TABLE OF CONTENTS
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Volume 92, Issue 3 (September 2012) |
| In this issue In This Issue Editorial News & Views Perspectives Discovery State of the Art Review Research Development Regulation & Use Corrigendum
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In This Issue | Top |
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In This IssueClin Pharmacol Ther 2012 92: 265; 10.1038/clpt.2012.134 Full Text |
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Editorial | Top |
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Gastrohepatology: Tools, Targets, and TrajectoriesL P James and J Senior Clin Pharmacol Ther 2012 92: 267-271; 10.1038/clpt.2012.123 Abstract | Full Text |
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News & Views | Top |
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HighlightsClin Pharmacol Ther 2012 92: 272-273; 10.1038/clpt.2012.135 Full Text |
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ASCPT NewsClin Pharmacol Ther 2012 92: 274-278; 10.1038/clpt.2012.132 Full Text |
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BOOKS |
Polypharmacology in Drug DiscoveryReviewed by F Innocenti Clin Pharmacol Ther 2012 92: 279-280; 10.1038/clpt.2012.129 Full Text |
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Perspectives | Top |
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COMMENTARIES |
Clinical Pharmacology Considerations in Development of Gastrohepatology ProductsS-C Lee, S Apparaju, I Kim, K Estes, D Jappar and E D Bashaw Clin Pharmacol Ther 2012 92: 281-283; 10.1038/clpt.2012.121 Abstract | Full Text |
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Model-Based Meta-Analysis: An Important Tool for Making Quantitative Decisions During Drug DevelopmentD R Mould Clin Pharmacol Ther 2012 92: 283-286; 10.1038/clpt.2012.122 Abstract | Full Text |
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Discovery | Top |
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CFTR Inhibitors for Treating Diarrheal DiseaseJ R Thiagarajah and A S Verkman Clin Pharmacol Ther 2012 92: 287-290; advance online publication, August 1, 2012; 10.1038/clpt.2012.114 Abstract | Full Text |
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Serum microRNA Biomarkers for Drug-Induced Liver InjuryP J Starkey Lewis, M Merz, P Couttet, O Grenet, J Dear, D J Antoine, C Goldring, B K Park and J G Moggs Clin Pharmacol Ther 2012 92: 291-293; advance online publication, July 25, 2012; 10.1038/clpt.2012.101 Abstract | Full Text |
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State of the Art | Top |
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New Pharmacotherapy for Hepatitis CD N Assis and J K Lim Clin Pharmacol Ther 2012 92: 294-305; advance online publication, August 1, 2012; 10.1038/clpt.2012.103 Abstract | Full Text |
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Evolving Molecular Targets in the Treatment of Nonmalignant Gastrointestinal DiseasesD A Katzka, E V Loftus, Jr and M Camilleri Clin Pharmacol Ther 2012 92: 306-320; advance online publication, July 25, 2012; 10.1038/clpt.2012.77 Abstract | Full Text |
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Ammonia-Lowering Strategies for the Treatment of Hepatic EncephalopathyC F Rose Clin Pharmacol Ther 2012 92: 321-331; advance online publication, August 8, 2012; 10.1038/clpt.2012.112 Abstract | Full Text |
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Alanine Aminotransferase: A Clinical and Regulatory Tool for Detecting Liver Injury–Past, Present, and FutureJ R Senior Clin Pharmacol Ther 2012 92: 332-339; advance online publication, August 8, 2012; 10.1038/clpt.2012.108 Abstract | Full Text |
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Review | Top |
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Nrf2: A Potential Target for New Therapeutics in Liver DiseaseA M Bataille and J E Manautou Clin Pharmacol Ther 2012 92: 340-348; advance online publication, August 8, 2012; 10.1038/clpt.2012.110 Abstract | Full Text |
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International Vision and Strategy for Drug Regulatory Authority: The PMDA's International VisionToshiyoshi Tominaga, Yuki Ando and Tatsuya Kondo Clin Pharmacol Ther 2012 92: 349-351; advance online publication, August 8, 2012; 10.1038/clpt.2012.90 Abstract | Full Text |
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Research | Top |
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ARTICLES |
Longitudinal Model-Based Meta-Analysis in Rheumatoid Arthritis: An Application Toward Model-Based Drug DevelopmentI Demin, B Hamrén, O Luttringer, G Pillai and T Jung Clin Pharmacol Ther 2012 92: 352-359; advance online publication, July 4, 2012; 10.1038/clpt.2012.69 Abstract | Full Text |
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Concordance of DMET Plus Genotyping Results With Those of Orthogonal Genotyping MethodsC A Fernandez, C Smith, W Yang, R Lorier, K R Crews, N Kornegay, J K Hicks, C F Stewart, J D Kawedia, L B Ramsey, C Liu, W E Evans, M V Relling and U Broeckel Clin Pharmacol Ther 2012 92: 360-365; advance online publication, August 8, 2012; 10.1038/clpt.2012.95 Abstract | Full Text |
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In Vivo CYP3A4 Activity, CYP3A5 Genotype, and Hematocrit Predict Tacrolimus Dose Requirements and Clearance in Renal Transplant PatientsH de Jonge, H de Loor, K Verbeke, Y Vanrenterghem and D R Kuypers Clin Pharmacol Ther 2012 92: 366-375; advance online publication, August 8, 2012; 10.1038/clpt.2012.109 Abstract | Full Text |
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Development | Top |
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Predictive Genetic Testing for Drug-Induced Liver Injury: Considerations of Clinical UtilityA Alfirevic and M Pirmohamed Clin Pharmacol Ther 2012 92: 376-380; advance online publication, August 1, 2012; 10.1038/clpt.2012.107 Abstract | Full Text |
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Molecular Targets for the Treatment of Fibrosing CholangiopathiesL J Maillette de Buy Wenniger, R P Oude Elferink and U Beuers Clin Pharmacol Ther 2012 92: 381-387; advance online publication, August 1, 2012; 10.1038/clpt.2012.111 Abstract | Full Text |
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Regulation & Use | Top |
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PRACTICE |
Failure of Proton Pump Inhibitors to Treat GERD in Neonates and Infants: A Question of Drug, Diagnosis, or DesignV Shakhnovich, R M Ward and G L Kearns Clin Pharmacol Ther 2012 92: 388-392; advance online publication, July 18, 2012; 10.1038/clpt.2012.86 Full Text |
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Construction of an Open-Access QT Database for Detecting the Proarrhythmia Potential of Marketed Drugs: ECG-ViEWM Y Park, D Yoon, N K Choi, J Lee, K Lee, H S Lim, B J Park, J H Kim and R W Park Clin Pharmacol Ther 2012 92: 393-396; advance online publication, July 25, 2012; 10.1038/clpt.2012.93 Abstract | Full Text |
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Corrigendum | Top |
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Corrigendum: Impact of the β1-Adrenoceptor Arg389Gly Polymorphism on Heart-Rate Responses to Bisoprolol and Carvedilol in Heart-Failure PatientsClin Pharmacol Ther 2012 92: 397; 10.1038/clpt.2012.98 Full Text |
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