Scientific Reports Biology Table of Contents e-alert: August 2012

01 August 2012      • Visit Scientific Reports • Submit your manuscript to Scientific Reports     Welcome to your Table of Contents e-alert for Scientific Reports             Nature Communications #4 in multidisciplinary sciences with first Impact Factor Nature Communications has joined Nature at the top of the multidisciplinary sciences category with its first impact factor of 7.396*. Launched in April 2010, Nature Communications is a multidisciplinary online-only journal publishing high quality research across the natural sciences. *2011 Journal Citation Reports® (Thomson Reuters, 2012)               Biological Sciences               The hOGG1Ser326Cys Polymorphism and Increased Lung Cancer Susceptibility in Caucasians: An Updated Meta-Analysis ▶     Dani Zhong, Guojian Li, Jianxiong Long et al.     hOGG1 encodes a DNA repair enzyme responsible for the excision of reactive oxygen species (ROS) in damaged DNA. Previous studies have obtained inconsistent results. To validate …             Overstimulation of newborn mice leads to behavioral differences and deficits in cognitive performance ▶     D. A. Christakis, J. S. B. Ramirez, J. M. Ramirez     Observational studies in humans have found associations between overstimulation in infancy via excessive television viewing and subsequent deficits in cognition and attention. We …             Iron biofortification in rice by the introduction of multiple genes involved in iron nutrition ▶     Hiroshi Masuda, Yasuhiro Ishimaru, May Sann Aung et al.     To address the problem of iron-deficiency anemia, one of the most prevalent human micronutrient deficiencies globally, iron-biofortified rice was produced using three transgenic …             Hippocampal protection in mice with an attenuated inflammatory monocyte response to acute CNS picornavirus infection ▶     Charles L. Howe, Reghann G. LaFrance-Corey, Rhianna S. Sundsbak et al.     Neuronal injury during acute viral infection of the brain is associated with the development of persistent cognitive deficits and seizures in humans. In C57BL/6 mice acutely …             A synthetic small molecule for rapid induction of multiple pluripotency genes in mouse embryonic fibroblasts ▶     Ganesh N. Pandian, Yusuke Nakano, Shinsuke Sato et al.     Cellular reprogramming involves profound alterations in genome-wide gene expression that is precisely controlled by a hypothetical epigenetic code. Small molecules have been shown …             Successful cryopreservation of human ovarian cortex tissues using supercooling ▶     Hisashi Moriguchi, Yue Zhang, Makoto Mihara et al.     The development of new method to cryopreserve human ovarian cortex tissues without damage is needed for the improvement of quality of life (QOL) of female cancer patients. Here we …             Altered Death Receptor Signaling Promotes Epithelial-to-Mesenchymal Transition and Acquired Chemoresistance ▶     James W. Antoon, Rongye Lai, Amanda P. Struckhoff et al.     Altered death receptor signaling and resistance to subsequent apoptosis is an important clinical resistance mechanism. Here, we investigated the role of death receptor resistance …             Gas-tight triblock-copolymer membranes are converted to CO2 permeable by insertion of plant aquaporins ▶     Norbert Uehlein, Beate Otto, Adrian Eilingsfeld et al.     We demonstrate that membranes consisting of certain triblock-copolymers were tight for CO2. Using a novel approach, we provide evidence for aquaporin facilitated CO2 diffusion. …             A Prospective Study of In-utero Exposure to Magnetic Fields and the Risk of Childhood Obesity ▶     De-Kun Li, Jeannette R. Ferber, Roxana Odouli et al.     We conducted a prospective study to examine whether in-utero exposure to magnetic fields (MFs) increases the risk of childhood obesity. Participating women carried a meter …             Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice ▶     Chihiro Tohda, Takuya Urano, Masahito Umezaki et al.     The aim of this study was to investigate the effects and the mechanism of diosgenin, a famous plant-derived steroidal sapogenin, on memory deficits in Alzheimer's disease (AD) …             The effect of temperature compensation on the circadian rhythmicity of photosynthesis in Symbiodinium, coral-symbiotic alga ▶     Michal Sorek, Oren Levy     Circadian rhythms, which are found in most eukaryotes, are defined as rhythms that persist under constant conditions with a periodicity close to 24 h. One central key …             Binding Mode of CpG Oligodeoxynucleotides to Nanoparticles Regulates Bifurcated Cytokine induction via Toll-like Receptor 9 ▶     Shanmugavel Chinnathambi, Song Chen, Singaravelu Ganesan et al.     The interaction of cytosine-phosphate-guanine oligodeoxynucleotides (CpG ODNs) with Toll-like receptor 9 (TLR9) activates the immune system. Multimeric class A CpG ODNs induce …             Measuring the Evolution of Contemporary Western Popular Music ▶     Joan Serrà, Álvaro Corral, Marián Boguñá et al.     Popular music is a key cultural expression that has captured listeners' attention for ages. Many of the structural regularities underlying musical discourse are yet to be …             The Bcl-2 family member BIM has multiple glaucoma-relevant functions in DBA/2J mice ▶     Jeffrey M. Harder, Kimberly A. Fernandes, Richard T. Libby     Axonal insult induces retinal ganglion cell (RGC) death through a BAX-dependent process. The pro-apoptotic Bcl-2 family member BIM is known to induce BAX activation. BIM …             Spatial distribution of prokaryotic symbionts and ammoxidation, denitrifier bacteria in marine sponge Astrosclera willeyana ▶     Zhenya Yang, Zhiyong Li     The present knowledge of microbial community mainly focus on total sponge, the spatial distribution of microbes in sponges is rarely known, especially those with potential …             Position-dependent FUS-RNA interactions regulate alternative splicing events and transcriptions ▶     Shinsuke Ishigaki, Akio Masuda, Yusuke Fujioka et al.     FUS is an RNA-binding protein that regulates transcription, alternative splicing, and mRNA transport. Aberrations of FUS are causally associated with familial and sporadic ALS/FTLD. …             β1 integrin deletion enhances progression of prostate cancer in the TRAMP mouse model ▶     Kim Moran-Jones, Anita Ledger, Matthew J. Naylor     β1 integrin regulates the response of both normal and cancer cells to their local environment. Although mis-localised in prostate cancer, the role β1 integrin plays in prostate …             Counting in the dark: Non-intrusive laser scanning for population counting and identifying roosting bats ▶     Suzanna Noor Azmy, Shahrul Anuar Mohd Sah, Nur Juliani Shafie et al.     Population surveys and species recognition for roosting bats are either based on capture, sight or optical-mechanical count methods. However, these methods are intrusive, are …             Global dispersion of bacterial cells on Asian dust ▶     Nobuyasu Yamaguchi, Tomoaki Ichijo, Akiko Sakotani et al.     The atmospheric dispersion of bacteria over long distances is an important facet of microbial ecology. Certain groups of dispersed bacteria can adapt to their new location and …             A Bayesian analysis of the chromosome architecture of human disorders by integrating reductionist data ▶     Frank Emmert-Streib, Ricardo de Matos Simoes, Shailesh Tripathi et al.     In this paper, we present a Bayesian approach to estimate a chromosome and a disorder network from the Online Mendelian Inheritance in Man (OMIM) database. In contrast to other …             Targeting JNK for therapeutic depletion of stem-like glioblastoma cells ▶     Ken-ichiro Matsuda, Atsushi Sato, Masashi Okada et al.     Control of the stem-like tumour cell population is considered key to realizing the long-term survival of patients with glioblastoma, one of the most devastating human …             Information Processing Capacity of Dynamical Systems ▶     Joni Dambre, David Verstraeten, Benjamin Schrauwen et al.     Many dynamical systems, both natural and artificial, are stimulated by time dependent external signals, somehow processing the information contained therein. We demonstrate how to …             Evolution of Cariogenic Character in Streptococcus mutans: Horizontal Transmission of Glycosyl Hydrolase Family 70 Genes ▶     Tomonori Hoshino, Taku Fujiwara, Shigetada Kawabata     Acquisition of the ability to produce polysaccharides from sucrose, i.e. the gtf gene encoding glucosyltransferase (GTF), is the key evolutionary event enabling dental biofilm …             Ultraviolet Shadowing of RNA Can Cause Significant Chemical Damage in Seconds ▶     Wipapat Kladwang, Justine Hum, Rhiju Das     Chemical purity of RNA samples is important for high-precision studies of RNA folding and catalytic behavior, but photodamage accrued during ultraviolet (UV) shadowing steps of …             Integrative analyses reveal novel strategies in HPV11,-16 and -45 early infection ▶     Bogumil Kaczkowski, Maria Rossing, Ditte K. Andersen et al.     The interaction between human papillomavirus (HPV) and host cells is not well understood. We investigate the early stage of HPV infections by global expression profiling in a cell …             Environmental conditioning in the control of macrophage thrombospondin-1 production ▶     Jezrom B. Fordham, Jing Hua, Sarah R. Morwood et al.     Thrombospondin-1 (TSP-1) is a multifunctional protein which is secreted into the extracellular matrix during inflammation, where it modulates numerous components of the immune …             Robust adhesion of flower-like few-layer graphene nanoclusters ▶     Shibing Tian, Lin Li, Wangning Sun et al.     Nanostructured surface possessing ultrahigh adhesion like “gecko foot” or “rose petal” can offer more opportunities for bionic application. We grow flower-like few-layer graphene …             Nucleoprotein filament formation is the structural basis for bacterial protein H-NS gene silencing ▶     Ci Ji Lim, Sin Yi Lee, Linda J. Kenney et al.     H-NS is an abundant nucleoid-associated protein in bacteria that globally silences genes, including horizontally-acquired genes related to pathogenesis. Although it has been shown …             Genetic mechanisms preventing the fusion of ecotypes even in the face of gene flow ▶     Issei Ohshima     Understanding the genetics behind adaptation and reproductive isolation contributes to our knowledge about how biodiversity is created and maintained. Host races of phytophagous …             The Perceptual Cues that Reshape Expert Reasoning ▶     Michael Harré, Terry Bossomaier, Allan Snyder     The earliest stages in our perception of the world have a subtle but powerful influence on later thought processes; they provide the contextual cues within which our thoughts are …             Detection and Segmentation of Cell Nuclei in Virtual Microscopy Images: A Minimum-Model Approach ▶     Stephan Wienert, Daniel Heim, Kai Saeger et al.     Automated image analysis of cells and tissues has been an active research field in medical informatics for decades but has recently attracted increased attention due to …             Trends in scale and shape of survival curves ▶     Byung Mook Weon, Jung Ho Je     The ageing of the population is an issue in wealthy countries worldwide because of increasing costs for health care and welfare. Survival curves taken from demographic life tables …             Hydrogen sulfide and resolution of acute inflammation: A comparative study utilizing a novel fluorescent probe ▶     Neil Dufton, Jane Natividad, Elena F. Verdu et al.     Hydrogen sulfide is an essential gasotransmitter associated with numerous pathologies. We assert that hydrogen sulfide plays an important role in regulating macrophage function in …             Temporally-regulated quick activation and inactivation of Ras is important for olfactory behaviour ▶     Takayuki Uozumi, Takaaki Hirotsu, Kazushi Yoshida et al.     Responses to environmental stimuli are mediated by the activation and inactivation of various signalling proteins. However, the temporal dynamics of these events in living animals …             Carcinogenicity evaluation for the application of carbon nanotubes as biomaterials in rasH2 mice ▶     Seiji Takanashi, Kazuo Hara, Kaoru Aoki et al.     The application of carbon nanotubes (CNTs) as biomaterials is of wide interest, and studies examining their application in medicine have had considerable significance. Biological …             The Pathophysiology of Inhalational Brucellosis in Balb/c Mice ▶     Lisa N. Henning, Karen T. Gillum, David A. Fisher et al.     To characterize the clinical presentation and pathophysiology of inhalational brucellosis, Balb/c mice were challenged with Brucella melitensis 16M in a nose-only aerosol exposure …             Intersectional Cre Driver Lines Generated Using Split-Intein Mediated Split-Cre Reconstitution ▶     Ping Wang, Tianrui Chen, Katsuyasu Sakurai et al.     Tissue and cell type highly specific Cre drivers are very rare due to the fact that most genes or promoters used to direct Cre expressions are generally expressed in more than one …             T1R3: A human calcium taste receptor ▶     Michael G. Tordoff, Laura K. Alarcón, Sitaram Valmeki et al.     Many animals can detect the taste of calcium but it is unclear how or whether humans have this ability. We show here that calcium activates hTAS1R3-transfected HEK293 cells and …             Genes down-regulated in spaceflight are involved in the control of longevity in Caenorhabditis elegans ▶     Yoko Honda, Akira Higashibata, Yohei Matsunaga et al.     How microgravitational space environments affect aging is not well understood. We observed that, in Caenorhabditis elegans, spaceflight suppressed the formation of transgenically …             Hypoxia inducible factor-1α is necessary for invasive phenotype in Vegf-deleted islet cell tumors ▶     Takaaki Takeda, Hiroaki Okuyama, Yasuko Nishizawa et al.     In the mouse model of pancreas endocrine tumor, loss of Vegf (VKO) results in dramatically decreased tumor progression; however, the residual microscopic lesions show increased …             Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies ▶     Scott B. Rothbart, Shu Lin, Laura-Mae Britton et al.     Antibodies specific for histone post-translational modifications (PTMs) have been central to our understanding of chromatin biology. Here, we describe an unexpected and novel …             The distinct roles of the nucleus and nucleus-cytoskeleton connections in three-dimensional cell migration ▶     Shyam B. Khatau, Ryan J. Bloom, Saumendra Bajpai et al.     Cells often migrate in vivo in an extracellular matrix that is intrinsically three-dimensional (3D) and the role of actin filament architecture in 3D cell migration is less well …             Metagenomes of Mediterranean Coastal Lagoons ▶     Rohit Ghai, Claudia Mella Hernandez, Antonio Picazo et al.     Coastal lagoons, both hypersaline and freshwater, are common, but still understudied ecosystems. We describe, for the first time, using high throughput sequencing, the extant …             Synthesis of two SAPAP3 isoforms from a single mRNA is mediated via alternative translational initiation ▶     John Jia En Chua, Claudia Schob, Monika Rehbein et al.     In mammalian neurons, targeting and translation of specific mRNAs in dendrites contribute to synaptic plasticity. After nuclear export, mRNAs designated for dendritic transport …             Genomic perspectives on the evolution of fungal entomopathogenicity in Beauveria bassiana ▶     Guohua Xiao, Sheng-Hua Ying, Peng Zheng et al.     The ascomycete fungus Beauveria bassiana is a pathogen of hundreds of insect species and is commercially produced as an environmentally friendly mycoinsecticide. We sequenced the …             Optimal spike-based communication in excitable networks with strong-sparse and weak-dense links ▶     Jun-nosuke Teramae, Yasuhiro Tsubo, Tomoki Fukai     The connectivity of complex networks and functional implications has been attracting much interest in many physical, biological and social systems. However, the significance of …                     The Arab world has a rich history of scientific breakthroughs. Ensure you're part of the scientific and medical community gaining access to the latest research in the region. 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