EMBO Reports - Table of Contents alert Volume 13 Issue 7, pp 577-659

TABLE OF CONTENTS July 2012 | Volume 13, Issue 7 Upfront Science & Society Reviews Scientific Reports Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Upfront Top Editorial At the cliff's edge With academic economists offering a plethora of views on how to solve the sovereign debt crisis, Howy suggests that muddling through might be a wiser course than paying heed to theoreticians. Howy Jacobs EMBO reports (2012), 13, 577; 10.1038/embor.2012.84 Full text | PDF Published online: 29 June 2012 Subject Categories: Economics & Business | Societal Issues & Politics Time to talk Debate over the publication of the H5N1 flu virus papers highlights the need for better risk management of dual-use research. Scientists should start this discussion instead of waiting for governments to implement regulation. Holger Breithaupt EMBO reports (2012), 13, 578; 10.1038/embor.2012.77 Full text | PDF Published online: 29 June 2012 Subject Categories: Societal Issues & Politics Opinion Adaptive governance of synthetic biology As resistance to synthetic biology slowly coalesces, governments and scientists need to be proactive to avoid a repetition of the near moratorium on genetically modified crops in Europe. Joyce Tait EMBO reports (2012), 13, 579; 10.1038/embor.2012.76 Full text | PDF Published online: 01 June 2012 Subject Categories: Societal Issues & Politics Meeting Point Singapore signalling: the 2012 hedgehog pathway cocktail The ‘Hedgehog Signalling in Development Evolution and Disease’ conference took place in Singapore in March 2012. It brought leading researchers together to discuss the latest findings, and exchange ideas, on every aspect of Hedgehog signalling. James Briscoe and Rajat Rohatgi EMBO reports (2012), 13, 580 - 583; 10.1038/embor.2012.79 Abstract | Full text | PDF Published online: 12 June 2012 Subject Categories: Signal Transduction | Molecular Biology of Disease | Development Science & Society Top Engineering and ethical perspectives in synthetic biology The applications of synthetic biology will involve the release of artificial life forms into the environment. These organisms will present unique safety challenges that need to be addressed by researchers and regulators to win public engagement and support. James Anderson, Natalja Strelkowa, Guy-Bart Stan, Thomas Douglas, Julian Savulescu, Mauricio Barahona and Antonis Papachristodoulou EMBO reports (2012), 13, 584 - 590; 10.1038/embor.2012.81 Full text | PDF Published online: 15 June 2012 Subject Categories: Genetically Modified Organisms | Technology, Development & Applications Heritability lost; intelligence found The rise of intelligence was vital to evolution; the ability to process and predict rapidly changing environments allowed increasingly complex organisms to survive and thrive. Intelligence remains a fundamental property of the system rather than a discretely heritable trait. Ken Richardson EMBO reports (2012), 13, 591 - 595; 10.1038/embor.2012.83 Full text | PDF Published online: 12 June 2012 Subject Categories: Evolution, Environment & Agriculture | Philosophy & History of Science Sex and gender differences in health The new concept of evidence-based sex and gender medicine—which includes the fundamental differences of biology and behaviour between women and men—should improve health care for both sexes. Vera Regitz-Zagrosek EMBO reports (2012), 13, 596 - 603; 10.1038/embor.2012.87 Full text | PDF Published online: 15 June 2012 Subject Categories: Health & Disease | Societal Issues & Politics H5N1 infects the biosecurity debate The generation of mutant H5N1 flu virus raised fundamental questions about the assessment and management of the risks of dual-use biological research. Governments might well increase oversight and regulation to rectify the current shortcomings. Philip Hunter EMBO reports (2012), 13, 604 - 607; 10.1038/embor.2012.80 Full text | PDF Published online: 12 June 2012 Subject Categories: Science Infrastructures & Publishing | Science Policy & Funding Reviews Top The base of the cilium: roles for transition fibres and the transition zone in ciliary formation, maintenance and compartmentalization This review discusses two underappreciated regions at the base of the cilium: the basal body distal end and the transition zone, both of which have varied and important roles in cilia biogenesis, maintenance and compartmentalization. Jeremy F Reiter, Oliver E Blacque and Michel R Leroux EMBO reports (2012), 13, 608 - 618; 10.1038/embor.2012.73 Abstract | Full text | PDF Published online: 01 June 2012 Subject Categories: Membranes & Transport | Molecular Biology of Disease Shaping the landscape: mechanistic consequences of ubiquitin modification of chromatin Post-translational modifications regulate the function of chromatin and thus gene expression. A spatially and temporally controlled spectrum of ubiquitylation events, including degradatory ubiquitylation of histones, histone-modifying enzymes, and non-histone chromatin factors, shapes the physical chromatin landscape. Sigurd Braun and Hiten D Madhani EMBO reports (2012), 13, 619 - 630; 10.1038/embor.2012.78 Abstract | Full text | PDF Published online: 12 June 2012 Subject Categories: Chromatin & Transcription | Proteins Scientific Reports Top SUMOylation of Blimp-1 is critical for plasma cell differentiation Blimp-1 is shown to be SUMOylated by PIAS1 at lysine 816. This modification is needed for HDAC2 interaction and transcriptional repression during plasma cell differentiation and its abrogation impairs the generation of antibody-secreting cells. Hsia-Yuan Ying, Shin-Tang Su, Pang-Hung Hsu, Che-Chang Chang, I-Ying Lin, Yu-Hsuan Tseng, Ming-Daw Tsai, Hsiu-Ming Shih and Kuo-I Lin EMBO reports (2012), 13, 631 - 637; 10.1038/embor.2012.60 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 04 May 2012 Subject Categories: Proteins | Differentiation & Death | Immunology Mutant p53 interactome identifies nardilysin as a p53R273H-specific binding partner that promotes invasion Mutant p53 promotes metastasis in vivo. By using advanced proteomics, this study identifies several mutant p53-specific binding partners, one of which—nardilysin—binds p53R273H and promotes a p53R273H-dependant invasive response to HB–EGF. Cynthia R Coffill, Patricia A J Muller, Hue Kian Oh, Suat Peng Neo, Kelly A Hogue, Chit Fang Cheok, Karen H Vousden, David P Lane, Walter P Blackstock and Jayantha Gunaratne EMBO reports (2012), 13, 638 - 644; 10.1038/embor.2012.74 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 June 2012 Subject Categories: Proteins | Molecular Biology of Disease Pds5 promotes cohesin acetylation and stable cohesin–chromosome interaction This study shows that Pds5 is essential for cohesin acetylation by Eso1 in S-phase, thereby mediating the establishment of sister chromatid cohesion. In addition, Pds5 promotes a stable interaction of cohesin with replicated chromosomes. Sabine Vaur, Amélie Feytout, Stéphanie Vazquez and Jean-Paul Javerzat EMBO reports (2012), 13, 645 - 652; 10.1038/embor.2012.72 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 29 May 2012 Subject Categories: Cell Cycle | Genome Stability & Dynamics Group I and II mammalian PAKs have different modes of activation by Cdc42 This study shows that PAK4—the prototypic group II p21-activated kinase—is constitutively phosphorylated in its activation-loop, in contrast to group I PAKs, and inhibited until its interaction with Cdc42 by a newly identified auto-inhibitory domain. Yohendran Baskaran, Yuen-Wai Ng, Widyawilis Selamat, Felicia Tay Pei Ling and Ed Manser EMBO reports (2012), 13, 653 - 659; 10.1038/embor.2012.75 Abstract | Full text | PDF | Supp. info. | Review Process File Published online: 01 June 2012 Subject Categories: Signal Transduction | Proteins | Structural Biology Please note that you need to be a subscriber or site-licence holder to enjoy full-text access to EMBO reports. In order to do so, please purchase a subscription. You have been sent this Table of Contents Alert because you have opted in to receive it. You can change or discontinue your e-mail alerts at any time, by modifying your preferences on your nature.com account at: www.nature.com/nams/svc/myaccount (You will need to log in to be recognised as a nature.com registrant). For further technical assistance, please contact our registration department. For print subscription enquiries, please contact our subscription department. 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