Nature Reviews Immunology Contents August 2012 Volume 12 Number 8 pp 549-614

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TABLE OF CONTENTS
August 2012 Volume 12 Number 8
Impact Factor 33.287 *	In this issue Research Highlights Reviews Perspectives Also this month  Featured article: Cross-presentation by dendritic cells Olivier P. Joffre, Elodie Segura, Ariel Savina & Sebastian Amigorena
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RESEARCH HIGHLIGHTS Top T cell responses: Silent commitment p549 | doi:10.1038/nri3268 Gene-silencing mechanisms promote stable commitment to different T helper cell lineages. PDF Mucosal immunology: IL-22 keeps commensals in their place p550 | doi:10.1038/nri3263 Innate lymphoid cells help to retain commensal bacteria in anatomical niches and prevent systemic inflammation. PDF Dendritic cells: A hairy pathway for migration p550 | doi:10.1038/nri3264 A population of precursor Langerhans cells is recruited to the epidermis via hair follicles. PDF Inflammation: Coordinating antimicrobial activity and wound repair p552 | doi:10.1038/nri3260 Linking the high levels of antimicrobial activity and keratinocyte hyperproliferation in psoriatic skin lesions. PDF Inflammation: IL-23 tees off enthesitis p552 | doi:10.1038/nri3269 IL-23 activates innate-like entheseal T cells to promote spondyloarthritis in mice. PDF Tolerance: PD1 — a multitasking receptor p553 | doi:10.1038/nri3266 PD1 inhibits T cell proliferation by targeting multiple cell cycle regulators. PDF Mucosal immunology: Any old bugs won't do p554 | doi:10.1038/nri3270 The host-specific microbiota is essential for a healthy immune system. PDF Tolerance: Induced TReg cells evolved to protect the fetus p554 | doi:10.1038/nri3274 Induced regulatory T cells emerged to protect allogeneic fetuses from immune-mediated attack. PDF Tumour immunology: Suppressing the rejection of pancreatic tumours p555 | doi:10.1038/nri3267 KRAS-transformed pancreatic tumour cells produce GM-CSF, which recruits MDSCs to promote an immunosuppressive microenvironment. PDF IN BRIEF T cells: Embryonic thymus required for IL-17-producing γδ T cells | Thymocytes: Self-renewing thymocytes | Autoimmunity: GWASs can explain why the drugs don't work | Tumour immunology: TH9 cells tackle tumours | Parasite immunity: γδ T cells boost DC responses to malaria PDF Immunology JOBS of the week Assistant / Associate / Professor in Immunology FlU -- Florida International University Postdoctoral Positions in Immunology St. Jude Children's Research Hospital Postdoctoral Positions - Developmental Immunology Massachusetts General Hospital Postdoctoral Researcher-Viral Immunology Louisiana State University (LSU) Department of Microbiology & Immunology Faculty Position University of Maryland at Baltimore More Science jobs from Immunology EVENT Frontiers in Basic Immunology: 2012 04.-05.10.12 MD, US More science events from
REVIEWS		Top
Cross-presentation by dendritic cells Olivier P. Joffre, Elodie Segura, Ariel Savina & Sebastian Amigorena p557 | doi:10.1038/nri3254 This Review integrates recent evidence regarding the intracellular trafficking pathways involved in cross-presentation into our understanding of the role of cross-presentation in immunity and tolerance. Abstract | Full Text | PDF
Lighting the fires within: the cell biology of autoinflammatory diseases Heiyoung Park, Ariel Bulua Bourla, Daniel L. Kastner, Robert A. Colbert & Richard M. Siegel p570 | doi:10.1038/nri3261 Patients with autoinflammatory diseases develop pathological tissue inflammation in the absence of any autoreactive B or T cell responses. Recent studies have shown that defective regulation of pro-inflammatory immune components or protein handling pathways can provoke such autoinflammatory attacks. This Review describes the latest findings in the field and discusses their therapeutic significance. Abstract | Full Text | PDF
The immunological life cycle of tuberculosis Joel D. Ernst p581 | doi:10.1038/nri3259 Here, Joel Ernst proposes that there are distinct stages in the immune response to Mycobacterium tuberculosis that form an 'immunological life cycle'. The description of this framework can help the understanding and study of immunity to tuberculosis in humans and animal models. Abstract | Full Text | PDF
Recent progress in mucosal vaccine development: potential and limitations Nils Lycke p592 | doi:10.1038/nri3251 This Review summarizes the past, current and future directions for the development of mucosal vaccines, with a particular focus on the importance of the formulation, the route of administration and the choice of adjuvant for the induction of protective mucosal immunity. Abstract | Full Text | PDF
PERSPECTIVES		Top
OPINION Towards an HIV cure: a global scientific strategy Steven G. Deeks, Brigitte Autran, Ben Berkhout, Monsef Benkirane, Scott Cairns, Nicolas Chomont, Tae-Wook Chun, Melissa Churchill, Michele Di Mascio, Christine Katlama, Alain Lafeuillade, Alan Landay, Michael Lederman, Sharon R. Lewin, Frank Maldarelli, David Margolis, Martin Markowitz, Javier Martinez-Picado, James I. Mullins, John Mellors, Santiago Moreno, Una O'Doherty, Sarah Palmer, Marie-Capucine Penicaud, Matija Peterlin, Guido Poli, Jean-Pierre Routy, Christine Rouzioux, Guido Silvestri, Mario Stevenson, Amalio Telenti, Carine Van Lint, Eric Verdin, Ann Woolfrey, John Zaia & Françoise Barré-Sinoussi for The International AIDS Society Scientific Working Group on HIV Cure p607 | doi:10.1038/nri3262 The development of effective antiretroviral therapies has greatly improved the disease prognosis for patients with HIV. However, the limitations of these therapies have renewed interest in developing alternative treatment strategies. Here, a group of experts from the International AIDS Society discuss the research steps that need to be taken to achieve the ultimate objective — a cure for HIV. Abstract | Full Text | PDF
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*2011 Journal Citation Report (Thomson Reuters, 2012)

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