Nature Reviews Cancer contents September 2012 Volume 12 Number 9 pp 579-653

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TABLE OF CONTENTS
September 2012 Volume 12 Number 9		Advertisement
Impact Factor 37.178 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Genomic instability in cancer Epigenetics and genetics  Featured article: The role of mutations in epigenetic regulators in myeloid malignancies Alan H. Shih, Omar Abdel-Wahab, Jay P. Patel & Ross L. Levine	The New BD FACSJazz™ Cell Sorter Perfectly tuned cell sorting is now available with the new BD FACSJazz. Built on a proven, dependable platform, it may change the way you'll think of cell sorting with ease of operation, affordability, and a benchtop fit. Exceedingly capable performance whether as a soloist or part of your core lab ensemble. bdbiosciences.com/jazz
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RESEARCH HIGHLIGHTS Top Cancer stem cells: Tracing clones p579 | doi:10.1038/nrc3354 Three papers have used lineage tracing to examine the contribution of individual cells to tumour growth. PDF Tumour suppressors: At the SHARP end of metastasis p580 | doi:10.1038/nrc3347 A new study uncovers a tumour suppressor role for SHARP1. PDF Micrornas: Lines of communication p580 | doi:10.1038/nrc3348 Tumour cell-derived miRNAs carried in microvesicles can communicate with endothelial cells to activate angiogenesis through Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signalling. PDF Migration: VEGF suppresses invasion p581 | doi:10.1038/nrc3345 Blocking vascular endothelial growth factor (VEGF) can promote the invasive growth of glioblastoma through a mechanism that involves MET and VEGF receptor 2. PDF Genomics: Viral vista p582 | doi:10.1038/nrc3346 Looking at the effects of proteins encoded by DNA tumour viruses on the host genome could aid the interpretation of high-throughput sequencing data from cancer samples. PDF IN THE NEWS Melanoma: something fishy? p582 | doi:10.1038/nrc3356 Skin cancer has been observed in wild marine fish (Plectropomus leopardus) for the first time. PDF Medulloblastoma: Pump up the volume p583 | doi:10.1038/nrc3353 The voltage-gated potassium channel EAG2 is overexpressed in medulloblastoma and contributes to tumorigenesis by regulating cell volume dynamics during mitosis. PDF Therapeutics: Holding JAK back p583 | doi:10.1038/nrc3357 A new study characterizes mechanisms of tolerance to JAK2 inhibitors. PDF Immunology: TIM3 suppresses antitumour DCs p584 | doi:10.1038/nrc3349 Chiba and colleagues characterize the role of TIM3 in suppressing innate antitumour immune responses. PDF Metastasis: No sympathy? p584 | doi:10.1038/nrc3351 Stimulation of the sympathetic nervous system through prolonged emotional stress might increase bone metastases in patients with breast cancer owing to effects on the bone marrow microenvironment. PDF Glioblastoma: Transforming fusions induce aneuploidy p585 | doi:10.1038/nrc3350 A recurrent oncogenic fusion of fibroblast growth factor receptor (FGFR) and transforming acidic coiled-coil (TACC) proteins in a subset of glioblastomas can directly interfere with cell division and induce aneuploidy, and this can be inhibited by FGFR kinase inhibitors. PDF Cancer JOBS of the week Cancer Research Scientist Stony Brook University Postdoctoral Research Scientists / Rab-Coupling Protein (RCP)-Mediated Receptor Trafficking in Breast Cancer Progression The Beatson Institute for Cancer Research Postdoctoral Research Scientists / Cancer Invasion and Metastasis The Beatson Institute for Cancer Research Bioinformatics Applied to Kidney Cancer UT Southwestern Medical Center at Dallas, TX Post-Docs in Cell Death Signaling & Cancer Institute for Expertimental Cancer Research in Pediatrics, Goethe University Frankfurt More Science jobs from Cancer EVENT Pancreatic Cancer: Translation of New Ideas 12.10.12 Ny, US More science events from
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REVIEWS		Top
Article series: Genomic instability in cancer The effects of deregulated DNA damage signalling on cancer chemotherapy response and resistance Peter Bouwman & Jos Jonkers p587 | doi:10.1038/nrc3342 DNA damage response signalling pathways are often altered in tumours, which can affect their response to chemotherapy and targeted therapies. This Review discusses the mechanisms by which altered DNA damage responses elicit such therapy resistance. Abstract | Full Text | PDF | Supplementary information
Article series: Epigenetics and genetics The role of mutations in epigenetic regulators in myeloid malignancies Alan H. Shih, Omar Abdel-Wahab, Jay P. Patel & Ross L. Levine p599 | doi:10.1038/nrc3343 Alterations to epigenetic regulators are a recently characterized class of oncogenic changes in myeloid malignancies. This Review discusses what these alterations mean for leukaemogenesis. Abstract | Full Text | PDF
MicroRNAs in the p53 network: micromanagement of tumour suppression Heiko Hermeking p613 | doi:10.1038/nrc3318 This Review discusses how microRNAs (miRNAs) are intricately involved in p53 signalling, from the regulation of p53 expression and activity to contributing to various tumour suppressor effector functions of p53. Evidence for the importance of these miRNAs from cancer-specific alterations, and the implications for diagnostics and therapeutics, are also considered. Abstract | Full Text | PDF
Aiding and abetting roles of NOX oxidases in cellular transformation Karen Block & Yves Gorin p627 | doi:10.1038/nrc3339 NADPH oxidases of the NOX family are reactive oxygen species-generating enzymes that regulate redox-sensitive signalling pathways. In this Review, the authors discuss primary targets and redox-linked signalling systems that are influenced by NOX-derived ROS and the biological role that NOX oxidases might have in the aetiology of cancer. Abstract | Full Text | PDF
Corrigendum: Targeting MET in cancer: rationale and progress Ermanno Gherardi, Walter Birchmeier, Carmen Birchmeier & George Vande Woude p637 | doi:10.1038/nrc3358 Full Text | PDF
PERSPECTIVES		Top
TIMELINE Retroviral oncogenes: a historical primer Peter K. Vogt p639 | doi:10.1038/nrc3320 More than 30 retroviral oncogenes have been discovered, and these predominantly function to control cellular signalling and replication. This Timeline article discusses a few of these oncogenes that are crucial in human cancer and that best illustrate the history of experimental and theoretical breakthroughs in this field. Abstract | Full Text | PDF
VIEWPOINT The influence of race and ethnicity on the biology of cancer Brian E. Henderson, Norman H. Lee, Victoria Seewaldt & Hongbing Shen p648 | doi:10.1038/nrc3341 Cancer incidence varies in different racial and ethnic groups, and this can be partly attributed to differences in biological factors. However, identifying these factors and exploiting them to help eliminate cancer disparities has proved challenging. This Viewpoint highlights the crucial advances and challenges, as well as what the future holds, for this area of research. Abstract | Full Text | PDF
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