Molecular Systems Biology - New articles published 17 July 2012

Latest Articles 17th July 2012   Featured Article Research Articles News and Views   Web feeds About Open access Advertisement 'How to get published?' session at ICSB 2012, Toronto, 19–23 August The session will be hosted by the Chief Editor of Molecular Systems Biology and take place on Tuesday, August 21 @12:00 pm, in the Carlu (bring along your conference lunch). Invitation is open to all attendees! Find out more!     Featured Article Chromatin measurements reveal contributions of synthesis and decay to steady-state mRNA levels Histone modification, polymerase binding, mRNA half-life, and miRNA abundance measurements in mouse cells are used to dissect the relative contribution of each to mRNA levels, revealing control primarily at the level of transcription, with minor contributions from post-transcriptional processes. Sylvia C Tippmann, Robert Ivanek, Dimos Gaidatzis, Anne Schöler, Leslie Hoerner, Erik van Nimwegen, Peter F Stadler, Michael B Stadler & Dirk Schübeler Molecular Systems Biology 8:593; doi:10.1038/msb.2012.23; published 17 July 2012 Full Text | PDF | Supp. Inf. | Review Process Research Articles Systems analysis of eleven rodent disease models reveals an inflammatome signature and key drivers A common inflammatome signature, as well as disease-specific expression patterns, was identified from 11 different rodent inflammatory disease models. Causal regulatory networks and the drivers of the inflammatome signature were uncovered and validated. I-Ming Wang, Bin Zhang, Xia Yang, Jun Zhu, Serguei Stepaniants, Chunsheng Zhang, Qingying Meng, Mette Peters, Yudong He, Chester Ni, Deborah Slipetz, Michael A Crackower, Hani Houshyar, Christopher M Tan, Ernest Asante-Appiah, Gary O'Neill, Mingjuan Jane Luo, Rolf Thieringer, Jeffrey Yuan, Chi-Sung Chiu, Pek Yee Lum, John Lamb, Yves Boie, Hilary A Wilkinson, Eric E Schadt, Hongyue Dai & Christopher Roberts Molecular Systems Biology 8:594; doi:10.1038/msb.2012.24; published 17 July 2012 Full Text | PDF | Supp. Inf. | Review Process INDI: a computational framework for inferring drug interactions and their associated recommendations INDI is a similarity-based drug–drug interaction prediction method that can infer both pharmacokinetic and pharmacodynamic interactions, as well as their severity levels. Both known and predicted drug interactions are found to be prevalent in clinical practice. Assaf Gottlieb, Gideon Y Stein, Yoram Oron, Eytan Ruppin & Roded Sharan Molecular Systems Biology 8:592; doi:10.1038/msb.2012.26; published 17 July 2012 Full Text | PDF | Supp. Inf. | Review Process Deciphering a global network of functionally associated post-translational modifications This study is the first large-scale comparative analysis of multiple types of post-translational modifications in different eukaryotic species. The resulting network of co-evolving and functionally associated modifications reveals the global landscape of post-translational regulation. Pablo Minguez, Luca Parca, Francesca Diella, Daniel R Mende, Runjun Kumar, Manuela Helmer-Citterich, Anne-Claude Gavin, Vera van Noort & Peer Bork Molecular Systems Biology 8:599; doi:10.1038/msb.2012.31; published 17 July 2012 Full Text | PDF | Supp. Inf. | Review Process Global biogeography of SAR11 marine bacteria Metagenomic samples from oceans around the globe were used to examine the biogeography of the dominant marine heterotrophic bacterial clade, SAR11. Analysis uncovers evidence of adaptive radiation in response to environmental parameters, particularly temperature. Mark V Brown, Federico M Lauro, Matthew Z DeMaere, Les Muir, David Wilkins, Torsten Thomas, Martin J Riddle, Jed A Fuhrman, Cynthia Andrews-Pfannkoch, Jeffrey M Hoffman, Jeffrey B McQuaid, Andrew Allen, Stephen R Rintoul & Ricardo Cavicchioli Molecular Systems Biology 8:595; doi:10.1038/msb.2012.28; published 17 July 2012 Full Text | PDF | Supp. Inf. | Review Process News and Views Cells, shared memory and breaking the PTM code Pau Creixell & Rune Linding Molecular Systems Biology 8:598; doi:10.1038/msb.2012.33; published 17 July 2012 Full Text | PDF

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