Nature Reviews Immunology Contents September 2012 Volume 12 Number 9 pp 615-677

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TABLE OF CONTENTS
September 2012 Volume 12 Number 9
Impact Factor 33.287 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: The impact of differential antiviral immunity in children and adults Andrew J. Prendergast, Paul Klenerman & Philip J. R. Goulder
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RESEARCH HIGHLIGHTS Top Immune regulation: Local government p615 | doi:10.1038/nri3289 Commensal bacteria in the skin promote local effector T cell responses. PDF Cell migration: (en)ABLing T cell migration p616 | doi:10.1038/nri3282 ABL family kinases modulate chemokine-induced T cell polarization and migration to sites of inflammation. PDF Antiviral immunity: LGP2 rigs CD8+ T cells for survival p616 | doi:10.1038/nri3286 The RIG-I-like receptor LGP2 is a cell-intrinsic regulator of antiviral CD8+ T cell responses. PDF Lymphoid follicles: FDCs — ubiquitous and ready for action p617 | doi:10.1038/nri3281 Follicular dendritic cells (FDCs) arise from ubiquitous perivascular PDGFRß+ cells. PDF Innate immunity: TLR13, unlucky, but just for some p618 | doi:10.1038/nri3284 An antibiotic evasion strategy in bacteria also confers resistance to the innate immune sensor TLR13. PDF Antiviral immunity: Deconstructing CD4+ T cell memory p618 | doi:10.1038/nri3290 Memory CD4+ T cells use multiple redundant and synergistic mechanisms to mediate protection against influenza A virus. PDF Vaccination: Oral vaccine induces genitorectal immunity p619 | doi:10.1038/nri3283 Oral delivery of a novel vaccine formulation induces immune protection against viral infection of rectal and vaginal mucosal sites. PDF Viral pathogenesis: HIV hitchhikes on migratory T cells p620 | doi:10.1038/nri3287 HIV-infected CD4+T cells have a reduced rate of migration and an elongated morphology, which might represent a strategy for direct cell-to-cell transfer of the virus. PDF Tumour immunology: TIM3 suppresses antitumour DCs p620 | doi:10.1038/nri3288 Chiba and colleagues characterize the role of TIM3 in suppressing innate antitumour immune responses. PDF IN BRIEF Inflammation: Linking malnutrition and intestinal inflammation | Immunotherapy: JAK inhibitor effective in rheumatoid arthritis | Cell migration: Walking frames for dendritic cells PDF Immunology JOBS of the week Postdoctoral fellow in molecular immunology City of Hope Postdoctoral Fellow- Virology and Immunology University of California, Riverside M.Sc. (Masters) in Immunology School of Biochemistry and Immunology, Trinity College Dublin Department of Microbiology & Immunology Faculty Position University of Maryland at Baltimore Senior Post-Doc - Cell Biology and Microscopy applied to Immunology Institut Curie, Paris, France More Science jobs from Immunology EVENT Frontiers in Basic Immunology: 2012 04.-05.10.12 MD, US More science events from
REVIEWS		Top
The anatomical and cellular basis of immune surveillance in the central nervous system Richard M. Ransohoff & Britta Engelhardt p623 | doi:10.1038/nri3265 In this Review, the authors describe how immune responses are initiated and propagated against antigens found in the central nervous system (CNS). They explain how the unique anatomy of the CNS affects immune surveillance of its tissues, and discuss the implications for autoimmune responses in the CNS. Abstract | Full Text | PDF
The impact of differential antiviral immunity in children and adults Andrew J. Prendergast, Paul Klenerman & Philip J. R. Goulder p636 | doi:10.1038/nri3277 Infections with HIV, hepatitis B virus and cytomegalovirus have markedly different outcomes depending on whether they are acquired during infancy or adult life. Information about the differences between antiviral immune responses in early and later life that can be gained from these examples should inform the development of new therapeutic strategies. Abstract | Full Text | PDF
FOXO transcription factors throughout T cell biology Stephen M. Hedrick, Rodrigo Hess Michelini, Andrew L. Doedens, Ananda W. Goldrath & Erica L. Stone p649 | doi:10.1038/nri3278 Forkhead box O (FOXO) transcription factors have many diverse physiological functions and regulate gene-expression programmes that are involved in immunity, metabolism and oncogenesis. This Review discusses how FOXO proteins integrate different environmental signals in order to regulate T cell differentiation and functions in a context-dependent manner. Abstract | Full Text | PDF
PERSPECTIVES		Top
ESSAY Pro-cognitive properties of T cells Jonathan Kipnis, Sachin Gadani & Nöel C. Derecki p663 | doi:10.1038/nri3280 Can the immune system influence how our brain works? Here, Jonathan Kipnis and colleagues discuss the emerging hypothesis that T cells, and in particular their production of interleukin-4, can have beneficial effects on learning and memory. Abstract | Full Text | PDF
OPINION Why must T cells be cross-reactive? Andrew K. Sewell p669 | doi:10.1038/nri3279 T cells must recognize a vast array of potential foreign peptide-MHC complexes. Comprehensive immune cover can only be provided if each T cell recognizes numerous peptides. The implications of this T cell cross-reactivity include autoimmune disease but also provide opportunities for multiple therapeutic interventions. Abstract | Full Text | PDF | Supplementary information
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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