Clinical Pharmacology and Therapeutics - Table of Contents alert Volume 92 Issue 2

TABLE OF CONTENTS Volume 92, Issue 2 (August 2012) In this issue In This Issue Editorial News & Views Perspectives Clinical Trial State of the Art Research Discovery & Development Also new AOP Sign up for e-alerts Recommend to your library Web feed Subscribe Advertisement Now accepting submissions Open Access - Peer Review - Renowned International Editorial Board A new online open access journal in the pharmacometrics and systems pharmacology space.   In This Issue Top In This Issue Clin Pharmacol Ther 2012 92: 133; 10.1038/clpt.2012.105 Full Text Editorial Top Rare Diseases: The Bane of Modern Society and the Quest for Cures N Azie and J Vincent Clin Pharmacol Ther 2012 92: 135-139; 10.1038/clpt.2012.97 Abstract | Full Text News & Views Top HIGHLIGHTS Clin Pharmacol Ther 2012 92: 140-141; 10.1038/clpt.2012.104 Full Text ASCPT NEWS Clin Pharmacol Ther 2012 92: 142-145; 10.1038/clpt.2012.91 Full Text MACROSCOPY The Future of Orphan Drug Development J Woodcock Clin Pharmacol Ther 2012 92: 146-148; 10.1038/clpt.2012.89 Full Text Perspectives Top OPINION The Current State of Therapeutic Drug Trials in Pregnancy S Endicott and D M Haas Clin Pharmacol Ther 2012 92: 149-150; 10.1038/clpt.2012.81 Abstract | Full Text COMMENTARIES The Challenges of Orphan Drugs and Orphan Diseases: Real and Imagined I Hudson and A Breckenridge Clin Pharmacol Ther 2012 92: 151-153; 10.1038/clpt.2012.72 Abstract | Full Text Ethical Considerations in Orphan Drug Approval and Use A S Kesselheim Clin Pharmacol Ther 2012 92: 153-155; 10.1038/clpt.2012.92 Abstract | Full Text Modeling Helps in Understanding Antidepressants N Holford Clin Pharmacol Ther 2012 92: 155-156; 10.1038/clpt.2012.88 Abstract | Full Text LETTERS TO THE EDITOR Off-Label Use of Medicines: Time for Action D Gnjidic, D G Le Couteur and S N Hilmer Clin Pharmacol Ther 2012 92: 157; advance online publication, June 20, 2012; 10.1038/clpt.2012.74 Full Text Clinical Trial Top LX4211, a Dual SGLT1/SGLT2 Inhibitor, Improved Glycemic Control in Patients With Type 2 Diabetes in a Randomized, Placebo-Controlled Trial B Zambrowicz, J Freiman, P M Brown, K S Frazier, A Turnage, J Bronner, D Ruff, M Shadoan, P Banks, F Mseeh, D B Rawlins, N C Goodwin, R Mabon, B A Harrison, A Wilson, A Sands and D R Powell Clin Pharmacol Ther 2012 92: 158-169; advance online publication, July 4, 2012; 10.1038/clpt.2012.58 Abstract | Full Text State of the Art Top Neglected Infections of Poverty in Texas and the Rest of the United States: Management and Treatment Options M A Barry, S Bezek, J A Serpa, P J Hotez and L Woc-Colburn Clin Pharmacol Ther 2012 92: 170-181; advance online publication, July 4, 2012; 10.1038/clpt.2012.85 Abstract | Full Text Gene, Stem Cell, and Future Therapies for Orphan Diseases M Ian Phillips Clin Pharmacol Ther 2012 92: 182-192; advance online publication, June 27, 2012; 10.1038/clpt.2012.82 Abstract | Full Text The Role of Academic Institutions in the Development of Drugs for Rare and Neglected Diseases L D Coles and J C Cloyd Clin Pharmacol Ther 2012 92: 193-202; advance online publication, July 4, 2012; 10.1038/clpt.2012.83 Abstract | Full Text Drug Absorption Interactions Between Oral Targeted Anticancer Agents and PPIs: Is pH-Dependent Solubility the Achilles Heel of Targeted Therapy? N R Budha, A Frymoyer, G S Smelick, J Y Jin, M R Yago, M J Dresser, S N Holden, L Z Benet and J A Ware Clin Pharmacol Ther 2012 92: 203-213; advance online publication, June 27, 2012; 10.1038/clpt.2012.73 Abstract | Full Text Research Top ARTICLES The Effects of Heparins on the Liver: Application of Mechanistic Serum Biomarkers in a Randomized Study in Healthy Volunteers A H Harrill, J Roach, I Fier, J S Eaddy, C L Kurtz, D J Antoine, D M Spencer, T K Kishimoto, D S Pisetsky, B K Park and P B Watkins Clin Pharmacol Ther 2012 92: 214-220; advance online publication, June 27, 2012; 10.1038/clpt.2012.40 Abstract | Full Text UGT1A4*3 Encodes Significantly Increased Glucuronidation of Olanzapine in Patients on Maintenance Treatment and in Recombinant Systems T Haslemo, I Loryan, N Ueda, B Mannheimer, L Bertilsson, M Ingelman-Sundberg, E Molden and E Eliasson Clin Pharmacol Ther 2012 92: 221-227; advance online publication, June 20, 2012; 10.1038/clpt.2012.46 Abstract | Full Text Detection of Pharmacovigilance-Related Adverse Events Using Electronic Health Records and Automated Methods K Haerian, D Varn, S Vaidya, L Ena, H S Chase and C Friedman Clin Pharmacol Ther 2012 92: 228-234; advance online publication, June 20, 2012; 10.1038/clpt.2012.54 Abstract | Full Text Optimizing Drug Outcomes Through Pharmacogenetics: A Case for Preemptive Genotyping J S Schildcrout, J C Denny, E Bowton, W Gregg, J M Pulley, M A Basford, J D Cowan, H Xu, A H Ramirez, D C Crawford, M D Ritchie, J F Peterson, D R Masys, R A Wilke and D M Roden Clin Pharmacol Ther 2012 92: 235-242; advance online publication, June 27, 2012; 10.1038/clpt.2012.66 Abstract | Full Text Equivalent Dynamic Human Brain NK1-Receptor Occupancy Following Single-Dose i.v. Fosaprepitant vs. Oral Aprepitant as Assessed by PET Imaging K Van Laere, J De Hoon, G Bormans, M Koole, I Derdelinckx, I De Lepeleire, R Declercq, S M Sanabria Bohorquez, T Hamill, P D Mozley, D Tatosian, W Xie, Y Liu, F Liu, P Zappacosta, C Mahon, K L Butterfield, L B Rosen, M G Murphy, R J Hargreaves, J A Wagner and C R Shadle Clin Pharmacol Ther 2012 92: 243-250; advance online publication, June 27, 2012; 10.1038/clpt.2012.62 Abstract | Full Text Time-Varying Belatacept Exposure and Its Relationship to Efficacy/Safety Responses in Kidney-Transplant Recipients Z Zhou, J Shen, Y Hong, S Kaul, M Pfister and A Roy Clin Pharmacol Ther 2012 92: 251-257; advance online publication, July 4, 2012; 10.1038/clpt.2012.84 Abstract | Full Text Discovery & Development Top TRANSLATION Quantitative Analysis to Guide Orphan Drug Development L J Lesko Clin Pharmacol Ther 2012 92: 258-261; advance online publication, June 27, 2012; 10.1038/clpt.2012.80 Abstract | Full Text DEVELOPMENT Raising Orphans: How Clinical Development Programs of Drugs for Rare and Common Diseases Are Different M Orfali, L Feldman, V Bhattacharjee, P Harkins, S Kadam, C Lo, M Ravi, D T Shringarpure, J Mardekian, C Cassino and T Coté Clin Pharmacol Ther 2012 92: 262-264; advance online publication, June 27, 2012; 10.1038/clpt.2012.87 Abstract | Full Text Advertisement Ensure your access If you are unable to access the articles in thisalert, your library may not subscribe to this journal. 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