Laboratory Investigation - Table of Contents alert Volume 92 Issue 8

TABLE OF CONTENTS Volume 92, Issue 8 (August 2012) In this issue Inside LI Research Articles Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Inside LI Top Inside Lab Invest 2012 92: 1098-1099; 10.1038/labinvest.2012.102 Full Text Research Articles Top BREAST, SKIN, SOFT TISSUE AND BONE An inhibitor of transforming growth factor beta type I receptor ameliorates muscle atrophy in a mouse model of caveolin 3-deficient muscular dystrophy A small-molecule TGF-β type I receptor kinase inhibitor that suppresses myostatin-, activin A-, and TGF-β1-induced anti-myogenic signals shows promise as a pharmaceutical for reversal of muscle atrophy. The inhibitor alleviates muscle atrophy based on enhanced intramuscular TGF-β signals in caveolin 3-deficient limb-girdle muscular dystrophy by reversing decreased satellite cell number and impaired myoblast differentiation. Yutaka Ohsawa, Tadashi Okada, Shin-ichiro Nishimatsu, Masatoshi Ishizaki, Tomohiro Suga, Masahiro Fujino, Tatsufumi Murakami, Makoto Uchino, Kunihiro Tsuchida, Sumihare Noji, Atsushi Hinohara, Toshiyuki Shimizu, Kiyoshi Shimizu and Yoshihide Sunada 2012 92: 1100-1114; advance online publication, May 14, 2012; 10.1038/labinvest.2012.78 Abstract | Full Text Targeting COX-2 and EP4 to control tumor growth, angiogenesis, lymphangiogenesis and metastasis to the lungs and lymph nodes in a breast cancer model COX-2 expression in human breast cancer stimulates cancer cell migration and invasiveness, largely due to endogenous prostaglandin E2-mediated stimulation of prostaglandin E (EP) 1 and EP4 receptors. EP4 antagonists are therefore a target for chemo-intervention of lymphatic metastasis in human breast cancer. Xiping Xin, Mousumi Majumder, Gannareddy V Girish, Vik Mohindra, Takayuki Maruyama and Peeyush K Lala 2012 92: 1115-1128; advance online publication, May 28, 2012; 10.1038/labinvest.2012.90 Abstract | Full Text BLOOD, LYMPHATICS, IMMUNE SYSTEM AND STEM CELLS Control of human hematopoietic stem/progenitor cell migration by the extracellular matrix protein Slit3 Exposure of Roundabout 1-positive human CD34+ hematopoietic stem/progenitor cells (HSPC) to the Roundabout ligand Slit3 rapidly reduces the levels of the small GTPase RhoA and inhibits HSPC migration, but increases homing of HSPC to the bone marrow. These findings may help with the design of future approaches aimed at improving transplantation efficiency of HSPCs. Sacha B Geutskens, William D Andrews, Anne-Marieke D van Stalborch, Kim Brussen, Sandra E Holtrop-de Haan, John G Parnavelas, Peter L Hordijk and Paula B van Hennik 2012 92: 1129-1139; advance online publication, May 21, 2012; 10.1038/labinvest.2012.81 Abstract | Full Text Cytokines induce tight junction disassembly in airway cells via an EGFR-dependent MAPK/ERK1/2-pathway TNF-α, IL-4 and IFN-γ down-regulate airway epithelial tight junction transmembrane proteins and disrupt epithelial barrier integrity. These changes are mediated by ERK1/2 phosphorylation, suggesting that the EGFR-dependent MAPK/ERK1/2 signaling pathway could be an important therapeutic target in inflammatory airway diseases. Loredana Petecchia, Federica Sabatini, Cesare Usai, Emanuela Caci, Luigi Varesio and Giovanni A Rossi 2012 92: 1140-1148; advance online publication, May 14, 2012; 10.1038/labinvest.2012.67 Abstract | Full Text GENITOURINARY AND REPRODUCTIVE SYSTEMS Involvement of matrix metalloproteinase-2 in the development of renal interstitial fibrosis in mouse obstructive nephropathy Matrix metalloproteinase (MMP)-2 mediates epithelial-to-mesenchymal transition in tubular epithelial cells through the degradation of tubular basement membrane, which is associated with the progression of interstitial fibrosis. Absence of MMP-2, or inhibition of MMP-2 and MMP-9, suppresses tubular epithelial-to-mesenchymal transition and protects against the progression of renal interstitial fibrosis. Xuanyi Du, Akira Shimizu, Yukinari Masuda, Naomi Kuwahara, Takashi Arai, Mitue Kataoka, Masaaki Uchiyama, Tomohiro Kaneko, Toshio Akimoto, Yasuhiko Iino and Yuh Fukuda 2012 92: 1149-1160; advance online publication, May 21, 2012; 10.1038/labinvest.2012.68 Abstract | Full Text 3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor simvastatin ameliorates renal fibrosis through HOXA13–USAG-1 pathway Simvastatin, a 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor, prevents renal fibrosis progression through a pathway including uterine sensitization-associated gene-1 (an antagonist of bone morphogenetic protein 7) and the transcription factor Hox-A13. This newly identified mechanism suggests a potential target for treatment of chronic kidney disease. Yoshifumi Hamasaki, Kent Doi, Koji Okamoto, Hideaki Ijichi, George Seki, Rui Maeda-Mamiya, Toshiro Fujita and Eisei Noiri 2012 92: 1161-1170; advance online publication, April 23, 2012; 10.1038/labinvest.2012.71 Abstract | Full Text ENDOCRINE, VISUAL AND AUDITORY SYSTEMS Insulin promotes macrophage foam cell formation: potential implications in diabetes-related atherosclerosis The role of hyperinsulinemia in atherosclerosis has been controversial. Insulin and adiponectin are now shown to promote human macrophage foam cell formation by inducing cholesterol accumulation via increased CD36 expression and decreased ATP-binding cassette transporter ABCA1 expression. Therefore, hyperinsulinemia may contribute to atherosclerosis in patients with type 2 diabetes. Young M Park, Sangeeta R Kashyap, Jennifer A Major and Roy L Silverstein 2012 92: 1171-1180; advance online publication, April 23, 2012; 10.1038/labinvest.2012.74 Abstract | Full Text Transcription factor Runx2 is a regulator of epithelial–mesenchymal transition and invasion in thyroid carcinomas The tumor-promoting properties of the transcription factor Runx2 are explored in thyroid carcinoma. Enhanced expression of Runx2 is functionally linked to tumor invasion and metastasis by the regulation of epithelial-mesenchymal transition-related molecules, matrix metalloproteinases and angiogenic/lymphangiogenic factors. Dong-Feng Niu, Tetsuo Kondo, Tadao Nakazawa, Naoki Oishi, Tomonori Kawasaki, Kunio Mochizuki, Tetsu Yamane and Ryohei Katoh 2012 92: 1181-1190; advance online publication, May 28, 2012; 10.1038/labinvest.2012.84 Abstract | Full Text GASTROINTESTINAL AND HEPATIC SYSTEMS Liver X receptor α-mediated regulation of lipogenesis by core and NS5A proteins contributes to HCV-induced liver steatosis and HCV replication A molecular mechanism for hepatitis C virus (HCV)-associated steatosis is proposed. HCV-gene expression stimulates hepatic lipid accumulation through the liver X receptor α (LXRα) pathway, which then regulates viral replication efficiency. Modulation of hepatic LXRα signaling may therefore be useful in the prevention and treatment of HCV-associated steatosis. María Victoria García-Mediavilla, Sandra Pisonero-Vaquero, Elena Lima-Cabello, Ignacio Benedicto, Pedro Lorenzo Majano, Francisco Jorquera, Javier González-Gallego and Sonia Sánchez-Campos 2012 92: 1191-1202; advance online publication, May 28, 2012; 10.1038/labinvest.2012.88 Abstract | Full Text Intestinal epithelial cell-specific CD98 expression regulates tumorigenesis in ApcMin/+ mice CD98, a regulator of integrin signaling, is shown to play a crucial role in intestinal tumorigenesis due to its role in cell proliferation and survival and its ability to modulate the production of cytokines and chemokines. CD98 may be an attractive target for the development of therapeutic agents for prevention and treatment of colorectal cancer. Hang Thi Thu Nguyen, Guillaume Dalmasso, Yutao Yan, Hamed Laroui, Moiz Charania, Sarah Ingersoll, Saravanan Ayyadurai, Yuchen Zhang, Shanthi Sitaraman and Didier Merlin 2012 92: 1203-1212; advance online publication, May 28, 2012; 10.1038/labinvest.2012.83 Abstract | Full Text PERIPHERAL AND CENTRAL NERVOUS SYSTEM CCL2 disrupts the adherens junction: implications for neuroinflammation The chemokine CCL2 is elevated during central nervous system inflammation and is associated with endothelial dysfunction. Complex cellular and molecular mechanisms facilitate the transient movement of adherens junctions in response to CCL2, and reveal how pathological conditions affect the highly regulated integrity of the blood-brain barrier. Toni K Roberts, Eliseo A Eugenin, Lillie Lopez, Ignacio A Romero, Babette B Weksler, Pierre-Olivier Couraud and Joan W Berman 2012 92: 1213-1233; advance online publication, May 28, 2012; 10.1038/labinvest.2012.80 Abstract | Full Text Estriol preserves synaptic transmission in the hippocampus during autoimmune demyelinating disease In an animal model of experimental autoimmune encephalomyelitis, transsynaptic binding protein levels and excitatory synaptic transmission are decreased in the hippocampus. Treatment with estriol prevents both hippocampal neuropathology and deficits in synaptic transmission. These findings may explain the relationship between hippocampal pathology and dysfunction in multiple sclerosis. Marina O Ziehn, Andrea A Avedisian, Shannon M Dervin, Thomas J O'Dell and Rhonda R Voskuhl 2012 92: 1234-1245; advance online publication, April 23, 2012; 10.1038/labinvest.2012.76 Abstract | Full Text Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to Laboratory Investigation. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. For other enquiries, please contact our customer feedback department. 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