Nature Reviews Molecular Cell Biology contents September 2012 Volume 13 Number 9 pp537-600

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TABLE OF CONTENTS
September 2012 Volume 13 Number 9		Advertisement
Impact Factor 39.123 *	In this issue Research Highlights Progress Reviews Perspectives Also this month  Featured article: DNA damage checkpoints in stem cells, ageing and cancer Tobias Sperka, Jianwei Wang & K. Lenhard Rudolph	Your next best friend in epigenetics Diagenode's IP-Star instrument completely automates your ChIP and methylated DNA immunoprecipitation assays. Eliminate the challenges of optimizing your epigenetics assay with the IP-Star. Achieve higher consistency, increased productivity, and higher quality data. Learn more about affordable epigenetics workflow automation with the IP-Star System.
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RESEARCH HIGHLIGHTS Top Cell polarity: Translating polar cues p537 | doi:10.1038/nrm3419 RAP2A provides a link between apical polarity cues and cytoskeletal regulators during brush border formation. PDF DNA Metabolism: MMS19: CIA agent for DNA-linked affairs p538 | doi:10.1038/nrm3411 MMS19-mediated Fe–S protein biogenesis is crucial for DNA metabolism. PDF Telomeres: Preventing unauthorized entry p538 | doi:10.1038/nrm3421 Uncapped telomeres signal a block in mitotic entry through two distinct mechanisms. PDF Chromatin: Nucleosomal dynamics at centromeres p539 | doi:10.1038/nrm3423 PDF Technologies: Seeing ubiquitin chains p540 | doi:10.1038/nrm3413 Fluorescence-based sensors allow the study of ubiquitin chains in vivo. PDF Cell signalling: A necrosome build-up p540 | doi:10.1038/nrm3415 RIP1–RIP3 complexes form amyloid-like fibrils to promote programmed necrosis. PDF Cell cycle: Maintaining centrosome copy number p542 | doi:10.1038/nrm3418 Two distinct regions in ORC1 control centrosome copy number and DNA replication. PDF Development: A gradual transition p542 | doi:10.1038/nrm3422 The transition from meiosis to mitosis in mouse embryos occurs gradually. PDF IN BRIEF Translation: tRNA methylation controls translation rate | Technique: Getting ready for S phase | Protein stability: The ADP ribosylation switch in BiP | Membrane trafficking: Insights at the pit | Stem cells: Tracking regenerative behaviour PDF Molecular Cell Biology JOBS of the week Sr. Associate Scientist / Scientist, Cystic Fibrosis Molecular Pfizer Research Associate in Molecular Cell Biology Cambridge University, Metabolic Research Laboratories Postdoctoral Positions available in Biochemistry and Molecular Biology University of Miami Postdoctoral Research Fellow: Plant Molecular Biology University of Southampton postdoc position for molecular systematics in entomology Palacky University Olomouc, Czech Republic More Science jobs from Molecular Cell Biology EVENT Molecular Diagnostics World Congress 25.- 26.09.12 CA, US More science events from
PROGRESS		Top
The super elongation complex (SEC) family in transcriptional control Zhuojuan Luo, Chengqi Lin & Ali Shilatifard p543 | doi:10.1038/nrm3417 The super elongation complex (SEC) consists of the RNA polymerase II (Pol II) elongation factors eleven-nineteen Lys-rich leukaemia (ELL) proteins, positive transcription elongation factor b (P-TEFb) and several frequent mixed lineage leukaemia (MLL) translocation partners. The SEC controls transcription elongation in the presence or absence of promoter-proximal paused Pol II, and its gene target specificity depends on protein components forming distinct SEC complexes. Abstract | Full Text | PDF
REVIEWS		Top
STIM proteins: dynamic calcium signal transducers Jonathan Soboloff, Brad S. Rothberg, Muniswamy Madesh & Donald L. Gill p549 | doi:10.1038/nrm3414 STIM proteins sense subtle changes in the levels of endoplasmice reticulum (ER)-stored Ca2+ and respond by regulating extracellular Ca2+ entry and cell signalling. New structural and functional data have shed light on the role of STIM proteins as stress sensors. Abstract | Full Text | PDF | Supplementary information
Mitochondria as sensors and regulators of calcium signalling Rosario Rizzuto, Diego De Stefani, Anna Raffaello & Cristina Mammucari p566 | doi:10.1038/nrm3412 Ca2+ uptake through specialized transporters allows mitochondria to act as buffers of intracellular Ca2+ levels. Moreover, mitochondrial Ca2+ signalling regulates vital processes, including metabolism and cell death. Therefore, mitochondrial Ca2+ signalling remains at the epicentre of cell biological research. Abstract | Full Text | PDF | Supplementary information
DNA damage checkpoints in stem cells, ageing and cancer Tobias Sperka, Jianwei Wang & K. Lenhard Rudolph p579 | doi:10.1038/nrm3420 Like all cell types, stem cells are subject to DNA damage, which results in the activation of checkpoint proteins, for example p53. These checkpoint responses lead to the clearance of damaged cells by cell-intrinsic and cell-extrinsic mechanisms, preventing carcinogenesis, but may also impair stem cell and tissue maintenance, thereby promoting ageing. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Transduction of mechanical and cytoskeletal cues by YAP and TAZ Georg Halder, Sirio Dupont & Stefano Piccolo p591 | doi:10.1038/nrm3416 Forces transmitted through cell-cell and cell-extracellular matrix adhesions control cell fate decisions. But how are mechanical cues translated into gene expression programmes? The transcriptional regulators YAP and TAZ have arisen as convergence points of mechanical and biochemical signals. Abstract | Full Text | PDF
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