Nature Reviews Genetics Contents June 2012 Volume 13 Number 6 pp 377-448

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TABLE OF CONTENTS
June 2012 Volume 13 Number 6		Advertisement
Impact Factor 32.745 *	In this issue Research Highlights Reviews Perspectives Also this month Article series: Translational genetics Modes of transcriptional regulation  Featured article: Maintaining differentiated cellular identity Johan Holmberg & Thomas Perlmann	DOMINANT TRAITS -Circulation: Cardiovascular Genetics for the iPad®. Research that's critical to your profession is now brought to you on the iPad. Sample issue is available - click here to download the app for free today!
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Nature Genetics and the Wellcome Trust present: The Genomics of Common Diseases 2012 September 19-22, 2012 - Potomac, MD, USA For more information and to register, visit: www.nature.com/natureconferences/gcd2012 Abstract submission deadline- June 28, 2012
RESEARCH HIGHLIGHTS Top Human genetics: Fruits of exome sequencing for autism p377 | doi:10.1038/nrg3248 PDF Bioinformatics: Next-generation omics p378 | doi:10.1038/nrg3250 PDF Small RNAs: miRNAs' strict schedule p378 | doi:10.1038/nrg3251 PDF Evolution: Converging on divergence p380 | doi:10.1038/nrg3247 PDF Gene regulation: Transcription factor clutch control p380 | doi:10.1038/nrg3249 PDF AN INTERVIEW WITH... Elaine Fuchs p381 | doi:10.1038/nrg3252 PDF IN BRIEF Technology: Less could be more for genome editing | Gene-environment interactions: Environmental effects on disease gene penetrance | Disease genetics: Population differentiation in type 2 diabetes risk | Stem cells: Mouse genetically tractable fertilization agent | Small RNAs: RNA-mediated mechanism for memory storage | Complex traits: Meta-analysis for mouse association mapping | Gene regulation: X chromosome spatial organization | Genotyping: Predicting genotypes from gene expression data PDF Genetics JOBS of the week Junior researcher in molecular biology and genetics field Faculty of Science, Palacky University Olomouc Postdoctoral Fellow in Mouse Genetics / Cancer Genomics Fred Hutchinson Cancer Research Center Full Professorship for Genetics Universität Leipzig Postdoctoral Fellowship University of Rochester Medical Center Research Associate - Genetics and Systems, 'An integrated study of RNA polymerase transcription' UCL More Science jobs from Genetics EVENT International conference on Genetic Syndromes & Gene Therapy 22.-24.10.12 Chicago, US More science events from
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REVIEWS		Top
Translational control in cellular and developmental processes Jian Kong & Paul Lasko p383 | doi:10.1038/nrg3184 Translational regulation in cellular and developmental processes allows a rapid response to external signals and contributes to protein localization. The mechanisms of translational regulation are shared between these processes and occur at all stages of translation. Abstract | Full Text | PDF
Article series: Translational genetics Mining electronic health records: towards better research applications and clinical care Peter B. Jensen, Lars J. Jensen & Søren Brunak p395 | doi:10.1038/nrg3208 The adoption of electronic health records will provide a rich resource for biomedical researchers. This Review discusses the potential for their use in informed decision making in the clinic, for a finer understanding of genotype-phenotype relationships and for selection of research cohorts, along with the current challenges for their mining and use. Abstract | Full Text | PDF
Foundations for the design and implementation of synthetic genetic circuits Adrian L. Slusarczyk, Allen Lin & Ron Weiss p406 | doi:10.1038/nrg3227 Progress in synthetic biology is facilitating the design and implementation of synthetic gene circuits. The parts and modules that must be combined in these systems and the barriers that must be overcome before more complex circuits are implemented are presented in this Review. Abstract | Full Text | PDF
Article series: Modes of transcriptional regulation Mechanisms and consequences of widespread random monoallelic expression Andrew Chess p421 | doi:10.1038/nrg3239 A suprisingly large proportion of mammalian genes are now known to be subject to random monoallelic expression. This Review discusses our latest understanding of the underlying mechanisms and of the implications for cellular functions and organismal evolution. Abstract | Full Text | PDF
Maintaining differentiated cellular identity Johan Holmberg & Thomas Perlmann p429 | doi:10.1038/nrg3209 The ability of cells to maintain their differentiated identity has important implications for therapeutic reprogramming approaches and for disease. This Review discusses the molecular mechanisms that maintain cellular identity; the robustness of these mechanisms seems to vary according to the organismal roles of distinct cell types. Abstract | Full Text | PDF
PERSPECTIVES		Top
SCIENCE AND SOCIETY The fate and future of patents on human genes and genetic diagnostic methods Isabelle Huys, Gert Matthijs & Geertrui Van Overwalle p441 | doi:10.1038/nrg3255 The authors argue that far from driving innovation, patent claims on human genes and genetic diagnostic methods are largely counterproductive. Although possible solutions to the inconsistencies in the current system are proposed, the authors expect patents to die out naturally. Abstract | Full Text | PDF | Supplementary information
Erratum: Regulation of cytoplasmic mRNA decay Daniel R. Schoenberg & Lynne E. Maquat p448 | doi:10.1038/nrg3254 Full Text | PDF
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