The EMBO Journal - Table of Contents alert Volume 31 Issue 16

TABLE OF CONTENTS 15 August 2012 | Volume 31, Issue 16 Have you seen? Articles Corrigenda Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement EMBO - Transparency in Scientific Publishing The EMBO Journal has a fair and transparent process to rapidly publish your best science. Transparent No confidential referee remarks Published referee reports Detailed decisions Source Data published alongside figures Fair Scooping protection Pre-decision cross-referee commenting Fixed bar for revisions Fast process   Have you seen? Top Polyvalent DP1 keeps the Wnt pathway neat and tidy Two opposite actions of DP1 on the Wnt signalling pathway, one negative in the cytoplasm and one positive in the nucleus, contribute to the generation of sharp responses to Wnt gradients. François Fagotto The EMBO Journal (2012), 31, 3377 - 3379; 10.1038/emboj.2012.201 Abstract | Full text | PDF | Related article Published online: 27 July 2012 Chromosome ends teach unexpected lessons on DNA damage signalling New work reveals that the mechanism of CDC25 regulation in the G2/M checkpoint triggered by telomere uncapping is distinct from the canonical DNA damage response to ionizing radiation. Sandy Chang The EMBO Journal (2012), 31, 3380 - 3381; 10.1038/emboj.2012.199 Abstract | Full text | PDF | Related article Published online: 27 July 2012 A POTluck of peptide transporters Diet-derived peptides are taken up by conserved proton-dependent oligopeptide transporters. Two papers on crystal structures of bacterial transporters in different conformations now shed light on the transport mechanism. Poul Nissen The EMBO Journal (2012), 31, 3382 - 3383; 10.1038/emboj.2012.206 Abstract | Full text | PDF | Related article | Related article Published online: 27 July 2012 Articles Top Dual functions of DP1 promote biphasic Wnt-on and Wnt-off states during anteroposterior neural patterning DP1 down-regulates beta-catenin in the cytoplasm by inhibiting Dvl-Axin interaction, while it promotes beta-catenin activity in the nucleus by antagonizing NLK. This dual role of DP1 transforms a gradient of Wnt signalling into sharp ON/OFF responses via regulation of DP1 sub-cellular localization. Wan-tae Kim, Hyunjoon Kim, Vladimir L Katanaev, Seung Joon Lee, Tohru Ishitani, Boksik Cha, Jin-Kwan Han and Eek-hoon Jho The EMBO Journal (2012), 31, 3384 - 3397; 10.1038/emboj.2012.181 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 06 July 2012 ATM/ATR checkpoint activation downregulates CDC25C to prevent mitotic entry with uncapped telomeres Telomere deprotection, despite triggering the same DNA damage response machinery as ionizing radiation, arrests the mammalian cell cycle via a distinct mechanism involving CDC25C phosphatase regulation. Maria Thanasoula, Jose Miguel Escandell, Natsuko Suwaki and Madalena Tarsounas The EMBO Journal (2012), 31, 3398 - 3410; 10.1038/emboj.2012.191 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 July 2012 Alternating access mechanism in the POT family of oligopeptide transporters Proton-dependent oligopeptide transporters are required for the uptake of diet-derived peptides in all kingdoms of life. The crystal structure of a bacterial transporter in the inward open conformation, together with a published structure in an occluded conformation, reveals the peptide transport mechanism. Nicolae Solcan, Jane Kwok, Philip W Fowler, Alexander D Cameron, David Drew, So Iwata and Simon Newstead The EMBO Journal (2012), 31, 3411 - 3421; 10.1038/emboj.2012.157 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 June 2012 Extremely stable Piwi-induced gene silencing in Caenorhabditis elegans RNA-induced epigenetic silencing (RNAe) is a new pathway in C. elegans initiated by the Piwi protein PRG-1. RNAe stably silences transgenes over many generations through a nuclear RNAi pathway that induces transcriptional silencing. Maartje J Luteijn, Petra van Bergeijk, Lucas J T Kaaij, Miguel Vasconcelos Almeida, Elke F Roovers, Eugene Berezikov and René F Ketting The EMBO Journal (2012), 31, 3422 - 3430; 10.1038/emboj.2012.213 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 31 July 2012 Regulation of human lung alveolar multipotent cells by a novel p38α MAPK/miR-17-92 axis This study characterizes putative human lung stem cells based on E-cadherin/Lgr6 expression. Long-term clonal expansion, the ability to form bronchioalveolar-like epithelia and the discovery of the miR-17-92 cluster as regulator of their proliferative capacity are features of this unique stem cell population. Feride Oeztuerk-Winder, Anna Guinot, Anna Ochalek and Juan-Jose Ventura The EMBO Journal (2012), 31, 3431 - 3441; 10.1038/emboj.2012.192 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 24 July 2012 Modulation of synaptic function by VAC14, a protein that regulates the phosphoinositides PI(3,5)P2 and PI(5)P Mice deficient for VAC14, a scaffolding protein required for PIP2 biosynthesis and linked to human neuropathies, show increased postsynaptic function due to altered AMPA receptor trafficking. Yanling Zhang, Amber J McCartney, Sergey N Zolov, Cole J Ferguson, Miriam H Meisler, Michael A Sutton and Lois S Weisman The EMBO Journal (2012), 31, 3442 - 3456; 10.1038/emboj.2012.200 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 July 2012 Phytochrome Kinase Substrate 4 is phosphorylated by the phototropin 1 photoreceptor Phototropism is an adaptive response that allows plants to optimize light capture under low light conditions. The Arabidopsis photoreceptor phot1 phosphorylates PKS4 as part of a negative feedback loop to prevent excessive phototropism. Emilie Demarsy, Isabelle Schepens, Koji Okajima, Micha Hersch, Sven Bergmann, John Christie, Ken-ichiro Shimazaki, Satoru Tokutomi and Christian Fankhauser The EMBO Journal (2012), 31, 3457 - 3467; 10.1038/emboj.2012.186 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 10 July 2012 Sister chromatid interactions in bacteria revealed by a site-specific recombination assay Sister chromatid cohesion is an established theme only in eukaryotes. A novel direct assay reveals that bacterial chromosomes also retain close proximity following replication. Christian Lesterlin, Emmanuelle Gigant, Frédéric Boccard and Olivier Espéli The EMBO Journal (2012), 31, 3468 - 3479; 10.1038/emboj.2012.194 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 20 July 2012 The Reb1-homologue Ydr026c/Nsi1 is required for efficient RNA polymerase I termination in yeast Employing insightful genetic experiments, this paper identifies cis- and trans-acting factors that influence termination of Pol I transcription on ribosomal genes with further reaching implications for general mechanisms of transcription termination. Alarich Reiter, Stephan Hamperl, Hannah Seitz, Philipp Merkl, Jorge Perez-Fernandez, Lydia Williams, Jochen Gerber, Attila Németh, Isabelle Léger, Olivier Gadal, Philipp Milkereit, Joachim Griesenbeck and Herbert Tschochner The EMBO Journal (2012), 31, 3480 - 3493; 10.1038/emboj.2012.185 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 17 July 2012 Pol II CTD kinases Bur1 and Kin28 promote Spt5 CTR-independent recruitment of Paf1 complex The Paf1 complex, a regulator of co-transcriptional processes, is recruited to coding regions by a novel Spt5-independent mechanism, involving RNA Polymerase CTD phosphorylation by the Kin28 and Bur1 kinases. Hongfang Qiu, Cuihua Hu, Naseem A Gaur and Alan G Hinnebusch The EMBO Journal (2012), 31, 3494 - 3505; 10.1038/emboj.2012.188 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 July 2012 Corrigenda Top Regulation of human lung alveolar multipotent cells by a novel p38α MAPK/miR-17-92 axis Feride Oeztuerk-Winder, Anna Guinot, Anna Ochalek and Juan-Jose Ventura The EMBO Journal (2012), 31, 3506; 10.1038/emboj.2012.234 Full text | PDF Published online: 15 August 2012 The tail sheath structure of bacteriophage T4: a molecular machine for infecting bacteria Anastasia A Aksyuk, Petr G Leiman, Lidia P Kurochkina, Mikhail M Shneider, Victor A Kostyuchenko, Vadim V Mesyanzhinov and Michael G Rossmann The EMBO Journal (2012), 31, 3507; 10.1038/emboj.2012.223 Full text | PDF Published online: 15 August 2012 Advertisement Follow EMBO on Twitter for as-it-happens access to news, comments and articles. 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