Nature Reviews Neuroscience contents September 2012 Volume 13 Number 9 pp 599-664

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TABLE OF CONTENTS
September 2012 Volume 13 Number 9		Advertisement
Impact Factor 30.455 *	In this issue Research Highlights Reviews Correspondence Perspectives Also this month  Featured article: Understanding adolescence as a period of social–affective engagement and goal flexibility Eveline A. Crone & Ronald E. Dahl	Handbook of QEEG & EEG Biofeedback Now Available New eBook allows readers to jump from simple to complex topics with a few clicks. Download the free Demo qEEG software and follow step by step tutorials to learn QEEG methods and learn to assess patients with epilepsy, traumatic brain injury and other disorders. Case studies prepare for Certification in QEEG and EEG.
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RESEARCH HIGHLIGHTS Top Neurogenesis: Determining fate is a local activity p599 | doi:10.1038/nrn3334 Local GABA release from parvalbumin-positive interneurons regulates neural stem cell fate decisions in the adult mouse hippocampus. PDF Motor system: Getting ready to reach p600 | doi:10.1038/nrn3321 The dorsal premotor cortex encodes both target direction and movement direction during a complex reaching task. PDF Glia: Oligodendrocyte transporters feed axons p601 | doi:10.1038/nrn3316 Oligodendrocytes use a lactate transporter to provide metabolic support to axons and neurons. PDF Neurogenetics: Driving Aβ into reverse p601 | doi:10.1038/nrn3318 There are currently no known mutations in the amyloid-β precursor protein gene that reduce the risk of developing Alzheimer's disease. Jonsson et al. now provide evidence for a mutation that protects against Alzheimer's disease and also confers a more general resistance against age-related cognitive decline. PDF Metabolism: Why high-protein diets work p602 | doi:10.1038/nrn3322 Protein-rich diets reduce food intake by activating gut–brain pathways through μ-opioid receptors in the portal vein. This activation promotes gluconeogenesis in the gut, which acts as a satiety signal. PDF Psychiatric disorders: Run for your MIF p602 | doi:10.1038/nrn3328 MIF mediates the antidepressant effects of voluntary exercise by increasing hippocampal Bdnf transcription and serotonin synthesis. PDF Motor system: Tadpoles keep their eyes on the prize p602 | doi:10.1038/nrn3329 Swimming tadpoles use motor feedforward signals without sensory feedback to produce eye movements that stabilize their gaze. PDF IN BRIEF Neurodegenerative disease: FYN gives Aβ the green light | Neuronal circuits: Starving for AGRP | Cognitive neuroscience: Grey matter shows its soft side | Learning and memory: Hippocampus plays multiple choice | Synaptic physiology: Neuroligin and neurexin go retro | Techniques: Optogenetic control in monkey brains | Reward: Serotonin promotes patience | Psychiatric disorders: Improving responses to antipsychotics PDF Neuroscience JOBS of the week Postdoctoral Research Associate in Neuroscience University of Leicester PhD Position in Neuroscience International PhD College SPIN Faculty Positions, Department of Neuroscience, Baylor College of Medicine Baylor College of Medicine (BCM) Neuroscience Research Scientist / Lab Manager / Staff PhD Beth Israel Deacon Medical Center - Harvard Medical School Research Assistant / Associate Position In Tinnitus and Auditory Neuroscience Research Wayne State Univeristy School of Medicine More Science jobs from Neuroscience EVENT Champalimaud Neuroscience Symposium 30.09.-03.10.12 Lisbon, Portugal More science events from
REVIEWS		Top
Getting neural circuits into shape with semaphorins R. Jeroen Pasterkamp p605 | doi:10.1038/nrn3302 The semaphorins have integral roles in various processes that underlie the development of neural circuits. In this article, Jeroen Pasterkamp explores novel aspects of neuronal semaphorin receptor regulation before discussing recent research into the involvement of semaphorins in establishing complex neuronal connections. Abstract | Full Text | PDF
Distributed synergistic plasticity and cerebellar learning Zhenyu Gao, Boeke J. van Beugen & Chris I. De Zeeuw p619 | doi:10.1038/nrn3312 In this Review, De Zeeuw and colleagues discuss the types of plasticity that occur at different synapses within the cerebellar cortex. They propose that the distributed and synergistic character of the various forms of plasticity promotes optimal motor learning. Abstract | Full Text | PDF
Understanding adolescence as a period of social-affective engagement and goal flexibility Eveline A. Crone & Ronald E. Dahl p636 | doi:10.1038/nrn3313 Crone and Dahl review functional imaging studies of cognitive, affective and social processing in adolescents. They suggest that, together with the development of cognitive control networks, changes in social and affective processing in adolescence may both confer adaptive advantages and induce vulnerability to risky behaviours. Abstract | Full Text | PDF | Supplementary information
CORRESPONDENCE		Top
Correspondence: Psychotropic medications and mitochondrial toxicity Rebecca Anglin, Patricia Rosebush & Michael Mazurek p650 | doi:10.1038/nrn3229-c1 Full Text | PDF
PERSPECTIVES		Top
OPINION The many paths to fear Cornelius T. Gross & Newton Sabino Canteras p651 | doi:10.1038/nrn3301 It is commonly thought that fear induced by distinct stimuli is processed by a single 'fear circuit'. Gross and Canteras discuss evidence showing that separate, parallel pathways process different types of innate fear but a common mechanism underlies the encoding of learned fear for all classes of stimuli. Abstract | Full Text | PDF
OPINION Common mechanisms of human perceptual and motor learning Nitzan Censor, Dov Sagi & Leonardo G. Cohen p658 | doi:10.1038/nrn3315 Improvement in the performance of a newly acquired skill with training occurs gradually over time. Here, Censor, Sagi and Cohen highlight similarities in such procedural learning between the motor and perceptual domains and suggest that a common mechanism supports this type of learning in various domains. Abstract | Full Text | PDF
Erratum: Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond Annette C. Dolphin 664 | doi:10.1038/nrn3317 Full Text | PDF
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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