the other. Michael A White, Davis S Parker, Scott Barolo & Barak A Cohen Molecular Systems Biology 8:614; doi:10.1038/msb.2012.48; published 25 September 2012 Full Text | PDF | Supp. Inf. | Review Process

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