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| | | How to Manage… | Top | | How to manage acute promyelocytic leukemiaJ-Q Mi, J-M Li, Z-X Shen, S-J Chen and Z Chen Leukemia 2012 26: 1743-1751; advance online publication, March 16, 2012; 10.1038/leu.2012.57 Abstract | Full Text | | Original Articles | Top | | MOLECULAR TARGETS FOR THERAPY
| Targeting microRNA-30a-mediated autophagy enhances imatinib activity against human chronic myeloid leukemia cellsY Yu, L Yang, M Zhao, S Zhu, R Kang, P Vernon, D Tang and L Cao Leukemia 2012 26: 1752-1760; advance online publication, March 7, 2012; 10.1038/leu.2012.65 Abstract | Full Text | | | | Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtypeC Stengel, C W Cheung, J Quinn, K Yong and A Khwaja Leukemia 2012 26: 1761-1770; advance online publication, March 14, 2012; 10.1038/leu.2012.69 Abstract | Full Text | | | | THERAPY
| Serial monitoring of human systemic and xenograft models of leukemia using a novel vascular disrupting agentM Benezra, E Phillips, D Tilki, B-S Ding, J Butler, K Dobrenkov, B Siim, D Chaplin, S Rafii, S Rabbany and M S Bradbury Leukemia 2012 26: 1771-1778; advance online publication, February 20, 2012; 10.1038/leu.2012.48 Abstract | Full Text | | | | Outcome of patients activating an unrelated donor search: the impact of transplant with reduced intensity conditioning in a large cohort of consecutive high-risk patientsA Rambaldi, A Bacigalupo, R Fanin, F Ciceri, F Bonifazi, M Falda, G Lambertenghi-Deliliers, F Benedetti, B Bruno, P Corradini, P E Alessandrino, P Iacopino, W Arcese, R Scimè, R Raimondi, S Sica, L Castagna, T Lamparelli, R Oneto, L Lombardini, S Pollichieni, A Algarotti, A Carobbio, N Sacchi and A Bosi on behalf of Gruppo Italiano Trapianto di Midollo Osseo, GITMO Leukemia 2012 26: 1779-1785; advance online publication, March 1, 2012; 10.1038/leu.2012.55 Abstract | Full Text | | | | ACUTE LEUKEMIAS
| Treatment of acute lymphoblastic leukemia with an rGel/BLyS fusion toxinR Parameswaran, M Yu, M-A Lyu, M Lim, M G Rosenblum, J Groffen and N Heisterkamp Leukemia 2012 26: 1786-1796; advance online publication, February 29, 2012; 10.1038/leu.2012.54 Abstract | Full Text | | | | CREBBP HAT domain mutations prevail in relapse cases of high hyperdiploid childhood acute lymphoblastic leukemiaA Inthal, P Zeitlhofer, M Zeginigg, M Morak, R Grausenburger, E Fronkova, B Fahrner, G Mann, O A Haas and R Panzer-Grümayer Leukemia 2012 26: 1797-1803; advance online publication, March 5, 2012; 10.1038/leu.2012.60 Abstract | Full Text | | | | MYELODYSPLASIAS
| 5-Azacitidine in aggressive myelodysplastic syndromes regulates chromatin structure at PU.1 gene and cell differentiation capacityN Curik, P Burda, K Vargova, V Pospisil, M Belickova, P Vlckova, F Savvulidi, E Necas, H Hajkova, C Haskovec, J Cermak, M Krivjanska, M Trneny, P Laslo, A Jonasova and T Stopka Leukemia 2012 26: 1804-1811; advance online publication, February 20, 2012; 10.1038/leu.2012.47 Abstract | Full Text | | | | CHRONIC LYMPHOCYTIC LEUKEMIA
| Stromal cells modulate TCL1 expression, interacting AP-1 components and TCL1-targeting micro-RNAs in chronic lymphocytic leukemiaM Sivina, E Hartmann, E Vasyutina, J M Boucas, A Breuer, M J Keating, W G Wierda, A Rosenwald, M Herling and J A Burger Leukemia 2012 26: 1812-1820; advance online publication, March 5, 2012; 10.1038/leu.2012.63 Abstract | Full Text | | | | The EuroChimerism concept for a standardized approach to chimerism analysis after allogeneic stem cell transplantationT Lion, F Watzinger, S Preuner, H Kreyenberg, M Tilanus, R de Weger, J van Loon, L de Vries, H Cavé, C Acquaviva, M Lawler, M Crampe, A Serra, B Saglio, F Colnaghi, A Biondi, J J M van Dongen, M van der Burg, M Gonzalez, M Alcoceba, G Barbany, M Hermanson, E Roosnek, C Steward, J Harvey, F Frommlet and P Bader on behalf of the EuroChimerism Consortium (EU-Project number: QLG1-CT-2002-01485) Leukemia 2012 26: 1821-1828; advance online publication, March 7, 2012; 10.1038/leu.2012.66 Abstract | Full Text | | | | ONCOGENES, FUSION GENES AND TUMOR SUPPRESSOR GENES
| Depletion of RUNX1/ETO in t(8;21) AML cells leads to genome-wide changes in chromatin structure and transcription factor bindingA Ptasinska, S A Assi, D Mannari, S R James, D Williamson, J Dunne, M Hoogenkamp, M Wu, M Care, H McNeill, P Cauchy, M Cullen, R M Tooze, D G Tenen, B D Young, P N Cockerill, D R Westhead, O Heidenreich and C Bonifer Leukemia 2012 26: 1829-1841; advance online publication, February 20, 2012; 10.1038/leu.2012.49 Abstract | Full Text | | | | Frequent loss of RAF kinase inhibitor protein expression in acute myeloid leukemiaA Zebisch, A Wölfler, I Fried, O Wolf, K Lind, C Bodner, M Haller, A Drasche, D Pirkebner, D Matallanas, O Rath, K Blyth, R Delwel, E Taskesen, F Quehenberger, W Kolch, J Troppmair and H Sill Leukemia 2012 26: 1842-1849; advance online publication, March 5, 2012; 10.1038/leu.2012.61 Abstract | Full Text | | | | DIFFERENTIATION
| p38αMAPK interacts with and inhibits RARα: suppression of the kinase enhances the therapeutic activity of retinoids in acute myeloid leukemia cellsM Gianni, M Peviani, N Bruck, A Rambaldi, G Borleri, M Terao, M Kurosaki, G Paroni, C Rochette-Egly and E Garattini Leukemia 2012 26: 1850-1861; advance online publication, February 22, 2012; 10.1038/leu.2012.50 Abstract | Full Text | | | | MYELOMA
| Clinical significance of CD81 expression by clonal plasma cells in high-risk smoldering and symptomatic multiple myeloma patientsB Paiva, N-C Gutiérrez, X Chen, M-B Vídriales, M-Á Montalbán, L Rosiñol, A Oriol, J Martínez-López, M-V Mateos, L López-Corral, E Díaz-Rodríguez, J-J Pérez, E Fernández-Redondo, F de Arriba, L Palomera, E Bengoechea, M-J Terol, R de Paz, A Martin, J Hernández, A Orfao, J-J Lahuerta, J Bladé, A Pandiella and J-F San Miguel on behalf of the GEM (Grupo Español de Mieloma)/PETHEMA (Programa para el Estudio de la Terapéutica en Hemopatías Malignas) cooperative study groups Leukemia 2012 26: 1862-1869; advance online publication, February 15, 2012; 10.1038/leu.2012.42 Abstract | Full Text | | | | Curative one-shot systemic virotherapy in murine myelomaS Naik, R Nace, M J Federspiel, G N Barber, K-W Peng and S J Russell Leukemia 2012 26: 1870-1878; advance online publication, March 19, 2012; 10.1038/leu.2012.70 Abstract | Full Text | | Letters to the Editor | Top | | Novel splicing-factor mutations in juvenile myelomonocytic leukemiaJ Takita, K Yoshida, M Sanada, R Nishimura, J Okubo, A Motomura, M Hiwatari, K Oki, T Igarashi, Y Hayashi and S Ogawa Leukemia 2012 26: 1879-1881; advance online publication, February 20, 2012; 10.1038/leu.2012.45 Full Text | | | | Sequencing histone-modifying enzymes identifies UTX mutations in acute lymphoblastic leukemiaB G Mar, L Bullinger, E Basu, K Schlis, L B Silverman, K Döhner and S A Armstrong Leukemia 2012 26: 1881-1883; advance online publication, March 1, 2012; 10.1038/leu.2012.56 Full Text | | | | Evaluating surface erythropoietin receptor in multiple myelomaC P Miller, K Rattray, Y Zhang, B L Wood, N Burwick, S Chien, W I Bensinger, C A Blau and P S Becker Leukemia 2012 26: 1883-1886; advance online publication, March 1, 2012; 10.1038/leu.2012.58 Full Text | | | | A low thymic function is associated with leukemia relapse in children given T-cell-depleted HLA-haploidentical stem cell transplantationE Clave, D Lisini, C Douay, G Giorgiani, M Busson, M Zecca, D Charron, M E Bernardo, A Toubert and F Locatelli Leukemia 2012 26: 1886-1888; advance online publication, March 5, 2012; 10.1038/leu.2012.59 Full Text | | | | Neoplastic B-cell growth is impaired by HLA-G/ILT2 interactionA Naji, C Menier, G Maki, E D Carosella and N Rouas-Freiss Leukemia 2012 26: 1889-1892; advance online publication, March 5, 2012; 10.1038/leu.2012.62 Full Text | | | | SKLB1028, a novel oral multikinase inhibitor of EGFR, FLT3 and Abl, displays exceptional activity in models of FLT3-driven AML and considerable potency in models of CML harboring Abl mutantsZ-X Cao, J-J Liu, R-L Zheng, J Yang, L Zhong, Y Xu, L-J Wang, C-H Zhang, B-L Wang, S Ma, Z-R Wang, H-Z Xie, Y-Q Wei and S-Y Yang Leukemia 2012 26: 1892-1895; advance online publication, March 9, 2012; 10.1038/leu.2012.67 Full Text | | | | Non-nodal type of mantle cell lymphoma is a specific biological and clinical subgroup of the diseaseC Royo, A Navarro, G Clot, I Salaverria, E Giné, P Jares, D Colomer, A Wiestner, W H Wilson, M C Vegliante, V Fernandez, E M Hartmann, N Trim, W N Erber, S H Swerdlow, W Klapper, M J S Dyer, M Vargas-Pabón, G Ott, A Rosenwald, R Siebert, A López-Guillermo, E Campo and S Beà Leukemia 2012 26: 1895-1898; advance online publication, March 19, 2012; 10.1038/leu.2012.72 Full Text | | | | | | Advertisement | | Take part in our reader survey for a chance to win a MacBook Air
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