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SciBx is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. Subscribe to SciBX and you won't miss the next big thing.
Tracing cancer stem cells Tim Fulmer doi:10.1038/scibx.2012.830 Three academic teams have independently developed techniques for in vivo detection of cancer stem cells in mice with solid tumors. The methods could be useful as next-generation target discovery platforms and screens for compounds targeting cancer stem cells. Full Text | PDF
Amyloids for inflammation Kai-Jye Lou doi:10.1038/scibx.2012.831 Stanford researchers have shown that systemic treatment with β-amyloid peptides could reduce inflammation in mouse models of multiple sclerosis. Cardinal Therapeutics has licensed the work along with related technologies and now is trying to develop anti-inflammatory compounds based on the mechanism. Full Text | PDF
Finding the perfect combination Tracey Baas doi:10.1038/scibx.2012.832 Two independent research teams have used cell culture methods to show that excessive HGF/SF activity drives resistance to BRAF inhibitors in melanoma. The findings could provide a rationale for combining HGF/SF or MET inhibitors with BRAF inhibitors to overcome treatment resistance in the disease. Full Text | PDF
CIRM: get a little closer Michael J. Haas doi:10.1038/scibx.2012.833 The California Institute for Regenerative Medicine's latest batch of grants reflects its interest in funding projects that are close to entering the clinic. Full Text | PDF
5-Methoxytryptophan (5-MTP) doi:10.1038/scibx.2012.834 Mouse and cell culture studies suggest 5-MTP could help treat cancer. Full Text | PDF
Cyclin dependent kinase 8 (CDK8); CDK19 (CDC2L6); cyclin-dependent kinase inhibitor 1A (p21, Cip1; CDKN1A; CIP1) doi:10.1038/scibx.2012.835 In vitro and mouse studies suggest dual CDK8 and CDK19 inhibitors could help improve chemotherapy efficacy. Full Text | PDF
Smoothened (SMO) doi:10.1038/scibx.2012.836 In vitro studies identified inhibitors of SMO ciliary localization and cilia assembly that could help treat Hedgehog pathway–driven cancers. Full Text | PDF
c-Myc (MYC); zinc finger protein 36 C3H type homolog (ZFP36; TTP) doi:10.1038/scibx.2012.837 Mouse and cell culture studies suggest increasing TTP signaling could help treat and prevent MYC-driven lymphomas. Full Text | PDF
Transforming growth factor-β receptor II (TGFβ-RII; TGFBR2) doi:10.1038/scibx.2012.838 In vitro studies suggest a TGFBR2 inhibitor could help regenerate damaged cardiac tissue. Full Text | PDF
Acid-sensing ion channel-3 (ASIC3; ACCN3) doi:10.1038/scibx.2012.839 Rodent studies suggest increasing ASIC3 channel activity could help prevent dermal ulcers. Full Text | PDF
ADAM metallopeptidase domain 12 (ADAM12) doi:10.1038/scibx.2012.840 Mouse studies suggest inhibiting ADAM12 could help prevent tissue fibrosis and scarring. Full Text | PDF
BR serine/threonine kinase 2 (BRSK2) doi:10.1038/scibx.2012.841 Human tissue and mouse studies suggest antagonizing BRSK2 could help treat type 2 diabetes. Full Text | PDF
Bacillus anthracis lethal factor doi:10.1038/scibx.2012.842 In vitro studies suggest depsidones could help treat anthrax exposure. Full Text | PDF
Transforming growth factor-β (TGFB; TGFβ) doi:10.1038/scibx.2012.843 Mouse and cell culture studies suggest inhibiting TGFb signaling could help protect newborns from infection. Full Text | PDF
Not applicable doi:10.1038/scibx.2012.844 Mouse studies suggest reducing proinflammatory cytokine levels could help treat AD. Full Text | PDF
β-Amyloid 40; β-amyloid 42 doi:10.1038/scibx.2012.845 Mouse studies suggest amyloid peptides could help treat MS. Full Text | PDF
Liver X receptor-β (NR1H2; LXR-β); LXR doi:10.1038/scibx.2012.846 Mouse studies suggest LXR agonists could help treat PD. Full Text | PDF
Nuclear factor (erythroid-derived 2)-like 2 (NFE2L2; NRF2); glial fibrillary acidic protein (GFAP) doi:10.1038/scibx.2012.847 Mouse studies suggest increasing NRF2 activity could help treat Alexander disease, a neurodegenerative condition caused by a GFAP mutation. Full Text | PDF
Solute carrier family 17 sodium-dependent inorganic phosphate cotransporter member 8 (SLC17A8; VGLUT3) doi:10.1038/scibx.2012.848 Mouse studies suggest gene therapy could help treat congenital deafness caused by mutations in VGLUT3. Full Text | PDF
Statistical genomic analysis approach to determine driver mutations in melanoma doi:10.1038/scibx.2012.849 A statistical genomic analysis approach to determine driver mutations in melanoma could help identify new targets to treat the disease. Full Text | PDF
Guinea pig models for assessing safety of human embryonic stem cell (hESC)-derived cardiomyocyte transplants doi:10.1038/scibx.2012.850 Guinea pigs could help assess the safety and efficacy of hESC-derived cardiomyocyte transplants. Full Text | PDF
Induced pluripotent stem (iPS) cell–derived neurons from patients with familial Parkinson's disease (PD) doi:10.1038/scibx.2012.851 iPS cell–derived neurons from patients with PD may help characterize disease phenotypes and aid in the identification of therapeutics that correct the phenotypes. Full Text | PDF
Mouse models of human CC chemokine receptor 9 (CCR9; CDw199)-expressing colorectal cancer doi:10.1038/scibx.2012.852 Mouse models based on CCR9-expressing human colorectal cancer cell lines could help identify new therapies to treat the disease. Full Text | PDF
Crystal structures of HCV NS3/4A protease complex with HCV protease inhibitors doi:10.1038/scibx.2012.853 Crystal structures of HCV NS3/4A proteases complexed with HCV protease inhibitors could aid the development of new therapeutics against drug-resistant HCV strains. Full Text | PDF
Genetic lineage markers for identifying glioma cancer stem cells doi:10.1038/scibx.2012.854 Mouse studies suggest cell-specific expression of GFP-based genetic elements could be useful for identifying compounds that target glioma stem cells. Full Text | PDF
Genetic lineage markers for identifying intestinal cancer stem cells doi:10.1038/scibx.2012.855 Mouse studies suggest genetic lineage markers may be useful for identifying compounds that target intestinal cancer stem cells. Full Text | PDF
Genetic lineage markers for identifying skin cancer stem cells doi:10.1038/scibx.2012.856 Mouse studies suggest genetic lineage markers could be useful for identifying compounds that target skin cancer stem cells. Full Text | PDF
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