The EMBO Journal - Table of Contents alert Volume 31 Issue 17

TABLE OF CONTENTS 29 August 2012 | Volume 31, Issue 17 Have you seen? Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Become an editor at The EMBO Journal Interested in cutting edge research? Fair, authoritative and decisive? Join The EMBO Journal. We encourage candidates with a strong research record in trafficking, metabolism, cell death and autophagy, or systems biology to apply. Apply here   Have you seen? Top microRNA regulation of cancer–endothelial interactions: vesicular microRNAs on the move… In a new twist for efficient tumour angiogenesis, tumour cells release miR-9 containing microvesicles to directly promote endothelial cell migration. Nils Halberg, Claudio Alarcón and Sohail F Tavazoie The EMBO Journal (2012), 31, 3509 - 3510; 10.1038/emboj.2012.198 Abstract | Full text | PDF Published online: 24 July 2012 Fanconi proteins get histones moving New work reveals an unexpected role of the FANCD2 protein as a histone chaperone, which appears to be essential for this DNA interstrand crosslink repair function. Andrew J Deans The EMBO Journal (2012), 31, 3511 - 3512; 10.1038/emboj.2012.222 Abstract | Full text | PDF Published online: 07 August 2012 Articles Top Tumour-secreted miR-9 promotes endothelial cell migration and angiogenesis by activating the JAK-STAT pathway Secreted miRNAs are increasingly recognized in multiple biological processes. Here, miR-9 is shown to be secreted from cancer cells to enhance endothelial recruitment. This contribution to tumour angiogenesis could be amenable for therapeutic intervention. Guanglei Zhuang, Xiumin Wu, Zhaoshi Jiang, Ian Kasman, Jenny Yao, Yinghui Guan, Jason Oeh, Zora Modrusan, Carlos Bais, Deepak Sampath and Napoleone Ferrara The EMBO Journal (2012), 31, 3513 - 3523; 10.1038/emboj.2012.183 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 July 2012 Histone chaperone activity of Fanconi anemia proteins, FANCD2 and FANCI, is required for DNA crosslink repair Unexpected nucleosome remodelling activities of FANCD2-FANCI proteins offer new clues as to their essential yet still enigmatic functions in DNA interstrand crosslink repair. Koichi Sato, Masamichi Ishiai, Kazue Toda, Satoshi Furukoshi, Akihisa Osakabe, Hiroaki Tachiwana, Yoshimasa Takizawa, Wataru Kagawa, Hiroyuki Kitao, Naoshi Dohmae, Chikashi Obuse, Hiroshi Kimura, Minoru Takata and Hitoshi Kurumizaka The EMBO Journal (2012), 31, 3524 - 3536; 10.1038/emboj.2012.197 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 July 2012 Human CST promotes telomere duplex replication and general replication restart after fork stalling The mammalian CTC1-STN1-TEN1 complex functions not only in maintenance and replication of telomeres, but also has a surprising genome-wide role in restart after replication fork stalling. Jason A Stewart, Feng Wang, Mary F Chaiken, Christopher Kasbek, Paul D Chastain II, Woodring E Wright and Carolyn M Price The EMBO Journal (2012), 31, 3537 - 3549; 10.1038/emboj.2012.215 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 August 2012 Generation of DNA single-strand displacement by compromised nucleotide excision repair Strong tumorigenic effects of a particular mutation in the key nucleotide excision repair factor XPD may not be due to DNA break generation, but caused by inefficient excision steps resulting in long single-strand gaps and genomic instability. Camille Godon, Sophie Mourgues, Julie Nonnekens, Amandine Mourcet, Fréderic Coin, Wim Vermeulen, Pierre-Olivier Mari and Giuseppina Giglia-Mari The EMBO Journal (2012), 31, 3550 - 3563; 10.1038/emboj.2012.193 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 August 2012 Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels The abundance of histone posttranslational modifications (HPTMs) that are crucial for recruitment of chromatin regulators varies. The deacetylase Rpd3S copes with such fluctuations by binding chromatin through both HPTM-dependent and -independent interactions. Jae-Wan Huh, Jun Wu, Chul-Hwan Lee, Miyong Yun, Daniel Gilada, Chad A Brautigam and Bing Li The EMBO Journal (2012), 31, 3564 - 3574; 10.1038/emboj.2012.221 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 August 2012 Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM Gdown1 inhibits gene expression by tight association with mammalian RNA polymerase II (RNAPII), which EM structures reveal to compete with binding of the basal general transcription factor TFIIF to RNAPII. Yi-Min Wu, Jen-Wei Chang, Chun-Hsiung Wang, Yen-Chen Lin, Pei-lun Wu, Shih-hsin Huang, Chia-Chi Chang, Xiaopeng Hu, Averell Gnatt and Wei-hau Chang The EMBO Journal (2012), 31, 3575 - 3587; 10.1038/emboj.2012.205 Abstract | Full text | PDF | Supp. info. Published online: 31 July 2012 Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs Argonaute forms the core of the RISC silencing complex, binding 5′-phosphate of small RNAs. Structures of the MID domain of three Arabidopsis Argonaute (AGO) proteins reveal how small RNAs are sorted into the appropriate AGO family member. Filipp Frank, Jesse Hauver, Nahum Sonenberg and Bhushan Nagar The EMBO Journal (2012), 31, 3588 - 3595; 10.1038/emboj.2012.204 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 July 2012 The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradation The novel RNA-binding E3 ubiquitin ligase MEX-3C targets the mRNA of MHC-I gene HLA-A2 for degradation in a RING-dependent manner. Depletion of MEX-3C in NK cells leads to reduced killing of target cells. Florencia Cano, Helen Bye, Lidia M Duncan, Karine Buchet-Poyau, Marc Billaud, Mark R Wills and Paul J Lehner The EMBO Journal (2012), 31, 3596 - 3606; 10.1038/emboj.2012.218 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 03 August 2012 Staphylococcus aureus Staphopain A inhibits CXCR2-dependent neutrophil activation and chemotaxis Neutrophil activation and recruitment to the site of infection are critical for host immunity. In humans, the cysteine protease Staphopain A of the pathogen S. aureus blocks this process by cleaving the chemokine receptor CXCR2. Alexander J Laarman, Gerdien Mijnheer, Joe M Mootz, Willemien J M van Rooijen, Maartje Ruyken, Cheryl L Malone, Erik C Heezius, Richard Ward, Graeme Milligan, Jos A G van Strijp, Carla J C de Haas, Alexander R Horswill, Kok P M van Kessel and Suzan H M Rooijakkers The EMBO Journal (2012), 31, 3607 - 3619; 10.1038/emboj.2012.212 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 July 2012 The Mitotic Exit Network and Cdc14 phosphatase initiate cytokinesis by counteracting CDK phosphorylations and blocking polarised growth Inhibition of cyclin-dependent kinases at the end of S. cerevisiae mitosis is essential to prevent premature polarisation and re-budding, which would confuse the actin-dependent cytokinesis machinery. Alberto Sanchez-Diaz, Pedro Junior Nkosi, Stephen Murray and Karim Labib The EMBO Journal (2012), 31, 3620 - 3634; 10.1038/emboj.2012.224 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 07 August 2012 A stomatin dimer modulates the activity of acid-sensing ion channels Stomatins govern membrane trafficking and ion channel activity. The banana-shaped stomatin-domain dimmers oligomerize into a cylindrical structure. A dynamic hydrophobic pocket at the concave side of the dimer mediates repression of acid-sensing ion channel 3 (ASIC3) activity. Janko Brand, Ewan St J Smith, David Schwefel, Liudmila Lapatsina, Kate Poole, Damir Omerbašić, Alexey Kozlenkov, Joachim Behlke, Gary R Lewin and Oliver Daumke The EMBO Journal (2012), 31, 3635 - 3646; 10.1038/emboj.2012.203 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 July 2012 Advertisement EMBO - Transparency in Scientific Publishing The EMBO Journal has a fair and transparent process to rapidly publish your best science. Transparent - No confidential referee remarks - Published referee reports - Detailed decisions - Source Data published alongside figures Fair - Scooping protection - Pre-decision cross-referee commenting - Fixed bar for revisions - Fast process   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to The EMBO Journal. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. 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