Nature Reviews Neuroscience contents August 2012 Volume 13 Number 8 pp 515-597

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TABLE OF CONTENTS
August 2012 Volume 13 Number 8
Impact Factor 30.455 *	In this issue Research Highlights Progress Reviews Perspectives Also this month  Featured article: Multisensory brain mechanisms of bodily self-consciousness Olaf Blanke
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RESEARCH HIGHLIGHTS Top Glia: Astrocytes know their place p515 | doi:10.1038/nrn3306 Astrocytes in the mouse CNS migrate radially from their points of origin within the ventricular zone to restricted spatial domains throughout the brain and spinal cord, with implications for localized astrocyte functions. PDF Neural development: A fruitless sexual switch p516 | doi:10.1038/nrn3290 Fruitless recruits two antagonistic chromatin modifying proteins to control the development of sexually dimorphic circuitry and behaviour in fruitflies. PDF Axon degeneration: A new pathway emerges p516 | doi:10.1038/nrn3294 Wallerian degeneration of severed axons is suppressed by the loss of dSarm/Sarm1 function, indicating the existence of an injury-induced axon death pathway. PDF Techniques: Propriospinal neurons — old but not forgotten p517 | doi:10.1038/nrn3299 A new technique to temporarily and selectively inactivate spinal interneurons reveals that spinal interneurons are crucial for reach and grasp movements. PDF Cognitive neuroscience: Adapting to cognitive load p518 | doi:10.1038/nrn3303 The dorsal anterior cingulate cortex provides an updated estimate of cognitive load to allow future behavioural adaption. PDF Neuroanatomy: Out with the old (model) p518 | doi:10.1038/nrn3304 The external globus pallidus contains two populations of interconnected GABAergic neurons, one of which exclusively targets the striatum. PDF Neurodevelopmental disorders: TSCerebellar autism in mice p518 | doi:10.1038/nrn3305 Loss of TSC1 function in cerebellar Purkinje cells in mice induces an autism-like phenotype that can be prevented by rapamycin treatment. PDF IN BRIEF Neuroimmunology: Harnessing adaptive immunity for AD | Neurological disorders: Focus on miR-134 for seizures | Synaptic physiology: No return for spiking axons | Neurological disorders: SHANK2 misbehaves in autism | Glia: Glial AMPA receptors finely tune motor behaviour | Learning and memory: Listen while you sleep | Addiction: Targeting nicotine | Sensory systems: The UV regulator PDF Neuroscience JOBS of the week Postdotoral position-Neuroscience and developmental biology University of Connecticut Health Center Postdoctoral Trainee - Neuroscience and Brain Function University of Tennessee Health Science Center Memphis Biological scientist or Postdoctoral position in neuroscience University of Florida Research assistant / internship and Ph.D. student (Neuroscience) Nanyang Technological University (NTU), Singapore Postdoc (Neuroscience) Nanyang Technological University (NTU), Singapore More Science jobs from Neuroscience EVENT Champalimaud Neuroscience Symposium 30.09.-03.10.12 Lisbon, Portugal More science events from
PROGRESS		Top
Control of central auditory processing by a brain-generated oestrogen Raphael Pinaud & Liisa A. Tremere p521 | doi:10.1038/nrn3291 Recent studies show that oestradiol, the classic female oestrogen, can be locally synthesized by central auditory neurons to rapidly modulate neuronal physiology and auditory-based behaviours in both sexes. Pinaud and Tremere review these findings, which indicate that oestradiol is an important, novel modulator of hearing function. Abstract | Full Text | PDF
REVIEWS		Top
Emerging roles of non-coding RNAs in brain evolution, development, plasticity and disease Irfan A. Qureshi & Mark F. Mehler p528 | doi:10.1038/nrn3234 The recent characterization of non-coding RNAs and their astonishingly diverse functions has led to a radical shift in our understanding of how the genome influences neuronal function. In this Review, Qureshi and Mehler describe the numerous classes of non-coding RNAs and how they might contribute to neuronal physiology and disease. Abstract | Full Text | PDF | Supplementary information
Calcium channel auxiliary α2δ and β subunits: trafficking and one step beyond Annette C. Dolphin p542 | doi:10.1038/nrn3311 The α2δ and β subunits of voltage-gated calcium channels (VGCCs) modulate the biophysical properties and trafficking of such channels. In this Review, Annette Dolphin examines the traditional roles of these auxillary subunits and their involvement in neuronal processes that are not linked to VGCC function. Abstract | Full Text | PDF
Multisensory brain mechanisms of bodily self-consciousness Olaf Blanke p556 | doi:10.1038/nrn3292 Bodily self-consciousness includes the conscious experience of identifying with the body, of where 'I' am in space, and of the perspective from where 'I' perceive the world. Olaf Blanke discusses the cortical mechanisms that underlie these experiences, highlighting data from neuroimaging, neurology and virtual reality. Abstract | Full Text | PDF
Knowing how much you don't know: a neural organization of uncertainty estimates Dominik R. Bach & Raymond J. Dolan p572 | doi:10.1038/nrn3289 Decision making is influenced by uncertainty, which arises from internal and external noise. A fundamental question is how uncertainty is encoded in the brain and how it influences behaviour. In this Review, Bach and Dolan integrate several theoretical concepts about uncertainty into a hierarchical decision-making framework. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Concept cells: the building blocks of declarative memory functions Rodrigo Quian Quiroga p587 | doi:10.1038/nrn3251 Neurons in the human medial temporal lobe respond in a selective and abstract manner to particular persons or objects. Rodrigo Quian Quiroga argues that these 'concept cells' are crucial for memory functions and the transition between related concepts that leads to the flow of consciousness. Abstract | Full Text | PDF
Corrigendum: Axonal mRNA localization and local protein synthesis in nervous system assembly, maintenance and repair Hosung Jung, Byung C. Yoon & Christine E. Holt p597 | doi:10.1038/nrn3274 Full Text | PDF
Erratum: Will the real multiple sclerosis please stand up? Peter K. Stys, Gerald W. Zamponi, Jan van Minnen & Jeroen J. G. Geurts p597 | doi:10.1038/nrn3300 Full Text | PDF
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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