EMBO Reports - Table of Contents alert Volume 31 Issue 9, pp 765-867

TABLE OF CONTENTS September 2012 | Volume 13, Issue 9 Upfront Science & Society Review Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement New in EMBO reports: Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells Emma Sandilands, Bryan Serrels, Simon Wilkinson & Margaret C Frame This paper reveals Src to be a general mediator of FAK-binding kinase degradation under adhesion stress, thus enabling cancer cell survival. EMBO reports advance online publication: 26 June, 2012   Upfront Top Editorial Of pirates and pogos Howy makes a strident plea for more resources to be dedicated to the research projects of gifted young investigators, and for the burden of other academic duties to be lifted from their shoulders. Howy Jacobs EMBO reports (2012), 13, 765; 10.1038/embor.2012.108 Full text | PDF Published online: 31 August 2012 Subject Categories: Science Infrastructures & Publishing Opinion Meiotic pairing by non-coding RNA? How are homologous chromosomes identified during meiosis? A report in Science suggests the answer may be non-coding RNAs, but much work remains to be done. Akira Yamashita, Ryo Kariyazono and Yoshinori Watanabe EMBO reports (2012), 13, 766; 10.1038/embor.2012.124 Full text | PDF Published online: 17 August 2012 Subject Categories: RNA | Cell Cycle Hot off the Press Cell-nonautonomous control of the UPR A study published in this issue of EMBO reports shows that the UPR at the intestine is under the control of the nervous system, to facilitate response to stress. This new way of understanding how the UPR is controlled at an organismal level is discussed here. Gabriela Martínez and Claudio Hetz EMBO reports (2012), 13, 767 - 768; 10.1038/embor.2012.117 Full text | PDF Published online: 07 August 2012 Subject Categories: Neuroscience | Development | Microbiology & Pathogens Meeting Point Integration in action The workshop on ‘Integration in Biology and Biomedicine’ was held in May 2012 at the University of Sydney. It brought together scientists and philosophers to discuss the need for, and practice of, integration in the life sciences. Sara Green and Olaf Wolkenhauer EMBO reports (2012), 13, 769 - 771; 10.1038/embor.2012.121 Abstract | Full text | PDF Published online: 17 August 2012 Subject Categories: Science Policy & Funding | Philosophy & History of Science | Technology, Development & Applications Correspondence Step back from the edge Monica M Zoppè EMBO reports (2012), 13, 772; 10.1038/embor.2012.123 Full text | PDF Published online: 17 August 2012 Subject Categories: Economics & Business | Societal Issues & Politics Plants are intelligent too Anthony J Trewavas EMBO reports (2012), 13, 772 - 773; 10.1038/embor.2012.118 Full text | PDF Published online: 07 August 2012 Subject Categories: Evolution, Environment & Agriculture Response to Anthony Trewavas Ken Richardson EMBO reports (2012), 13, 773; 10.1038/embor.2012.122 Full text | PDF Published online: 17 August 2012 Subject Categories: Evolution, Environment & Agriculture Science & Society Top The evolutionary success of sex Sexual reproduction remains a major puzzle for biologists. How did it evolve and why have so many species maintained it, despite its extensive costs? Recent research is shedding light on the answers to some of these questions. Nick Colegrave EMBO reports (2012), 13, 774 - 778; 10.1038/embor.2012.109 Full text | PDF Published online: 07 August 2012 Subject Categories: Evolution, Environment & Agriculture The (bi)sexual brain When it comes to sexual behaviour in vertebrates, the two sexes are more alike than different. Yet whilst their bodies are usually male or female, their brains are bisexual and intrinsically capable of behaving as either sex. David Crews EMBO reports (2012), 13, 779 - 784; 10.1038/embor.2012.107 Full text | PDF Published online: 27 July 2012 Subject Categories: Evolution, Environment & Agriculture The neurobiology of overeating Is overeating a neurological disorder like drug or alcohol addiction? Recent advances in neuroscience suggest it might be, which could have profound consequences for the treatment of obese people and public health policies to address the growing epidemic of obesity. Natalia M Lee, Adrian Carter, Neville Owen and Wayne D Hall EMBO reports (2012), 13, 785 - 790; 10.1038/embor.2012.115 Full text | PDF Published online: 17 August 2012 Subject Categories: Health & Disease | Societal Issues & Politics To ban or not to ban? Direct-to-consumer genetic tests remain popular with consumers in Europe and the USA. Clinical geneticists and genetic counsellors, however, favour banning certain tests that have serious consequences for public health policies and general health care. Heidi Carmen Howard and Pascal Borry EMBO reports (2012), 13, 791 - 794; 10.1038/embor.2012.114 Full text | PDF Published online: 14 August 2012 Subject Categories: Health & Disease | Societal Issues & Politics Academic labour shortages A shortage of skilled science labour in Europe could hold back research progress. The EU will increase science funding to address the problem, but real long-term measures need to start in schools, not universities. Philip Hunter EMBO reports (2012), 13, 795 - 797; 10.1038/embor.2012.120 Full text | PDF Published online: 17 August 2012 Subject Categories: Scientific Training & Careers Review Top Activation of B cells by non-canonical helper signals Cells of the innate immune system contribute to B-cell activation and plasma cell survival. This review analyses their role in initiating rapid B-cell responses at sites of continuous antigen exposure, which is crucial for proper immune system function. Andrea Cerutti, Montserrat Cols and Irene Puga EMBO reports (2012), 13, 798 - 810; 10.1038/embor.2012.111 Abstract | Full text | PDF Published online: 07 August 2012 Subject Categories: Immunology Scientific Reports Top NEDDylation regulates E2F-1-dependent transcription This study shows that NEDDylation of E2F-1 decreases its stability and transcriptional activity, thereby inhibiting E2F-1-mediated cell growth. An interplay between E2F-1 acetylation and NEDDylation is highlighted. Sarah J Loftus, Geng Liu, Simon M Carr, Shonagh Munro and Nicholas B La Thangue EMBO reports (2012), 13, 811 - 818; 10.1038/embor.2012.113 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 July 2012 Subject Categories: Chromatin & Transcription | Proteins Long-range genomic interactions epigenetically regulate the expression of a cytokine receptor This study shows that the expression of the interferon gamma receptor 1 gene is regulated via long-range intrachromosomal interactions with the Ifnγ locus and is mediated by CTCF. Chrysoula Deligianni and Charalampos G Spilianakis EMBO reports (2012), 13, 819 - 826; 10.1038/embor.2012.112 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 July 2012 Subject Categories: Chromatin & Transcription | Immunology Myelin Basic Protein synthesis is regulated by small non-coding RNA 715 Myelin Basic Protein (MBP) synthesis is essential for myelin formation in the central nervous system. The small non-coding RNA715 inhibits MBP translation and is upregulated in demyelinated human multiple sclerosis lesions that contain MBP mRNA but lack MBP protein. Nina M Bauer, Christina Moos, Jack van Horssen, Maarten Witte, Paul van der Valk, Benjamin Altenhein, Heiko J Luhmann and Robin White EMBO reports (2012), 13, 827 - 834; 10.1038/embor.2012.97 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 29 June 2012 Subject Categories: Neuroscience Positive allosteric feedback regulation of the stringent response enzyme RelA by its product This report identifies a new mechanism of enzyme activation—positive allosteric regulation by the product—in the context of the bacterial stringent response, which is essential for bacterial adaptation to environmental conditions. Viktoriya Shyp, Stoyan Tankov, Andrey Ermakov, Pavel Kudrin, Brian P English, Måns Ehrenberg, Tanel Tenson, Johan Elf and Vasili Hauryliuk EMBO reports (2012), 13, 835 - 839; 10.1038/embor.2012.106 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 20 July 2012 Subject Categories: RNA | Proteins LUBAC synthesizes linear ubiquitin chains via a thioester intermediate The N-terminus of the LUBAC catalytic subunit is shown to be autoinhibitory and counteracted by the other subunits of the complex. Linear ubiquitination proceeds through a thioesther intermediate, indicative of a RING/HECT hybrid mechanism. Benjamin Stieglitz, Aylin C Morris-Davies, Marios G Koliopoulos, Evangelos Christodoulou and Katrin Rittinger EMBO reports (2012), 13, 840 - 846; 10.1038/embor.2012.105 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 July 2012 Subject Categories: Proteins Mps1 promotes rapid centromere accumulation of Aurora B Mps1 is shown to stimulate Aurora B centromere recruitment through the Bub1–H2A phosphorylation-Shugoshin pathway. This recruitment circuitry ensures rapid accumulation of Aurora B at the onset of mitosis and proper chromosome biorientation. Maike S van der Waal, Adrian T Saurin, Martijn J M Vromans, Mathijs Vleugel, Claudia Wurzenberger, Daniel W Gerlich, René H Medema, Geert J P L Kops and Susanne M A Lens EMBO reports (2012), 13, 847 - 854; 10.1038/embor.2012.93 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 26 June 2012 Subject Categories: Cell Cycle Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation Neuronal receptor OCTR-1 is shown to control the XBP-1-mediated unfolded protein response in adult nematodes, but not during development. This controls ER homeostasis and immune activation, suggesting different requirements in these processes throughout development. Jingru Sun, Yiyong Liu and Alejandro Aballay EMBO reports (2012), 13, 855 - 860; 10.1038/embor.2012.100 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 13 July 2012 Subject Categories: Development | Immunology | Microbiology & Pathogens Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue The controversy about the number of substrate binding sites in the neurotransmitter sodium symporter model protein LeuT is ongoing. Ligand binding assays and crystal structures of the LeuT F253A mutant support the presence of a single high affinity substrate binding site. Hui Wang and Eric Gouaux EMBO reports (2012), 13, 861 - 866; 10.1038/embor.2012.110 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 27 July 2012 Subject Categories: Membranes & Transport | Neuroscience | Structural Biology Corrections Top Erratum Src-dependent autophagic degradation of Ret in FAK-signalling-defective cancer cells Emma Sandilands, Bryan Serrels, Simon Wilkinson and Margaret C Frame EMBO reports (2012), 13, 867; 10.1038/embor.2012.126 Full text | PDF Published online: 07 August 2012 Advertisement The EMBO Meeting 2012 22 - 25 September in Nice, France Keynotes: Paul Nurse & Linda Partridge 20 concurrent sessions covering the life sciences Speakers include: Kari Alitalo, Karl Deisseroth, Steven Henikoff, Ruth Lehmann, Dirk Schübeler & Rob Singer www.the-embo-meeting.org   Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. 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