Molecular Systems Biology - New articles published 31 July 2012

Latest Articles 31st July 2012   Featured Article Research Articles News and Views   Web feeds About Open access Advertisement Take a look at this recent article published in Molecular Systems Biology: Deciphering a global network of functionally associated post-translational modifications open Pablo Minguez, Peer Bork and Colleagues This study is the first large-scale comparative analysis of multiple types of post-translational modifications in different eukaryotic species. The resulting network of co-evolving and functionally associated modifications reveals the global landscape of post-translational regulation.   Featured Article The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2-positive breast cancer cells This study implicates the glucose deprivation response in breast cancer cell resistance to lapatinib and high relapse rates in Her2-positive patients. Identification of these compensatory networks suggests novel strategies to target cancer signaling and metabolism. Kakajan Komurov, Jen-Te Tseng, Melissa Muller, Elena G Seviour, Tyler J Moss, Lifeng Yang, Deepak Nagrath & Prahlad T Ram Molecular Systems Biology 8:596; doi:10.1038/msb.2012.25; published 31 July 2012 Full Text | PDF | Supp. Inf. | Review Process Research Articles Effects of diet and development on the Drosophila lipidome High-resolution shotgun mass spectrometry is used to rigorously quantify the lipidomes of individual Drosophila tissues under different dietary conditions and throughout development. The flies’ diet is found to have a surprisingly direct effect on phospholipid composition throughout the animal. Maria Carvalho, Julio L Sampaio, Wilhelm Palm, Marko Brankatschk, Suzanne Eaton & Andrej Shevchenko Molecular Systems Biology 8:600; doi:10.1038/msb.2012.29; published 31 July 2012 Full Text | PDF | Supp. Inf. | Review Process Reverse engineering a hierarchical regulatory network downstream of oncogenic KRAS Systematic RNA interference perturbations within ovarian cancer cells reveal a hierarchically organized transcription factor network downstream of the oncogenic RAS pathway. Modules within the network are shown to control distinct aspects of cell growth and migration. Iwona Stelniec-Klotz, Stefan Legewie, Oleg Tchernitsa, Franziska Witzel, Bertram Klinger, Christine Sers, Hanspeter Herzel, Nils Blüthgen & Reinhold Schäfer Molecular Systems Biology 8:601; doi:10.1038/msb.2012.32; published 31 July 2012 Full Text | PDF | Supp. Inf. | Review Process News and Views Metabolic rewiring drives resistance to targeted cancer therapy Jason W Locasale Molecular Systems Biology 8:597; doi:10.1038/msb.2012.30; published 31 July 2012 Full Text | PDF

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