Drug Discovery@nature.com 27 July 2012

TABLE OF CONTENTS 27 July 2012 News Analysis Research Highlights Research & Reviews Careers Nature Reviews Drug Discovery is on Twitter Advertisement Nature Medicine and the Volkswagen Foundation present: Herrenhausen Symposium on Metastasis October 8-10, 2012 - Seeon, Germany A subset of leaders in the field will attend the Herrenhausen Symposium and participate in an interdisciplinary discussion that will point in the direction of solutions to the greatest challenges that the field of viral pathogenesis faces. Apply today!   News Top Europe nears first approval for gene therapy treatment doi:10.1038/nature.2012.11048 Therapy for rare fat-processing disease gains medicines regulator’s approval. Full Text The great gene-patent debate doi:10.1038/nature.2012.11044 How the Myriad Genetics gene-patent case might affect personalized medicine. Full Text Artificial jellyfish built from rat cells doi:10.1038/nature.2012.11046 Reverse-engineered life form could be used to test drugs. Full Text Debate over details of US biosimilar pathway continues to rage doi:10.1038/nbt0712-577 Despite the publication of draft guidance for biosimilar products early this year, opinions about regulatory standards remain sharply divided. Full Text Analysis Top PI3Kδ turns schizophrenic doi:10.1038/scibx.2012.718 NIH researchers have linked phosphoinositide 3-kinase-δ to neuregulin signaling and shown that inhibiting the kinase improved behavior in rodent models of schizophrenia. Full Text FDA advisory committee meeting outcomes doi:10.1038/nrd3747 This analysis of the outcomes of advisory committee meetings held by the US FDA over the past decade investigates issues such as the consistency between advisory committee votes and FDA approval decisions. Full Text Pipeline pioneers: Vismodegib doi:10.1038/nrd3753 First-in-class inhibitor of the Hedgehog signalling pathway approved in the United States for the treatment of basal cell carcinoma. Full Text Research Highlights Top Cancer: Of targets and anti-targets doi:10.1038/nrd3781 Polypharmacology is difficult to predict. Now, researchers have taken a systems pharmacology approach, identifying targets and anti-targets for the rational design of drugs with an optimized polypharmacological profile. Full Text Metabolic disorders: Heart microRNA provides new route to metabolic control doi:10.1038/nrd3779 Researchers have discovered a novel role of the heart in systemic metabolic control and suggest that miR-208a inhibition may have applications in the treatment of metabolic disorders. Full Text Anticancer drugs: Antipsychotic to anticancer agent? doi:10.1038/nrd3783 A new study has screened for compounds that selectively differentiate cancer stem cell-like cells and has identified dopamine receptor antagonists as promising candidates. Full Text Research & Reviews Top Analytical tools for characterizing biopharmaceuticals and the implications for biosimilars doi:10.1038/nrd3746 This review looks at the analytical technologies available to assess biosimilars, focusing on the assessment of post-translational modifications, three-dimensional structures and protein aggregation. Full Text Ophthalmic drug discovery: novel targets and mechanisms for retinal diseases and glaucoma doi:10.1038/nrd3745 This Review discusses the current state of ocular drug therapy and highlights future therapeutic opportunities. Full Text IL-23 induces spondyloarthropathy by acting on ROR-γt+ CD3+CD4−CD8−entheseal resident T cells doi:10.1038/nm.2817 The identification of an IL-23–responsive CD4−CD8− T cell population points to new therapeutic targets for this group of rheumatic disorders. Full Text A new isoform of steroid receptor coactivator-1 is crucial for pathogenic progression of endometriosis doi:10.1038/nm.2826 Researchers have discovered a new axis that mediates the pathogenic progression of endometriosis, and suggest that the antibody to TNF-α etanercept might offer a therapy. Full Text Drug Discovery JOBS of the week Principal Investigator positions in Biological Chemistry & Drug Discovery University of Dundee, College of Life Sciences PhD position - Smart nanoparticles for targeted drug delivery in pulmonary fibrosis Comprehensive Pneumology Center Institute Research Scientist – Drug Metabolism MD Anderson Cancer Center Sr Research Associate / Principle Investigator – EnVivo Drug Discovery H3 Biomedicine PhD studentship on large-scale quantum chemistry methods applied to drug discovery University of Southampton - Chemistry More Science jobs from Drug Discovery EVENT Effective Risk Based Applications of cGMPs to Cosmetics and OTC Drug Products 01.-02.10.12 PA, US More science events from Careers Top Career snapshots archive Career snapshots feature people associated with drug discovery and drug development, with the aim of providing expert insights and advice on a wide range of positions and career paths in this field. Full Text Top Advertisement SciBX: Science-Business eXchange is a weekly publication that identifies and analyzes the most important translational research articles from over 40 journals. Find out which papers have real scientific and commercial potential, and why. Recommend SciBX to your library today.   Natureevents is a fully searchable, multi-disciplinary database designed to maximise exposure for events organisers. The contents of the Natureevents Directory are now live. The digital version is available here. Find the latest scientific conferences, courses, meetings and symposia on natureevents.com. For event advertising opportunities across the Nature Publishing Group portfolio please contact natureevents@nature.com More Nature Events

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