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Subscribe now! | | | | | | | Latest Articles | View all Articles | | | | | Organellar mechanosensitive channels in fission yeast regulate the hypo-osmotic shock response | | | Yoshitaka Nakayama, Kenjiro Yoshimura and Hidetoshi Iida | | | Mechanosensitive channels are required to sense cell swelling in response to osmotic shock. Nakayama et al. report that Msy1 and Msy2 are the fission yeast homologues of the bacterial mechanosensitive channel MscS, and are required for regulating intracellular calcium in response to cell swelling. | | | 21 Aug | Nat Commun 3:1020 doi:10.1038/ncomms2014 (2012) | | | Biological sciences Biophysics | | | Cell biology Microbiology | | Abstract | Full Text | PDF (1,619 kB) |
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| In situ measurement of exciton energy in hybrid singlet-fission solar cells | | | Bruno Ehrler, Brian J. Walker, Marcus L. Böhm, Mark W.B. Wilson, Yana Vaynzof, Richard H. Friend and Neil C. Greenham | | | Singlet fission converts single singlet excitons into pairs of triplet excitons, and it has been proposed to give additional photocurrent to solar cells. Ehrler et al. use lead selenide nanocrystals of varying sizes to measure the triplet energy in pentacene photovoltaic cells, and achieve efficiencies approaching 5%. | | | 21 Aug | Nat Commun 3:1019 doi:10.1038/ncomms2012 (2012) | | | Physical sciences Applied physics | | | Materials science Optical physics | | | | Abstract | Full Text | PDF (725 kB) |
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| Flexible and transparent all-graphene circuits for quaternary digital modulations | | | Seunghyun Lee, Kyunghoon Lee, Chang-Hua Liu, Girish S. Kulkarni and Zhaohui Zhong | | | Signal modulation is a mechanism which embeds an information-carrying signal into a carrier wave to broadcast information and is essential for high-speed communication. Zhong et al. report a flexible, transparent all-graphene modulator circuit performing quaternary modulation schemes with only two transistors. | | | 21 Aug | Nat Commun 3:1018 doi:10.1038/ncomms2021 (2012) | | | Physical sciences Applied physics | | | | Abstract | Full Text | PDF (1,680 kB) |
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| Non-transgenic genome modifications in a hemimetabolous insect using zinc-finger and TAL effector nucleases OPEN | | | Takahito Watanabe, Hiroshi Ochiai, Tetsushi Sakuma, Hadley W. Horch, Naoya Hamaguchi, Taro Nakamura, Tetsuya Bando, Hideyo Ohuchi, Takashi Yamamoto, Sumihare Noji and Taro Mito | | | Hemimetabolous insects comprise many pests but introducing targeted mutations into these species has been difficult. This paper reports efficient targeted mutagenesis, and the generation of homozygous knockouts, in crickets based on zinc finger nucleases or transcription activator-like effector nucleases. | | | 21 Aug | Nat Commun 3:1017 doi:10.1038/ncomms2020 (2012) | | | Biological sciences Genetics | | | Abstract | Full Text | PDF (880 kB) |
| PINK1 autophosphorylation upon membrane potential dissipation is essential for Parkin recruitment to damaged mitochondria OPEN | | | Kei Okatsu, Toshihiko Oka, Masahiro Iguchi, Kenji Imamura, Hidetaka Kosako, Naoki Tani, Mayumi Kimura, Etsu Go, Fumika Koyano, Manabu Funayama, Kahori Shiba-Fukushima, Shigeto Sato, Hideaki Shimizu, Yuko Fukunaga, Hisaaki Taniguchi, Masaaki Komatsu, Nobutaka Hattori, Katsuyoshi Mihara, Keiji Tanaka and Noriyuki Matsuda | | | The kinase PINK1 is mutated in Parkinson's disease and accumulates in defective mitochondria, where it recruits Parkin. Here, PINK1 is shown to be autophosphorylated and this is required for the localization of PINK1 to mitochondria with a reduced membrane potential, and for the recruitment of Parkin. | | | 21 Aug | Nat Commun 3:1016 doi:10.1038/ncomms2016 (2012) | | | Biological sciences Biochemistry | | | Neuroscience | | Abstract | Full Text | PDF (1,442 kB) |
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| Structured neuronal encoding and decoding of human speech features | | | Ariel Tankus, Itzhak Fried and Shy Shoham | | | Speech is encoded by the firing patterns of speech-controlling neurons in different regions of the brain, which Tankus and colleagues analyse in this study. They find highly specific encoding of vowels in medial—frontal neurons and nonspecific tuning in superior temporal gyrus neurons. | | | 21 Aug | Nat Commun 3:1015 doi:10.1038/ncomms1995 (2012) | | | Biological sciences Neuroscience | | | | Abstract | Full Text | PDF (906 kB) |
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| Structures of Pup ligase PafA and depupylase Dop from the prokaryotic ubiquitin-like modification pathway | | | Dennis Özcelik, Jonas Barandun, Nikolaus Schmitz, Markus Sutter, Ethan Guth, Fred F. Damberger, Frédéric H.-T. Allain, Nenad Ban and Eilika Weber-Ban | | | Pupylation is a bacterial posttranslational modification pathway with functional analogies to ubiquitination. Here, Özcelik et al. report the structures of the Pup Ligase, PafA and the Depupylase, Dop. Mutational analysis revealed residues required for catalysis and for the interaction with Pup. | | | 21 Aug | Nat Commun 3:1014 doi:10.1038/ncomms2009 (2012) | | | Biological sciences Biochemistry | | | Molecular biology | | Abstract | Full Text | PDF (1,674 kB) |
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| Protein sliding and DNA denaturation are essential for DNA organization by human mitochondrial transcription factor A | | | Géraldine Farge, Niels Laurens, Onno D. Broekmans, Siet M.J.L. van den Wildenberg, Linda C.M. Dekker, Martina Gaspari, Claes M. Gustafsson, Erwin J.G. Peterman, Maria Falkenberg and Gijs J.L. Wuite | | | The mitochondrial transcription factor A (TFAM) mediates both mitochondrial transcription and DNA compaction, but how it achieves these two functions is unknown. In this study, TFAM is shown to slide along DNA and cause local melting, suggesting a mechanism for how TFAM modulates both transcription and compaction. | | | 21 Aug | Nat Commun 3:1013 doi:10.1038/ncomms2001 (2012) | | | Biological sciences Biophysics | | | | Abstract | Full Text | PDF (1,598 kB) |
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| The critical size is set at a single-cell level by growth rate to attain homeostasis and adaptation | | | Francisco Ferrezuelo, Neus Colomina, Alida Palmisano, Eloi Garí, Carme Gallego, Attila Csikász-Nagy and Martí Aldea | | | It is assumed that budding yeast need to reach a certain size before entering the cell cycle. Here, using imaging and a mathematical model, Ferrezuelo et al. show that there is variability in the size of cells entering the cell cycle and this is controlled by growth rate in G1. | | | 21 Aug | Nat Commun 3:1012 doi:10.1038/ncomms2015 (2012) | | | Biological sciences Cell biology | | | | Abstract | Full Text | PDF (1,254 kB) |
Supplementary Information |
| High-mobility and low-power thin-film transistors based on multilayer MoS2 crystals | | | Sunkook Kim, Aniruddha Konar, Wan-Sik Hwang, Jong Hak Lee, Jiyoul Lee, Jaehyun Yang, Changhoon Jung, Hyoungsub Kim, Ji-Beom Yoo, Jae-Young Choi, Yong Wan Jin, Sang Yoon Lee, Debdeep Jena, Woong Choi and Kinam Kim | | | Molybdenum disulphide offers some tantalizing advantages over graphene as a material with which to fabricate field-effect transistors. Kim et al. present a comprehensive study of field-effect transistors made from multilayer samples of MoS2 and find that they can achieve high carrier mobilities. | | | 21 Aug | Nat Commun 3:1011 doi:10.1038/ncomms2018 (2012) | | | Physical sciences Applied physics | | | Materials science | | Abstract | Full Text | PDF (672 kB) |
Supplementary Information |
| Distant residues mediate picomolar binding affinity of a protein cofactor OPEN | | | Yves J.M. Bollen, Adrie H. Westphal, Simon Lindhoud, Willem J.H. van Berkel and Carlo P.M. van Mierlo | | | Flavodoxin requires tight binding of its FMN cofactor to be active, but the residues involved are unknown. In this biophysical study, FMN binding is shown to change from nanomolar to picomolar affinity on extremely slow protein relaxation and the residues responsible for cofactor binding are identified. | | | 21 Aug | Nat Commun 3:1010 doi:10.1038/ncomms2010 (2012) | | | Biological sciences Biochemistry | | | Biophysics | | Abstract | Full Text | PDF (1,207 kB) |
Supplementary Information |
| Aβ alters the connectivity of olfactory neurons in the absence of amyloid plaques in vivo | | | Luxiang Cao, Benjamin R. Schrank, Steve Rodriguez, Eric G. Benz, Thomas W. Moulia, Gregory T. Rickenbacher, Alexis C. Gomez, Yona Levites, Sarah R. Edwards, Todd E. Golde, Bradley T. Hyman, Gilad Barnea and Mark W. Albers | | | The amyloid beta peptide can aggregate into insoluble plaques, which may indicate the onset of Alzheimer's disease. In a mouse model of Alzheimer's disease, Cao and colleagues report a phenotype of altered connectivity in the olfactory neuronal circuit that precedes amyloid plaque deposition. | | | 21 Aug | Nat Commun 3:1009 doi:10.1038/ncomms2013 (2012) | | | Biological sciences Neuroscience | | Abstract | Full Text | PDF (2,082 kB) |
Supplementary Information |
| Macrophage VLDL receptor promotes PAFAH secretion in mother's milk and suppresses systemic inflammation in nursing neonates | | | Yang Du, Marie Yang, Wei Wei, Hoang Dinh Huynh, Joachim Herz, Alan Saghatelian and Yihong Wan | | | Mother's milk contains a number of protective factors, such as the anti-inflammatory enzyme PAFAH. Here, Du et al. show that the VLDL receptor protects nursing newborns from systemic inflammation by maintaining secretion of PAFAH from maternal macrophages into mother's milk. | | | 21 Aug | Nat Commun 3:1008 doi:10.1038/ncomms2011 (2012) | | | Biological sciences Immunology | | | | Abstract | Full Text | PDF (722 kB) |
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